Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0051 | 0.0615 | 0.1072 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0281 | 0.0353 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0281 | 0.0333 |
Brugia malayi | intermediate filament protein | 0.0053 | 0.0647 | 0.1293 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0051 | 0.0615 | 0.1211 |
Echinococcus granulosus | lamin | 0.0053 | 0.0647 | 0.0566 |
Onchocerca volvulus | 0.0053 | 0.0647 | 0.0994 | |
Brugia malayi | Pre-SET motif family protein | 0.0217 | 0.4036 | 1 |
Leishmania major | trypanothione reductase | 0.0054 | 0.067 | 0.0949 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0031 | 0.0192 | 0.0136 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.0281 | 0.2474 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0051 | 0.0615 | 0.1072 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.005 | 0.0601 | 0.0519 |
Schistosoma mansoni | lamin | 0.0053 | 0.0647 | 0.1303 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0031 | 0.0192 | 0.0136 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0041 | 0.0412 | 0.0475 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.0041 | 0.0401 | 0.0716 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.005 | 0.0601 | 0.0519 |
Brugia malayi | TAR-binding protein | 0.0196 | 0.36 | 0.888 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0028 | 0.0131 | 0.0002 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0293 | 0.5599 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0293 | 0.5599 | 1 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0293 | 0.5599 | 1 |
Onchocerca volvulus | 0.0247 | 0.4654 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0153 | 0.0219 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0028 | 0.0131 | 0.0002 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0281 | 0.0333 |
Schistosoma mansoni | lamin | 0.0053 | 0.0647 | 0.1303 |
Trypanosoma brucei | phosphatidylinositol 3-kinase tor, putative | 0.0024 | 0.0061 | 0.0108 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0159 | 0.2844 | 0.6937 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0038 | 0.0345 | 0.0476 |
Brugia malayi | RNA binding protein | 0.0196 | 0.36 | 0.888 |
Toxoplasma gondii | ABC1 family protein | 0.0035 | 0.0281 | 0.2474 |
Plasmodium vivax | SET domain protein, putative | 0.0031 | 0.0205 | 0.0996 |
Echinococcus multilocularis | lamin | 0.0053 | 0.0647 | 0.0566 |
Echinococcus multilocularis | GPCR, family 2 | 0.005 | 0.0601 | 0.0519 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0.0281 | 0.0502 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0196 | 0.36 | 0.8902 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0038 | 0.0345 | 0.0476 |
Onchocerca volvulus | 0.0035 | 0.0281 | 0.0172 | |
Trypanosoma brucei | trypanothione reductase | 0.0054 | 0.067 | 0.1196 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.005 | 0.0601 | 0.1175 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0044 | 0.0461 | 0.0732 |
Schistosoma mansoni | tar DNA-binding protein | 0.0196 | 0.36 | 1 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0041 | 0.0412 | 0.0475 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0136 | 0.237 | 0.5399 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0086 | 0.005 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0054 | 0.067 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0041 | 0.0412 | 0.0475 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0281 | 0.0541 |
Schistosoma mansoni | tar DNA-binding protein | 0.0196 | 0.36 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0217 | 0.4036 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0196 | 0.36 | 0.3544 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0041 | 0.04 | 0.0596 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0601 | 0.1168 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0223 | 0.415 | 1 |
Echinococcus granulosus | tumor protein p63 | 0.0353 | 0.6825 | 0.6797 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0281 | 0.0541 |
Onchocerca volvulus | 0.0052 | 0.0626 | 0.0947 | |
Echinococcus multilocularis | geminin | 0.0172 | 0.3106 | 0.3046 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0626 | 0.141 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.2844 | 0.6997 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0054 | 0.067 | 0.0949 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0293 | 0.5599 | 1 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0601 | 0.1168 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0109 | 0.1806 | 0.427 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0136 | 0.237 | 1 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0139 | 0.242 | 0.4162 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0054 | 0.067 | 0.0589 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0281 | 0.0353 |
Brugia malayi | glutathione reductase | 0.0054 | 0.067 | 0.1352 |
Echinococcus multilocularis | lamin dm0 | 0.0053 | 0.0647 | 0.0566 |
Leishmania major | target of rapamycin kinase (TOR) kinase 3 | 0.0041 | 0.0401 | 0.0455 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0136 | 0.237 | 0.5399 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0281 | 0.0541 |
Onchocerca volvulus | 0.0035 | 0.0281 | 0.0172 | |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.0051 | 0.0615 | 0.1098 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0281 | 0.0333 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.0281 | 0.0235 |
Echinococcus multilocularis | tar DNA binding protein | 0.0196 | 0.36 | 0.3544 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.003 | 0.0185 | 0.0122 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.0281 | 0.0196 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0123 | 0.2088 | 0.4671 |
Echinococcus granulosus | geminin | 0.0172 | 0.3106 | 0.3046 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0053 | 0.0647 | 0.1293 |
Plasmodium vivax | glutathione reductase, putative | 0.0054 | 0.067 | 1 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0601 | 0.1168 |
Schistosoma mansoni | tar DNA-binding protein | 0.0196 | 0.36 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.0246 | 0.0256 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0053 | 0.0647 | 0.1463 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0123 | 0.2088 | 0.4671 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0627 | 0.1413 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0031 | 0.0205 | 0.0119 |
Echinococcus granulosus | lamin dm0 | 0.0053 | 0.0647 | 0.0566 |
Plasmodium falciparum | glutathione reductase | 0.0054 | 0.067 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0028 | 0.0144 | 0.0195 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.0281 | 0.0196 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0281 | 0.0541 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0136 | 0.237 | 0.5399 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.3106 | 0.8546 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0038 | 0.0345 | 0.0476 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.005 | 0.0601 | 0.1347 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0281 | 0.0333 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0159 | 0.2844 | 0.6997 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.005 | 0.0601 | 0.0519 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0038 | 0.0345 | 0.0476 |
