TDR Targets

Basic information

Technical information

TDR Targets ID: 738147
Name: 2-[(6-amino-7H-purin-8-yl)sulfanylmethyl]-6-i odo-3-phenylquinazolin-4-one
MW: 527.341 | Formula: C20H14IN7OS
H donors: 2 H acceptors: 4 LogP: 3.03 Rotable bonds: 4
Rule of 5 violations (Lipinski): 2
SMILES: Ic1ccc2c(c1)c(=O)n(c(n2)CSc1nc2c(n1)c(N)[nH]cn2)c1ccccc1
InChi: 1S/C20H14IN7OS/c21-11-6-7-14-13(8-11)19(29)28(12-4-2-1-3-5-12)15(25-14)9-30-20-26-16-17(22)23-10-24-18(16)27-20/h1-8,10H,9H2,(H3,22,23,24,26,27)
InChiKey: NZRVQCHTGVQQMR-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

2-[(6-amino-7H-purin-8-yl)sulfanylmethyl]-6-iodo-3-phenyl-quinazolin-4-one
2-[[(6-amino-7H-purin-8-yl)thio]methyl]-6-iodo-3-phenyl-4-quinazolinone
2-[[(6-amino-7H-purin-8-yl)thio]methyl]-6-iodo-3-phenyl-quinazolin-4-one
CBKinase1_007466
CBKinase1_019866
TULIP021942

