Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | pyruvate kinase | 0.0033 | 0.0487 | 0.0607 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0082 | 0.0986 |
Leishmania major | pyruvate kinase | 0.0033 | 0.0487 | 0.3993 |
Echinococcus multilocularis | pyruvate kinase | 0.0017 | 0.0041 | 0.0041 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0813 | 0.1013 |
Loa Loa (eye worm) | pyruvate kinase | 0.0033 | 0.0487 | 0.0607 |
Plasmodium vivax | pyruvate kinase, putative | 0.0033 | 0.0487 | 1 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0045 | 0.0829 | 0.6792 |
Echinococcus granulosus | smad | 0.0017 | 0.0043 | 0.0043 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0154 | 0.0237 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.4431 | 0.552 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0031 | 0.0428 | 0.0533 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.0813 | 0.1252 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0033 | 0.0487 | 0.3993 |
Echinococcus multilocularis | Smad4 | 0.0017 | 0.0043 | 0.0043 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0023 | 0.0213 | 0.2572 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0363 | 0.0452 |
Schistosoma mansoni | Smad4 | 0.0017 | 0.0043 | 0.0053 |
Brugia malayi | TAR-binding protein | 0.0124 | 0.3053 | 0.4698 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0428 | 0.0533 |
Echinococcus granulosus | geminin | 0.0174 | 0.4431 | 0.4431 |
Echinococcus multilocularis | snurportin 1 | 0.0302 | 0.8028 | 0.8028 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0247 | 0.6499 | 0.8095 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0247 | 0.6499 | 0.8095 |
Echinococcus multilocularis | pyruvate kinase | 0.0017 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0017 | 0.0043 | 0.0053 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.0813 | 0.1013 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.0082 | 0.0986 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0023 | 0.021 | 0.1717 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.0082 | 0.067 |
Echinococcus multilocularis | tar DNA binding protein | 0.0124 | 0.3053 | 0.3053 |
Brugia malayi | RNA, U transporter 1 | 0.008 | 0.1824 | 0.2806 |
Echinococcus granulosus | pyruvate kinase | 0.0033 | 0.0487 | 0.0487 |
Brugia malayi | MH1 domain containing protein | 0.0017 | 0.0043 | 0.0066 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0.0082 | 0.067 |
Echinococcus granulosus | GPCR family 2 | 0.0031 | 0.0428 | 0.0428 |
Schistosoma mansoni | tar DNA-binding protein | 0.0124 | 0.3053 | 0.3803 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0045 | 0.0829 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0428 | 0.0533 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0021 | 0.0154 | 0.1856 |
Plasmodium vivax | GTP-binding nuclear protein RAN/TC4, putative | 0.0021 | 0.0154 | 0.3157 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0017 | 0.0043 | 0.0043 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0028 | 0.0363 | 0.438 |
Schistosoma mansoni | tar DNA-binding protein | 0.0124 | 0.3053 | 0.3803 |
Schistosoma mansoni | importin beta-1 | 0.0028 | 0.0363 | 0.0452 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.122 | 0.152 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0154 | 0.143 |
Loa Loa (eye worm) | TAR-binding protein | 0.0124 | 0.3053 | 0.3803 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0813 | 0.1013 |
Brugia malayi | Importin beta-1 subunit | 0.0028 | 0.0363 | 0.0559 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0124 | 0.3053 | 0.3803 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0028 | 0.0363 | 0.438 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0028 | 0.0363 | 0.2975 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.4431 | 0.552 |
Entamoeba histolytica | Ran family GTPase | 0.0021 | 0.0154 | 0.0966 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0302 | 0.8028 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0097 | 0.2279 | 0.3507 |
Loa Loa (eye worm) | pyruvate kinase | 0.0033 | 0.0487 | 0.0607 |
Echinococcus multilocularis | geminin | 0.0174 | 0.4431 | 0.4431 |
Schistosoma mansoni | hypothetical protein | 0.0066 | 0.1422 | 0.1772 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0045 | 0.0829 | 0.0829 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0033 | 0.0487 | 0.5429 |
