Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0014 | 0.036 | 0.0089 | |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.2094 | 0.2701 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0035 | 0.144 | 0.6332 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0014 | 0.036 | 0.0351 |
Onchocerca volvulus | 0.0014 | 0.036 | 0.0089 | |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0034 | 0.1373 | 0.3906 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.2063 | 0.2662 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0146 | 0.7149 | 0.7149 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0044 | 0.1912 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0079 | 0.368 | 0.4019 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0.144 | 0.7053 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.284 | 0.3003 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0055 | 0.2489 | 0.3211 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0048 | 0.2094 | 1 |
Onchocerca volvulus | 0.0091 | 0.4331 | 0.7118 | |
Leishmania major | long-chain-fatty-acid-CoA ligase, putative | 0.0014 | 0.036 | 0.0281 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.036 | 0.0464 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0035 | 0.144 | 0.7053 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.284 | 0.284 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0014 | 0.036 | 0.0444 |
Mycobacterium ulcerans | hydrolase | 0.0068 | 0.311 | 1 |
Onchocerca volvulus | 0.0014 | 0.036 | 0.0089 | |
Onchocerca volvulus | Matrilysin homolog | 0.0055 | 0.2489 | 0.3857 |
Leishmania major | acetyl-CoA synthetase, putative | 0.0014 | 0.036 | 0.0281 |
Brugia malayi | RNA binding protein | 0.0062 | 0.284 | 0.3664 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0048 | 0.2094 | 0.6305 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0035 | 0.144 | 0.144 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0036 | 0.1473 | 0.8173 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0041 | 0.1722 | 0.5 |
Echinococcus granulosus | geminin | 0.0175 | 0.8619 | 0.8619 |
Brugia malayi | acetyl-Coenzyme A synthetase 2 | 0.0014 | 0.036 | 0.0464 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1473 | 0.1901 |
Onchocerca volvulus | 0.0048 | 0.2094 | 0.3158 | |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.2063 | 0.2063 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1473 | 0.1901 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.284 | 0.3003 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.284 | 0.3003 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1473 | 0.1901 |
Brugia malayi | Hemopexin family protein | 0.0079 | 0.368 | 0.4747 |
Brugia malayi | AMP-binding enzyme family protein | 0.0048 | 0.2094 | 0.2701 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0034 | 0.1373 | 0.3906 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0048 | 0.2094 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0014 | 0.036 | 0.0464 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.284 | 0.284 |
Leishmania major | acetyl-CoA synthetase, putative | 0.0014 | 0.036 | 0.0281 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0034 | 0.1373 | 0.3906 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0055 | 0.2489 | 0.2578 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0202 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.2063 | 0.2063 |
Brugia malayi | AMP-binding enzyme family protein | 0.0048 | 0.2094 | 0.2701 |
Schistosoma mansoni | alpha glucosidase | 0.0035 | 0.144 | 0.1307 |
Schistosoma mansoni | alpha-glucosidase | 0.0136 | 0.6622 | 0.7582 |
Loa Loa (eye worm) | oxidoreductase | 0.0014 | 0.036 | 0.0464 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0048 | 0.2094 | 0.6305 |
Brugia malayi | Matrixin family protein | 0.0134 | 0.6529 | 0.8423 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0048 | 0.2094 | 1 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0044 | 0.1912 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.2063 | 0.2062 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0044 | 0.1912 | 1 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0035 | 0.144 | 0.7053 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0035 | 0.144 | 0.6332 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0036 | 0.1473 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.031 | 0.04 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0041 | 0.1722 | 0.7917 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1473 | 0.1901 |
Mycobacterium tuberculosis | Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) | 0.0014 | 0.036 | 0.0351 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0014 | 0.036 | 0.0444 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.2489 | 0.3211 |
Echinococcus granulosus | acetyl coenzyme A synthetase cytoplasmic | 0.0014 | 0.036 | 0.036 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0035 | 0.144 | 0.6958 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0158 | 0.7752 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.144 | 1 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0014 | 0.036 | 0.0313 |
Brugia malayi | AMP-binding enzyme family protein | 0.0014 | 0.036 | 0.0464 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0014 | 0.036 | 0.0351 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.284 | 0.3664 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.2489 | 0.3211 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0014 | 0.036 | 0.0464 |
Brugia malayi | Matrixin family protein | 0.0055 | 0.2489 | 0.3211 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.2063 | 0.2063 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0041 | 0.1722 | 1 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0068 | 0.311 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.2063 | 0.2062 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.144 | 1 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0014 | 0.036 | 0.0351 |
Mycobacterium tuberculosis | Probable peptide synthetase Nrp (peptide synthase) | 0.0014 | 0.036 | 0.0351 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0036 | 0.1473 | 0.4048 |
Brugia malayi | AMP-binding enzyme family protein | 0.0014 | 0.036 | 0.0464 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.284 | 0.3003 |
