Detailed information for compound 735418

Basic information

Technical information
  • TDR Targets ID: 735418
  • Name: N-(2-fluorophenyl)-2-[[2-[4-(2-methoxyphenyl) piperazin-1-yl]acetyl]amino]-5-nitrobenzamide
  • MW: 507.514 | Formula: C26H26FN5O5
  • H donors: 2 H acceptors: 4 LogP: 4.05 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccccc1N1CCN(CC1)CC(=O)Nc1ccc(cc1C(=O)Nc1ccccc1F)[N+](=O)[O-]
  • InChi: 1S/C26H26FN5O5/c1-37-24-9-5-4-8-23(24)31-14-12-30(13-15-31)17-25(33)28-21-11-10-18(32(35)36)16-19(21)26(34)29-22-7-3-2-6-20(22)27/h2-11,16H,12-15,17H2,1H3,(H,28,33)(H,29,34)
  • InChiKey: HGXUGOBQGVADMG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-fluorophenyl)-2-[[2-[4-(2-methoxyphenyl)piperazin-1-yl]acetyl]amino]-5-nitro-benzamide
  • N-(2-fluorophenyl)-2-[[2-[4-(2-methoxyphenyl)-1-piperazinyl]-1-oxoethyl]amino]-5-nitrobenzamide
  • N-(2-fluorophenyl)-2-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethanoylamino]-5-nitro-benzamide
  • CBKinase1_002986
  • CBKinase1_015386

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major glucosamine-6-phosphate isomerase, putative 0.0017 0.0005 0.0012
Loa Loa (eye worm) latrophilin receptor protein 2 0.0192 0.0548 0.1357
Brugia malayi Sodium:solute symporter family protein 0.0039 0.0075 0.0185
Loa Loa (eye worm) hypothetical protein 0.0078 0.0195 0.0483
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0014 0.0034
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.0005 0.0013
Loa Loa (eye worm) hypothetical protein 0.0032 0.0051 0.0127
Loa Loa (eye worm) hypothetical protein 0.007 0.017 0.0421
Loa Loa (eye worm) hypothetical protein 0.0073 0.0179 0.0443
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0014 0.03
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0014 0.0033
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.075 0.1832
Echinococcus multilocularis solute carrier family 5 0.0039 0.0075 0.0075
Schistosoma mansoni hypothetical protein 0.1032 0.3155 0.7811
Trypanosoma brucei unspecified product 0.0019 0.0014 0.0033
Schistosoma mansoni chromobox protein 0.0069 0.0168 0.0417
Schistosoma mansoni hypothetical protein 0.0414 0.1238 0.3065
Brugia malayi MH2 domain containing protein 0.0121 0.0331 0.0818
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0101 0.34
Brugia malayi PHD-finger family protein 0.0028 0.0041 0.0102
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.0179 0.1204
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0058 0.0325
Brugia malayi PHD-finger family protein 0.0026 0.0035 0.0087
Brugia malayi hypothetical protein 0.0159 0.0448 0.1109
Loa Loa (eye worm) hypothetical protein 0.0028 0.0041 0.0102
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.1317 0.404 1
Trypanosoma cruzi transcription factor btf3, putative 0.0107 0.0286 0.0706
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0006 0.0014
Plasmodium vivax hypothetical protein, conserved 0.0073 0.0179 0.0408
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.0051 0.0127
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0101 0.0248
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0476 0.1163
Brugia malayi nuclear receptor NHR-88 0.0032 0.0051 0.0127
Onchocerca volvulus 0.0047 0.0101 0.1371
Brugia malayi nuclear receptor RXR 0.0017 0.0005 0.0013
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.002
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0051 0.0127
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.1333 0.4091 1
Mycobacterium tuberculosis Conserved protein 0.0073 0.0179 0.1204
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0092 0.024 0.0594
Brugia malayi GH02984p 0.0354 0.1051 0.2602
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0047 0.0101 0.0216
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.0179 0.043
Trypanosoma brucei 6-phosphogluconolactonase 0.0017 0.0005 0.0012
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0101 0.0248
Leishmania major GTP-binding protein, putative 0.0021 0.0018 0.0043
Onchocerca volvulus Glucosylceramidase homolog 0.0168 0.0476 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.0051 0.0127
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0064 0.0153 0.0377
Echinococcus granulosus zinc finger protein 0.0021 0.0019 0.0047
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.0195 0.0447
Schistosoma mansoni hypothetical protein 0.0192 0.0548 0.1357
Mycobacterium leprae conserved hypothetical protein 0.0073 0.0179 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0051 0.0127
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0014 0.0033
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0192 0.0548 0.0548
Loa Loa (eye worm) hypothetical protein 0.0047 0.0101 0.0249
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0275 0.0807 0.0807
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0075 0.0075
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0018 0.0044
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0064 0.0125
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0074 0.018
Trypanosoma cruzi glucosamine-6-phosphate isomerase, putative 0.0017 0.0005 0.0012
Trypanosoma brucei transcription factor BTF3, putative 0.0107 0.0286 0.0706
