TDR Targets

Basic information

Technical information

TDR Targets ID: 736582
Name: 2-methyl-N-(3-morpholin-4-ylpropyl)furan-3-ca rboxamide
MW: 252.309 | Formula: C13H20N2O3
H donors: 1 H acceptors: 1 LogP: 0.69 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1ccoc1C)NCCCN1CCOCC1
InChi: 1S/C13H20N2O3/c1-11-12(3-8-18-11)13(16)14-4-2-5-15-6-9-17-10-7-15/h3,8H,2,4-7,9-10H2,1H3,(H,14,16)
InChiKey: ALXSFPCHYBVGLY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-methyl-N-(3-morpholinopropyl)furan-3-carboxamide
2-methyl-N-(3-morpholinopropyl)-3-furancarboxamide
2-methyl-N-(3-morpholinopropyl)-3-furamide
IVK/8195397

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.0809	0.0809
Loa Loa (eye worm)	phosphatidylinositol 3	0.005	0.1126	0.1126
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0754	0.0754
Brugia malayi	MH2 domain containing protein	0.014	0.3684	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0037	0.0756	0.6498
Toxoplasma gondii	HEAT repeat-containing protein	0.0034	0.0649	0.7045
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0178	0.0178
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.007	0.1675	0.1675
Trichomonas vaginalis	importin beta-1, putative	0.0027	0.0466	0.3754
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.0166	0.0916
Brugia malayi	RNA, U transporter 1	0.0096	0.2431	0.6598
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.083	0.7204
Leishmania major	GTP-binding protein, putative	0.0025	0.0393	0.2369
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.005	0.1126	1
Schistosoma mansoni	tar DNA-binding protein	0.007	0.1675	0.1675
Loa Loa (eye worm)	RNA binding protein	0.007	0.1675	0.1675
Echinococcus granulosus	tar DNA binding protein	0.007	0.1675	0.1675
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	0.0536	0.4418
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0649	0.0649
Brugia malayi	latrophilin 2 splice variant baaae	0.0037	0.0754	0.2047
Onchocerca volvulus	Protein ultraspiracle homolog	0.0011	0	0.5
Giardia lamblia	GTOR	0.005	0.1126	1
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0017	0.0166	0.0166
Schistosoma mansoni	tar DNA-binding protein	0.007	0.1675	0.1675
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0461	0.3713
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0178	0.0484
Entamoeba histolytica	hypothetical protein	0.0039	0.0809	0.567
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.036	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.083	0.7204
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	0.0545	0.4499
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.004	0.0831	0.6934
Loa Loa (eye worm)	MH2 domain-containing protein	0.014	0.3684	0.3684
Loa Loa (eye worm)	TAR-binding protein	0.007	0.1675	0.1675
Leishmania major	importin beta-1 subunit, putative	0.0027	0.0466	0.3123
Brugia malayi	Importin beta-1 subunit	0.0034	0.0649	0.1761
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.083	0.7204
Brugia malayi	hypothetical protein	0.0039	0.0809	0.2195
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.0178	0.0178
Schistosoma mansoni	hypothetical protein	0.0017	0.0178	0.0178
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.005	0.1126	1
Trypanosoma brucei	importin beta-1 subunit, putative	0.0034	0.0649	0.5029
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.046	0.3702
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.005	0.1126	1
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0025	0.0393	0.0393
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0039	0.0809	0.0809
Schistosoma mansoni	importin beta-1	0.0034	0.0649	0.0649
Echinococcus multilocularis	GPCR, family 2	0.0017	0.0178	0.0178
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0461	0.3713
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.0178	0.0178
Onchocerca volvulus		0.0011	0	0.5
Entamoeba histolytica	hypothetical protein	0.0027	0.0466	0.0989
Echinococcus multilocularis	importin subunit beta 1	0.0034	0.0649	0.0649
Schistosoma mansoni	hypothetical protein	0.0017	0.0178	0.0178
Loa Loa (eye worm)	transcription factor SMAD2	0.014	0.3684	0.3684
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	0.0536	0.4418
Loa Loa (eye worm)	hypothetical protein	0.0055	0.125	0.125
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.0178	0.0178
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.083	0.7204
Schistosoma mansoni	thyroid hormone receptor	0.0149	0.396	0.396
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.005	0.1126	0.3055
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0138	0.3642	0.3642
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	0.0545	0.4499
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0037	0.0756	0.6498
Trypanosoma brucei	importin beta-1 subunit, putative	0.0034	0.0649	0.5029
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.046	0.3702
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0037	0.0756	0.6498
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.005	0.1126	1
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0027	0.0466	0.3754
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0039	0.0809	0.0809
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.005	0.1126	1
