Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0015 | 0.5 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0015 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0015 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0015 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0015 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0015 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.0015 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0015 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0015 | 0.5 | 0.5 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0015 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0015 | 0.5 | 0.5 | |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0015 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0015 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0015 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0015 | 0.5 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0015 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0015 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0015 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.0015 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0015 | 0.5 | 0.5 |
Brugia malayi | hypothetical protein | 0.0015 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0015 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0015 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0015 | 0.5 | 0.5 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0015 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0015 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0015 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.5 | 0.5 |
Loa Loa (eye worm) | SRC-1 | 0.0015 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0015 | 0.5 | 0.5 |
Brugia malayi | protein-tyrosine kinase | 0.0015 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0015 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0015 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0015 | 0.5 | 0.5 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0015 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0015 | 0.5 | 0.5 |
Brugia malayi | SRC-1 | 0.0015 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0015 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.0015 | 0.5 | 0.5 |
Brugia malayi | SH2 domain containing protein | 0.0015 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0015 | 0.5 | 0.5 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0015 | 0.5 | 0.5 |
Echinococcus granulosus | c src tyrosine kinase | 0.0015 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0015 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0015 | 0.5 | 0.5 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0015 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0015 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0015 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0015 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0015 | 0.5 | 0.5 |
Brugia malayi | SH2 domain containing protein | 0.0015 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0015 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK protein kinase | 0.0015 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0015 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0015 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase | 0.0015 | 0.5 | 0.5 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0015 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0015 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine kinase | 0.0015 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0015 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0015 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase | 0.0015 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0015 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0015 | 0.5 | 0.5 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0015 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0015 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0015 | 0.5 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0015 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0015 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0015 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0015 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0015 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0015 | 0.5 | 0.5 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0015 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0015 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GDP ED50 (binding) | = 1.15 mg kg-1 | Inhibition of GDP binding against beta-3 adrenergic receptor in brown adipose tissue (BAT) mitochondria of rats after peroral administration (Dose necessary to produce 50% of the isoprenaline effect). | ChEMBL. | 1350310 |
GDP ED50 (binding) | = 1.15 mg kg-1 | Inhibition of GDP binding against beta-3 adrenergic receptor in brown adipose tissue (BAT) mitochondria of rats after peroral administration (Dose necessary to produce 50% of the isoprenaline effect). | ChEMBL. | 1350310 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.