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0005 0.0013
Brugia malayi ecdysteroid receptor 0.0032 0.0051 0.0127
Echinococcus granulosus sodium:glucose cotransporter 0.0039 0.0075 0.0185
Leishmania major DNA polymerase kappa, putative 0.0019 0.0014 0.0033
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.001 0.0024
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0047 0.0101 0.0249
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.0051 0.0127
Loa Loa (eye worm) hypothetical protein 0.0192 0.0548 0.1357
Echinococcus granulosus protein kinase shaggy 0.0047 0.0101 0.0249
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0101 0.34
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0476 0.1163
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0275 0.0807 0.1998
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0058 0.0325
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0424 0.1268 0.3139
Loa Loa (eye worm) hypothetical protein 0.0032 0.0051 0.0127
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.0051 0.0127
Echinococcus multilocularis chromobox protein 1 0.0069 0.0168 0.0168
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0504 0.1232
Schistosoma mansoni hypothetical protein 0.0042 0.0085 0.021
Toxoplasma gondii isocitrate dehydrogenase 0.0064 0.0153 0.0344
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0005 0.0013
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0013 0.0031
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.0179 0.1204
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0101 0.5491
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.0051 0.0127
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.0051 0.0051
Trypanosoma cruzi glucosamine-6-phosphate isomerase, putative 0.0017 0.0005 0.0012
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0476 0.1163
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0024 0.0059
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0179 0.0442
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0028 0.0069
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.1333 0.4091 1
Mycobacterium tuberculosis Conserved protein 0.0073 0.0179 0.1204
Leishmania major importin beta-1 subunit, putative 0.0023 0.0024 0.0059
Brugia malayi chromobox protein homolog 3 0.0039 0.0074 0.0183
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0014 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0051 0.0127
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0168 0.0417
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0005 0.0013
Entamoeba histolytica hypothetical protein 0.0107 0.0286 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0192 0.0548 0.1357
Giardia lamblia Kinase, CMGC GSK 0.0047 0.0101 0.0233
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0275 0.0807 0.1998
Brugia malayi Latrophilin receptor protein 2 0.0192 0.0548 0.1357
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0476 0.1163
Schistosoma mansoni coup transcription factor 0.0032 0.0051 0.0127
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.0179 0.0443
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.0051 0.0127
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0018 0.0018
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.0195 0.0447
Brugia malayi Muscleblind-like protein 0.1049 0.3208 0.7941
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0041 0.007
Echinococcus granulosus GPCR family 2 0.0192 0.0548 0.1357
Brugia malayi Bromodomain containing protein 0.0076 0.0189 0.0467
Loa Loa (eye worm) hypothetical protein 0.003 0.0048 0.0119
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.1317 0.404 0.404
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.1317 0.404 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.0179 0.0179
Leishmania major hypothetical protein, conserved 0.0073 0.0179 0.0442
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.075 0.1832
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.1333 0.4091 1
Echinococcus granulosus high affinity choline transporter 1 0.0354 0.1051 0.2602
Onchocerca volvulus 0.0073 0.0179 0.3169
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.0042 0.0085 0.0177
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0101 0.0236
Schistosoma mansoni transcription factor LCR-F1 0.0107 0.0285 0.0706
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0064 0.0153 0.0377
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0047 0.0101 0.0101
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0179 0.0443
Schistosoma mansoni tar DNA-binding protein 0.013 0.0357 0.0884
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.1333 0.4091 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0013 0.003
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0039 0.0075 0.0075
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0064 0.0153 0.0153
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0051 0.0127
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0014 0.0021
Onchocerca volvulus 0.0039 0.0075 0.0773
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0064 0.0153 0.0379
