Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | dna polymerase kappa | 0.0019 | 0.0056 | 0.0063 |
Schistosoma mansoni | bromodomain containing protein | 0.0074 | 0.2241 | 0.4257 |
Leishmania major | cathepsin L-like protease | 0.0066 | 0.1941 | 1 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0019 | 0.0056 | 0.0288 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.027 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0056 | 0.0196 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0039 | 0.0845 | 1 |
Trypanosoma brucei | glucosidase, putative | 0.0039 | 0.0845 | 0.4299 |
Brugia malayi | MH2 domain containing protein | 0.0018 | 0.0038 | 0.0038 |
Schistosoma mansoni | tar DNA-binding protein | 0.0141 | 0.4914 | 0.9334 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0039 | 0.0845 | 1 |
Schistosoma mansoni | Smad4 | 0.0018 | 0.0038 | 0.0072 |
Schistosoma mansoni | tar DNA-binding protein | 0.0141 | 0.4914 | 0.9334 |
Brugia malayi | Bromodomain containing protein | 0.0045 | 0.1084 | 0.1084 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0039 | 0.0845 | 0.0955 |
Echinococcus multilocularis | dna polymerase eta | 0.0019 | 0.0056 | 0.0063 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0026 | 0.0354 | 0.04 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0265 | 0.0504 |
Trypanosoma brucei | unspecified product | 0.0019 | 0.0056 | 0.0196 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.002 | 0.0099 | 0.0189 |
Loa Loa (eye worm) | Smad1 | 0.0018 | 0.0038 | 0.0038 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0021 | 0.0128 | 0.0128 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0056 | 0.0196 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.002 | 0.0099 | 0.0189 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0018 | 0.0038 | 0.0043 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.1941 | 1 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0018 | 0.0038 | 0.0043 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0056 | 0.0056 |
Schistosoma mansoni | smad1 5 8 and | 0.0018 | 0.0038 | 0.0072 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0175 | 0.6228 | 0.7042 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0056 | 0.0196 |
Trypanosoma cruzi | ISWI complex protein | 0.0018 | 0.0018 | 0.0094 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0056 | 0.0196 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.007 | 0.2075 | 0.2347 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0019 | 0.0056 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.1941 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.1941 | 1 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0039 | 0.0845 | 0.4352 |
Echinococcus multilocularis | zinc finger protein | 0.0023 | 0.0216 | 0.0245 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0056 | 0.0288 |
Brugia malayi | PHD-finger family protein | 0.0029 | 0.0464 | 0.0464 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.0056 | 0.0063 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0135 | 0.4656 | 0.5264 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.002 | 0.0099 | 0.0189 |
Brugia malayi | MH2 domain containing protein | 0.0018 | 0.0038 | 0.0038 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0056 | 0.0288 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.1285 | 0.1285 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0056 | 0.0288 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.0056 | 0.0056 |
Schistosoma mansoni | alpha glucosidase | 0.0039 | 0.0845 | 0.1604 |
Leishmania major | DNA polymerase kappa, putative | 0.0019 | 0.0056 | 0.0288 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0018 | 0.0038 | 0.0072 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0056 | 0.0196 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0146 | 0.5085 | 0.575 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0019 | 0.0056 | 0.0661 |
Echinococcus granulosus | zinc finger protein | 0.0023 | 0.0216 | 0.0245 |
Echinococcus multilocularis | tar DNA binding protein | 0.0141 | 0.4914 | 0.5556 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.1941 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.2586 | 0.2586 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0052 | 0.1378 | 0.7098 |
Brugia malayi | RNA binding protein | 0.0141 | 0.4914 | 0.4914 |
Echinococcus granulosus | dna polymerase eta | 0.0019 | 0.0056 | 0.0063 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0019 | 0.0056 | 0.0196 |
Echinococcus granulosus | smad | 0.0018 | 0.0038 | 0.0043 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0056 | 0.0196 |
Brugia malayi | Bromodomain containing protein | 0.0088 | 0.2784 | 0.2784 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0135 | 0.4656 | 0.5264 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0019 | 0.0056 | 0.0106 |
Leishmania major | cathepsin L-like protease | 0.0066 | 0.1941 | 1 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0018 | 0.0038 | 0.0043 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.002 | 0.0099 | 0.0112 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0056 | 0.0196 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.1941 | 1 |
Schistosoma mansoni | survival motor neuron protein | 0.0049 | 0.1254 | 0.2382 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.027 | 1 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0023 | 0.0216 | 0.0411 |
Plasmodium vivax | vivapain-2 | 0.0017 | 0 | 0.5 |
Brugia malayi | MH1 domain containing protein | 0.0018 | 0.0038 | 0.0038 |
Brugia malayi | Smad1 | 0.0018 | 0.0038 | 0.0038 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0099 | 0.0099 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0017 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.1087 | 0.1087 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0039 | 0.0845 | 0.0845 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.1941 | 1 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.002 | 0.0099 | 0.0112 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.1941 | 1 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.002 | 0.0099 | 0.0112 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0039 | 0.0845 | 0.0955 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 0.0056 | 0.0288 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0141 | 0.4914 | 0.4914 |
