Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.146 | 0.1662 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0077 | 0.146 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0038 | 0.0232 | 0.0264 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.0232 | 0.5 |
Loa Loa (eye worm) | beta-lactamase | 0.0038 | 0.0232 | 0.0264 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0232 | 0.0264 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0038 | 0.0232 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0126 | 0.304 | 0.5761 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.146 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0306 | 0.8783 | 0.8783 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0037 | 0.0207 | 0.0207 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0176 | 0.0333 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0101 | 0.2243 | 0.2243 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0232 | 0.0264 |
Brugia malayi | beta-lactamase family protein | 0.0038 | 0.0232 | 0.0439 |
Onchocerca volvulus | 0.0038 | 0.0232 | 0.4096 | |
Onchocerca volvulus | 0.0038 | 0.0232 | 0.4096 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.0232 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0038 | 0.0232 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0038 | 0.0232 | 0.0232 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0038 | 0.0232 | 0.0232 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.146 | 0.5 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0123 | 0.2951 | 0.2951 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.005 | 0.0617 | 0.314 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0176 | 0.0176 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0043 | 0.0386 | 0.0386 |
Schistosoma mansoni | hypothetical protein | 0.0344 | 1 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0062 | 0.0996 | 0.0996 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.3296 | 0.3753 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0062 | 0.0996 | 0.1134 |
Schistosoma mansoni | thyroid hormone receptor | 0.0133 | 0.3267 | 0.3267 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.146 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.146 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0038 | 0.0232 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.0232 | 0.5 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.005 | 0.0617 | 0.0588 |
Brugia malayi | RNA binding protein | 0.0126 | 0.304 | 0.5761 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0049 | 0.0565 | 0.0565 |
Echinococcus multilocularis | geminin | 0.0344 | 1 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0038 | 0.0232 | 0.0232 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0176 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0038 | 0.0232 | 0.1587 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0062 | 0.0996 | 0.0996 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.146 | 0.5 |
Toxoplasma gondii | ABC1 family protein | 0.0038 | 0.0232 | 0.1587 |
Echinococcus granulosus | jumonji domain containing protein | 0.0043 | 0.0386 | 0.0386 |
Echinococcus multilocularis | GPCR, family 2 | 0.0062 | 0.0996 | 0.0996 |
Echinococcus granulosus | tar DNA binding protein | 0.0126 | 0.304 | 0.304 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0176 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0126 | 0.304 | 0.3462 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0123 | 0.2951 | 0.2951 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0077 | 0.146 | 0.146 |
Onchocerca volvulus | 0.0038 | 0.0232 | 0.4096 | |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0037 | 0.0207 | 0.0207 |
Echinococcus granulosus | GPCR family 2 | 0.0062 | 0.0996 | 0.0996 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0134 | 0.3296 | 0.6245 |
Echinococcus multilocularis | tar DNA binding protein | 0.0126 | 0.304 | 0.304 |
Brugia malayi | jmjC domain containing protein | 0.0037 | 0.0207 | 0.0393 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.0232 | 0.5 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0064 | 0.105 | 0.1195 |
Schistosoma mansoni | hypothetical protein | 0.0123 | 0.2951 | 0.2951 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0077 | 0.146 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0196 | 0.5278 | 0.6009 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0062 | 0.0996 | 0.0996 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0038 | 0.0232 | 0.5 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.005 | 0.0617 | 0.0617 |
Schistosoma mansoni | hypothetical protein | 0.0062 | 0.0996 | 0.0996 |
Onchocerca volvulus | 0.0049 | 0.0565 | 1 | |
Brugia malayi | beta-lactamase | 0.0038 | 0.0232 | 0.0439 |
Echinococcus granulosus | snurportin 1 | 0.0306 | 0.8783 | 0.8783 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0306 | 0.8783 | 1 |
Echinococcus granulosus | tumor protein p63 | 0.0332 | 0.9612 | 0.9612 |
Echinococcus multilocularis | snurportin 1 | 0.0306 | 0.8783 | 0.8783 |
Schistosoma mansoni | thyroid hormone receptor | 0.0133 | 0.3267 | 0.3267 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0038 | 0.0232 | 0.0439 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0176 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0038 | 0.0232 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0704 | 0.0802 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0232 | 0.0264 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0232 | 0.0264 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0565 | 0.0644 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.304 | 0.304 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.304 | 0.304 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0062 | 0.0996 | 0.1887 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0101 | 0.2243 | 0.2243 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.0176 | 0.0176 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.304 | 0.304 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0176 | 0.0176 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0232 | 0.0264 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0062 | 0.0996 | 0.0996 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.304 | 0.304 |
Brugia malayi | beta-lactamase family protein | 0.0038 | 0.0232 | 0.0439 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0062 | 0.0996 | 0.1887 |
Brugia malayi | TAR-binding protein | 0.0126 | 0.304 | 0.5761 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0244 | 0.6792 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0232 | 0.0264 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.304 | 0.304 |
Schistosoma mansoni | hypothetical protein | 0.0344 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0196 | 0.5278 | 0.6009 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.0176 | 0.0176 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0037 | 0.0207 | 0.0236 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0196 | 0.5278 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0176 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0062 | 0.0996 | 0.0996 |
Schistosoma mansoni | hypothetical protein | 0.0134 | 0.3296 | 0.3296 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0077 | 0.146 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0101 | 0.2243 | 0.425 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.146 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0077 | 0.146 | 1 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0037 | 0.0207 | 0.0207 |
Schistosoma mansoni | jumonji domain containing protein | 0.008 | 0.1579 | 0.1579 |
Echinococcus multilocularis | tumor protein p63 | 0.0332 | 0.9612 | 0.9612 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0077 | 0.146 | 0.146 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0196 | 0.5278 | 1 |
Giardia lamblia | PHD finger protein 15 | 0.0031 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.005 | 0.0617 | 0.0588 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0038 | 0.0232 | 0.0232 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0077 | 0.146 | 0.146 |
Brugia malayi | RNA, U transporter 1 | 0.0082 | 0.1616 | 0.3063 |
Loa Loa (eye worm) | TAR-binding protein | 0.0126 | 0.304 | 0.3462 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0996 | 0.1134 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.146 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0062 | 0.0996 | 0.0996 |
Schistosoma mansoni | hypothetical protein | 0.0062 | 0.0996 | 0.0996 |
Trichomonas vaginalis | esterase, putative | 0.0038 | 0.0232 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0126 | 0.304 | 0.3462 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0037 | 0.0207 | 0.0207 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0133 | 0.3267 | 0.3267 |
Echinococcus granulosus | peptidase Clp S14 family | 0.005 | 0.0617 | 0.0617 |
Brugia malayi | Probable ClpP-like protease | 0.0077 | 0.146 | 0.2766 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.