Schistosoma mansoni tar DNA-binding protein 0.013 0.0357 0.0884
Echinococcus multilocularis 6 phosphogluconolactonase 0.0017 0.0005 0.0005
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.0331 0.0818
Plasmodium vivax importin-beta 2, putative 0.0028 0.0041 0.0069
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.0051 0.0127
Brugia malayi Calcitonin receptor-like protein seb-1 0.0605 0.1832 0.4536
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0047 0.0101 0.0248
Schistosoma mansoni zinc finger protein 0.0015 0 0.0001
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0064 0.0153 0.0344
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0074 0.0758
Loa Loa (eye worm) RNA binding protein 0.013 0.0357 0.0884
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0006 0.0014
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0051 0.0127
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0286 0.0697
Echinococcus granulosus cpg binding protein 0.0034 0.0059 0.0146
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.075 0.1832
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.0051 0.0127
Entamoeba histolytica protein kinase, putative 0.0047 0.0101 0.3401
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0064 0.0153 0.0153
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.0179 0.1204
Echinococcus multilocularis geminin 0.1032 0.3155 0.3155
Onchocerca volvulus 0.0047 0.0101 0.1371
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.0051 0.0238
Loa Loa (eye worm) hypothetical protein 0.0028 0.0041 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0039 0.0095
Echinococcus granulosus tar DNA binding protein 0.013 0.0357 0.0884
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0014 0.0033
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.0179 0.0443
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0041 0.01
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0605 0.1832 0.4536
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0107 0.0285 0.0285
Echinococcus granulosus muscleblind protein 0.1049 0.3208 0.7941
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0014 0.0008
Mycobacterium leprae Probable lipase LipE 0.0073 0.0179 1
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.075 0.1832
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.0051 0.0127
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0047 0.0101 0.0248
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0014 0.0033
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0071 0.0175
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0014 0.0034
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0032 0.0051 0.0238
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0014 0.0033
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0064 0.0154 0.1021
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.0051 0.0127
Loa Loa (eye worm) hypothetical protein 0.0032 0.0051 0.0127
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0013 0.003
Schistosoma mansoni 6-phosphogluconolactonase 0.0017 0.0005 0.0013
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0083 0.0968
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0058 0.0325
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0275 0.0807 0.1998
Echinococcus multilocularis high affinity choline transporter 1 0.0354 0.1051 0.1051
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0014 0.0033
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0035 0.0062 0.0062
Brugia malayi glucose-6-phosphate dehydrogenase 0.1317 0.404 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0192 0.0548 0.1357
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0071 0.0175
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0014 0.0033
Plasmodium falciparum phd finger protein, putative 0.0028 0.0041 0.007
Loa Loa (eye worm) hypothetical protein 0.0035 0.0064 0.0157
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0014 0.0033
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.0051 0.0051
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0008 0.0019
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.0051 0.0127
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0051 0.0127
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.1333 0.4091 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0041 0.0041
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0504 0.1232
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.0179 0.1204
Entamoeba histolytica hypothetical protein 0.0107 0.0285 0.9992
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0014 0.0033
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.0051 0.0127
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0101 0.0249
Schistosoma mansoni ran 0.0021 0.0018 0.0044
Schistosoma mansoni hypothetical protein 0.0192 0.0548 0.1357
Echinococcus granulosus tumor protein p63 0.0333 0.0988 0.2445
Mycobacterium ulcerans lipase LipD 0.0073 0.0179 0.043
Trypanosoma cruzi 6-phosphogluconolactonase, putative 0.0017 0.0005 0.0012
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0107 0.0285 0.0706
Schistosoma mansoni ap endonuclease 0.0019 0.0013 0.0031
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0134 0.037 0.259
