Detailed information for compound 734524

Basic information

Technical information
  • TDR Targets ID: 734524
  • Name: N-[2-[1-methyl-5-(phenylcarbamoylamino)benzim idazol-2-yl]ethyl]acetamide
  • MW: 351.402 | Formula: C19H21N5O2
  • H donors: 3 H acceptors: 3 LogP: 1.61 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccccc1)Nc1ccc2c(c1)nc(n2C)CCNC(=O)C
  • InChi: 1S/C19H21N5O2/c1-13(25)20-11-10-18-23-16-12-15(8-9-17(16)24(18)2)22-19(26)21-14-6-4-3-5-7-14/h3-9,12H,10-11H2,1-2H3,(H,20,25)(H2,21,22,26)
  • InChiKey: KNZCRLUUZUYQKV-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-[2-[1-methyl-5-[[oxo-(phenylamino)methyl]amino]-2-benzimidazolyl]ethyl]acetamide
  • N-[2-[1-methyl-5-(phenylcarbamoylamino)benzimidazol-2-yl]ethyl]ethanamide
  • CBKinase1_010713
  • ZINC02355447
  • STOCK5S-57127
  • CBKinase1_023113

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0049 0.0318 0.0256
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0046 0.0285 0.0211
Onchocerca volvulus 0.006 0.0428 0.1371
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0382 0.1517
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0381 0.0712
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0533 0.5356 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0093 0.077 0.7084
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0034 0.0157 0.0028
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.0054
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0104 0.0123
Mycobacterium tuberculosis Probable lipase LipD 0.011 0.095 0.1315
Brugia malayi RNA recognition motif domain containing protein 0.0533 0.5356 1
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0143 0.0268
Plasmodium vivax hypothetical protein, conserved 0.011 0.095 1
Mycobacterium ulcerans beta-lactamase 0.011 0.095 1
Mycobacterium leprae conserved hypothetical protein 0.011 0.095 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0093 0.077 0.7084
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0143 0.0268
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0129 0.0489
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0326 0.1292
Loa Loa (eye worm) hypothetical protein 0.011 0.095 0.1774
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.095 0.383
Brugia malayi beta-lactamase family protein 0.011 0.095 0.1774
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0573 0.2294
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0129 0.0489
Schistosoma mansoni chromobox protein 0.0084 0.0682 0.075
Onchocerca volvulus 0.011 0.095 0.3582
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0017
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0093 0.077 0.1437
Echinococcus granulosus mothers against decapentaplegic 5 0.0034 0.0157 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0573 0.2294
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0154 0.0588
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0093 0.077 0.087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0523 0.2091
Echinococcus granulosus tar DNA binding protein 0.0533 0.5356 0.7096
Schistosoma mansoni hypothetical protein 0.0032 0.0143 0.0019
Mycobacterium tuberculosis Probable hydrolase 0.011 0.095 0.1315
Schistosoma mansoni smad1 5 8 and 0.0034 0.0157 0.0037
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0428 0.0405
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0297 0.1172
Brugia malayi beta-lactamase 0.011 0.095 0.1774
Loa Loa (eye worm) beta-lactamase 0.011 0.095 0.1774
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0143 0.0014
Schistosoma mansoni microtubule-associated protein tau 0.0739 0.7495 1
Leishmania major hypothetical protein, conserved 0.011 0.095 1
Schistosoma mansoni smad1 5 8 and 0.0034 0.0157 0.0037
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0102 0.0872 0.1628
Mycobacterium tuberculosis Conserved protein 0.011 0.095 0.1315
Loa Loa (eye worm) hypothetical protein 0.0119 0.1044 0.1949
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0093 0.077 0.7804
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0629 0.2523
Echinococcus granulosus tumor protein p63 0.0408 0.4054 0.5328
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0523 0.2091
Loa Loa (eye worm) MH2 domain-containing protein 0.0034 0.0157 0.0293
Schistosoma mansoni tar DNA-binding protein 0.0533 0.5356 0.7096
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0143 0.002
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0104 0.0194
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.0054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0376 0.1494
Echinococcus granulosus smad 0.0034 0.0157 0.0038
Trichomonas vaginalis set domain proteins, putative 0.0255 0.2466 1
