Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0265 | 0.2986 | 0.7243 |
Schistosoma mansoni | hypothetical protein | 0.0075 | 0.066 | 0.1736 |
Schistosoma mansoni | hypothetical protein | 0.0113 | 0.1129 | 0.2973 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0113 | 0.1129 | 0.1129 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0073 | 0.0638 | 0.168 |
Trichomonas vaginalis | esterase, putative | 0.0073 | 0.0638 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0466 | 0.5455 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0073 | 0.0638 | 0.1548 |
Leishmania major | hypothetical protein, conserved | 0.0073 | 0.0638 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0331 | 0.3799 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0073 | 0.0638 | 1 |
Brugia malayi | RNA binding protein | 0.0331 | 0.3799 | 0.9217 |
Loa Loa (eye worm) | hypothetical protein | 0.0265 | 0.2986 | 0.7243 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0334 | 0.0811 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0063 | 0.0153 |
Mycobacterium leprae | Probable lipase LipE | 0.0073 | 0.0638 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0113 | 0.1129 | 0.274 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0244 | 0.2737 | 0.664 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0638 | 0.1548 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0073 | 0.0638 | 0.1548 |
Loa Loa (eye worm) | hypothetical protein | 0.0357 | 0.4122 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0331 | 0.3799 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0331 | 0.3799 | 0.9217 |
Brugia malayi | TAR-binding protein | 0.0331 | 0.3799 | 0.9217 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0331 | 0.3799 | 0.9217 |
Echinococcus multilocularis | GPCR, family 2 | 0.0113 | 0.1129 | 0.1129 |
Echinococcus multilocularis | tumor protein p63 | 0.0329 | 0.3774 | 0.3774 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0073 | 0.0638 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0075 | 0.066 | 0.1736 |
Schistosoma mansoni | tar DNA-binding protein | 0.0331 | 0.3799 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0073 | 0.0638 | 0.1548 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0073 | 0.0638 | 1 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0048 | 0.0334 | 0.088 |
Loa Loa (eye worm) | beta-lactamase | 0.0073 | 0.0638 | 0.1548 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0073 | 0.0638 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0638 | 0.1548 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0063 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0113 | 0.1129 | 0.274 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0063 | 0.0153 |
Onchocerca volvulus | 0.0048 | 0.0334 | 0.5237 | |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.066 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0113 | 0.1129 | 0.2973 |
Mycobacterium ulcerans | hypothetical protein | 0.0073 | 0.0638 | 0.5 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0073 | 0.0638 | 0.0638 |
Echinococcus multilocularis | tar DNA binding protein | 0.0331 | 0.3799 | 0.3799 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0073 | 0.0638 | 0.5 |
Brugia malayi | hypothetical protein | 0.0075 | 0.066 | 0.16 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0638 | 0.1548 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0073 | 0.0638 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0244 | 0.2737 | 0.664 |
Mycobacterium ulcerans | beta-lactamase | 0.0073 | 0.0638 | 0.5 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0113 | 0.1129 | 0.2973 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0638 | 0.1548 |
Echinococcus granulosus | tumor protein p63 | 0.0329 | 0.3774 | 0.9935 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.1129 | 0.274 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0638 | 0.1548 |
Mycobacterium ulcerans | lipase LipD | 0.0073 | 0.0638 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0244 | 0.2737 | 0.7204 |
Onchocerca volvulus | 0.0073 | 0.0638 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0113 | 0.1129 | 0.2973 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0113 | 0.1129 | 0.274 |
Schistosoma mansoni | tar DNA-binding protein | 0.0331 | 0.3799 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0073 | 0.0638 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0075 | 0.066 | 0.066 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0063 | 0.5 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0073 | 0.0638 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0357 | 0.4122 | 1 |
Onchocerca volvulus | 0.0073 | 0.0638 | 1 | |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0075 | 0.066 | 0.1736 |
Brugia malayi | beta-lactamase | 0.0073 | 0.0638 | 0.1548 |
Schistosoma mansoni | hypothetical protein | 0.0113 | 0.1129 | 0.2973 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0073 | 0.0638 | 0.1548 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0073 | 0.0638 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.066 | 0.5 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0073 | 0.0638 | 0.168 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0357 | 0.4122 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0073 | 0.0638 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.066 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0073 | 0.0638 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0113 | 0.1129 | 0.1129 |
Onchocerca volvulus | 0.0073 | 0.0638 | 1 | |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.066 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0331 | 0.3799 | 0.9217 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0357 | 0.4122 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0073 | 0.0638 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0113 | 0.1129 | 0.2973 |
Schistosoma mansoni | tar DNA-binding protein | 0.0331 | 0.3799 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0113 | 0.1129 | 0.2973 |
Schistosoma mansoni | tar DNA-binding protein | 0.0331 | 0.3799 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0073 | 0.0638 | 0.168 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0638 | 0.1548 |
Toxoplasma gondii | ABC1 family protein | 0.0073 | 0.0638 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0331 | 0.3799 | 0.9217 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.