Detailed information for compound 735098

Basic information

Technical information
  • TDR Targets ID: 735098
  • Name: ST5426557
  • MW: 289.353 | Formula: C14H15N3O2S
  • H donors: 1 H acceptors: 4 LogP: 2.64 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCn1c(SCC(=O)O)nnc1c1cccc(c1)C
  • InChi: 1S/C14H15N3O2S/c1-3-7-17-13(11-6-4-5-10(2)8-11)15-16-14(17)20-9-12(18)19/h3-6,8H,1,7,9H2,2H3,(H,18,19)
  • InChiKey: WRESDJFYJKVBCD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • CBKinase1_013136
  • CBKinase1_000736

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0151 0.1614 0.4132
Echinococcus granulosus jumonji domain containing protein 0.004 0.0151 0.0178
Echinococcus multilocularis importin subunit beta 1 0.003 0.0017 0.0017
Giardia lamblia PHD finger protein 15 0.0029 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0072 0.0565 0.1446
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0565 0.0932
Onchocerca volvulus 0.0072 0.0565 1
Schistosoma mansoni hypothetical protein 0.0048 0.0248 0.0293
Schistosoma mansoni hypothetical protein 0.0073 0.0579 0.0685
Echinococcus granulosus tumor protein p63 0.0333 0.4034 0.4772
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0565 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0653 1
Brugia malayi RNA, U transporter 1 0.0086 0.0759 0.2526
Loa Loa (eye worm) TAR-binding protein 0.0255 0.3003 0.7688
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0151 0.0151
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0579 0.0685
Loa Loa (eye worm) hypothetical protein 0.003 0.0017 0.0045
Onchocerca volvulus 0.0072 0.0565 1
Schistosoma mansoni tar DNA-binding protein 0.0255 0.3003 0.3553
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0152 0.1628 0.1926
Schistosoma mansoni inositol monophosphatase 0.0036 0.0088 0.0105
Brugia malayi RNA binding protein 0.0255 0.3003 1
Echinococcus multilocularis geminin 0.0168 0.1851 0.1851
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0088 0.0088
Entamoeba histolytica hypothetical protein 0.0073 0.0579 1
Echinococcus multilocularis microtubule associated protein 2 0.0666 0.8453 0.8453
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.0296 0.0455
Entamoeba histolytica hypothetical protein 0.0073 0.0579 1
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0078 0.0653 0.0772
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0565 1
Leishmania major hypothetical protein, conserved 0.0072 0.0565 1
Plasmodium vivax importin-beta 2, putative 0.003 0.0017 0.0267
Schistosoma mansoni tar DNA-binding protein 0.0255 0.3003 0.3553
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0128 0.1316 0.1316
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0152 0.1628 0.1628
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0248 0.0293
Mycobacterium tuberculosis Conserved protein 0.0072 0.0565 0.0932
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0296 0.4179
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.0296 0.0455
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0296 0.0296
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0653 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0565 0.1446
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0078 0.0653 1
Loa Loa (eye worm) beta-lactamase 0.0072 0.0565 0.1446
Mycobacterium ulcerans hypothetical protein 0.0072 0.0565 0.8441
Loa Loa (eye worm) hypothetical protein 0.0103 0.0982 0.2513
Brugia malayi RNA recognition motif domain containing protein 0.0255 0.3003 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0476 0.1217
Brugia malayi Calcitonin receptor-like protein seb-1 0.0151 0.1614 0.5375
Brugia malayi Importin beta-1 subunit 0.003 0.0017 0.0058
Schistosoma mansoni tar DNA-binding protein 0.0255 0.3003 0.3553
Echinococcus multilocularis tumor protein p63 0.0333 0.4034 0.4034
Echinococcus multilocularis thyroid hormone receptor alpha 0.0138 0.1453 0.1453
Mycobacterium tuberculosis Conserved protein 0.0072 0.0565 0.0932
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0653 0.5
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0579 0.0685
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0078 0.0653 1
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0262 0.031
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0248 0.0825
Loa Loa (eye worm) hypothetical protein 0.0049 0.0262 0.0671
Echinococcus granulosus GPCR family 2 0.0048 0.0248 0.0293
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0565 0.0668
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0565 0.0932
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0151 0.1614 0.5375
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0565 0.0565
Toxoplasma gondii ABC1 family protein 0.0072 0.0565 0.8653
Schistosoma mansoni hypothetical protein 0.0168 0.1851 0.2189
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0565 1
Entamoeba histolytica hypothetical protein 0.0073 0.0579 1
Schistosoma mansoni tar DNA-binding protein 0.0255 0.3003 0.3553
Schistosoma mansoni thyroid hormone receptor 0.0138 0.1453 0.1719
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0565 0.8567
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0565 0.0668
Echinococcus granulosus microtubule associated protein 2 0.0666 0.8453 1
Schistosoma mansoni hypothetical protein 0.0048 0.0248 0.0293
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0565 0.0932
Mycobacterium tuberculosis Conserved protein 0.0072 0.0565 0.0932
Schistosoma mansoni jumonji/arid domain-containing protein 0.0092 0.0834 0.0987
Onchocerca volvulus 0.0049 0.0262 0.4641
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0565 0.0932
