Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.0856 | 0.1737 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0127 | 0.493 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.493 | 1 |
Brugia malayi | TAR-binding protein | 0.0127 | 0.493 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.493 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0127 | 0.493 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.493 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0127 | 0.493 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0127 | 0.493 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.4512 | 0.9154 |
Brugia malayi | hypothetical protein | 0.0119 | 0.4512 | 0.9154 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0127 | 0.493 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0 | 0.5 |
Brugia malayi | RNA binding protein | 0.0127 | 0.493 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.493 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0119 | 0.4512 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0 | 0.5 |
Trichomonas vaginalis | esterase, putative | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0856 | 0.1737 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.0856 | 0.1737 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0 | 0.5 |
Onchocerca volvulus | Huntingtin homolog | 0.0119 | 0.4512 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.0856 | 0.1737 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0 | 0.5 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.4512 | 0.9154 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.493 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0127 | 0.493 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0 | 0.5 |
Toxoplasma gondii | ABC1 family protein | 0.0035 | 0 | 0.5 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.