Schistosoma mansoni | hypothetical protein | 0.0302 | 0.8028 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.122 | 1 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0028 | 0.0363 | 0.0363 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0045 | 0.0829 | 1 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0045 | 0.0829 | 0.1032 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0059 | 0.122 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0082 | 0.1677 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0045 | 0.0829 | 0.0829 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.122 | 0.152 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0082 | 0.0102 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0021 | 0.0154 | 0.0154 |
Echinococcus multilocularis | pyruvate kinase | 0.0033 | 0.0487 | 0.0487 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.0082 | 0.0514 |
Echinococcus granulosus | pyruvate kinase | 0.0033 | 0.0487 | 0.0487 |
Loa Loa (eye worm) | pyruvate kinase-PB | 0.0023 | 0.021 | 0.0262 |
Loa Loa (eye worm) | RNA binding protein | 0.0124 | 0.3053 | 0.3803 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0082 | 0.0102 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0045 | 0.0829 | 0.0829 |
Brugia malayi | MH2 domain containing protein | 0.0017 | 0.0043 | 0.0066 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.0082 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0829 | 0.1032 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0017 | 0.0043 | 0.0043 |
Mycobacterium ulcerans | pyruvate kinase | 0.0033 | 0.0487 | 0.3562 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0428 | 0.0428 |
Schistosoma mansoni | tar DNA-binding protein | 0.0124 | 0.3053 | 0.3803 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0097 | 0.2279 | 0.3507 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0033 | 0.0487 | 0.588 |
Plasmodium vivax | pyruvate kinase 2, putative | 0.0017 | 0.0041 | 0.0846 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0813 | 0.0813 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0813 | 0.1013 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0045 | 0.0829 | 1 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0017 | 0.0043 | 0.0053 |
Echinococcus granulosus | pyruvate kinase | 0.0017 | 0.0041 | 0.0041 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0045 | 0.0829 | 0.1275 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.0082 | 0.0082 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.2279 | 0.2839 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0059 | 0.122 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.1422 | 0.1772 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0031 | 0.0428 | 0.0658 |
Schistosoma mansoni | ran | 0.0021 | 0.0154 | 0.0192 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0033 | 0.0487 | 0.588 |
Toxoplasma gondii | GTP-binding nuclear protein ran/tc4 | 0.0021 | 0.0154 | 0.1261 |
Toxoplasma gondii | pyruvate kinase PyKII | 0.0017 | 0.0041 | 0.0338 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0428 | 0.0428 |
Giardia lamblia | Pyruvate kinase | 0.0033 | 0.0487 | 0.5664 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0033 | 0.0487 | 0.588 |
Echinococcus multilocularis | smad | 0.0017 | 0.0043 | 0.0043 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0045 | 0.0829 | 0.0829 |
Schistosoma mansoni | ran | 0.0021 | 0.0154 | 0.0192 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0045 | 0.0829 | 1 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0017 | 0.0043 | 0.0043 |
Schistosoma mansoni | smad1 5 8 and | 0.0017 | 0.0043 | 0.0053 |
Plasmodium falciparum | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0154 | 0.3157 |
Schistosoma mansoni | smad1 5 8 and | 0.0017 | 0.0043 | 0.0053 |
Echinococcus granulosus | Smad4 | 0.0017 | 0.0043 | 0.0043 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0059 | 0.122 | 1 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0213 | 0.176 |
Brugia malayi | MH2 domain containing protein | 0.0247 | 0.6499 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0428 | 0.0428 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0082 | 0.0986 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0045 | 0.0829 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.0082 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0428 | 0.0533 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0082 | 0.1677 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0021 | 0.0154 | 0.1856 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0428 | 0.0533 |
Brugia malayi | MH1 domain containing protein | 0.0017 | 0.0043 | 0.0066 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0033 | 0.0487 | 0.5 |
Echinococcus multilocularis | pyruvate kinase | 0.0033 | 0.0487 | 0.0487 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0428 | 0.0428 |
Plasmodium falciparum | pyruvate kinase | 0.0033 | 0.0487 | 1 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0033 | 0.0487 | 0.5429 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0031 | 0.0428 | 0.0658 |
