Detailed information for compound 736262

Basic information

Technical information
  • TDR Targets ID: 736262
  • Name: 3-(1,3-benzothiazol-2-yl)-6-ethyl-7-hydroxych romen-4-one
  • MW: 323.366 | Formula: C18H13NO3S
  • H donors: 1 H acceptors: 3 LogP: 4.11 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1cc2c(cc1O)occ(c2=O)c1nc2c(s1)cccc2
  • InChi: 1S/C18H13NO3S/c1-2-10-7-11-15(8-14(10)20)22-9-12(17(11)21)18-19-13-5-3-4-6-16(13)23-18/h3-9,20H,2H2,1H3
  • InChiKey: RNNAZOQXNOLIGU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-(1,3-benzothiazol-2-yl)-6-ethyl-7-hydroxy-chromen-4-one
  • 3-(1,3-benzothiazol-2-yl)-6-ethyl-7-hydroxy-4-chromenone
  • 3-(1,3-benzothiazol-2-yl)-6-ethyl-7-hydroxy-chromone
  • Oprea1_365456
  • CBDivE_003701
  • STOCK1S-19773
  • ZINC00044168
  • IFLab1_000644
  • 3-Benzothiazol-2-yl-6-ethyl-7-hydroxy-chromen-4-one
  • BAS 01057700
  • AG-690/36540054
  • IDI1_008863