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0075	0.0269	0.0255
Schistosoma mansoni	tar DNA-binding protein	0.0535	0.3479	0.3479
Mycobacterium tuberculosis	Probable hydrolase	0.0108	0.0504	0.0877
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0108	0.0504	0.0504
Echinococcus multilocularis	microtubule associated protein 2	0.147	1	1
Trichomonas vaginalis	esterase, putative	0.0108	0.0504	0.0613
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0097	0.0424	0.0424
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0057	0.0149	0.0085
Echinococcus granulosus	histone acetyltransferase MYST2	0.0057	0.0149	0.0149
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0097	0.0424	0.0424
Leishmania major	hypothetical protein, conserved	0.0054	0.0124	0.0053
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0063	0.0187	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0149	0.024
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0057	0.0149	0.0149
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0094	0.0403	1
Brugia malayi	hypothetical protein	0.0511	0.3315	0.5604
Loa Loa (eye worm)	TAR-binding protein	0.0535	0.3479	0.5956
Brugia malayi	Latrophilin receptor protein 2	0.0067	0.0214	0.0198
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0108	0.0504	0.0504
Schistosoma mansoni	thyroid hormone receptor	0.0141	0.0729	0.0729
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0119	0.058	0.1046
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0535	0.3479	0.5956
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0692	0.4575	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0108	0.0504	0.1963
Loa Loa (eye worm)	hypothetical protein	0.0149	0.0791	0.1342
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0075	0.0269	0.1147
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0504	0.085
Echinococcus multilocularis	tumor protein p63	0.1068	0.7193	0.7193
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0108	0.0504	0.0877
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0067	0.0214	0.0214
Trichomonas vaginalis	penicillin-binding protein, putative	0.0108	0.0504	0.0613
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0108	0.0504	0.0704
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0051	0.0102	0.0001
Trichomonas vaginalis	PIKK family atypical protein kinase	0.007	0.0235	0.0203
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0094	0.0403	0.0458
Echinococcus granulosus	SAM and MBT domain containing protein	0.005	0.01	0.01
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0067	0.0214	0.0198
Loa Loa (eye worm)	beta-lactamase	0.0108	0.0504	0.085
Leishmania major	mitochondrial DNA polymerase beta	0.035	0.2191	1
Giardia lamblia	GTOR	0.0094	0.0403	0.5
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.006	0.0167	0.0358
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0078	0.0296	0.0296
Onchocerca volvulus		0.0108	0.0504	0.0614
Trypanosoma cruzi	target of rapamycin kinase 3	0.0075	0.0269	0.0844
Onchocerca volvulus		0.0994	0.6677	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0161	0.0873	0.0873
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0119	0.058	0.1046
Loa Loa (eye worm)	glutathione reductase	0.0052	0.0113	0.0178
Brugia malayi	PHD-finger family protein	0.0053	0.0116	0.0027
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0094	0.0403	0.0403
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0108	0.0504	0.085
Echinococcus granulosus	GPCR family 2	0.0067	0.0214	0.0214
Leishmania major	hypothetical protein, conserved	0.0108	0.0504	0.1882
Loa Loa (eye worm)	RNA binding protein	0.0535	0.3479	0.5956
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.013	0.0656	0.0656
Toxoplasma gondii	hypothetical protein	0.0057	0.0143	0.0583
Trichomonas vaginalis	PIKK family atypical protein kinase	0.007	0.0235	0.0203
Plasmodium vivax	ataxin-2 like protein, putative	0.0054	0.0124	0.0218
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0057	0.0149	0.0149
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0048	0.0081	0.0081
Schistosoma mansoni	tar DNA-binding protein	0.0535	0.3479	0.3479
Loa Loa (eye worm)	thioredoxin reductase	0.0052	0.0113	0.0178
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0094	0.0403	0.1393
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0094	0.0403	0.0527
Schistosoma mansoni	hypothetical protein	0.0144	0.0753	0.0753
Trypanosoma brucei	hypothetical protein, conserved	0.0108	0.0504	0.2229
Mycobacterium tuberculosis	Probable lipase LipD	0.0108	0.0504	0.0877
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0504	0.085
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0199	0.1134	0.1134
Brugia malayi	Bromodomain containing protein	0.0158	0.0854	0.1314
Loa Loa (eye worm)	transcription factor SMAD2	0.0491	0.3175	0.5433
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.013	0.0656	0.0656
Schistosoma mansoni	hypothetical protein	0.0078	0.0296	0.0296
Onchocerca volvulus		0.0108	0.0504	0.0614
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0049	0.0092	0.0331
Echinococcus multilocularis	survival motor neuron protein 1	0.0511	0.3315	0.3315
Echinococcus multilocularis	SAM and MBT domain containing protein	0.005	0.01	0.01
Plasmodium vivax	SET domain protein, putative	0.0125	0.0622	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0097	0.0424	0.0424
Trichomonas vaginalis	D-aminoacylase, putative	0.0108	0.0504	0.0613
Schistosoma mansoni	tar DNA-binding protein	0.0535	0.3479	0.3479