Schistosoma mansoni chromobox protein 0.0069 0.0168 0.0417
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.001 0.0024
Brugia malayi Heterochromatin protein 1 0.0069 0.0168 0.0417
Schistosoma mansoni tar DNA-binding protein 0.013 0.0357 0.0884
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0101 0.0236
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.0051 0.0127
Schistosoma mansoni hypothetical protein 0.0192 0.0548 0.1357
Loa Loa (eye worm) hypothetical protein 0.0073 0.0179 0.0443
Brugia malayi CXXC zinc finger family protein 0.003 0.0048 0.0118
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.0051 0.0127
Mycobacterium ulcerans hypothetical protein 0.0047 0.0101 0.0236
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0179 0.0437
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0047 0.0101 0.0249
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0013 0.0018
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0064 0.0064
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.075 0.1832
Onchocerca volvulus 0.0032 0.0051 0.0238
Loa Loa (eye worm) hypothetical protein 0.0032 0.0051 0.0127
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0013 0.0018
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.1317 0.404 1
Giardia lamblia DINP protein human, muc B family 0.0019 0.0014 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0051 0.0127
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0438 0.1314 0.3252
Mycobacterium ulcerans hypothetical protein 0.0073 0.0179 0.043
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.1317 0.404 1
Echinococcus multilocularis zinc finger protein 0.0021 0.0019 0.0019
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0051 0.0051
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0017 0.0005 0.0013
Loa Loa (eye worm) TAR-binding protein 0.013 0.0357 0.0884
Echinococcus granulosus 6 phosphogluconolactonase 0.0017 0.0005 0.0013
Mycobacterium ulcerans lipoprotein LpqF 0.0064 0.0154 0.0367
Brugia malayi hypothetical protein 0.0078 0.0195 0.0483
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0257 0.075 0.1856
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.1317 0.404 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0014 0.0033
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.1317 0.404 1
Onchocerca volvulus 0.0073 0.0179 0.3169
Brugia malayi Bromodomain containing protein 0.0038 0.0071 0.0175
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0051 0.0127
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.0051 0.0127
Brugia malayi hypothetical protein 0.0107 0.0285 0.0706
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0105 0.026
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0013 0.0031
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0101 0.0638
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0064 0.0144
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0014 0.0034
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0014 0.0033
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0039 0.0075 0.0152
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0064 0.0153 0.1016
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0071 0.0175
Loa Loa (eye worm) hypothetical protein 0.0044 0.009 0.0222
Schistosoma mansoni hypothetical protein 0.0015 0 0.0001
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0192 0.0548 0.1357
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.0051 0.0127
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0142 0.0351
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0013 0.003
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.0331 0.0818
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0039 0.0075 0.0075
Brugia malayi nuclear hormone receptor 0.0032 0.0051 0.0127
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.0042 0.0085 0.0177
Loa Loa (eye worm) hypothetical protein 0.0035 0.0064 0.0157
Brugia malayi jmjC domain containing protein 0.0038 0.0071 0.0175
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0018 0.0013
Echinococcus multilocularis transcription factor eb 0.044 0.132 0.132
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.001 0.0024
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0153 0.0378
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.044 0.132 0.3269
Loa Loa (eye worm) beta-lactamase 0.0073 0.0179 0.0443
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0083 0.0203
Trypanosoma cruzi 6-phosphogluconolactonase, putative 0.0017 0.0005 0.0012
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0041 0.0102
Schistosoma mansoni ran 0.0021 0.0018 0.0044
Schistosoma mansoni hypothetical protein 0.002 0.0017 0.0042
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0179 0.0437
Brugia malayi jmjC domain containing protein 0.0092 0.024 0.0594
Schistosoma mansoni tar DNA-binding protein 0.013 0.0357 0.0884
Echinococcus multilocularis isocitrate dehydrogenase 0.0064 0.0153 0.0153
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.0051 0.0127
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0041 0.0041
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0013 0.5
