Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0138 | 0.0231 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0138 | 0.0025 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0072 | 0.0386 | 0.1189 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.005 | 0.0229 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0029 | 0.0088 | 0.0111 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0032 | 0.0108 | 0.0233 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0138 | 0.0424 |
Schistosoma mansoni | hypothetical protein | 0.0114 | 0.0673 | 0.0566 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0138 | 0.0231 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.003 | 0.009 | 0.0123 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0037 | 0.0141 | 0.0432 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0116 | 0.0003 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0397 | 0.2643 | 0.8134 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0138 | 0.0414 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.005 | 0.0229 | 0.0118 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.0619 | 0.1743 |
Trypanosoma brucei | phosphatidylinositol 3-kinase tor, putative | 0.0024 | 0.0047 | 0.0985 |
Brugia malayi | beta-lactamase | 0.0037 | 0.0138 | 0.0424 |
Mycobacterium leprae | conserved hypothetical protein | 0.0037 | 0.0138 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0037 | 0.0141 | 0.0432 |
Leishmania major | hypothetical protein, conserved | 0.0037 | 0.0138 | 0.445 |
Mycobacterium ulcerans | hypothetical protein | 0.0037 | 0.0138 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0138 | 0.0414 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0037 | 0.0138 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0138 | 0.0424 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0029 | 0.0088 | 0.0111 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0138 | 0.0231 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0034 | 0.0116 | 0.0003 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0037 | 0.0138 | 0.0231 |
Schistosoma mansoni | microtubule-associated protein tau | 0.1456 | 1 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0033 | 0.0113 | 0.0009 |
Schistosoma mansoni | hypothetical protein | 0.0072 | 0.0386 | 0.0276 |
Entamoeba histolytica | hypothetical protein | 0.0114 | 0.0673 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0027 | 0.007 | 0.0002 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.004 | 0.0159 | 0.0542 |
Brugia malayi | RNA binding protein | 0.0397 | 0.2643 | 0.8134 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.004 | 0.0159 | 0.0542 |
Loa Loa (eye worm) | TAR-binding protein | 0.0397 | 0.2643 | 0.8096 |
Plasmodium vivax | hypothetical protein, conserved | 0.0037 | 0.0138 | 1 |
Onchocerca volvulus | 0.0099 | 0.057 | 0.2865 | |
Mycobacterium leprae | Probable lipase LipE | 0.0037 | 0.0138 | 0.5 |
Schistosoma mansoni | survival motor neuron protein | 0.0099 | 0.057 | 0.0462 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0138 | 0.0231 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0121 | 0.0727 | 0.208 |
Brugia malayi | Pre-SET motif family protein | 0.0033 | 0.0113 | 0.0348 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0037 | 0.0138 | 0.5 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0037 | 0.0138 | 0.0033 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.1456 | 1 | 1 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.005 | 0.0229 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0386 | 0.1012 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0037 | 0.0138 | 0.0424 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0034 | 0.0116 | 0.0012 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0037 | 0.0141 | 0.0432 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.004 | 0.0159 | 0.6514 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0037 | 0.0138 | 0.5466 |
Echinococcus granulosus | GPCR family 2 | 0.0034 | 0.0116 | 0.0012 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0027 | 0.007 | 0.0002 |
Brugia malayi | Pre-SET motif family protein | 0.0231 | 0.1486 | 0.4573 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.005 | 0.0229 | 0.0974 |
Brugia malayi | hypothetical protein | 0.0114 | 0.0673 | 0.207 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.003 | 0.009 | 0.0123 |
Entamoeba histolytica | hypothetical protein | 0.0114 | 0.0673 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0027 | 0.007 | 0.0002 |
Loa Loa (eye worm) | RNA binding protein | 0.0397 | 0.2643 | 0.8096 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0034 | 0.0116 | 0.0003 |
Plasmodium vivax | SET domain protein, putative | 0.0033 | 0.0113 | 0.6676 |
Onchocerca volvulus | 0.0037 | 0.0138 | 0.0153 | |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0034 | 0.0116 | 0.0164 |
Leishmania major | target of rapamycin (TOR) kinase 1, putative | 0.005 | 0.0229 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0113 | 0.0154 |
Leishmania major | target of rapamycin (TOR) kinase 2, putative | 0.005 | 0.0229 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0114 | 0.0673 | 0.0566 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.005 | 0.0229 | 0.0519 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0138 | 0.0025 |
Echinococcus multilocularis | GPCR, family 2 | 0.0034 | 0.0116 | 0.0003 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0121 | 0.0727 | 0.208 |