Brugia malayi | MH1 domain containing protein | 0.0018 | 0.0038 | 0.0038 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0039 | 0.0845 | 1 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0019 | 0.0056 | 0.0661 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0066 | 0.1941 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0141 | 0.4914 | 0.5556 |
Giardia lamblia | DINP protein human, muc B family | 0.0019 | 0.0056 | 0.5 |
Echinococcus multilocularis | dna polymerase kappa | 0.0019 | 0.0056 | 0.0063 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0049 | 0.1254 | 0.1254 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0056 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0056 | 0.0196 |
Brugia malayi | TAR-binding protein | 0.0141 | 0.4914 | 0.4914 |
Echinococcus multilocularis | smad | 0.0018 | 0.0038 | 0.0043 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.002 | 0.0099 | 0.0112 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0039 | 0.0845 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0141 | 0.4914 | 0.9334 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0019 | 0.0056 | 0.0288 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0018 | 0.0035 |
Schistosoma mansoni | hypothetical protein | 0.0135 | 0.4656 | 0.8843 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0042 | 0.0974 | 0.1102 |
Schistosoma mansoni | smad | 0.0018 | 0.0038 | 0.0072 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0175 | 0.6228 | 0.6228 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0241 | 0.8844 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0175 | 0.6228 | 0.7042 |
Loa Loa (eye worm) | hypothetical protein | 0.0241 | 0.8844 | 0.8844 |
Loa Loa (eye worm) | TAR-binding protein | 0.0141 | 0.4914 | 0.4914 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0019 | 0.0056 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0056 | 0.0196 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0017 | 0 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0019 | 0.0056 | 0.0288 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0039 | 0.0845 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0056 | 0.0196 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0024 | 0.0265 | 0.0265 |
Schistosoma mansoni | DNA polymerase eta | 0.0019 | 0.0056 | 0.0106 |
Onchocerca volvulus | 0.0049 | 0.1254 | 0.3788 | |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0017 | 0 | 0.5 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0175 | 0.6228 | 0.6228 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0039 | 0.0845 | 1 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0039 | 0.0845 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.002 | 0.0099 | 0.0189 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0018 | 0.0038 | 0.0038 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0039 | 0.0845 | 1 |
Trypanosoma cruzi | ISWI complex protein | 0.0018 | 0.0018 | 0.0094 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0026 | 0.0354 | 0.0672 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0066 | 0.1941 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0141 | 0.4914 | 0.4914 |
Schistosoma mansoni | smad1 5 8 and | 0.0018 | 0.0038 | 0.0072 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0018 | 0.0038 | 0.0043 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1197 | 0.1197 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0039 | 0.0845 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0039 | 0.0845 | 0.4352 |
Plasmodium vivax | vivapain-2 | 0.0017 | 0 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0066 | 0.1941 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0039 | 0.0845 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0141 | 0.4914 | 0.9334 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0056 | 0.5 |
Echinococcus granulosus | Smad4 | 0.0018 | 0.0038 | 0.0043 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0039 | 0.0845 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0061 | 0.1712 | 0.8824 |
Loa Loa (eye worm) | RNA binding protein | 0.0141 | 0.4914 | 0.4914 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.1941 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0018 | 0.0018 | 0.0035 |
Schistosoma mansoni | alpha-glucosidase | 0.015 | 0.5265 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0018 | 0.0018 | 0.0094 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0026 | 0.0354 | 0.04 |
Schistosoma mansoni | smad1 5 8 and | 0.0018 | 0.0038 | 0.0072 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0056 | 0.0196 |
Echinococcus multilocularis | Smad4 | 0.0018 | 0.0038 | 0.0043 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.1941 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.0056 | 0.0056 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0039 | 0.0845 | 1 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0018 | 0.0038 | 0.0038 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.1941 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.1941 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.007 | 0.2075 | 0.2347 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0066 | 0.1941 | 1 |
Leishmania major | cathepsin L-like protease | 0.0066 | 0.1941 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0019 | 0.0056 | 0.0661 |
Brugia malayi | hypothetical protein | 0.0241 | 0.8844 | 0.8844 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.1254 | 0.2382 |
Onchocerca volvulus | 0.0101 | 0.3311 | 1 | |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0039 | 0.0845 | 0.0845 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0039 | 0.0845 | 0.4352 |
Schistosoma mansoni | tar DNA-binding protein | 0.0141 | 0.4914 | 0.9334 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0241 | 0.8844 | 1 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0019 | 0.0056 | 0.0106 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0175 | 0.6228 | 0.7042 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.0056 | 0.0063 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0019 | 0.0056 | 0.0056 |
Schistosoma mansoni | thyroid hormone receptor | 0.0146 | 0.5085 | 0.9658 |
Schistosoma mansoni | alpha-glucosidase | 0.015 | 0.5265 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0056 | 0.0196 |
Schistosoma mansoni | thyroid hormone receptor | 0.0146 | 0.5085 | 0.9658 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0056 | 0.0196 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0042 | 0.0974 | 0.1102 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.