Detailed information for compound 736481

Basic information

Technical information
  • TDR Targets ID: 736481
  • Name: ethyl 2-oxo-2-[2-(4-sulfamoylphenyl)ethylamin o]acetate
  • MW: 300.331 | Formula: C12H16N2O5S
  • H donors: 2 H acceptors: 4 LogP: 0.71 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)C(=O)NCCc1ccc(cc1)S(=O)(=O)N
  • InChi: 1S/C12H16N2O5S/c1-2-19-12(16)11(15)14-8-7-9-3-5-10(6-4-9)20(13,17)18/h3-6H,2,7-8H2,1H3,(H,14,15)(H2,13,17,18)
  • InChiKey: IUAAEOIZASMSEP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-oxo-2-[2-(4-sulfamoylphenyl)ethylamino]acetic acid ethyl ester
  • 2-keto-2-[2-(4-sulfamoylphenyl)ethylamino]acetic acid ethyl ester
  • ethyl 2-oxo-2-[2-(4-sulfamoylphenyl)ethylamino]ethanoate
  • ZINC02831861

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0042 0.0862 0.6934
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0861 0.7204
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0185 0.0185
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0783 0.6498
Toxoplasma gondii HEAT repeat-containing protein 0.0034 0.0638 0.6376
Echinococcus multilocularis thyroid hormone receptor alpha 0.0155 0.4103 0.4103
Loa Loa (eye worm) TAR-binding protein 0.0072 0.1735 0.1735
Loa Loa (eye worm) MH2 domain-containing protein 0.014 0.3677 0.3677
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.1295 0.1295
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0783 0.6498
Entamoeba histolytica hypothetical protein 0.0027 0.0455 0.0924
Echinococcus multilocularis tar DNA binding protein 0.0072 0.1735 0.1735
Brugia malayi RNA binding protein 0.0072 0.1735 0.4719
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0052 0.1167 1
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0025 0.0378 0.207
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0565 0.4499
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0478 0.3713
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0172 0.0172
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0172 0.0916
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0 0.5
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0172 0.0172
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.1295 0.3523
Plasmodium vivax importin-beta 2, putative 0.0034 0.0638 1
Echinococcus multilocularis importin subunit beta 1 0.0034 0.0638 0.0638
Entamoeba histolytica hypothetical protein 0.0039 0.0798 0.5299
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0172 0.0916
Entamoeba histolytica hypothetical protein 0.0039 0.0798 0.5299
Loa Loa (eye worm) hypothetical protein 0.0034 0.0638 0.0638
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0025 0.0383 0.1041
Brugia malayi MH2 domain containing protein 0.014 0.3677 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0052 0.1167 0.1167
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.1167 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0185 0.0185
Schistosoma mansoni tar DNA-binding protein 0.0072 0.1735 0.1735
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0052 0.1167 0.1167
Schistosoma mansoni thyroid hormone receptor 0.0155 0.4103 0.4103
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0185 0.0502
Schistosoma mansoni hypothetical protein 0.0362 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0783 0.6498
Toxoplasma gondii target of rapamycin (TOR), putative 0.0039 0.0783 1
Trypanosoma cruzi target of rapamycin kinase 3 0.0042 0.0862 0.6934
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0477 0.3702
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0455 0.2844
Brugia malayi RNA recognition motif domain containing protein 0.0072 0.1735 0.4719
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.1167 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.1167 1
Leishmania major GTP-binding protein, putative 0.0025 0.0383 0.2116
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.1295 0.3523
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0477 0.3702
Plasmodium falciparum importin beta, putative 0.0034 0.0638 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0798 0.0798
Schistosoma mansoni hypothetical protein 0.0039 0.0798 0.0798
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0781 0.2125
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0798 0.0798
Schistosoma mansoni hypothetical protein 0.0018 0.0185 0.0185
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0172 0.0916
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0172 0.0916
Onchocerca volvulus Bile acid receptor homolog 0.0012 0 0.5
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0025 0.0383 0.0383
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0383 0.2116
Schistosoma mansoni tar DNA-binding protein 0.0072 0.1735 0.1735
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0052 0.1167 1
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0172 0.0172
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0052 0.1167 1
Trichomonas vaginalis ran, putative 0.0025 0.0383 0.2838
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0022 0.0292 0.1204
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0052 0.1167 0.1167
