Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.1614 | 0.4132 |
Echinococcus granulosus | jumonji domain containing protein | 0.004 | 0.0151 | 0.0178 |
Echinococcus multilocularis | importin subunit beta 1 | 0.003 | 0.0017 | 0.0017 |
Giardia lamblia | PHD finger protein 15 | 0.0029 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0565 | 0.1446 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0072 | 0.0565 | 0.0932 |
Onchocerca volvulus | 0.0072 | 0.0565 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0248 | 0.0293 |
Schistosoma mansoni | hypothetical protein | 0.0073 | 0.0579 | 0.0685 |
Echinococcus granulosus | tumor protein p63 | 0.0333 | 0.4034 | 0.4772 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0072 | 0.0565 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.0653 | 1 |
Brugia malayi | RNA, U transporter 1 | 0.0086 | 0.0759 | 0.2526 |
Loa Loa (eye worm) | TAR-binding protein | 0.0255 | 0.3003 | 0.7688 |
Echinococcus multilocularis | jumonji domain containing protein | 0.004 | 0.0151 | 0.0151 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0073 | 0.0579 | 0.0685 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0017 | 0.0045 |
Onchocerca volvulus | 0.0072 | 0.0565 | 1 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0255 | 0.3003 | 0.3553 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0152 | 0.1628 | 0.1926 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.0088 | 0.0105 |
Brugia malayi | RNA binding protein | 0.0255 | 0.3003 | 1 |
Echinococcus multilocularis | geminin | 0.0168 | 0.1851 | 0.1851 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0036 | 0.0088 | 0.0088 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.0579 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0666 | 0.8453 | 0.8453 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0051 | 0.0296 | 0.0455 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.0579 | 1 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0078 | 0.0653 | 0.0772 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0072 | 0.0565 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0072 | 0.0565 | 1 |
Plasmodium vivax | importin-beta 2, putative | 0.003 | 0.0017 | 0.0267 |
Schistosoma mansoni | tar DNA-binding protein | 0.0255 | 0.3003 | 0.3553 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0128 | 0.1316 | 0.1316 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0152 | 0.1628 | 0.1628 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0048 | 0.0248 | 0.0293 |
Mycobacterium tuberculosis | Conserved protein | 0.0072 | 0.0565 | 0.0932 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0051 | 0.0296 | 0.4179 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0051 | 0.0296 | 0.0455 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0051 | 0.0296 | 0.0296 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0078 | 0.0653 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0565 | 0.1446 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0078 | 0.0653 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0072 | 0.0565 | 0.1446 |
Mycobacterium ulcerans | hypothetical protein | 0.0072 | 0.0565 | 0.8441 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0982 | 0.2513 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0255 | 0.3003 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0476 | 0.1217 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0151 | 0.1614 | 0.5375 |
Brugia malayi | Importin beta-1 subunit | 0.003 | 0.0017 | 0.0058 |
Schistosoma mansoni | tar DNA-binding protein | 0.0255 | 0.3003 | 0.3553 |
Echinococcus multilocularis | tumor protein p63 | 0.0333 | 0.4034 | 0.4034 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0138 | 0.1453 | 0.1453 |
Mycobacterium tuberculosis | Conserved protein | 0.0072 | 0.0565 | 0.0932 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.0653 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0073 | 0.0579 | 0.0685 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0078 | 0.0653 | 1 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0049 | 0.0262 | 0.031 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0048 | 0.0248 | 0.0825 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0262 | 0.0671 |
Echinococcus granulosus | GPCR family 2 | 0.0048 | 0.0248 | 0.0293 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0072 | 0.0565 | 0.0668 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0072 | 0.0565 | 0.0932 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0151 | 0.1614 | 0.5375 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0072 | 0.0565 | 0.0565 |
Toxoplasma gondii | ABC1 family protein | 0.0072 | 0.0565 | 0.8653 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.1851 | 0.2189 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0072 | 0.0565 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.0579 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0255 | 0.3003 | 0.3553 |
Schistosoma mansoni | thyroid hormone receptor | 0.0138 | 0.1453 | 0.1719 |
Mycobacterium leprae | conserved hypothetical protein | 0.0072 | 0.0565 | 0.8567 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0072 | 0.0565 | 0.0668 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0666 | 0.8453 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0248 | 0.0293 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0072 | 0.0565 | 0.0932 |
Mycobacterium tuberculosis | Conserved protein | 0.0072 | 0.0565 | 0.0932 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0092 | 0.0834 | 0.0987 |
Onchocerca volvulus | 0.0049 | 0.0262 | 0.4641 | |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0072 | 0.0565 | 0.0932 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0255 | 0.3003 | 0.7688 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0072 | 0.0565 | 0.0932 |