Schistosoma mansoni hypothetical protein 0.0032 0.0143 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0523 0.2091
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0141 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0523 0.2091
Mycobacterium ulcerans hypothetical protein 0.011 0.095 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0034 0.0157 0.0038
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0143 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0382 0.1517
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0682 0.2739
Brugia malayi MH2 domain containing protein 0.0034 0.0157 0.0293
Mycobacterium tuberculosis Probable lipase LipE 0.011 0.095 0.1315
Trypanosoma brucei hypothetical protein, conserved 0.011 0.095 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0141 0.0016
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0093 0.077 0.0649
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0573 0.2294
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.1044 0.0926
Schistosoma mansoni hypothetical protein 0.0032 0.0143 0.0019
Echinococcus multilocularis chromobox protein 1 0.0084 0.0682 0.056
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0141 0.0017
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.095 0.1114
Echinococcus granulosus chromobox protein 1 0.0084 0.0682 0.0751
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0104 0.0194
Schistosoma mansoni hypothetical protein 0.0049 0.0318 0.0256
Echinococcus multilocularis expressed conserved protein 0.0112 0.0969 0.085
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0381 0.0342
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0141 0.0016
Onchocerca volvulus 0.0046 0.0285 0.0764
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0044 0.0262 0.1615
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.1575 0.1963
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0104 0.0818
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0104 0.0123
Loa Loa (eye worm) hypothetical protein 0.0029 0.0104 0.0194
Schistosoma mansoni patched 1 0.0051 0.0337 0.0282
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0376 0.1494
Echinococcus granulosus beta LACTamase domain containing family member 0.011 0.095 0.1115
Loa Loa (eye worm) MH1 domain-containing protein 0.0034 0.0157 0.0293
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0129 0.0489
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.011 0.095 0.1315
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0224 0.2143 0.4001
Brugia malayi MH1 domain containing protein 0.0034 0.0157 0.0293
Schistosoma mansoni hypothetical protein 0.0032 0.0143 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0093 0.077 0.3096
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.095 0.1114
Trichomonas vaginalis PIKK family atypical protein kinase 0.0093 0.077 0.3096
Onchocerca volvulus 0.011 0.095 0.3582
Echinococcus granulosus GPCR family 2 0.0032 0.0143 0.002
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0381 0.0342
Toxoplasma gondii ABC1 family protein 0.011 0.095 1
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0337 0.1335
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0029 0.5
Brugia malayi RNA binding protein 0.0533 0.5356 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.011 0.095 0.1774
Loa Loa (eye worm) hypothetical protein 0.0029 0.0104 0.0194
Trypanosoma cruzi target of rapamycin kinase 3 0.0074 0.0573 0.5411
Loa Loa (eye worm) hypothetical protein 0.006 0.0428 0.0799
Echinococcus multilocularis mothers against decapentaplegic 5 0.0034 0.0157 0.0028
Brugia malayi MH1 domain containing protein 0.0034 0.0157 0.0293
Loa Loa (eye worm) TAR-binding protein 0.0533 0.5356 1
Loa Loa (eye worm) hypothetical protein 0.011 0.095 0.1774
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0382 0.1517
Brugia malayi MH2 domain containing protein 0.0494 0.4952 0.9245
Schistosoma mansoni tar DNA-binding protein 0.0533 0.5356 0.7096
Echinococcus multilocularis Smad4 0.0034 0.0157 0.0028
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0104 0.0818
Schistosoma mansoni hypothetical protein 0.0205 0.1936 0.2453
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0573 0.2294
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.095 0.383
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0102 0.0872 0.1628
Loa Loa (eye worm) hypothetical protein 0.0032 0.0141 0.0264
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0702 0.7115 1
Schistosoma mansoni Smad4 0.0034 0.0157 0.0037
Mycobacterium tuberculosis Probable esterase LipL 0.011 0.095 0.1315
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0104 0.0818
Brugia malayi beta-lactamase family protein 0.011 0.095 0.1774
Mycobacterium leprae Probable lipase LipE 0.011 0.095 1
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0104 0.0194
