Detailed information for compound 734174

Basic information

Technical information
  • TDR Targets ID: 734174
  • Name: 2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-phen ylpropanamide
  • MW: 287.38 | Formula: C15H17N3OS
  • H donors: 1 H acceptors: 3 LogP: 3.15 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(Sc1nc(C)cc(n1)C)C)Nc1ccccc1
  • InChi: 1S/C15H17N3OS/c1-10-9-11(2)17-15(16-10)20-12(3)14(19)18-13-7-5-4-6-8-13/h4-9,12H,1-3H3,(H,18,19)
  • InChiKey: YJUPOUJZZZOVAZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-phenyl-propanamide
  • 2-[(4,6-dimethyl-2-pyrimidinyl)thio]-N-phenylpropanamide
  • 2-[(4,6-dimethylpyrimidin-2-yl)thio]-N-phenyl-propionamide
  • CBKinase1_017827
  • STK213738
  • CBKinase1_005427

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Latrophilin receptor protein 2 0.0063 0.073 0.1046
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0033 0.0271 0.0271
Loa Loa (eye worm) MH1 domain-containing protein 0.0033 0.0271 0.0389
Onchocerca volvulus 0.0016 0.0025 0.0196
Onchocerca volvulus 0.0036 0.0325 0.2578
Mycobacterium ulcerans hypothetical protein 0.0036 0.0325 0.4253
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0325 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0325 0.0465
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0067 0.0023
Echinococcus granulosus smad 0.0033 0.0271 0.0271
Brugia malayi Calcitonin receptor-like protein seb-1 0.0201 0.2781 0.3983
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.006 0.006
Echinococcus multilocularis cysteine protease 0.0016 0.0025 0.0025
Echinococcus granulosus dna polymerase kappa 0.0019 0.0067 0.0067
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.071 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0067 0.0112
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0067 0.0112
Loa Loa (eye worm) RNA binding protein 0.019 0.2624 0.3758
Loa Loa (eye worm) transcription factor SMAD2 0.0482 0.6982 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.006 0.5
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0325 0.4253
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.006 0.0516
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0067 0.0096
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0067 0.1421
Brugia malayi MH1 domain containing protein 0.0018 0.0052 0.0075
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.071 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.1175 0.1175
Brugia malayi MH2 domain containing protein 0.0033 0.0271 0.0389
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0025 0.0025
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0067 0.0622
Loa Loa (eye worm) hypothetical protein 0.0016 0.0025 0.0035
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0682 1
Loa Loa (eye worm) hypothetical protein 0.0137 0.1832 0.2624
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0033 0.0271 0.0271
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0067 0.0112
Onchocerca volvulus 0.0016 0.0025 0.0196
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0682 0.0682
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0067 0.0117
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0325 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0682 0.1947
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0036 0.0325 0.0465
Echinococcus multilocularis tumor protein p63 0.0676 0.9885 0.9885
Echinococcus granulosus tar DNA binding protein 0.019 0.2624 0.2624
Loa Loa (eye worm) hypothetical protein 0.0201 0.2781 0.3983
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0025 0.0025
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0682 0.0682
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0063 0.073 0.1046
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0325 0.4072
Echinococcus multilocularis GPCR, family 2 0.0063 0.073 0.073
Onchocerca volvulus 0.0036 0.0325 0.2578
Loa Loa (eye worm) Smad1 0.0033 0.0271 0.0389
Trypanosoma brucei unspecified product 0.0019 0.0067 0.0112
Giardia lamblia DINP protein human, muc B family 0.0019 0.0067 1
Schistosoma mansoni ap endonuclease 0.0019 0.006 0.006
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0201 0.2781 0.3983
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0067 0.0023
Schistosoma mansoni tar DNA-binding protein 0.019 0.2624 0.2624
Echinococcus multilocularis microtubule associated protein 2 0.0683 1 1
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0325 0.0828
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0682 0.0682
Schistosoma mansoni tar DNA-binding protein 0.019 0.2624 0.2624
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0067 0.0622
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0067 0.0067
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0325 0.0325
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0067 0.1421
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0067 0.0112
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0325 0.4378
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.063 0.8824
Echinococcus granulosus tumor protein p63 0.0676 0.9885 0.9885
Leishmania major cathepsin L-like protease 0.0062 0.071 1
Brugia malayi MH2 domain containing protein 0.0033 0.0271 0.0389
Leishmania major DNA polymerase eta, putative 0.0019 0.0067 0.0622
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.006 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0067 0.0112
Brugia malayi MH1 domain containing protein 0.0033 0.0271 0.0389
Onchocerca volvulus 0.0099 0.126 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0325 0.0325
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0325 1
Schistosoma mansoni cellular tumor antigen P53 0.0099 0.126 0.126
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0201 0.2781 0.3983
Loa Loa (eye worm) MH2 domain-containing protein 0.0033 0.0271 0.0389