Onchocerca volvulus 0.0073 0.0179 0.3169
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0275 0.0807 0.1998
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0014 0.0033
Loa Loa (eye worm) hypothetical protein 0.0039 0.0075 0.0185
Schistosoma mansoni hypothetical protein 0.0192 0.0548 0.1357
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0014 0.0033
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.075 0.1832
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0018 0.0043
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0101 0.5491
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0064 0.0368
Echinococcus granulosus importin subunit beta 1 0.0028 0.0041 0.0102
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0064 0.0154 0.8539
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.0051 0.0127
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0024 0.0059
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0275 0.0807 0.1998
Echinococcus multilocularis thyroid hormone receptor alpha 0.0032 0.0051 0.0051
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.1317 0.404 1
Mycobacterium ulcerans beta-lactamase 0.0073 0.0179 0.043
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0014 0.0033
Echinococcus granulosus dna polymerase eta 0.0019 0.0014 0.0034
Loa Loa (eye worm) hypothetical protein 0.0035 0.0064 0.0157
Entamoeba histolytica protein kinase domain containing protein 0.0047 0.0101 0.3401
Echinococcus multilocularis tumor protein p63 0.0333 0.0988 0.0988
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0035 0.0062 0.0153
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0013
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.001 0.0024
Brugia malayi hypothetical protein 0.0038 0.0072 0.0178
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0092 0.024 0.024
Schistosoma mansoni bromodomain containing protein 0.0064 0.0153 0.0378
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0058 0.0325
Brugia malayi hypothetical protein 0.0017 0.0005 0.0013
Trichomonas vaginalis esterase, putative 0.0073 0.0179 0.0437
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0008 0.0008
Schistosoma mansoni DNA polymerase eta 0.0019 0.0014 0.0034
Mycobacterium tuberculosis Conserved protein 0.0073 0.0179 0.1204
Loa Loa (eye worm) hypothetical protein 0.0032 0.0051 0.0127
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0017 0.0042
Leishmania major DNA polymerase eta, putative 0.0019 0.0014 0.0033
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0041 0.007
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0018 0.0044
Echinococcus multilocularis snurportin 1 0.03 0.0886 0.0886
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0028 0.0069
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0014 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0039 0.0095
Echinococcus multilocularis muscleblind protein 0.1049 0.3208 0.3208
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0014 0.0014
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.0051 0.0127
Echinococcus granulosus sodium:glucose cotransporter 2 0.0039 0.0075 0.0185
Loa Loa (eye worm) hypothetical protein 0.0438 0.1314 0.3252
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0142 0.0142
Brugia malayi beta-NAC-like protein 0.0107 0.0286 0.0707
Echinococcus multilocularis cpg binding protein 0.0034 0.0059 0.0059
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0464 0.1393 1
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0051 0.0127
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0018 0.0031
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0134 0.037 0.0904
Echinococcus granulosus sodium:myo inositol cotransporter 0.0039 0.0075 0.0185
Brugia malayi hypothetical protein 0.005 0.011 0.0271
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.0051 0.0127
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0028 0.0028
Brugia malayi beta-lactamase family protein 0.0073 0.0179 0.0443
Schistosoma mansoni hypothetical protein 0.0107 0.0285 0.0706
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0018 0.0043
Loa Loa (eye worm) hypothetical protein 0.0073 0.0179 0.0443
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.0051 0.0127
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0041 0.007
Onchocerca volvulus 0.0049 0.0105 0.147
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.0179 0.1204
Brugia malayi Bromodomain containing protein 0.003 0.0048 0.012
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0041 0.0069
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.086 0.2622 0.6398
Loa Loa (eye worm) hypothetical protein 0.0032 0.0051 0.0127
Plasmodium vivax glycogen synthase kinase 3, putative 0.0047 0.0101 0.0216
Loa Loa (eye worm) hypothetical protein 0.0354 0.1051 0.2602
Plasmodium falciparum importin beta, putative 0.0028 0.0041 0.0069
Brugia malayi hypothetical protein 0.0017 0.0005 0.0013
Echinococcus granulosus dna polymerase kappa 0.0019 0.0014 0.0034
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0018 0.0043
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0017 0.0005 0.0013
Schistosoma mansoni 6-phosphogluconolactonase 0.0017 0.0005 0.0013