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0093 0.077 0.7804
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0093 0.077 0.7869
Loa Loa (eye worm) hypothetical protein 0.011 0.095 0.1774
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0381 0.0342
Loa Loa (eye worm) phosphatidylinositol 3 0.0031 0.0129 0.0241
Brugia malayi MH2 domain containing protein 0.0034 0.0157 0.0293
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.0453 0.1805
Echinococcus granulosus expressed conserved protein 0.0112 0.0969 0.114
Leishmania major phosphatidylinositol 3-kinase, putative 0.0031 0.0129 0.0297
Echinococcus multilocularis GPCR, family 2 0.0032 0.0143 0.0014
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.1044 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0093 0.077 0.087
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0104 0.0818
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0334 0.1324
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0337 0.063
Mycobacterium tuberculosis Conserved protein 0.011 0.095 0.1315
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0326 0.1288
Mycobacterium ulcerans esterase/lipase LipP 0.011 0.095 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.006 0.0432 0.172
Echinococcus granulosus Smad4 0.0034 0.0157 0.0038
Brugia malayi CHE-14 protein 0.0051 0.0337 0.063
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.0054
Loa Loa (eye worm) hypothetical protein 0.0102 0.0872 0.1628
Brugia malayi Pre-SET motif family protein 0.0032 0.0141 0.0264
Echinococcus multilocularis protein dispatched 1 0.0058 0.0412 0.0287
Toxoplasma gondii target of rapamycin (TOR), putative 0.0069 0.0523 0.5459
Trichomonas vaginalis PIKK family atypical protein kinase 0.0093 0.077 0.3096
Echinococcus multilocularis tar DNA binding protein 0.0533 0.5356 0.5296
Schistosoma mansoni hypothetical protein 0.0049 0.0318 0.0256
Schistosoma mansoni smad 0.0034 0.0157 0.0037
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0334 0.1324
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0381 0.0255
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.095 0.383
Echinococcus multilocularis beta LACTamase domain containing family member 0.011 0.095 0.0832
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0065 0.0226
Schistosoma mansoni tar DNA-binding protein 0.0533 0.5356 0.7096
Echinococcus multilocularis tumor protein p63 0.0408 0.4054 0.3976
Echinococcus multilocularis smad 0.0034 0.0157 0.0028
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.095 1
Brugia malayi TAR-binding protein 0.0533 0.5356 1
Mycobacterium ulcerans lipase LipD 0.011 0.095 1
Schistosoma mansoni hypothetical protein 0.0049 0.0318 0.0256
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0031 0.0129 0.0297
Mycobacterium tuberculosis Conserved protein 0.011 0.095 0.1315
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0381 0.0712
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0154 0.0588
Trichomonas vaginalis esterase, putative 0.011 0.095 0.383
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0034 0.0157 0.0037
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.095 0.383
Schistosoma mansoni chromobox protein 0.0084 0.0682 0.075
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0104 0.0818
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0337 0.0283
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0029 0.0017
Brugia malayi Pre-SET motif family protein 0.0224 0.2143 0.4001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0523 0.2091
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.095 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.011 0.095 0.1315
Loa Loa (eye worm) hypothetical protein 0.0029 0.0104 0.0194
Brugia malayi Heterochromatin protein 1 0.0084 0.0682 0.1273
Echinococcus multilocularis protein patched 0.0051 0.0337 0.0211
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0682 0.2739
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0326 0.1288
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.1044 0.1242
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0104 0.0818
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0141 0.0012
Echinococcus granulosus geminin 0.0205 0.1936 0.2454
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0297 0.0817
Mycobacterium ulcerans hypothetical protein 0.0029 0.0104 0.0818
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0326 0.1292
Echinococcus granulosus microtubule associated protein 2 0.0739 0.7495 1
Echinococcus multilocularis chromobox protein 1 0.0084 0.0682 0.056
Loa Loa (eye worm) Smad1 0.0034 0.0157 0.0293
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0129 0.0489
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0143 0.0268
