Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | 0.0019 | 0.003 | 0.003 |
Schistosoma mansoni | alpha glucosidase | 0.004 | 0.0837 | 0.1591 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.2417 | 0.2417 |
Loa Loa (eye worm) | bromodomain containing protein | 0.002 | 0.0079 | 0.0079 |
Schistosoma mansoni | alpha-glucosidase | 0.0155 | 0.5257 | 1 |
Schistosoma mansoni | survival motor neuron protein | 0.005 | 0.122 | 0.232 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.1964 | 1 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.004 | 0.0837 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.018 | 0.6221 | 0.6221 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.004 | 0.0837 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0071 | 0.2044 | 0.2044 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.2044 | 0.3888 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0069 | 0.1964 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.1964 | 1 |
Echinococcus granulosus | Smad4 | 0.0019 | 0.003 | 0.0035 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0992 | 0.0992 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.1964 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.015 | 0.5077 | 0.9658 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0052 | 0.0052 |
Schistosoma mansoni | hypothetical protein | 0.0139 | 0.4648 | 0.8841 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0026 | 0.0294 | 0.0338 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.004 | 0.0837 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0068 | 0.1931 | 0.2218 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.018 | 0.6221 | 0.7144 |
Brugia malayi | Bromodomain containing protein | 0.0086 | 0.2605 | 0.2605 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0278 | 1 | 1 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0054 | 0.1394 | 0.7098 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0069 | 0.1964 | 1 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0026 | 0.0294 | 0.056 |
Brugia malayi | MH2 domain containing protein | 0.0019 | 0.003 | 0.003 |
Leishmania major | cathepsin L-like protease | 0.0069 | 0.1964 | 1 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.004 | 0.0837 | 1 |
Echinococcus granulosus | zinc finger protein | 0.0022 | 0.0164 | 0.0188 |
Echinococcus granulosus | tar DNA binding protein | 0.0071 | 0.2044 | 0.2347 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.004 | 0.0837 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.002 | 0.0052 | 0.01 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0069 | 0.1964 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0063 | 0.1733 | 0.8824 |
Schistosoma mansoni | Smad4 | 0.0019 | 0.003 | 0.0057 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.002 | 0.0052 | 0.01 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.002 | 0.0052 | 0.006 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.004 | 0.0837 | 0.0961 |
Loa Loa (eye worm) | Smad1 | 0.0019 | 0.003 | 0.003 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.118 | 0.118 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.004 | 0.0837 | 0.0961 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.018 | 0.6221 | 0.6221 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.021 | 0.04 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.2044 | 0.3888 |
Schistosoma mansoni | smad1 5 8 and | 0.0019 | 0.003 | 0.0057 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0069 | 0.1964 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.004 | 0.0837 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0837 | 0.4259 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.002 | 0.0052 | 0.006 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.1964 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0041 | 0.0884 | 0.1015 |
Schistosoma mansoni | zinc finger protein | 0.0022 | 0.0164 | 0.0311 |
Brugia malayi | Bromodomain containing protein | 0.0044 | 0.0989 | 0.0989 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.1964 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0245 | 0.8708 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.1964 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.018 | 0.6221 | 0.7144 |
Brugia malayi | PHD-finger family protein | 0.0029 | 0.0399 | 0.0399 |
Leishmania major | cathepsin L-like protease | 0.0069 | 0.1964 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.015 | 0.5077 | 0.5831 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0068 | 0.1931 | 0.2218 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0024 | 0.021 | 0.021 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.002 | 0.0052 | 0.01 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0041 | 0.0884 | 0.1015 |
Brugia malayi | hypothetical protein | 0.0245 | 0.8708 | 0.8708 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.004 | 0.0837 | 0.0837 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.2044 | 0.3888 |
Schistosoma mansoni | smad | 0.0019 | 0.003 | 0.0057 |
Schistosoma mansoni | alpha-glucosidase | 0.0155 | 0.5257 | 1 |
Leishmania major | cathepsin L-like protease | 0.0069 | 0.1964 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.8708 | 0.8708 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.2044 | 0.3888 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0139 | 0.4648 | 0.5338 |
Echinococcus multilocularis | Smad4 | 0.0019 | 0.003 | 0.0035 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.004 | 0.0837 | 1 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0019 | 0.003 | 0.0035 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.005 | 0.122 | 0.122 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.004 | 0.0837 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.004 | 0.0837 | 1 |
Onchocerca volvulus | 0.005 | 0.122 | 0.3693 | |
Brugia malayi | RNA binding protein | 0.0071 | 0.2044 | 0.2044 |
Schistosoma mansoni | smad1 5 8 and | 0.0019 | 0.003 | 0.0057 |
Brugia malayi | MH1 domain containing protein | 0.0019 | 0.003 | 0.003 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0019 | 0.003 | 0.003 |
Echinococcus multilocularis | smad | 0.0019 | 0.003 | 0.0035 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0026 | 0.0294 | 0.0338 |
Echinococcus multilocularis | zinc finger protein | 0.0022 | 0.0164 | 0.0188 |
Loa Loa (eye worm) | RNA binding protein | 0.0071 | 0.2044 | 0.2044 |
Schistosoma mansoni | bromodomain containing protein | 0.0073 | 0.2089 | 0.3974 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0071 | 0.2044 | 0.2044 |
Leishmania major | alpha glucosidase II subunit, putative | 0.004 | 0.0837 | 0.4259 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.002 | 0.0052 | 0.006 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.018 | 0.6221 | 0.7144 |
Echinococcus multilocularis | tar DNA binding protein | 0.0071 | 0.2044 | 0.2347 |
Schistosoma mansoni | thyroid hormone receptor | 0.015 | 0.5077 | 0.9658 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0245 | 0.8708 | 1 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.004 | 0.0837 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.004 | 0.0837 | 0.0837 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.1964 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.1964 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.002 | 0.0052 | 0.01 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.1964 | 1 |
Brugia malayi | Smad1 | 0.0019 | 0.003 | 0.003 |
Plasmodium vivax | vivapain-2 | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0019 | 0.003 | 0.0035 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0019 | 0.003 | 0.003 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0278 | 1 | 1 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0019 | 0.003 | 0.0035 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0139 | 0.4648 | 0.5338 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.1964 | 1 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0019 | 0.003 | 0.0035 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0019 | 0.003 | 0.0057 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0069 | 0.1964 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0018 | 0 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0071 | 0.2044 | 0.2044 |
Onchocerca volvulus | 0.0104 | 0.3303 | 1 | |
Echinococcus granulosus | smad | 0.0019 | 0.003 | 0.0035 |
Brugia malayi | MH1 domain containing protein | 0.0019 | 0.003 | 0.003 |
Plasmodium vivax | vivapain-2 | 0.0018 | 0 | 0.5 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.1096 | 0.1096 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.004 | 0.0837 | 1 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.122 | 0.232 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0837 | 0.4259 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.004 | 0.0837 | 1 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.002 | 0.0052 | 0.006 |
Loa Loa (eye worm) | TAR-binding protein | 0.0071 | 0.2044 | 0.2044 |
Schistosoma mansoni | smad1 5 8 and | 0.0019 | 0.003 | 0.0057 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.2044 | 0.3888 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.