Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0017 | 0.0357 | 0.0855 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.3726 | 0.3726 |
Loa Loa (eye worm) | glutathione reductase | 0.0048 | 0.2574 | 0.3323 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.004 | 0.1984 | 0.9031 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.0531 | 0.2063 |
Brugia malayi | Heterochromatin protein 1 | 0.0071 | 0.418 | 0.5396 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0531 | 0.0531 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0048 | 0.2574 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.0531 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0017 | 0.0357 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0064 | 0.3726 | 0.481 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.0531 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.004 | 0.1984 | 0.4746 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.3726 | 0.3726 |
Toxoplasma gondii | thioredoxin reductase | 0.0048 | 0.2574 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0064 | 0.3726 | 0.8914 |
Trichomonas vaginalis | conserved hypothetical protein | 0.004 | 0.1984 | 0.4746 |
Trichomonas vaginalis | chromobox protein, putative | 0.0071 | 0.418 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.0531 | 0.0234 |
Echinococcus multilocularis | chromobox protein 1 | 0.0071 | 0.418 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0048 | 0.2574 | 0.3323 |
Echinococcus granulosus | tar DNA binding protein | 0.0064 | 0.3726 | 0.8914 |
Brugia malayi | TAR-binding protein | 0.0064 | 0.3726 | 0.481 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0109 | 0.692 | 0.8837 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.0531 | 0.1271 |
Plasmodium falciparum | glutathione reductase | 0.0048 | 0.2574 | 1 |
Leishmania major | trypanothione reductase | 0.0048 | 0.2574 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0017 | 0.0357 | 0.0855 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0017 | 0.0357 | 0.1389 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0122 | 0.7783 | 1 |
Onchocerca volvulus | 0.0031 | 0.1378 | 0.6276 | |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0048 | 0.2574 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0043 | 0.2196 | 0.5254 |
Brugia malayi | glutathione reductase | 0.0048 | 0.2574 | 0.3323 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1984 | 0.2561 |
Trichomonas vaginalis | chromobox protein, putative | 0.0043 | 0.2196 | 0.5254 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0048 | 0.2574 | 0.6158 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0531 | 0.0784 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0531 | 0.2063 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0121 | 0.7747 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0048 | 0.2574 | 0.6158 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0017 | 0.0357 | 0.1389 |
Loa Loa (eye worm) | RNA binding protein | 0.0064 | 0.3726 | 0.481 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.1378 | 0.1779 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0048 | 0.2574 | 0.2985 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0109 | 0.692 | 0.8837 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0012 | 0.0045 | 0.0059 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0122 | 0.7783 | 1 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0017 | 0.0357 | 0.0855 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.3726 | 0.3726 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0109 | 0.692 | 0.8837 |
Echinococcus granulosus | chromobox protein 1 | 0.0071 | 0.418 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.3726 | 0.3726 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0.0531 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.0531 | 0.1271 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0531 | 0.0686 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0071 | 0.418 | 0.5396 |
Schistosoma mansoni | chromobox protein | 0.0071 | 0.418 | 0.418 |
Plasmodium vivax | glutathione reductase, putative | 0.0048 | 0.2574 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0048 | 0.2574 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0064 | 0.3726 | 0.481 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0531 | 0.0531 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0531 | 0.1271 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0122 | 0.7783 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0531 | 0.0686 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0028 | 0.1166 | 0.2789 |
Echinococcus granulosus | chromobox protein 1 | 0.0071 | 0.418 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0.0531 | 0.0784 |
Echinococcus multilocularis | chromobox protein 1 | 0.0071 | 0.418 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0071 | 0.418 | 1 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0017 | 0.0357 | 0.1389 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0017 | 0.0357 | 0.0357 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0017 | 0.0357 | 0.0855 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0017 | 0.0357 | 0.0461 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0531 | 0.1271 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.3726 | 0.3726 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0064 | 0.3726 | 0.481 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.0531 | 0.0784 |
Brugia malayi | chromobox protein homolog 3 | 0.004 | 0.1984 | 0.2561 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0122 | 0.7783 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0121 | 0.7747 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0121 | 0.7747 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0109 | 0.692 | 0.8837 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0109 | 0.692 | 0.8837 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0048 | 0.2574 | 0.3323 |
Schistosoma mansoni | chromobox protein | 0.0071 | 0.418 | 0.418 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0017 | 0.0357 | 0.1389 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.0531 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0109 | 0.692 | 0.8837 |
Trypanosoma brucei | trypanothione reductase | 0.0048 | 0.2574 | 1 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0043 | 0.2196 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0028 | 0.1166 | 0.2789 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0012 | 0.0045 | 0.0059 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0017 | 0.0357 | 0.1389 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0017 | 0.0357 | 0.1389 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0531 | 0.0784 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.0531 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0531 | 0.2063 |
Brugia malayi | RNA binding protein | 0.0064 | 0.3726 | 0.481 |
Plasmodium falciparum | thioredoxin reductase | 0.0017 | 0.0357 | 0.1389 |
Plasmodium falciparum | glutathione reductase | 0.0017 | 0.0357 | 0.1389 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.