Leishmania major | target of rapamycin (TOR) kinase 1, putative | 0.0051 | 0.0615 | 0.0848 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0028 | 0.0131 | 0.0002 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0051 | 0.0615 | 0.1072 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0052 | 0.0626 | 0.1241 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0123 | 0.2088 | 0.8651 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0054 | 0.067 | 0.1521 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.0315 | 0.0326 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0031 | 0.0205 | 0.0996 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0139 | 0.242 | 0.4162 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0281 | 0.0235 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0029 | 0.0153 | 0.0273 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0281 | 0.0333 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0205 | 0.0348 |
Trypanosoma cruzi | target of rapamycin kinase 3 | 0.0041 | 0.0401 | 0.0455 |
Echinococcus granulosus | GPCR family 2 | 0.005 | 0.0601 | 0.0519 |
Trichomonas vaginalis | esterase, putative | 0.0035 | 0.0281 | 0.0333 |
Trichomonas vaginalis | set domain proteins, putative | 0.0247 | 0.4654 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0281 | 0.0541 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0054 | 0.067 | 0.1005 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0281 | 0.0235 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.0051 | 0.0615 | 0.0848 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.0315 | 0.0231 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.0051 | 0.0615 | 0.1209 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0281 | 0.0225 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.0051 | 0.0615 | 0.0533 |
Brugia malayi | Latrophilin receptor protein 2 | 0.005 | 0.0601 | 0.1175 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.0051 | 0.0615 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.005 | 0.0597 | 0.0816 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.0051 | 0.0615 | 0.0533 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0051 | 0.0615 | 0.1098 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0054 | 0.067 | 0.0589 |
Schistosoma mansoni | tar DNA-binding protein | 0.0196 | 0.36 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0053 | 0.0647 | 0.0566 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0281 | 0.0541 |
Loa Loa (eye worm) | RNA binding protein | 0.0196 | 0.36 | 0.8902 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0281 | 0.0541 |
Echinococcus multilocularis | musashi | 0.0053 | 0.0647 | 0.0566 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0041 | 0.04 | 0.0596 |
Schistosoma mansoni | intermediate filament proteins | 0.0053 | 0.0647 | 0.1303 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0031 | 0.0205 | 0.0119 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0507 | 1 | 1 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0041 | 0.0412 | 0.0735 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0123 | 0.2088 | 0.4671 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0139 | 0.242 | 0.4322 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.0315 | 0.0231 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0647 | 0.1463 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0281 | 0.0353 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.3106 | 0.8546 |
Onchocerca volvulus | 0.0053 | 0.0647 | 0.0994 | |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0038 | 0.0345 | 0.0476 |
Giardia lamblia | GTOR | 0.0051 | 0.0615 | 0.5 |
Mycobacterium tuberculosis | Probable reductase | 0.0123 | 0.2088 | 0.4671 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0051 | 0.0615 | 0.1382 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0123 | 0.2088 | 0.4671 |
Loa Loa (eye worm) | intermediate filament protein | 0.0053 | 0.0647 | 0.1463 |
Brugia malayi | Thioredoxin reductase | 0.0054 | 0.067 | 0.1352 |
Brugia malayi | Pre-SET motif family protein | 0.0031 | 0.0205 | 0.0156 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0601 | 0.1347 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0281 | 0.0225 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0034 | 0.0269 | 0.0306 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0031 | 0.0192 | 0.0136 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.0051 | 0.0615 | 0.0848 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0031 | 0.0205 | 0.0119 |
Echinococcus multilocularis | tumor protein p63 | 0.0353 | 0.6825 | 0.6797 |
Toxoplasma gondii | thioredoxin reductase | 0.0054 | 0.067 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0123 | 0.2088 | 0.4671 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.005 | 0.0601 | 0.0519 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0041 | 0.04 | 0.0596 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0281 | 0.0541 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.1806 | 0.4382 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0159 | 0.2844 | 0.6937 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0038 | 0.0345 | 0.0476 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0154 | 0.2742 | 0.6362 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.003 | 0.0185 | 0.0122 |
Brugia malayi | hypothetical protein | 0.0037 | 0.0315 | 0.0441 |
Onchocerca volvulus | 0.0035 | 0.0281 | 0.0172 | |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0041 | 0.04 | 0.0596 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0315 | 0.0326 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0196 | 0.36 | 0.888 |
Loa Loa (eye worm) | glutathione reductase | 0.0054 | 0.067 | 0.1521 |
Mycobacterium ulcerans | hypothetical protein | 0.0154 | 0.2742 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0109 | 0.1806 | 0.4716 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0028 | 0.0131 | 0.0002 |
Toxoplasma gondii | hypothetical protein | 0.0047 | 0.0537 | 0.742 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.0051 | 0.0615 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0196 | 0.36 | 1 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.003 | 0.0181 | 0.0096 |
Loa Loa (eye worm) | TAR-binding protein | 0.0196 | 0.36 | 0.8902 |
Toxoplasma gondii | target of rapamycin (TOR), putative | 0.0038 | 0.0345 | 0.3722 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0281 | 0.0353 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0601 | 0.1168 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0041 | 0.04 | 0.0596 |
Brugia malayi | hypothetical protein | 0.0029 | 0.0153 | 0.0024 |
Leishmania major | target of rapamycin (TOR) kinase 2, putative | 0.0051 | 0.0615 | 0.0848 |
Plasmodium falciparum | thioredoxin reductase | 0.0054 | 0.067 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0038 | 0.0345 | 0.0476 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.