TDR Targets

Basic information

Technical information

TDR Targets ID: 736444
Name: 2-morpholin-4-ylethyl 2-(phenoxy)acetate
MW: 265.305 | Formula: C14H19NO4
H donors: 0 H acceptors: 1 LogP: 1.48 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=C(COc1ccccc1)OCCN1CCOCC1
InChi: 1S/C14H19NO4/c16-14(12-19-13-4-2-1-3-5-13)18-11-8-15-6-9-17-10-7-15/h1-5H,6-12H2
InChiKey: PJKPGKKTDVINIP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-morpholinoethyl 2-(phenoxy)acetate
2-(phenoxy)acetic acid 2-morpholinoethyl ester
2-morpholin-4-ylethyl 2-(phenoxy)ethanoate
Oprea1_195362

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0565	0.4499
Loa Loa (eye worm)	transcription factor SMAD2	0.0131	0.3676	0.3676
Schistosoma mansoni	thyroid hormone receptor	0.0145	0.4119	0.4119
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0049	0.1169	0.318
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0049	0.1169	1
Brugia malayi	hypothetical protein	0.0037	0.0799	0.2174
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0478	0.3702
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.0784	0.2133
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0049	0.1169	1
Trichomonas vaginalis	importin beta-1, putative	0.0026	0.0454	0.3484
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0036	0.0785	1
Echinococcus granulosus	importin subunit beta 1	0.0032	0.0637	0.0637
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0016	0.0172	0.0469
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0862	0.7204
Echinococcus multilocularis	GPCR, family 2	0.0017	0.0185	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0053	0.13	0.13
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0565	0.4499
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0135	0.3788	0.3788
Toxoplasma gondii	HEAT repeat-containing protein	0.0032	0.0637	0.6336
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0799	0.0799
Leishmania major	GTP-binding protein, putative	0.0023	0.0382	0.2099
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0675	0.5501
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0026	0.0454	0.3484
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0016	0.0172	0.0916
Onchocerca volvulus		0.0011	0	0.5
Entamoeba histolytica	hypothetical protein	0.0026	0.0454	0.092
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.0185	0.0185
Entamoeba histolytica	hypothetical protein	0.0037	0.0799	0.5301
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0862	0.7204
Plasmodium vivax	importin-beta 2, putative	0.0032	0.0637	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0479	0.3713
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0049	0.1169	1
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0026	0.0454	0.3484
Echinococcus multilocularis	importin subunit beta 1	0.0032	0.0637	0.0637
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0185	0.0504
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0016	0.0172	0.0172
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0049	0.1169	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0565	0.4499
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0862	0.7204
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0799	0.0799
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0338	1	1
Brugia malayi	TAR-binding protein	0.0068	0.1742	0.4738
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0135	0.3788	0.3788
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0039	0.0863	0.6934
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0643	0.5205
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0557	0.4418
Echinococcus granulosus	tar DNA binding protein	0.0068	0.1742	0.1742
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0016	0.0172	0.0916
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0026	0.0454	0.2826
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.1742	0.1742
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0016	0.0172	0.0916
Giardia lamblia	GTOR	0.0049	0.1169	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0785	0.6498
Onchocerca volvulus	Protein ultraspiracle homolog	0.0011	0	0.5
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0049	0.1169	1
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0023	0.0382	0.0382
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0862	0.7204
Loa Loa (eye worm)	RNA binding protein	0.0068	0.1742	0.1742
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.1742	0.1742
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0785	0.6498
Schistosoma mansoni	hypothetical protein	0.0135	0.3788	0.3788
Schistosoma mansoni	hypothetical protein	0.0036	0.0784	0.0784
Loa Loa (eye worm)	phosphatidylinositol 3	0.0049	0.1169	0.1169
Entamoeba histolytica	hypothetical protein	0.0037	0.0799	0.5301
Brugia malayi	RNA, U transporter 1	0.009	0.2421	0.6587
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0016	0.0172	0.0172
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0479	0.3713
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0068	0.1742	0.1742
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.0185	0.0185
Trypanosoma brucei	importin beta-1 subunit, putative	0.0032	0.0637	0.4663