Schistosoma mansoni | tar DNA-binding protein | 0.0124 | 0.3053 | 0.3803 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0045 | 0.0829 | 1 |
Brugia malayi | RNA binding protein | 0.0124 | 0.3053 | 0.4698 |
Plasmodium falciparum | pyruvate kinase 2 | 0.0017 | 0.0041 | 0.0846 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0813 | 0.0813 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.0082 | 0.0126 |
Echinococcus multilocularis | tumor protein p63 | 0.0372 | 1 | 1 |
Chlamydia trachomatis | pyruvate kinase | 0.0033 | 0.0487 | 0.5 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0017 | 0.0043 | 0.0053 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0213 | 0.176 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0813 | 0.0813 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0059 | 0.122 | 0.122 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0154 | 0.0192 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.021 | 0.0262 |
Onchocerca volvulus | 0.0055 | 0.1097 | 1 | |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0033 | 0.0487 | 0.075 |
Echinococcus multilocularis | pyruvate kinase | 0.0017 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0097 | 0.2279 | 0.2839 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0033 | 0.0487 | 0.588 |
Entamoeba histolytica | hypothetical protein | 0.0023 | 0.0213 | 0.176 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0033 | 0.0487 | 0.075 |
Loa Loa (eye worm) | pyruvate kinase | 0.0033 | 0.0487 | 0.0607 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.1097 | 0.1367 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0059 | 0.122 | 0.122 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0487 | 0.0607 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0813 | 0.0813 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0017 | 0.0043 | 0.0043 |
Echinococcus multilocularis | GPCR, family 2 | 0.0031 | 0.0428 | 0.0428 |
Schistosoma mansoni | smad1 5 8 and | 0.0017 | 0.0043 | 0.0053 |
Echinococcus granulosus | pyruvate kinase | 0.0017 | 0.0041 | 0.0041 |
Brugia malayi | Smad1 | 0.0017 | 0.0043 | 0.0066 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0045 | 0.0829 | 1 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0055 | 0.1097 | 0.1367 |
Echinococcus multilocularis | pyruvate kinase | 0.0026 | 0.0294 | 0.0294 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0428 | 0.0533 |
Schistosoma mansoni | pyruvate kinase | 0.0033 | 0.0487 | 0.0607 |
Echinococcus granulosus | snurportin 1 | 0.0302 | 0.8028 | 0.8028 |
Brugia malayi | MH2 domain containing protein | 0.0017 | 0.0043 | 0.0066 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0045 | 0.0829 | 0.1032 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.0082 | 0.0102 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.122 | 1 |
Schistosoma mansoni | smad | 0.0017 | 0.0043 | 0.0053 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0021 | 0.0154 | 0.0154 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0066 | 0.1422 | 0.2189 |
Trypanosoma brucei | GTP-binding nuclear protein rtb2, putative | 0.0021 | 0.0154 | 0.1856 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0.0082 | 0.067 |
Echinococcus granulosus | importin subunit beta 1 | 0.0028 | 0.0363 | 0.0363 |
Schistosoma mansoni | tar DNA-binding protein | 0.0124 | 0.3053 | 0.3803 |
Leishmania major | GTP-binding protein, putative | 0.0021 | 0.0154 | 0.1261 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.122 | 1 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0045 | 0.0829 | 1 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0045 | 0.0829 | 0.0829 |
Plasmodium vivax | importin-beta 2, putative | 0.0028 | 0.0363 | 0.7449 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0033 | 0.0487 | 0.3993 |
Echinococcus granulosus | tar DNA binding protein | 0.0124 | 0.3053 | 0.3053 |
Echinococcus granulosus | pyruvate kinase | 0.0017 | 0.0041 | 0.0041 |
Schistosoma mansoni | pyruvate kinase | 0.0017 | 0.0041 | 0.0051 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0124 | 0.3053 | 0.4698 |
Trichomonas vaginalis | ran, putative | 0.0021 | 0.0154 | 0.0966 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0045 | 0.0829 | 0.0829 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.0082 | 0.0082 |
Plasmodium falciparum | importin beta, putative | 0.0028 | 0.0363 | 0.7449 |
Trichomonas vaginalis | importin beta-1, putative | 0.0023 | 0.0213 | 0.176 |
Loa Loa (eye worm) | Smad1 | 0.0017 | 0.0043 | 0.0053 |
Leishmania major | importin beta-1 subunit, putative | 0.0023 | 0.0213 | 0.1747 |
Leishmania major | pyruvate kinase | 0.0033 | 0.0487 | 0.3993 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.