Detailed information for compound 736089

Basic information

Technical information
  • TDR Targets ID: 736089
  • Name: N-[3-[2-(3-methoxyphenyl)-2-oxoethoxy]phenyl] -2-methylbenzamide
  • MW: 375.417 | Formula: C23H21NO4
  • H donors: 1 H acceptors: 2 LogP: 4.47 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)C(=O)COc1cccc(c1)NC(=O)c1ccccc1C
  • InChi: 1S/C23H21NO4/c1-16-7-3-4-12-21(16)23(26)24-18-9-6-11-20(14-18)28-15-22(25)17-8-5-10-19(13-17)27-2/h3-14H,15H2,1-2H3,(H,24,26)
  • InChiKey: FJBHJPFPYJJSMK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[3-[2-(3-methoxyphenyl)-2-oxo-ethoxy]phenyl]-2-methyl-benzamide
  • N-[3-[2-keto-2-(3-methoxyphenyl)ethoxy]phenyl]-2-methyl-benzamide
  • STK258168
  • AK-918/42028907
  • ZINC02845600

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.1084 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.1084 1
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0252 0.0194
Echinococcus granulosus muscleblind protein 0.0147 0.8772 0.8765
Loa Loa (eye worm) hypothetical protein 0.001 0.0252 0.0221
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0252 0.0194
Schistosoma mansoni Smad4 0.0008 0.0131 0.0072
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0252 0.1878
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0252 0.0194
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0252 0.0221
Brugia malayi Muscleblind-like protein 0.0147 0.8772 1
Onchocerca volvulus 0.0023 0.1084 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0252 0.0194
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.52 0.5172
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.6232 0.8943
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0636 0.2337
Brugia malayi AMP-binding enzyme family protein 0.0023 0.1084 0.1176
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0252 0.0221
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.52 0.5172
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.52 0.5172
Loa Loa (eye worm) hypothetical protein 0.001 0.0252 0.0221
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0142 0.8406 0.8397
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0252 0.0194
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0636 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0.0717 0.0755
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0252 0.0194
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.2213 0.8732
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0131 0.0082
Brugia malayi AMP-binding enzyme family protein 0.0023 0.1084 0.1176
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0252 0.0221
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.2526 0.2482
Brugia malayi Thioredoxin reductase 0.0047 0.2526 0.2831
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0007 0.0059 0.0085
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0252 0.0221
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0252 0.0194
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.1084 0.1483
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0636 0.5
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0636 0.2337
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.1084 1
Plasmodium falciparum thioredoxin reductase 0.0047 0.2526 1
Brugia malayi glutathione reductase 0.0047 0.2526 0.2831
Echinococcus granulosus smad 0.0008 0.0131 0.0072
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0636 0.058
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0636 0.2337
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.6232 0.8943
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0252 0.0221
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.1084 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.1084 0.1176
Loa Loa (eye worm) hypothetical protein 0.0017 0.0717 0.0755
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0252 0.0194
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.6232 0.8943
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0636 0.2677
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.1084 0.5284
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.2213 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0252 0.0194
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0717 0.1029
Brugia malayi nuclear receptor NHR-88 0.001 0.0252 0.0221
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0636 0.2337
Trypanosoma brucei trypanothione reductase 0.0047 0.2526 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0252 0.0221
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0131 0.0082
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.037 0.0356
Echinococcus granulosus histone acetyltransferase KAT2B 0.0138 0.816 0.8149
Echinococcus multilocularis muscleblind protein 0.0147 0.8772 0.8765
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0131 0.0072
Brugia malayi MH2 domain containing protein 0.0008 0.0131 0.0082
Brugia malayi nuclear hormone receptor 0.001 0.0252 0.0221
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0252 0.0221
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0059 0.0085
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0658 0.0944
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0252 0.0194
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0636 0.5627
Loa Loa (eye worm) glutathione reductase 0.0047 0.2526 0.2831
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.037 0.0356
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0658 0.0944
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0636 0.5627
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0636 0.2337
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0007 0.0059 0.0085
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0636 0.2337
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0252 0.0194
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.2526 0.2482
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.2526 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0252 0.0194
Schistosoma mansoni smad1 5 8 and 0.0008 0.0131 0.0072
Schistosoma mansoni smad1 5 8 and 0.0008 0.0131 0.0072
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0252 0.0221
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0717 0.2667
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0007 0.0059 0.0085
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.6968 1
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0636 0.2677
Schistosoma mansoni nuclear hormone receptor 0.001 0.0252 0.0194
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.2213 0.8732
Loa Loa (eye worm) hypothetical protein 0.0023 0.1084 0.1176
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0636 0.2337
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0252 0.1878
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.1084 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0252 0.0194
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.52 0.5901
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0252 0.1878
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0252 0.0221
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.6937 0.7894
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0636 0.2337
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0131 0.0072
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0252 0.0221
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.1084 0.1555
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0636 0.2337
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.6232 0.8943
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.52 0.5172
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0059 0.0085
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.2526 0.3625
Loa Loa (eye worm) hypothetical protein 0.0147 0.8772 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0636 0.2337
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0717 0.2667
Plasmodium vivax glutathione reductase, putative 0.0047 0.2526 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.6232 0.8934
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.1084 0.5284