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.1333 0.4091 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.0051 0.0127
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0013 0.003
Brugia malayi beta-lactamase family protein 0.0073 0.0179 0.0443
Loa Loa (eye worm) hypothetical protein 0.0073 0.0179 0.0443
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.0179 0.1204
Echinococcus multilocularis peregrin 0.003 0.0048 0.0048
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.0051 0.0127
Schistosoma mansoni cpg binding protein 0.0034 0.0059 0.0146
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.0179 0.043
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0257 0.075 0.1856
Plasmodium falciparum basic transcription factor 3b, putative 0.0107 0.0286 0.0669
Entamoeba histolytica hypothetical protein 0.0107 0.0285 0.9992
Loa Loa (eye worm) hypothetical protein 0.0605 0.1832 0.4536
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0457 0.1371 0.9843
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0064 0.0153 0.0153
Brugia malayi RNA recognition motif domain containing protein 0.013 0.0357 0.0884
Echinococcus multilocularis GPCR, family 2 0.0192 0.0548 0.0548
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0074 0.018
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0071 0.0175
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0101 0.0236
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0101 0.0236
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.086 0.2622 0.6487
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0101 0.0236
Brugia malayi hypothetical protein 0.0038 0.0072 0.0178
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0014 0.0033
Toxoplasma gondii NAC domain-containing protein 0.0107 0.0286 0.0669
Entamoeba histolytica hypothetical protein 0.0107 0.0285 0.9992
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0476 0.1163
Echinococcus multilocularis tar DNA binding protein 0.013 0.0357 0.0357
Schistosoma mansoni inositol transporter 0.0039 0.0075 0.0185
Onchocerca volvulus 0.003 0.0048 0.016
Brugia malayi 6-phosphogluconolactonase family protein 0.0017 0.0005 0.0013
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0047 0.0101 0.0249
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.0051 0.0127
Entamoeba histolytica protein kinase domain containing protein 0.0047 0.0101 0.3401
Brugia malayi RNA, U transporter 1 0.008 0.0202 0.05
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.0051 0.0051
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0064 0.0153 0.0377
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.0051 0.0127
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0179 0.0437
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0008 0.002
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0017 0.0005 0.0013
Echinococcus granulosus geminin 0.1032 0.3155 0.7811
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0006 0.0014
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.0042 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0032 0.0051 0.0127
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0042 0.0085 0.021
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0286 0.0697
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0064 0.0153 0.0379
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0179 0.0437
Brugia malayi TAR-binding protein 0.013 0.0357 0.0884
Echinococcus granulosus peregrin 0.003 0.0048 0.012
Entamoeba histolytica transcription factor BTF3, putative 0.0107 0.0286 1
Entamoeba histolytica hypothetical protein 0.0023 0.0024 0.068
Schistosoma mansoni cpg binding protein 0.003 0.0048 0.0118
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0013 0.0031
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0134 0.0332
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.1049 0.3208 0.7941
Schistosoma mansoni glucosamine-6-phosphate isomerase 0.0017 0.0005 0.0013
Entamoeba histolytica Ran family GTPase 0.0021 0.0018 0.0446
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0013 0.0013
Entamoeba histolytica hypothetical protein 0.0107 0.0285 0.9992
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0014 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.0051 0.0127
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0041 0.01
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0013
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0051 0.0127
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.0051 0.0127
Echinococcus multilocularis muscleblind protein 1 0.1049 0.3208 0.3208
Loa Loa (eye worm) hypothetical protein 0.0073 0.0179 0.0443
Trypanosoma brucei glucosamine-6-phosphate isomerase, putative 0.0017 0.0005 0.0012
Echinococcus multilocularis chromobox protein 1 0.0069 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0047 0.0101 0.0249
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0051 0.0127
Loa Loa (eye worm) hypothetical protein 0.0049 0.0105 0.026
Echinococcus granulosus FTZ F1 alpha 0.0032 0.0051 0.0127
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0101 0.0249
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0014 0.0033