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0129 0.0489
Loa Loa (eye worm) MH2 domain-containing protein 0.0494 0.4952 0.9245
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0523 0.2091
Brugia malayi chromobox protein homolog 3 0.0047 0.0297 0.0555
Loa Loa (eye worm) phosphatidylinositol 3 0.0093 0.077 0.1437
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0031 0.0129 0.0241
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0523 0.2091
Schistosoma mansoni smad1 5 8 and 0.0034 0.0157 0.0037
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0141 0.1404
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.1575 0.1465
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0535 0.0998
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0093 0.077 0.7869
Echinococcus granulosus chromobox protein 1 0.0084 0.0682 0.0751
Onchocerca volvulus 0.0037 0.0191 0.0368
Loa Loa (eye worm) transcription factor SMAD2 0.0494 0.4952 0.9245
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0104 0.0818
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0381 0.0255
Loa Loa (eye worm) hypothetical protein 0.0051 0.0337 0.063
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.0682 0.1273
Brugia malayi Calcitonin receptor-like protein seb-1 0.0102 0.0872 0.1628
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0093 0.077 0.7804
Loa Loa (eye worm) hypothetical protein 0.0047 0.0297 0.0555
Schistosoma mansoni tar DNA-binding protein 0.0533 0.5356 0.7096
Brugia malayi Smad1 0.0034 0.0157 0.0293
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.095 0.383
Loa Loa (eye worm) hypothetical protein 0.0062 0.0457 0.0853
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0038 0.0206 0.0939
Schistosoma mansoni tar DNA-binding protein 0.0533 0.5356 0.7096
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.011 0.095 0.1774
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0143 0.0014
Onchocerca volvulus 0.0255 0.2466 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0381 0.0342
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0141 0.0012
Loa Loa (eye worm) RNA binding protein 0.0533 0.5356 1
Echinococcus multilocularis geminin 0.0205 0.1936 0.1831
Loa Loa (eye worm) hypothetical protein 0.0037 0.0191 0.0357
Loa Loa (eye worm) hypothetical protein 0.011 0.095 0.1774
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0381 0.0342
Giardia lamblia GTOR 0.0093 0.077 0.5
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0337 0.0283
Echinococcus multilocularis microtubule associated protein 2 0.0739 0.7495 0.7462
Schistosoma mansoni hypothetical protein 0.007 0.0535 0.0551
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0334 0.0975
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.011 0.095 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0326 0.1288
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0297 0.1172
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0326 0.1292
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0326 0.1292
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0337 0.0211
Loa Loa (eye worm) hypothetical protein 0.011 0.095 0.1774
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.011 0.095 0.1774
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0029 0.5
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.011 0.095 0.1315
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.0054
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0074 0.0573 0.5547
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0573 0.2294
Loa Loa (eye worm) hypothetical protein 0.007 0.0535 0.0998
Schistosoma mansoni hypothetical protein 0.0205 0.1936 0.2453
Plasmodium vivax SET domain protein, putative 0.0032 0.0141 0.1221
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0093 0.077 0.7804
Loa Loa (eye worm) hypothetical protein 0.0032 0.0143 0.0268
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0074 0.0573 0.5411
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.1063 0.1267
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.1044 0.1949
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.0054
Onchocerca volvulus 0.011 0.095 0.3582

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.3162 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 1.8526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 2.2387 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.9362 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5131 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.7456 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 10.3183 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5878 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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