Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, putative | 0.0035 | 0.0726 | 0.5 |
Onchocerca volvulus | 0.005 | 0.1183 | 0.5 | |
Echinococcus multilocularis | tumor protein p63 | 0.0341 | 1 | 1 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0127 | 0.352 | 0.2993 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase/rotamase, putative | 0.0035 | 0.0726 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.1676 | 0.3005 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.1676 | 0.3005 |
Brugia malayi | RNA binding protein | 0.0066 | 0.1676 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0127 | 0.352 | 0.8996 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0035 | 0.0726 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.1676 | 0.3005 |
Toxoplasma gondii | peptidylprolyl isomerase | 0.0035 | 0.0726 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0127 | 0.352 | 0.2993 |
Wolbachia endosymbiont of Brugia malayi | parvulin-like peptidyl-prolyl isomerase, PPID | 0.0011 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0036 | 0.0752 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0035 | 0.0726 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0137 | 0.3829 | 0.3327 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.005 | 0.1183 | 0.1403 |
Schistosoma mansoni | thyroid hormone receptor | 0.0137 | 0.3829 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.1676 | 0.3005 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 0.1676 | 0.1 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 0.1676 | 0.1 |
Brugia malayi | TAR-binding protein | 0.0066 | 0.1676 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 0.1676 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.1183 | 0.467 |
Trichomonas vaginalis | rotamase, putative | 0.0036 | 0.0752 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 0.1676 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 0.1676 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.1676 | 0.3005 |
Schistosoma mansoni | thyroid hormone receptor | 0.0137 | 0.3829 | 1 |
Leishmania major | peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative | 0.0035 | 0.0726 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 0.1676 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.