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0179 0.0442
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0014 0.0033
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0018 0.0044
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0275 0.0807 0.1998
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0101 0.0248
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0042 0.0085 0.021
Schistosoma mansoni zinc finger protein 0.0021 0.0019 0.0047
Onchocerca volvulus 0.003 0.0048 0.015
Brugia malayi beta-lactamase 0.0073 0.0179 0.0443
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0014 0.0034
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0006 0.0006
Trichomonas vaginalis CMGC family protein kinase 0.0047 0.0101 0.0246
Schistosoma mansoni importin beta-1 0.0028 0.0041 0.0102
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0048 0.0118
Brugia malayi RNA binding protein 0.013 0.0357 0.0884
Echinococcus multilocularis transcription factor btf3 0.0107 0.0286 0.0286
Brugia malayi steroid hormone receptor 0.0032 0.0051 0.0127
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.1317 0.404 1
Echinococcus granulosus transcription factor eb 0.044 0.132 0.3269
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0041 0.0102
Schistosoma mansoni sodium/solute symporter 0.0039 0.0075 0.0185
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0101 0.0236
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.001 0.0024
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0039 0.0074 0.0183
Trypanosoma brucei beta lactamase 0.0064 0.0154 0.0379
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0018 0.0013
Loa Loa (eye worm) hypothetical protein 0.1049 0.3208 0.7941
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0039 0.0075 0.0075
Plasmodium falciparum glycogen synthase kinase 3 0.0047 0.0101 0.0216
Loa Loa (eye worm) hypothetical protein 0.0048 0.0104 0.0256
Toxoplasma gondii LsmAD domain-containing protein 0.0078 0.0195 0.0447
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0168 0.0411
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0051 0.0127
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0179 0.0437
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0286 0.0697
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0024 0.0059
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0179 0.0442
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0013 0.0018
Brugia malayi isocitrate dehydrogenase 0.0064 0.0153 0.0379
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0101 0.0249
Brugia malayi Importin beta-1 subunit 0.0028 0.0041 0.0102
Schistosoma mansoni cpg binding protein 0.0034 0.0059 0.0146
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0275 0.0807 0.0807
Echinococcus granulosus chromobox protein 1 0.0069 0.0168 0.0417
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0014 0.0021
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0051 0.0051
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0013 0.003
Giardia lamblia PHD finger protein 15 0.0028 0.0041 0.0087
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0017 0.0041
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.0051 0.0051
Schistosoma mansoni hypothetical protein 0.03 0.0886 0.2194
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.0051 0.0238
Echinococcus multilocularis dna polymerase eta 0.0019 0.0014 0.0014
Loa Loa (eye worm) ICD-1 protein 0.0107 0.0286 0.0707
Onchocerca volvulus 0.0159 0.0448 0.9354
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0039 0.0075 0.0185
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.0051 0.0127
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0139 0.0309
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0008 0.002
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0064 0.0157
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0176
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.1317 0.404 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0013 0.0258
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0476 0.1163
Schistosoma mansoni inositol transporter 0.0039 0.0075 0.0185
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.0195 0.0482
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.0195 0.0482
Trichomonas vaginalis ran, putative 0.0021 0.0018 0.0043
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0041 0.0102
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0042 0.0085 0.021
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.0051 0.0127
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0179 0.0443
Loa Loa (eye worm) hypothetical protein 0.0042 0.0085 0.021
Leishmania major basic transcription factor 3a, putative 0.0107 0.0286 0.0706
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0192 0.0548 0.0548
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0476 0.1163
Loa Loa (eye worm) hypothetical protein 0.0035 0.0064 0.0157
Toxoplasma gondii isocitrate dehydrogenase 0.0064 0.0153 0.0344
Brugia malayi latrophilin 2 splice variant baaae 0.0414 0.1238 0.3065
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0064 0.0153 0.0377
Loa Loa (eye worm) isocitrate dehydrogenase 0.0064 0.0153 0.0379
