Detailed information for compound 738117

Basic information

Technical information
  • TDR Targets ID: 738117
  • Name: N-(4-bromo-2-chlorophenyl)-2-[(6-ethoxy-1,3-b enzothiazol-2-yl)sulfanyl]acetamide
  • MW: 457.792 | Formula: C17H14BrClN2O2S2
  • H donors: 1 H acceptors: 2 LogP: 5.78 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc2c(c1)sc(n2)SCC(=O)Nc1ccc(cc1Cl)Br
  • InChi: 1S/C17H14BrClN2O2S2/c1-2-23-11-4-6-14-15(8-11)25-17(21-14)24-9-16(22)20-13-5-3-10(18)7-12(13)19/h3-8H,2,9H2,1H3,(H,20,22)
  • InChiKey: HOJOQFYMOMYGLE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-bromo-2-chloro-phenyl)-2-[(6-ethoxy-1,3-benzothiazol-2-yl)sulfanyl]acetamide
  • N-(4-bromo-2-chlorophenyl)-2-[(6-ethoxy-1,3-benzothiazol-2-yl)thio]acetamide
  • N-(4-bromo-2-chloro-phenyl)-2-[(6-ethoxy-1,3-benzothiazol-2-yl)thio]acetamide
  • N-(4-bromo-2-chloro-phenyl)-2-[(6-ethoxy-1,3-benzothiazol-2-yl)sulfanyl]ethanamide
  • CBKinase1_007588
  • CBKinase1_019988
  • STK202427

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis neuropeptide s receptor 0.0463 0.5615 0.5598
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0037 0.0265 0.0894
Mycobacterium ulcerans carboxylesterase, LipT 0.0037 0.0265 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0946 0.3583
Loa Loa (eye worm) carboxylesterase 0.0037 0.0265 0.0894
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0037 0.0265 1
Echinococcus granulosus BC026374 protein S09 family 0.0037 0.0265 0.0406
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0261 0.0223
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0261 0.0399
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0112 0.5
Loa Loa (eye worm) hypothetical protein 0.0037 0.0265 0.0894
Brugia malayi Carboxylesterase family protein 0.0037 0.0265 0.1028
Schistosoma mansoni acetylcholinesterase 0.0037 0.0265 0.0894
Loa Loa (eye worm) hypothetical protein 0.0037 0.0265 0.0894
Loa Loa (eye worm) hypothetical protein 0.0037 0.0265 0.0894
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0946 0.1629
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0261 0.0399
Brugia malayi Carboxylesterase family protein 0.0037 0.0265 0.1028
Schistosoma mansoni gliotactin 0.0037 0.0265 0.0894
Brugia malayi Carboxylesterase family protein 0.0037 0.0265 0.1028
Loa Loa (eye worm) hypothetical protein 0.0221 0.2573 1
Brugia malayi hypothetical protein 0.0025 0.0112 0.0437
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0261 0.9821
Loa Loa (eye worm) hypothetical protein 0.0037 0.0265 0.0894
Echinococcus multilocularis neuropeptide receptor A26 0.0463 0.5615 0.5598
Echinococcus multilocularis BC026374 protein (S09 family) 0.0037 0.0265 0.0227
Echinococcus granulosus carboxylesterase 5A 0.0221 0.2573 0.4547
Leishmania major hypothetical protein, conserved 0.0025 0.0112 0.3341
Onchocerca volvulus 0.0037 0.0265 0.5
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0037 0.0265 0.0894
Echinococcus granulosus para nitrobenzyl esterase 0.0037 0.0265 0.0406
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0038 0.0148
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0112 0.5
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0261 0.0223
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0037 0.0265 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0261 1
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0112 0.5
Schistosoma mansoni hypothetical protein 0.0071 0.069 0.2573
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0261 0.1013
Echinococcus multilocularis para nitrobenzyl esterase 0.0037 0.0265 0.0227
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0037 0.0265 0.0894
Onchocerca volvulus 0.0037 0.0265 0.5
Onchocerca volvulus 0.0037 0.0265 0.5
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0261 0.3411
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0112 0.5
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0261 1
Echinococcus granulosus neuropeptide s receptor 0.0463 0.5615 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0221 0.2573 1
Schistosoma mansoni BC026374 protein (S09 family) 0.0037 0.0265 0.0894
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0261 1
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0261 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0946 0.3583
Onchocerca volvulus 0.0037 0.0265 0.5
Echinococcus granulosus acetylcholinesterase 0.0221 0.2573 0.4547
Echinococcus multilocularis acetylcholinesterase 0.0221 0.2573 0.2545
Loa Loa (eye worm) hypothetical protein 0.0037 0.0265 0.0894
Schistosoma mansoni neuroligin 3 (S09 family) 0.0037 0.0265 0.0894
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0261 1
Echinococcus granulosus neuroligin 0.0037 0.0265 0.0406
Brugia malayi hypothetical protein 0.0037 0.0265 0.1028
Loa Loa (eye worm) hypothetical protein 0.0037 0.0265 0.0894
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0037 0.0265 0.0227
Mycobacterium tuberculosis Carboxylesterase LipT 0.0037 0.0265 1
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0261 0.9821
Loa Loa (eye worm) hypothetical protein 0.0221 0.2573 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0946 0.0912
Echinococcus multilocularis acetylcholinesterase 0.0221 0.2573 0.2545
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0261 0.9821
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0037 0.0265 0.0406
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0946 0.3678
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0946 0.0912
Echinococcus multilocularis carboxylesterase 5A 0.0221 0.2573 0.2545
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0112 0.3341
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0261 0.0399
Trichomonas vaginalis spcc417.12 protein, putative 0.0037 0.0265 1
Brugia malayi Carboxylesterase family protein 0.0037 0.0265 0.1028
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0112 0.3341
Loa Loa (eye worm) hypothetical protein 0.0025 0.0112 0.0293
Loa Loa (eye worm) hypothetical protein 0.0037 0.0265 0.0894
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0038 0.0148
Brugia malayi Carboxylesterase family protein 0.0221 0.2573 1
Echinococcus granulosus neuropeptide receptor A26 0.0463 0.5615 1
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0037 0.0265 1
Echinococcus granulosus acetylcholinesterase 0.0221 0.2573 0.4547
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0112 0.114
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0261 0.0878
Onchocerca volvulus 0.0037 0.0265 0.5
Brugia malayi Carboxylesterase family protein 0.0221 0.2573 1
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0261 0.0878
Echinococcus multilocularis neuroligin 0.0037 0.0265 0.0227
Loa Loa (eye worm) carboxylesterase 0.0037 0.0265 0.0894
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0946 0.3583
Loa Loa (eye worm) hypothetical protein 0.0037 0.0261 0.0878
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0946 0.3583
Loa Loa (eye worm) carboxylesterase 0.0221 0.2573 1
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0261 0.0223
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0946 0.1629
Loa Loa (eye worm) acetylcholinesterase 1 0.0221 0.2573 1
Trypanosoma brucei RNA helicase, putative 0.0071 0.069 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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