Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0 | 0.5 |
Echinococcus multilocularis | geminin | 0.0169 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.5202 | 0.7859 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.01 | 0.5202 | 0.7859 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.01 | 0.5202 | 0.7859 |
Brugia malayi | MH2 domain containing protein | 0.0121 | 0.6619 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0121 | 0.6619 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0032 | 0.0451 | 0.0682 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2654 | 0.2306 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0032 | 0.0451 | 0.0682 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0121 | 0.6619 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0774 | 0.0338 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0069 | 0.3003 | 0.2672 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.0774 | 0.0338 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.01 | 0.5202 | 0.7859 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.2654 | 0.4009 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.2654 | 0.4009 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0069 | 0.3003 | 0.4537 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.2654 | 0.4009 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0774 | 0.5 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0774 | 0.1169 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0451 | 0.0682 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2654 | 0.2306 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0032 | 0.0451 | 0.0682 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2654 | 0.2306 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2654 | 0.2306 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.2654 | 0.4009 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.2654 | 0.2306 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.2654 | 0.4009 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.2654 | 0.2306 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0774 | 0.0338 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0774 | 0.5 |
Brugia malayi | RNA binding protein | 0.0063 | 0.2654 | 0.4009 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.3003 | 0.4537 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2654 | 0.2306 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.0774 | 0.0338 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0774 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0774 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.7079 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 2.5119 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.