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0101 0.0638
Trichomonas vaginalis CMGC family protein kinase 0.0047 0.0101 0.0246
Loa Loa (eye worm) hypothetical protein 0.0414 0.1238 0.3065
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0014 0.0014
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0014 0.0033
Loa Loa (eye worm) hypothetical protein 0.0047 0.0101 0.0249
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0013 0.003
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0008 0.002
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0101 0.0236
Schistosoma mansoni ap endonuclease 0.0019 0.0013 0.0031
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.03 0.0886 0.2194
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0064 0.0144
Echinococcus multilocularis protein kinase shaggy 0.0047 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0013
Loa Loa (eye worm) hypothetical protein 0.0073 0.0179 0.0443
Trypanosoma brucei PAB1-binding protein , putative 0.0078 0.0195 0.0482
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0436 0.1308 0.3236
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.1333 0.4091 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0018 0.0013
Loa Loa (eye worm) hypothetical protein 0.0019 0.0014 0.0034
Brugia malayi intracellular kinase 0.0047 0.0101 0.0249
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0168 0.0411
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0051 0.0127
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0275 0.0807 0.1998
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0101 0.34
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0013
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0024 0.0059
Echinococcus granulosus transcription factor btf3 0.0107 0.0286 0.0707
Echinococcus granulosus solute carrier family 5 0.0039 0.0075 0.0185
Toxoplasma gondii ABC1 family protein 0.0073 0.0179 0.0408
Schistosoma mansoni hypothetical protein 0.0028 0.0041 0.0102
Trypanosoma brucei protein kinase, putative 0.0047 0.0101 0.0248
Loa Loa (eye worm) 6-phosphogluconolactonase 0.0017 0.0005 0.0013
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.0179 0.1204
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.0179 0.0443
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0017 0.0005 0.0005
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0605 0.1832 0.4536
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.0051 0.0127
Schistosoma mansoni jumonji domain containing protein 0.0073 0.0181 0.0448
Schistosoma mansoni hypothetical protein 0.1032 0.3155 0.7811
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.013 0.0357 0.0884
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0014 0.0008
Loa Loa (eye worm) hypothetical protein 0.0035 0.0064 0.0157
Plasmodium vivax ataxin-2 like protein, putative 0.0078 0.0195 0.0447
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0064 0.0125
Echinococcus granulosus snurportin 1 0.03 0.0886 0.2194
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0014 0.0034
Echinococcus granulosus chromobox protein 1 0.0069 0.0168 0.0417
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0014 0.0033
Brugia malayi Isocitrate dehydrogenase 0.0064 0.0153 0.0379
Schistosoma mansoni high-affinity choline transporter 0.0354 0.1051 0.2602
Leishmania major 6-phosphogluconolactonase 0.0017 0.0005 0.0012
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.0051 0.0051
Schistosoma mansoni tar DNA-binding protein 0.013 0.0357 0.0884
Plasmodium vivax basic transcription factor 3b, putative 0.0107 0.0286 0.0669
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0064 0.0153 0.0344
Loa Loa (eye worm) hypothetical protein 0.004 0.0078 0.0194
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0006 0.0014
Leishmania major hypothetical protein, conserved 0.0078 0.0195 0.0482
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.001 0.0024
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.001 0.0024
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0014 0.0033
Giardia lamblia Kinase, CMGC GSK 0.0047 0.0101 0.0233
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.001 0.0024
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0083 0.0203
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0064 0.0153 0.0153
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.0051 0.0127
Schistosoma mansoni hypothetical protein 0.0035 0.0062 0.0153
Schistosoma mansoni transcription factor btf3 0.0107 0.0286 0.0707
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0051 0.0127
Trypanosoma cruzi transcription factor btf3, putative 0.0107 0.0286 0.0706
Loa Loa (eye worm) hypothetical protein 0.0017 0.0005 0.0013
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.0042 0.0085 0.0177
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0064 0.0153 0.0377
Loa Loa (eye worm) hypothetical protein 0.0159 0.0448 0.1109
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0047 0.0101 0.0249
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0075 0.0186

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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