Detailed information for compound 736549

Basic information

Technical information
  • TDR Targets ID: 736549
  • Name: 4-chloro-N-(2-methylbutan-2-yl)benzenesulfona mide
  • MW: 261.768 | Formula: C11H16ClNO2S
  • H donors: 1 H acceptors: 2 LogP: 3.03 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(NS(=O)(=O)c1ccc(cc1)Cl)(C)C
  • InChi: 1S/C11H16ClNO2S/c1-4-11(2,3)13-16(14,15)10-7-5-9(12)6-8-10/h5-8,13H,4H2,1-3H3
  • InChiKey: QXGRMPZSNJQFFX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-chloro-N-(1,1-dimethylpropyl)benzenesulfonamide
  • N-tert-amyl-4-chloro-benzenesulfonamide
  • AK-968/40944504
  • ZINC00371903
  • STK128048

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0049 0.1143 0.3108
Schistosoma mansoni hypothetical protein 0.0017 0.0185 0.0185
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0049 0.1143 1
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.002 0.0282 0.1204
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0382 0.0382
Loa Loa (eye worm) TAR-binding protein 0.0069 0.1739 0.1739
Schistosoma mansoni hypothetical protein 0.0017 0.0185 0.0185
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0023 0.0366 0.207
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0382 0.1039
Entamoeba histolytica hypothetical protein 0.0042 0.0927 0.7164
Leishmania major GTP-binding protein, putative 0.0024 0.0382 0.223
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0164 0.0916
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0382 0.0382
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0185 0.0185
Schistosoma mansoni hypothetical protein 0.0343 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.1143 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.1739 0.1739
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0765 0.6498
Plasmodium falciparum importin beta, putative 0.0032 0.0638 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.1298 0.1298
Leishmania major importin beta-1 subunit, putative 0.0026 0.0455 0.2971
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0382 0.0382
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0049 0.1143 1
Trichomonas vaginalis ran, putative 0.0024 0.0382 0.2942
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0382 0.223
Onchocerca volvulus Bile acid receptor homolog 0.0011 0 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0164 0.0916
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0016 0.0164 0.0164
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0185 0.0185
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0841 0.7204
Toxoplasma gondii target of rapamycin (TOR), putative 0.0036 0.0765 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0841 0.7204
Schistosoma mansoni ran 0.0024 0.0382 0.0382
Echinococcus multilocularis thyroid hormone receptor alpha 0.0147 0.4112 0.4112
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0049 0.1143 1
Schistosoma mansoni tar DNA-binding protein 0.0069 0.1739 0.1739
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0049 0.1143 1
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0185 0.0504
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0049 0.1143 0.1143
Loa Loa (eye worm) MH2 domain-containing protein 0.0133 0.3676 0.3676
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0638 0.0638
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0626 0.5205
Trypanosoma cruzi target of rapamycin kinase 3 0.0039 0.0842 0.6934
Schistosoma mansoni importin beta-1 0.0032 0.0638 0.0638
Schistosoma mansoni hypothetical protein 0.0017 0.0185 0.0185
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0841 0.7204
Echinococcus granulosus GPCR family 2 0.0017 0.0185 0.0185
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0 0.5
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0185 0.0185
Loa Loa (eye worm) hypothetical protein 0.0017 0.0185 0.0185
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.1298 0.3532
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0049 0.1143 0.1143
Loa Loa (eye worm) RNA binding protein 0.0069 0.1739 0.1739
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0465 0.3713
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0465 0.3713
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0927 0.0927
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0765 0.6498
Echinococcus multilocularis snurportin 1 0.0343 1 1
Schistosoma mansoni hypothetical protein 0.0017 0.0185 0.0185
Schistosoma mansoni hypothetical protein 0.0037 0.0783 0.0783
Schistosoma mansoni tar DNA-binding protein 0.0069 0.1739 0.1739
Echinococcus multilocularis tar DNA binding protein 0.0069 0.1739 0.1739
Loa Loa (eye worm) hypothetical protein 0.0054 0.1298 0.1298
Brugia malayi MH2 domain containing protein 0.0133 0.3676 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0465 0.3713
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0765 0.6498
Brugia malayi RNA binding protein 0.0069 0.1739 0.4731
Entamoeba histolytica hypothetical protein 0.0042 0.0927 0.7164
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0927 0.8002