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0067 0.0622
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0325 0.0828
Loa Loa (eye worm) latrophilin receptor protein 2 0.0063 0.073 0.1046
Entamoeba histolytica hypothetical protein 0.0071 0.0838 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0067 0.0112
Loa Loa (eye worm) hypothetical protein 0.0063 0.073 0.1046
Brugia malayi Smad1 0.0033 0.0271 0.0389
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0838 0.0838
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.1175 0.1175
Loa Loa (eye worm) hypothetical protein 0.0036 0.0325 0.0465
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.071 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0325 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0325 0.4253
Schistosoma mansoni tar DNA-binding protein 0.019 0.2624 0.2624
Entamoeba histolytica hypothetical protein 0.0071 0.0838 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0067 0.0112
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0325 0.0828
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0025 0.0025
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0025 0.0196
Schistosoma mansoni ap endonuclease 0.0019 0.006 0.006
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0067 0.0622
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.071 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0325 0.0325
Toxoplasma gondii ABC1 family protein 0.0036 0.0325 0.4562
Mycobacterium ulcerans lipase LipD 0.0036 0.0325 0.4253
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0067 0.0112
Brugia malayi Cathepsin L-like precursor 0.0016 0.0025 0.0035
Schistosoma mansoni smad1 5 8 and 0.0033 0.0271 0.0271
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.1175 0.1175
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0682 0.9596
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.006 0.0435
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0067 0.0525
Loa Loa (eye worm) TAR-binding protein 0.019 0.2624 0.3758
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0325 0.0828
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0325 0.0465
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.071 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0067 0.0112
Loa Loa (eye worm) beta-lactamase 0.0036 0.0325 0.0465
Schistosoma mansoni smad 0.0033 0.0271 0.0271
Brugia malayi Cathepsin L-like precursor 0.0016 0.0025 0.0035
Brugia malayi beta-lactamase family protein 0.0036 0.0325 0.0465
Schistosoma mansoni smad1 5 8 and 0.0033 0.0271 0.0271
Leishmania major cathepsin L-like protease 0.0062 0.071 1
Mycobacterium ulcerans beta-lactamase 0.0036 0.0325 0.4253
Echinococcus multilocularis thyroid hormone receptor alpha 0.0139 0.1855 0.1855
Schistosoma mansoni hypothetical protein 0.0071 0.0838 0.0838
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.1175 0.1175
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0325 0.5
Echinococcus granulosus cathepsin l1 0.0016 0.0025 0.0025
Loa Loa (eye worm) fibroinase 0.0016 0.0025 0.0035
Schistosoma mansoni thyroid hormone receptor 0.0139 0.1855 0.1855
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.071 1
Brugia malayi TAR-binding protein 0.019 0.2624 0.3758
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.006 0.0516
Brugia malayi beta-lactamase family protein 0.0036 0.0325 0.0465
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0067 0.0067
Loa Loa (eye worm) ctsf protein 0.0016 0.0025 0.0035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.071 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.071 1
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0128 0.1701 0.1701
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0682 1
Schistosoma mansoni hypothetical protein 0.0063 0.073 0.073
Schistosoma mansoni hypothetical protein 0.0063 0.073 0.073
Entamoeba histolytica hypothetical protein 0.0071 0.0838 1
Onchocerca volvulus 0.0016 0.0025 0.0196
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0025 0.0196
Brugia malayi Cathepsin L-like precursor 0.0016 0.0025 0.0035
Brugia malayi MH1 domain containing protein 0.0018 0.0052 0.0075
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0025 0.0025
Echinococcus multilocularis tar DNA binding protein 0.019 0.2624 0.2624
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0838 0.0838
Echinococcus granulosus dna polymerase eta 0.0019 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0036 0.0325 0.0465
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0325 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.126 0.1804
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0063 0.073 0.073
Mycobacterium leprae Probable lipase LipE 0.0036 0.0325 0.5
Schistosoma mansoni smad1 5 8 and 0.0033 0.0271 0.0271
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.071 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0067 0.0622
Loa Loa (eye worm) nuclear factor I 0.0018 0.0052 0.0075
Loa Loa (eye worm) hypothetical protein 0.0036 0.0325 0.0465
Loa Loa (eye worm) hypothetical protein 0.0018 0.0052 0.0075
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0025 0.0025
Schistosoma mansoni microtubule-associated protein tau 0.0683 1 1
Mycobacterium tuberculosis Conserved protein 0.0036 0.0325 0.0828
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0067 0.0067
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0838 0.0838
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.1175 0.1175
Echinococcus granulosus mothers against decapentaplegic 5 0.0033 0.0271 0.0271
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.071 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.006 0.1178
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0067 0.0112
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0325 0.0325