Schistosoma mansoni tar DNA-binding protein 0.0072 0.1735 0.1735
Echinococcus multilocularis snurportin 1 0.0362 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0172 0.0916
Echinococcus granulosus GTP binding nuclear protein Ran 0.0025 0.0383 0.0383
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0383 0.2116
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0185 0.0502
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0172 0.0172
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0025 0.0383 0.2116
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0948 0.8002
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0025 0.0383 0.0383
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0565 0.4499
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0861 0.7204
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0362 1 1
Entamoeba histolytica hypothetical protein 0.0039 0.0798 0.5299
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0144 0.3774 0.3774
Brugia malayi TAR-binding protein 0.0072 0.1735 0.4719
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0042 0.0862 0.6934
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0638 0.4685
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0556 0.4418
Echinococcus granulosus tar DNA binding protein 0.0072 0.1735 0.1735
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0185 0.0185
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0478 0.3713
Schistosoma mansoni tar DNA-binding protein 0.0072 0.1735 0.1735
Schistosoma mansoni hypothetical protein 0.0018 0.0185 0.0185
Loa Loa (eye worm) hypothetical protein 0.0039 0.0781 0.0781
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0 0.5
Giardia lamblia GTOR 0.0052 0.1167 1
Schistosoma mansoni ran 0.0025 0.0383 0.0383
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0052 0.1167 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0861 0.7204
Loa Loa (eye worm) RNA binding protein 0.0072 0.1735 0.1735
Schistosoma mansoni tar DNA-binding protein 0.0072 0.1735 0.1735
Schistosoma mansoni hypothetical protein 0.0144 0.3774 0.3774
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0783 0.6498
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0783 0.6498
Entamoeba histolytica hypothetical protein 0.0039 0.0798 0.5299
Loa Loa (eye worm) phosphatidylinositol 3 0.0052 0.1167 0.1167
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0185 0.0185
Brugia malayi RNA, U transporter 1 0.0096 0.2422 0.6588
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0455 0.35
Echinococcus granulosus importin subunit beta 1 0.0034 0.0638 0.0638
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0185 0.0185
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0072 0.1735 0.1735
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0565 0.4499
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0052 0.1167 0.3173
Schistosoma mansoni thyroid hormone receptor 0.0155 0.4103 0.4103
Loa Loa (eye worm) transcription factor SMAD2 0.014 0.3677 0.3677
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0783 0.6498
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0052 0.1167 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0477 0.3702
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0052 0.1167 1
Brugia malayi hypothetical protein 0.0039 0.0798 0.2171
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0798 0.0798
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0638 0.4685
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0478 0.3713
Schistosoma mansoni hypothetical protein 0.0018 0.0185 0.0185
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0861 0.7204
Loa Loa (eye worm) hypothetical protein 0.0057 0.1295 0.1295
Echinococcus multilocularis GPCR, family 2 0.0018 0.0185 0.0185
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0144 0.3774 0.3774
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0556 0.4418
Brugia malayi Importin beta-1 subunit 0.0034 0.0638 0.1736
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0783 0.6498
Schistosoma mansoni ran 0.0025 0.0383 0.0383
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0455 0.35
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0674 0.5501
Onchocerca volvulus 0.0012 0 0.5
Echinococcus granulosus GPCR family 2 0.0018 0.0185 0.0185
Leishmania major importin beta-1 subunit, putative 0.0027 0.0455 0.2844
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0185 0.0185
Schistosoma mansoni hypothetical protein 0.0039 0.0781 0.0781
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0861 0.7204
Schistosoma mansoni importin beta-1 0.0034 0.0638 0.0638
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0455 0.35
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0052 0.1167 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0478 0.3713
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0642 0.5205
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0052 0.1167 1
Schistosoma mansoni hypothetical protein 0.0018 0.0185 0.0185
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0172 0.0469

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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