Trypanosoma cruzi	target of rapamycin kinase 3	0.004	0.0831	0.6934
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0461	0.3713
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0027	0.0466	0.3754
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0037	0.0756	0.6498
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.0166	0.0916
Schistosoma mansoni	hypothetical protein	0.036	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0037	0.0756	0.6498
Trichomonas vaginalis	PIKK family atypical protein kinase	0.005	0.1126	1
Brugia malayi	RNA recognition motif domain containing protein	0.007	0.1675	0.4547
Entamoeba histolytica	hypothetical protein	0.0039	0.0809	0.567
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0178	0.0484
Plasmodium vivax	importin-beta 2, putative	0.0034	0.0649	1
Plasmodium falciparum	importin beta, putative	0.0034	0.0649	1
Entamoeba histolytica	hypothetical protein	0.0039	0.0809	0.567
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0055	0.125	0.3394
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.0166	0.0916
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0017	0.0166	0.0451
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0011	0	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.0166	0.0916
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0017	0.0166	0.0166
Trichomonas vaginalis	PIKK family atypical protein kinase	0.005	0.1126	1
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.005	0.1126	0.1126
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0138	0.3642	0.3642
Schistosoma mansoni	tar DNA-binding protein	0.007	0.1675	0.1675
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.005	0.1126	0.1126
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0149	0.396	0.396
Schistosoma mansoni	ran	0.0025	0.0393	0.0393
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.065	0.5501
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.005	0.1126	1
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0025	0.0393	0.2369
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	0.0545	0.4499
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0027	0.0466	0.3123
Schistosoma mansoni	tar DNA-binding protein	0.007	0.1675	0.1675
Schistosoma mansoni	hypothetical protein	0.0017	0.0178	0.0178
Schistosoma mansoni	thyroid hormone receptor	0.0149	0.396	0.396
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0037	0.0756	0.6498
Echinococcus granulosus	importin subunit beta 1	0.0034	0.0649	0.0649
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.004	0.0831	0.6934
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.083	0.7204
Brugia malayi	RNA binding protein	0.007	0.1675	0.4547
Echinococcus multilocularis	tar DNA binding protein	0.007	0.1675	0.1675
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0037	0.0756	0.6498
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.046	0.3702
Schistosoma mansoni	hypothetical protein	0.0138	0.3642	0.3642
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0055	0.125	0.125
Loa Loa (eye worm)	phosphatidylinositol 3	0.0017	0.0166	0.0166
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0025	0.0393	0.2369
Echinococcus multilocularis	snurportin 1	0.036	1	1
Schistosoma mansoni	tar DNA-binding protein	0.007	0.1675	0.1675
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.005	0.1126	0.1126
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0025	0.0393	0.0393
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0914	0.8002
Echinococcus granulosus	GPCR family 2	0.0017	0.0178	0.0178
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0024	0.0365	0.207
Schistosoma mansoni	hypothetical protein	0.0017	0.0178	0.0178
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0025	0.0393	0.2369
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0025	0.0393	0.1068
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0021	0.0282	0.1204
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.005	0.1126	1
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.005	0.1126	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.0166	0.0916
Brugia malayi	TAR-binding protein	0.007	0.1675	0.4547
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.0178	0.0178
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0017	0.0166	0.0166
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.0178	0.0178
Schistosoma mansoni	hypothetical protein	0.0039	0.0809	0.0809
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0037	0.0756	1
Entamoeba histolytica	hypothetical protein	0.0039	0.0809	0.567
Schistosoma mansoni	ran	0.0025	0.0393	0.0393
Onchocerca volvulus	Bile acid receptor homolog	0.0011	0	0.5
Trichomonas vaginalis	ran, putative	0.0025	0.0393	0.3068
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0025	0.0393	0.0393
Trichomonas vaginalis	PIKK family atypical protein kinase	0.005	0.1126	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0619	0.5205
Schistosoma mansoni	hypothetical protein	0.0037	0.0754	0.0754
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0461	0.3713
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0055	0.125	0.3394

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 736582