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0025 0.0196
Echinococcus multilocularis dna polymerase eta 0.0019 0.0067 0.0067
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0325 0.4378
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0067 0.0096
Brugia malayi RNA recognition motif domain containing protein 0.019 0.2624 0.3758
Echinococcus granulosus Smad4 0.0033 0.0271 0.0271
Schistosoma mansoni hypothetical protein 0.0063 0.073 0.073
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.006 0.0086
Toxoplasma gondii exonuclease III APE 0.0019 0.006 0.0537
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.006 1
Onchocerca volvulus 0.0036 0.0325 0.2578
Echinococcus multilocularis mothers against decapentaplegic 5 0.0033 0.0271 0.0271
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.1175 0.1175
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0067 0.0112
Brugia malayi latrophilin 2 splice variant baaae 0.0137 0.1832 0.2624
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0025 0.0025
Echinococcus granulosus GPCR family 2 0.0063 0.073 0.073
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0067 0.0067
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0325 0.0828
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.071 1
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0325 0.0828
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.019 0.2624 0.3758
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0025 0.0035
Echinococcus granulosus TGF beta signal transducer SmadC 0.0033 0.0271 0.0271
Loa Loa (eye worm) hypothetical protein 0.0019 0.0067 0.0096
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.071 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0067 0.0112
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0232 0.3257 1
Echinococcus multilocularis smad 0.0033 0.0271 0.0271
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.071 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0067 0.0112
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.071 1
Schistosoma mansoni hypothetical protein 0.0128 0.1701 0.1701
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0067 0.0117
Brugia malayi RNA binding protein 0.019 0.2624 0.3758
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0325 0.0465
Schistosoma mansoni Smad4 0.0033 0.0271 0.0271
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.006 0.1178
Schistosoma mansoni hypothetical protein 0.0063 0.073 0.073
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.1175 0.1683
Onchocerca volvulus 0.0016 0.0025 0.0196
Schistosoma mansoni DNA polymerase eta 0.0019 0.0067 0.0067
Leishmania major hypothetical protein, conserved 0.0036 0.0325 0.4378
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0682 1
Schistosoma mansoni thyroid hormone receptor 0.0139 0.1855 0.1855
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0063 0.073 0.073
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.071 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0025 0.0035
Echinococcus multilocularis Smad4 0.0033 0.0271 0.0271
Brugia malayi Cathepsin L-like precursor 0.0016 0.0025 0.0035
Loa Loa (eye worm) hypothetical protein 0.0036 0.0325 0.0465
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0067 0.0112
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.006 0.0516
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0511 0.7098
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0063 0.073 0.073
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0325 1
Brugia malayi Cathepsin L-like precursor 0.0016 0.0025 0.0035
Entamoeba histolytica hypothetical protein 0.0071 0.0838 1
Mycobacterium tuberculosis Conserved protein 0.0036 0.0325 0.0828
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0067 0.0067
Loa Loa (eye worm) cysteine protease 0.0016 0.0025 0.0035
Schistosoma mansoni tar DNA-binding protein 0.019 0.2624 0.2624
Brugia malayi MH2 domain containing protein 0.0482 0.6982 1
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0325 0.0828
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.006 0.0086
Brugia malayi Cathepsin L-like precursor 0.0016 0.0025 0.0035
Echinococcus multilocularis cysteine protease 0.0016 0.0025 0.0025
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0025 0.0035
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0025 0.0025
Onchocerca volvulus 0.0016 0.0025 0.0196
Brugia malayi MH1 domain containing protein 0.0033 0.0271 0.0389
Brugia malayi beta-lactamase 0.0036 0.0325 0.0465
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0682 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.1175 0.1175
Trichomonas vaginalis esterase, putative 0.0036 0.0325 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.1175 0.1683
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0067 0.0096
Onchocerca volvulus 0.0016 0.0025 0.0196
Leishmania major DNA polymerase kappa, putative 0.0019 0.0067 0.0622
Leishmania major cathepsin L-like protease 0.0062 0.071 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0067 0.0622
Brugia malayi hypothetical protein 0.0071 0.0838 0.12
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0025 0.0025
Schistosoma mansoni tar DNA-binding protein 0.019 0.2624 0.2624
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0128 0.1701 0.1701
Schistosoma mansoni hypothetical protein 0.0137 0.1832 0.1832
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.006 0.1178
Loa Loa (eye worm) MH2 domain-containing protein 0.0482 0.6982 1
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0682 0.0682
Onchocerca volvulus 0.0016 0.0025 0.0196
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0063 0.073 0.073
Mycobacterium tuberculosis Conserved protein 0.0036 0.0325 0.0828

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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