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0764 0.1303
Loa Loa (eye worm) hypothetical protein 0.003 0.0813 0.0932
Schistosoma mansoni egf-like domain protein 0.0013 0.0069 0.0108
Brugia malayi Pre-SET motif family protein 0.0206 0.8724 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0323 0.5
Schistosoma mansoni hypothetical protein 0.0018 0.0287 0.045
Loa Loa (eye worm) hypothetical protein 0.0079 0.3038 0.3483
Schistosoma mansoni tar DNA-binding protein 0.0068 0.2557 0.401
Loa Loa (eye worm) hypothetical protein 0.0027 0.0709 0.0813
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0079 0.3038 1
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0045 0.1491 0.1709
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0323 0.037
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0142 0.5865 1
Brugia malayi RNA binding protein 0.0068 0.2557 0.2931
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0079 0.3038 0.4765
Schistosoma mansoni peptidase Clp (S14 family) 0.0079 0.3038 0.4765
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0287 0.0489
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0813 0.1275
Loa Loa (eye worm) hypothetical protein 0.0018 0.0287 0.0329
Schistosoma mansoni hypothetical protein 0.0018 0.0287 0.045
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 0.3038 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.1214 0.1392
Echinococcus granulosus GPCR family 2 0.0018 0.0287 0.0489
Echinococcus granulosus Tolloid protein 1 0.0045 0.1491 0.2542
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0709 1
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0709 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.2013 0.2308
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0287 0.0329
Loa Loa (eye worm) transcription factor SMAD2 0.0129 0.5271 0.6042
Schistosoma mansoni tar DNA-binding protein 0.0068 0.2557 0.401
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 0.3038 1
Loa Loa (eye worm) TAR-binding protein 0.0068 0.2557 0.2931
Brugia malayi Probable ClpP-like protease 0.0079 0.3038 0.3483
Echinococcus multilocularis fibrillin 1 0.0014 0.0134 0.021
Schistosoma mansoni tar DNA-binding protein 0.0068 0.2557 0.401
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0287 0.0489
Schistosoma mansoni ap endonuclease 0.0019 0.0323 0.0506
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.2013 0.2308
Schistosoma mansoni hypothetical protein 0.0142 0.5865 0.9197
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.3038 1
Schistosoma mansoni ap endonuclease 0.0019 0.0323 0.0506
Brugia malayi hypothetical protein 0.0018 0.0276 0.0317
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0813 0.1275
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0711 0.1431
Loa Loa (eye worm) hypothetical protein 0.0013 0.0069 0.0079
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.2557 0.2931
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.2013 0.2308
Schistosoma mansoni hypothetical protein 0.0039 0.1214 0.1904
Schistosoma mansoni hypothetical protein 0.0018 0.0287 0.045
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0323 0.055
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0079 0.3038 0.5
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0287 0.045
Schistosoma mansoni thyroid hormone receptor 0.0154 0.6377 1
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0014 0.0134 0.0154
Trichomonas vaginalis set domain proteins, putative 0.0235 1 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0036 0.0056
Toxoplasma gondii exonuclease III APE 0.0019 0.0323 0.065
Loa Loa (eye worm) hypothetical protein 0.0013 0.0069 0.0079
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.8724 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.1409 0.1616
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0323 0.5
Brugia malayi Fibulin-1 precursor 0.0014 0.0134 0.0154
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0052 0.1815 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0709 0.1423
Echinococcus granulosus tar DNA binding protein 0.0068 0.2557 0.436
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0813 0.1275
Loa Loa (eye worm) hypothetical protein 0.0018 0.0304 0.0348
Schistosoma mansoni tar DNA-binding protein 0.0068 0.2557 0.401
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0079 0.3038 0.5181
Schistosoma mansoni thyroid hormone receptor 0.0154 0.6377 1
Echinococcus granulosus peptidase Clp S14 family 0.0052 0.1815 0.3095
Brugia malayi hypothetical protein 0.0027 0.0709 0.0813
Brugia malayi TAR-binding protein 0.0068 0.2557 0.2931
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0013 0.0069 0.0079
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0079 0.3038 1
Onchocerca volvulus Arrow homolog 0.0013 0.0069 0.0069
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0287 0.0329
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0711 0.1431
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0813 0.1275
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0323 0.037
Echinococcus multilocularis laminin 0.0014 0.0134 0.021
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0079 0.3038 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0079 0.3038 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0711 0.1431
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0045 0.1491 0.2338
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0287 0.0329
Onchocerca volvulus 0.003 0.0813 0.0813
Echinococcus multilocularis Tolloid protein 1 0.0045 0.1491 0.2338
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0052 0.1815 1
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0013 0.0069 0.0079
Loa Loa (eye worm) hypothetical protein 0.0014 0.0134 0.0154
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0287 0.045
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0323 0.0506
Schistosoma mansoni tar DNA-binding protein 0.0068 0.2557 0.401
Echinococcus granulosus laminin 0.0014 0.0134 0.0228
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0813 0.2337
Loa Loa (eye worm) MH2 domain-containing protein 0.0129 0.5271 0.6042
Echinococcus multilocularis GPCR, family 2 0.0018 0.0287 0.045
Echinococcus multilocularis tar DNA binding protein 0.0068 0.2557 0.401
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0036 0.0061
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0813 0.1275
Loa Loa (eye worm) hypothetical protein 0.0039 0.1214 0.1392
Plasmodium vivax SET domain protein, putative 0.003 0.0813 0.1805
Echinococcus multilocularis peptidase Clp (S14 family) 0.0052 0.1815 0.2847
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0052 0.1815 0.4744
Brugia malayi MH2 domain containing protein 0.0129 0.5271 0.6042
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.2013 0.2308
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0079 0.3038 1
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0813 0.1386
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0813 0.1275
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0709 1
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0709 0.198
Brugia malayi Pre-SET motif family protein 0.003 0.0813 0.0932
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0709 0.1423
Echinococcus multilocularis thyroid hormone receptor alpha 0.0154 0.6377 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0079 0.3038 1
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0142 0.5865 0.9197
Loa Loa (eye worm) AStacin protease 0.0028 0.074 0.0848
Schistosoma mansoni hypothetical protein 0.0018 0.0287 0.045
Toxoplasma gondii hypothetical protein 0.0027 0.0711 0.1988
Loa Loa (eye worm) RNA binding protein 0.0068 0.2557 0.2931
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0079 0.3038 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0709 0.1423
Brugia malayi Calcium binding EGF domain containing protein 0.0014 0.0134 0.0154
Schistosoma mansoni hypothetical protein 0.0012 0.0036 0.0056
Leishmania major hypothetical protein, conserved 0.0027 0.0709 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.2557 0.2931

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.