Brugia malayi Importin beta-1 subunit 0.0032 0.0638 0.1734
Schistosoma mansoni thyroid hormone receptor 0.0147 0.4112 0.4112
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0765 0.6498
Loa Loa (eye worm) phosphatidylinositol 3 0.0016 0.0164 0.0164
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0464 0.3702
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0382 0.223
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0541 0.4418
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0049 0.1143 0.1143
Entamoeba histolytica hypothetical protein 0.0026 0.0455 0.0953
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0185 0.0185
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0658 0.5501
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0455 0.3615
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0164 0.0916
Onchocerca volvulus 0.0011 0 0.5
Schistosoma mansoni ran 0.0024 0.0382 0.0382
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0638 0.6668
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0039 0.0842 0.6934
Loa Loa (eye worm) hypothetical protein 0.0032 0.0638 0.0638
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0016 0.0164 0.0164
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.1143 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0185 0.0504
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0049 0.1143 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0455 0.3615
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0465 0.3713
Plasmodium vivax importin-beta 2, putative 0.0032 0.0638 1
Entamoeba histolytica hypothetical protein 0.0042 0.0927 0.7164
Entamoeba histolytica hypothetical protein 0.0042 0.0927 0.7164
Loa Loa (eye worm) hypothetical protein 0.0037 0.0783 0.0783
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0049 0.1143 1
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0455 0.3615
Echinococcus granulosus importin subunit beta 1 0.0032 0.0638 0.0638
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0765 0.6498
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.1143 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0039 0.0842 0.6934
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0464 0.3702
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.055 0.4499
Loa Loa (eye worm) transcription factor SMAD2 0.0133 0.3676 0.3676
Schistosoma mansoni thyroid hormone receptor 0.0147 0.4112 0.4112
Loa Loa (eye worm) phosphatidylinositol 3 0.0049 0.1143 0.1143
Echinococcus multilocularis GPCR, family 2 0.0017 0.0185 0.0185
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.1298 0.3532
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.055 0.4499
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0136 0.3782 0.3782
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0927 0.0927
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0016 0.0164 0.0445
Schistosoma mansoni tar DNA-binding protein 0.0069 0.1739 0.1739
Schistosoma mansoni tar DNA-binding protein 0.0069 0.1739 0.1739
Brugia malayi hypothetical protein 0.0042 0.0927 0.2521
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0382 0.223
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0049 0.1143 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0464 0.3702
Schistosoma mansoni tar DNA-binding protein 0.0069 0.1739 0.1739
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0185 0.0185
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0638 0.484
Brugia malayi RNA, U transporter 1 0.0091 0.2422 0.6587
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0016 0.0164 0.0164
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0765 0.6498
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0049 0.1143 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0841 0.7204
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0765 0.6498
Schistosoma mansoni hypothetical protein 0.0136 0.3782 0.3782
Schistosoma mansoni hypothetical protein 0.0042 0.0927 0.0927
Echinococcus granulosus tar DNA binding protein 0.0069 0.1739 0.1739
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0136 0.3782 0.3782
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0343 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0841 0.7204
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.055 0.4499
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0927 0.0927
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0164 0.0916
Giardia lamblia GTOR 0.0049 0.1143 1
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0783 0.213
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0164 0.0916
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0455 0.2971
Brugia malayi TAR-binding protein 0.0069 0.1739 0.4731
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.1739 0.4731
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0638 0.484
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0541 0.4418

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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