Toxoplasma gondii | ABC1 family protein | 0.0037 | 0.0138 | 0.9601 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0037 | 0.0141 | 0.0432 |
Onchocerca volvulus | 0.0037 | 0.0138 | 0.0153 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0397 | 0.2643 | 0.2559 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.005 | 0.0229 | 0.0974 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0064 | 0.5 |
Trichomonas vaginalis | esterase, putative | 0.0037 | 0.0138 | 0.0414 |
Onchocerca volvulus | 0.0037 | 0.0138 | 0.0153 | |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0485 | 0.325 | 0.3178 |
Echinococcus multilocularis | tar DNA binding protein | 0.0397 | 0.2643 | 0.2559 |
Loa Loa (eye worm) | hypothetical protein | 0.0485 | 0.325 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0397 | 0.2643 | 0.2565 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.0138 | 0.0414 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0138 | 0.445 |
Mycobacterium ulcerans | lipase LipD | 0.0037 | 0.0138 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.0115 | 0.0278 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0034 | 0.0116 | 0.0012 |
Trichomonas vaginalis | set domain proteins, putative | 0.0263 | 0.1707 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0138 | 0.445 |
Mycobacterium ulcerans | beta-lactamase | 0.0037 | 0.0138 | 0.5 |
Toxoplasma gondii | target of rapamycin (TOR), putative | 0.0037 | 0.0141 | 1 |
Leishmania major | target of rapamycin kinase (TOR) kinase 3 | 0.004 | 0.0159 | 0.5733 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0114 | 0.0673 | 0.0574 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0231 | 0.1486 | 0.4464 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0033 | 0.0113 | 0.6409 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0116 | 0.0003 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0034 | 0.0116 | 0.0358 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0106 | 0.0619 | 0.1906 |
Onchocerca volvulus | 0.0263 | 0.1707 | 1 | |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0234 | 0.1508 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.003 | 0.009 | 0.0123 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0064 | 0.0197 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0043 | 0.0179 | 0.0665 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.0138 | 0.0414 |
Brugia malayi | TAR-binding protein | 0.0397 | 0.2643 | 0.8134 |
Brugia malayi | hypothetical protein | 0.0485 | 0.325 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.0064 | 0.183 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0138 | 0.0231 |
Entamoeba histolytica | hypothetical protein | 0.0114 | 0.0673 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0037 | 0.0138 | 0.0025 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0114 | 0.0673 | 0.0566 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.005 | 0.0229 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0034 | 0.0116 | 0.0358 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.004 | 0.0159 | 0.0542 |
Schistosoma mansoni | tar DNA-binding protein | 0.0397 | 0.2643 | 0.2559 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0027 | 0.007 | 0.0002 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0397 | 0.2643 | 0.8096 |
Schistosoma mansoni | tar DNA-binding protein | 0.0397 | 0.2643 | 0.2559 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0037 | 0.0141 | 0.0432 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0116 | 0.0003 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0106 | 0.0619 | 0.1743 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.005 | 0.0229 | 1 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.005 | 0.0229 | 0.0118 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0485 | 0.325 | 0.3172 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0116 | 0.0164 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.005 | 0.0229 | 0.0126 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0099 | 0.057 | 0.1754 |
Giardia lamblia | GTOR | 0.005 | 0.0229 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0037 | 0.0141 | 0.0432 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0116 | 0.0003 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0064 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0099 | 0.057 | 0.0462 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0037 | 0.0141 | 0.0432 |
Schistosoma mansoni | tar DNA-binding protein | 0.0397 | 0.2643 | 0.2559 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.004 | 0.0159 | 0.0542 |
Brugia malayi | MH2 domain containing protein | 0.0121 | 0.0727 | 0.2236 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0106 | 0.0619 | 0.1906 |
Entamoeba histolytica | hypothetical protein | 0.0114 | 0.0673 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0138 | 0.0414 |
Schistosoma mansoni | tar DNA-binding protein | 0.0397 | 0.2643 | 0.2559 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.005 | 0.0229 | 0.0706 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0138 | 0.0231 |
Trypanosoma cruzi | target of rapamycin kinase 3 | 0.004 | 0.0159 | 0.5733 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.005 | 0.0229 | 0.0974 |
Loa Loa (eye worm) | beta-lactamase | 0.0037 | 0.0138 | 0.0231 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.004 | 0.0159 | 0.0542 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.