Onchocerca volvulus | 0.0079 | 0.368 | 0.5965 | |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0014 | 0.036 | 0.0464 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0048 | 0.2094 | 0.6435 |
Mycobacterium tuberculosis | Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0014 | 0.036 | 0.0351 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.2063 | 0.2662 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0048 | 0.2094 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0048 | 0.2094 | 0.6305 |
Brugia malayi | Matrixin family protein | 0.0055 | 0.2489 | 0.3211 |
Loa Loa (eye worm) | matrixin family protein | 0.0134 | 0.6529 | 0.8423 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0048 | 0.2094 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0048 | 0.2094 | 0.6305 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0035 | 0.144 | 0.1857 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0068 | 0.311 | 0.4012 |
Brugia malayi | Matrixin family protein | 0.0055 | 0.2489 | 0.3211 |
Entamoeba histolytica | long-chain-fatty-acid--CoA ligase, putative | 0.0014 | 0.036 | 0.0281 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.015 | 0.7366 | 0.9502 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0014 | 0.036 | 0.0351 |
Trypanosoma brucei | long-chain-fatty-acid-CoA ligase, putative | 0.0014 | 0.036 | 0.0444 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.284 | 0.3664 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0014 | 0.036 | 0.0444 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0044 | 0.1912 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.036 | 0.0464 |
Brugia malayi | AMP-binding enzyme family protein | 0.0048 | 0.2094 | 0.2701 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0.144 | 0.7053 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.2489 | 0.3211 |
Brugia malayi | AMP-binding enzyme family protein | 0.0014 | 0.036 | 0.0464 |
Brugia malayi | Matrixin family protein | 0.0055 | 0.2489 | 0.3211 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.284 | 0.3664 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.284 | 0.3664 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0.144 | 0.7053 |
Onchocerca volvulus | 0.0055 | 0.2489 | 0.3857 | |
Echinococcus multilocularis | geminin | 0.0175 | 0.8619 | 0.8619 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.284 | 0.3664 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0048 | 0.2094 | 0.6305 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.2063 | 0.2062 |
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | 0.0014 | 0.036 | 0.0351 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.8619 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.311 | 0.4012 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.2063 | 0.2063 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0158 | 0.7752 | 1 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.015 | 0.7366 | 0.7366 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0035 | 0.144 | 0.7053 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0035 | 0.144 | 0.6332 |
Loa Loa (eye worm) | acetyltransferase | 0.015 | 0.7366 | 0.9502 |
Trypanosoma brucei | acetyl-CoA synthetase, putative | 0.0014 | 0.036 | 0.0444 |
Schistosoma mansoni | alpha-glucosidase | 0.0136 | 0.6622 | 0.7582 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0.144 | 0.7053 |
Mycobacterium ulcerans | hypothetical protein | 0.0048 | 0.2094 | 0.6305 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0035 | 0.144 | 0.7053 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0123 | 0.596 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.284 | 0.3003 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0035 | 0.144 | 0.144 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.2094 | 0.2701 |
Trypanosoma brucei | glucosidase, putative | 0.0035 | 0.144 | 1 |
Echinococcus multilocularis | acetyl coenzyme A synthetase, cytoplasmic | 0.0014 | 0.036 | 0.036 |
Mycobacterium tuberculosis | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | 0.0014 | 0.036 | 0.0351 |
Onchocerca volvulus | Matrilysin homolog | 0.0123 | 0.596 | 1 |
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | 0.0014 | 0.036 | 0.0351 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1473 | 0.1901 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0048 | 0.2094 | 1 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0014 | 0.036 | 0.0464 |
Onchocerca volvulus | 0.0014 | 0.036 | 0.0089 | |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0081 | 0.3804 | 0.417 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0068 | 0.311 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0048 | 0.2094 | 0.6305 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0014 | 0.036 | 0.0313 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0158 | 0.7752 | 0.7752 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.8619 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0158 | 0.7752 | 0.7752 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0158 | 0.7752 | 0.7752 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0034 | 0.1373 | 0.3906 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0035 | 0.144 | 0.7053 |
Loa Loa (eye worm) | matrixin family protein | 0.0123 | 0.596 | 0.7688 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0036 | 0.1473 | 0.4258 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0035 | 0.144 | 0.1857 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0048 | 0.2094 | 0.6305 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0044 | 0.1912 | 0.1912 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0048 | 0.2094 | 0.6435 |
Mycobacterium tuberculosis | Peptide synthetase MbtF (peptide synthase) | 0.0014 | 0.036 | 0.0351 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.015 | 0.7366 | 0.8482 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.2094 | 0.2701 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0048 | 0.2094 | 0.6305 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0036 | 0.1473 | 0.7176 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0014 | 0.036 | 0.0444 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0048 | 0.2094 | 0.6305 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0013 | 0.031 | 0.04 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0044 | 0.1912 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.