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0049	0.1169	1
Schistosoma mansoni	ran	0.0023	0.0382	0.0382
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0053	0.13	0.3537
Leishmania major	importin beta-1 subunit, putative	0.0026	0.0454	0.2826
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0784	0.0784
Plasmodium falciparum	importin beta, putative	0.0032	0.0637	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0799	0.0799
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0785	0.6498
Entamoeba histolytica	hypothetical protein	0.0037	0.0799	0.5301
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0016	0.0172	0.0916
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0016	0.0172	0.0172
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.0185	0.0185
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0023	0.0382	0.0382
Onchocerca volvulus	Bile acid receptor homolog	0.0011	0	0.5
Trichomonas vaginalis	ran, putative	0.0023	0.0382	0.2823
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.1742	0.1742
Schistosoma mansoni	hypothetical protein	0.0017	0.0185	0.0185
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0049	0.1169	1
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0049	0.1169	1
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.002	0.0292	0.1204
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0023	0.0382	0.0382
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0049	0.1169	0.1169
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.1742	0.1742
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.0185	0.0185
Echinococcus multilocularis	snurportin 1	0.0338	1	1
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0023	0.0382	0.2099
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0023	0.0382	0.2099
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0016	0.0172	0.0916
Schistosoma mansoni	hypothetical protein	0.0017	0.0185	0.0185
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0023	0.0382	0.2099
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0023	0.0382	0.1038
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0042	0.095	0.8002
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0862	0.7204
Trypanosoma cruzi	target of rapamycin kinase 3	0.0039	0.0863	0.6934
Brugia malayi	Importin beta-1 subunit	0.0032	0.0637	0.1733
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0145	0.4119	0.4119
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0785	0.6498
Loa Loa (eye worm)	phosphatidylinositol 3	0.0016	0.0172	0.0172
Loa Loa (eye worm)	TAR-binding protein	0.0068	0.1742	0.1742
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0053	0.13	0.13
Loa Loa (eye worm)	MH2 domain-containing protein	0.0131	0.3676	0.3676
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0479	0.3713
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0785	0.6498
Echinococcus multilocularis	tar DNA binding protein	0.0068	0.1742	0.1742
Brugia malayi	RNA binding protein	0.0068	0.1742	0.4738
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0049	0.1169	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0478	0.3702
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0557	0.4418
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0023	0.0379	0.207
Echinococcus granulosus	GPCR family 2	0.0017	0.0185	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0185	0.0185
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0011	0	0.5
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.0185	0.0185
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0053	0.13	0.3537
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0637	0.0637
Schistosoma mansoni	hypothetical protein	0.0037	0.0799	0.0799
Schistosoma mansoni	importin beta-1	0.0032	0.0637	0.0637
Schistosoma mansoni	hypothetical protein	0.0017	0.0185	0.0185
Entamoeba histolytica	hypothetical protein	0.0037	0.0799	0.5301
Trypanosoma brucei	importin beta-1 subunit, putative	0.0032	0.0637	0.4663
Schistosoma mansoni	ran	0.0023	0.0382	0.0382
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.1742	0.1742
Schistosoma mansoni	thyroid hormone receptor	0.0145	0.4119	0.4119
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0049	0.1169	0.1169
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0185	0.0504
Brugia malayi	MH2 domain containing protein	0.0131	0.3676	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0049	0.1169	1
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0049	0.1169	0.1169
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0785	0.6498
Schistosoma mansoni	hypothetical protein	0.0338	1	1
Schistosoma mansoni	hypothetical protein	0.0017	0.0185	0.0185
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0785	0.6498
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0478	0.3702
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0479	0.3713
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0039	0.0863	0.6934
Brugia malayi	RNA recognition motif domain containing protein	0.0068	0.1742	0.4738
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0049	0.1169	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 736444