Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | carboxylesterase 5A | 0.0066 | 0.3516 | 0.3516 |
Brugia malayi | Carboxylesterase family protein | 0.0066 | 0.3516 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0066 | 0.3516 | 0.3516 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0011 | 0 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0011 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0066 | 0.3516 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0066 | 0.3516 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0066 | 0.3516 | 0.3516 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.3516 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0011 | 0 | 0.5 |
Onchocerca volvulus | 0.0011 | 0 | 0.5 | |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0011 | 0 | 0.5 |
Onchocerca volvulus | 0.0011 | 0 | 0.5 | |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0011 | 0 | 0.5 |
Onchocerca volvulus | 0.0011 | 0 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0066 | 0.3516 | 0.3516 |
Echinococcus multilocularis | acetylcholinesterase | 0.0066 | 0.3516 | 0.3516 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0066 | 0.3516 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0066 | 0.3516 | 0.3516 |
Echinococcus granulosus | acetylcholinesterase | 0.0066 | 0.3516 | 0.3516 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.3516 | 1 |
Echinococcus multilocularis | geminin | 0.0167 | 1 | 1 |
Onchocerca volvulus | 0.0011 | 0 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0167 | 1 | 1 |
Onchocerca volvulus | 0.0011 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.