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0255 0.3003 0.7688
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0565 0.0932
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0565 0.8653
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0128 0.1316 0.1557
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0151 0.1614 0.4132
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0296 0.035
Schistosoma mansoni inositol monophosphatase 0.0036 0.0088 0.0105
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0565 0.8441
Loa Loa (eye worm) hypothetical protein 0.0072 0.0565 0.1446
Schistosoma mansoni importin beta-1 0.003 0.0017 0.0021
Echinococcus multilocularis tar DNA binding protein 0.0255 0.3003 0.3003
Brugia malayi beta-lactamase 0.0072 0.0565 0.1881
Echinococcus granulosus tar DNA binding protein 0.0255 0.3003 0.3553
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0248 0.0293
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0078 0.0653 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0248 0.0634
Loa Loa (eye worm) jmjC domain-containing protein 0.0092 0.0834 0.2135
Schistosoma mansoni hypothetical protein 0.0048 0.0248 0.0293
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0248 0.0248
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0565 1
Echinococcus granulosus lysine specific demethylase 5A 0.0092 0.0834 0.0987
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0017 0.0267
Schistosoma mansoni microtubule-associated protein tau 0.0666 0.8453 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0653 0.5
Echinococcus granulosus snurportin 1 0.0323 0.3907 0.4622
Schistosoma mansoni tar DNA-binding protein 0.0255 0.3003 0.3553
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0078 0.0653 0.0653
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0323 0.3907 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0579 0.0579
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0653 1
Schistosoma mansoni jumonji domain containing protein 0.0132 0.1369 0.162
Entamoeba histolytica hypothetical protein 0.0073 0.0579 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0248 0.0825
Brugia malayi TAR-binding protein 0.0255 0.3003 1
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0088 0.0105
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0565 0.0932
Mycobacterium ulcerans beta-lactamase 0.0072 0.0565 0.8441
Loa Loa (eye worm) RNA binding protein 0.0255 0.3003 0.7688
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0565 1
Brugia malayi jmjC domain containing protein 0.0092 0.0834 0.2777
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0565 0.0668
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0653 0.5
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0088 0.1355
Schistosoma mansoni hypothetical protein 0.0168 0.1851 0.2189
Echinococcus granulosus geminin 0.0168 0.1851 0.2189
Echinococcus granulosus importin subunit beta 1 0.003 0.0017 0.0021
Loa Loa (eye worm) hypothetical protein 0.0048 0.0248 0.0634
Echinococcus multilocularis lysine specific demethylase 5A 0.0092 0.0834 0.0834
Schistosoma mansoni hypothetical protein 0.0323 0.3907 0.4622
Loa Loa (eye worm) hypothetical protein 0.0072 0.0565 0.1446
Brugia malayi jmjC domain containing protein 0.0152 0.1628 0.5421
Brugia malayi beta-lactamase family protein 0.0072 0.0565 0.1881
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0088 0.1297
Loa Loa (eye worm) inositol-1 0.0036 0.0088 0.0226
Schistosoma mansoni jumonji/arid domain-containing protein 0.0092 0.0834 0.0987
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0457 0.5682 1
Echinococcus multilocularis snurportin 1 0.0323 0.3907 0.3907
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0565 0.1446
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0565 0.0932
Schistosoma mansoni peptidase Clp (S14 family) 0.0078 0.0653 0.0772
Brugia malayi latrophilin 2 splice variant baaae 0.0103 0.0982 0.3269
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0565 0.8441
Brugia malayi hypothetical protein 0.0073 0.0579 0.1929
Brugia malayi beta-lactamase family protein 0.0072 0.0565 0.1881
Loa Loa (eye worm) hypothetical protein 0.0078 0.0653 0.1671
Schistosoma mansoni hypothetical protein 0.0103 0.0982 0.1162
Brugia malayi Probable ClpP-like protease 0.0078 0.0653 0.2174
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0653 1
Brugia malayi Inositol-1 0.0036 0.0088 0.0295
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0565 1
Trichomonas vaginalis esterase, putative 0.0072 0.0565 1
Mycobacterium ulcerans lipase LipD 0.0072 0.0565 0.8441
Schistosoma mansoni thyroid hormone receptor 0.0138 0.1453 0.1719
Schistosoma mansoni hypothetical protein 0.0128 0.1316 0.1557
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0409 0.1048
Schistosoma mansoni hypothetical protein 0.0048 0.0248 0.0293
Loa Loa (eye worm) hypothetical protein 0.0072 0.0565 0.1446
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0653 1
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0565 1
Plasmodium falciparum importin beta, putative 0.003 0.0017 0.0267
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0565 0.1881
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0248 0.0248
Echinococcus multilocularis GPCR, family 2 0.0048 0.0248 0.0248
Onchocerca volvulus 0.0072 0.0565 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0565 0.1446
Mycobacterium leprae Probable lipase LipE 0.0072 0.0565 0.8567
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0565 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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