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0636 0.2337
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0252 0.0221
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0636 0.2337
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.1998 1
Mycobacterium ulcerans hypothetical protein 0.0023 0.1084 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0252 0.0194
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0252 0.0194
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.6968 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0059 0.0085
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0252 0.0194
Treponema pallidum NADH oxidase 0.0016 0.0636 0.5
Loa Loa (eye worm) hypothetical protein 0.0023 0.1084 0.1176
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.1084 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0636 0.2337
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0658 0.0944
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.1084 0.5284
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0636 0.058
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.52 0.5172
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0252 0.0194
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0636 0.2337
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0252 0.0194
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.1084 0.1483
Plasmodium falciparum glutathione reductase 0.0047 0.2526 1
Schistosoma mansoni smad 0.0008 0.0131 0.0072
Echinococcus multilocularis smad 0.0008 0.0131 0.0072
Brugia malayi acetyltransferase, GNAT family protein 0.0142 0.8406 0.958
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.6937 0.7894
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.1084 0.1555
Schistosoma mansoni thyroid hormone receptor 0.001 0.0252 0.0194
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0252 0.0221
Echinococcus multilocularis muscleblind protein 1 0.0147 0.8772 0.8765
Schistosoma mansoni thyroid hormone receptor 0.001 0.0252 0.0194
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0007 0.0059 0.0085
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0252 0.0221
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0636 0.2337
Loa Loa (eye worm) Smad1 0.0008 0.0131 0.0082
Brugia malayi ecdysteroid receptor 0.001 0.0252 0.0221
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0142 0.8406 0.8397
Brugia malayi MH2 domain containing protein 0.0008 0.0131 0.0082
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.2526 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.1084 0.1176
Schistosoma mansoni smad1 5 8 and 0.0008 0.0131 0.0072
Leishmania major trypanothione reductase 0.0047 0.2526 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0636 0.2337
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0131 0.0072
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0636 0.2337
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0252 0.0221
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0252 0.0221
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0636 0.2337
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.1084 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0252 0.0221
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.52 0.5901
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.1998 1
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0007 0.0059 0.0085
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0252 0.0194
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.52 0.5172
Onchocerca volvulus 0.001 0.0252 0.1878
Loa Loa (eye worm) hypothetical protein 0.0017 0.0717 0.0755
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0131 0.0072
Loa Loa (eye worm) hypothetical protein 0.001 0.0252 0.0221
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0717 0.6421
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0636 0.2337
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0007 0.0059 0.0085
Schistosoma mansoni hypothetical protein 0.0167 1 1
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0252 0.0194
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0636 0.2337
Brugia malayi Smad1 0.0008 0.0131 0.0082
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0636 0.0912
Echinococcus multilocularis geminin 0.0167 1 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0636 0.2337
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.2213 0.8732
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0252 0.0221
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0717 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0717 0.0755
Toxoplasma gondii thioredoxin reductase 0.0047 0.2526 1
Loa Loa (eye worm) hypothetical protein 0.0147 0.8772 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.6968 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0252 0.0194
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0131 0.0072
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0636 0.2337
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0252 0.0194
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.1084 0.4153
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.1084 0.4153
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0636 0.0662
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0252 0.0221
Loa Loa (eye worm) hypothetical protein 0.001 0.0252 0.0221
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.2213 0.2167
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0252 0.0221
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0007 0.0059 0.0085
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0636 0.058
Brugia malayi MH2 domain containing protein 0.0118 0.6937 0.7894
Brugia malayi MH1 domain containing protein 0.0008 0.0131 0.0082
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0252 0.0221
Loa Loa (eye worm) hypothetical protein 0.001 0.0252 0.0221
Echinococcus multilocularis Smad4 0.0008 0.0131 0.0072
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.2213 1
Brugia malayi MH1 domain containing protein 0.0008 0.0131 0.0082
Loa Loa (eye worm) hypothetical protein 0.001 0.0252 0.0221
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0252 0.0194
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.2526 0.2831
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0252 0.0221
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0252 0.0194
Brugia malayi steroid hormone receptor 0.001 0.0252 0.0221
Loa Loa (eye worm) acetyltransferase 0.0142 0.8406 0.958
Plasmodium falciparum glutathione reductase 0.0016 0.0636 0.2337
Loa Loa (eye worm) hypothetical protein 0.001 0.0252 0.0221
Mycobacterium tuberculosis Probable reductase 0.0106 0.6232 0.8943
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.52 0.5172
Schistosoma mansoni hypothetical protein 0.0167 1 1
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.1998 0.786
Plasmodium falciparum thioredoxin reductase 0.0016 0.0636 0.2337
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0658 0.0944
Schistosoma mansoni coup transcription factor 0.001 0.0252 0.0194
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.1084 0.4153
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0252 0.0221
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.6232 0.8943
Echinococcus granulosus FTZ F1 alpha 0.001 0.0252 0.0194
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.6968 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0636 0.2337
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0252 0.0221
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0252 0.0221
Echinococcus granulosus Smad4 0.0008 0.0131 0.0072
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0636 0.5627
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0252 0.0221
Loa Loa (eye worm) hypothetical protein 0.0017 0.0717 0.0755
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0252 0.0194
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0252 0.0194
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0059 0.0085

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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