Plasmodium vivax | hypothetical protein, conserved | 0.0072 | 0.0565 | 0.8653 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0128 | 0.1316 | 0.1557 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0151 | 0.1614 | 0.4132 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0051 | 0.0296 | 0.035 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.0088 | 0.0105 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0072 | 0.0565 | 0.8441 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0565 | 0.1446 |
Schistosoma mansoni | importin beta-1 | 0.003 | 0.0017 | 0.0021 |
Echinococcus multilocularis | tar DNA binding protein | 0.0255 | 0.3003 | 0.3003 |
Brugia malayi | beta-lactamase | 0.0072 | 0.0565 | 0.1881 |
Echinococcus granulosus | tar DNA binding protein | 0.0255 | 0.3003 | 0.3553 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0048 | 0.0248 | 0.0293 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.0653 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0048 | 0.0248 | 0.0634 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0092 | 0.0834 | 0.2135 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0248 | 0.0293 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0048 | 0.0248 | 0.0248 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0072 | 0.0565 | 1 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0092 | 0.0834 | 0.0987 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.003 | 0.0017 | 0.0267 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0666 | 0.8453 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.0653 | 0.5 |
Echinococcus granulosus | snurportin 1 | 0.0323 | 0.3907 | 0.4622 |
Schistosoma mansoni | tar DNA-binding protein | 0.0255 | 0.3003 | 0.3553 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0078 | 0.0653 | 0.0653 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0323 | 0.3907 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0073 | 0.0579 | 0.0579 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.0653 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.0132 | 0.1369 | 0.162 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.0579 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0048 | 0.0248 | 0.0825 |
Brugia malayi | TAR-binding protein | 0.0255 | 0.3003 | 1 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0036 | 0.0088 | 0.0105 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0072 | 0.0565 | 0.0932 |
Mycobacterium ulcerans | beta-lactamase | 0.0072 | 0.0565 | 0.8441 |
Loa Loa (eye worm) | RNA binding protein | 0.0255 | 0.3003 | 0.7688 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0072 | 0.0565 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0092 | 0.0834 | 0.2777 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0072 | 0.0565 | 0.0668 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.0653 | 0.5 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0036 | 0.0088 | 0.1355 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.1851 | 0.2189 |
Echinococcus granulosus | geminin | 0.0168 | 0.1851 | 0.2189 |
Echinococcus granulosus | importin subunit beta 1 | 0.003 | 0.0017 | 0.0021 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0248 | 0.0634 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0092 | 0.0834 | 0.0834 |
Schistosoma mansoni | hypothetical protein | 0.0323 | 0.3907 | 0.4622 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0565 | 0.1446 |
Brugia malayi | jmjC domain containing protein | 0.0152 | 0.1628 | 0.5421 |
Brugia malayi | beta-lactamase family protein | 0.0072 | 0.0565 | 0.1881 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0088 | 0.1297 |
Loa Loa (eye worm) | inositol-1 | 0.0036 | 0.0088 | 0.0226 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0092 | 0.0834 | 0.0987 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0457 | 0.5682 | 1 |
Echinococcus multilocularis | snurportin 1 | 0.0323 | 0.3907 | 0.3907 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0072 | 0.0565 | 0.1446 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0072 | 0.0565 | 0.0932 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0078 | 0.0653 | 0.0772 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0103 | 0.0982 | 0.3269 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0072 | 0.0565 | 0.8441 |
Brugia malayi | hypothetical protein | 0.0073 | 0.0579 | 0.1929 |
Brugia malayi | beta-lactamase family protein | 0.0072 | 0.0565 | 0.1881 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.0653 | 0.1671 |
Schistosoma mansoni | hypothetical protein | 0.0103 | 0.0982 | 0.1162 |
Brugia malayi | Probable ClpP-like protease | 0.0078 | 0.0653 | 0.2174 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0078 | 0.0653 | 1 |
Brugia malayi | Inositol-1 | 0.0036 | 0.0088 | 0.0295 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0072 | 0.0565 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0072 | 0.0565 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0072 | 0.0565 | 0.8441 |
Schistosoma mansoni | thyroid hormone receptor | 0.0138 | 0.1453 | 0.1719 |
Schistosoma mansoni | hypothetical protein | 0.0128 | 0.1316 | 0.1557 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.006 | 0.0409 | 0.1048 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0248 | 0.0293 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0565 | 0.1446 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0078 | 0.0653 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0072 | 0.0565 | 1 |
Plasmodium falciparum | importin beta, putative | 0.003 | 0.0017 | 0.0267 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0072 | 0.0565 | 0.1881 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0048 | 0.0248 | 0.0248 |
Echinococcus multilocularis | GPCR, family 2 | 0.0048 | 0.0248 | 0.0248 |
Onchocerca volvulus | 0.0072 | 0.0565 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0565 | 0.1446 |
Mycobacterium leprae | Probable lipase LipE | 0.0072 | 0.0565 | 0.8567 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0072 | 0.0565 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.