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0094	0.0403	0.0403
Schistosoma mansoni	hypothetical protein	0.0044	0.0053	0.0053
Brugia malayi	Bromodomain containing protein	0.0081	0.0313	0.0371
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0108	0.0504	0.0877
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0067	0.0214	0.0214
Mycobacterium tuberculosis	Conserved protein	0.0108	0.0504	0.0877
Onchocerca volvulus		0.0104	0.0476	0.0572
Mycobacterium tuberculosis	Probable esterase LipL	0.0108	0.0504	0.0877
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0056	0.0139	0.0058
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0056	0.0139	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0504	0.085
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0166	0.0905	0.3809
Schistosoma mansoni	sex comb on midleg homolog	0.005	0.01	0.01
Brugia malayi	hypothetical protein	0.0078	0.0296	0.0342
Trichomonas vaginalis	PIKK family atypical protein kinase	0.007	0.0235	0.0203
Brugia malayi	hypothetical protein	0.0054	0.0124	0.0042
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0055	0.0136	0.0052
Mycobacterium tuberculosis	Probable reductase	0.0119	0.058	0.1046
Schistosoma mansoni	hypothetical protein	0.0067	0.0214	0.0214
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0097	0.0424	0.0565
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.005	0.01	0.01
Echinococcus multilocularis	zinc finger protein	0.0041	0.0037	0.0037
Mycobacterium tuberculosis	Probable lipase LipE	0.0108	0.0504	0.0877
Plasmodium vivax	hypothetical protein, conserved	0.0108	0.0504	0.7687
Toxoplasma gondii	ABC1 family protein	0.0108	0.0504	0.7687
Mycobacterium tuberculosis	Probable dehydrogenase	0.0119	0.058	0.1046
Mycobacterium ulcerans	hypothetical protein	0.0185	0.1035	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0161	0.0873	0.0873
Onchocerca volvulus		0.0157	0.0845	0.1132
Loa Loa (eye worm)	hypothetical protein	0.0511	0.3315	0.5673
Schistosoma mansoni	bromodomain containing protein	0.0134	0.0681	0.0681
Loa Loa (eye worm)	phosphatidylinositol 3	0.0094	0.0403	0.0676
Brugia malayi	TAR-binding protein	0.0535	0.3479	0.5891
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0094	0.0403	0.1479
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0067	0.0214	0.0214
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0211	0.1218	0.2075
Schistosoma mansoni	hypothetical protein	0.0104	0.0476	0.0476
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0314	0.0524
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0132	0.0673	0.1254
Schistosoma mansoni	hypothetical protein	0.0067	0.0214	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0161	0.0873	0.1483
Toxoplasma gondii	LsmAD domain-containing protein	0.0054	0.0124	0.0218
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0094	0.0403	0.1761
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0067	0.0214	0.0214
Trichomonas vaginalis	PIKK family atypical protein kinase	0.007	0.0235	0.0203
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0094	0.0403	0.1479
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0126	0.0628	0.0628
Echinococcus granulosus	tumor protein p63	0.1068	0.7193	0.7193
Brugia malayi	beta-lactamase family protein	0.0108	0.0504	0.0704
Loa Loa (eye worm)	hypothetical protein	0.0211	0.1218	0.2075
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0119	0.058	0.1046
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0094	0.0403	0.0458
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0067	0.0214	0.0351
Loa Loa (eye worm)	hypothetical protein	0.0144	0.0753	0.1277
Loa Loa (eye worm)	hypothetical protein	0.005	0.01	0.0156
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0075	0.0269	0.0752
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0052	0.0113	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0349	0.0583
Echinococcus granulosus	tar DNA binding protein	0.0535	0.3479	0.3479
Echinococcus granulosus	beta LACTamase domain containing family member	0.0108	0.0504	0.0504
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0124	0.0198
Schistosoma mansoni	cellular tumor antigen P53	0.0156	0.0838	0.0838
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0056	0.0139	0.0058
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0078	0.0296	0.0296
Brugia malayi	MH2 domain containing protein	0.0491	0.3175	0.536
Trichomonas vaginalis	PIKK family atypical protein kinase	0.007	0.0235	0.0203
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0094	0.0403	0.1393
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0185	0.1035	0.2067
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0108	0.0504	0.0504
Echinococcus multilocularis	GPCR, family 2	0.0067	0.0214	0.0214
Plasmodium falciparum	ataxin-2 like protein, putative	0.0054	0.0124	1
Schistosoma mansoni	hypothetical protein	0.0067	0.0214	0.0214
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0119	0.058	0.4491
Loa Loa (eye worm)	hypothetical protein	0.009	0.0377	0.0632
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0211	0.1218	0.1949
Schistosoma mansoni	tar DNA-binding protein	0.0535	0.3479	0.3479
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0061	0.0173	0.0109
Schistosoma mansoni	hypothetical protein	0.0067	0.0214	0.0214
Mycobacterium tuberculosis	Conserved protein	0.0108	0.0504	0.0877
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0051	0.0102	0.0001
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0097	0.0424	0.0424
Schistosoma mansoni	microtubule-associated protein tau	0.147	1	1
Loa Loa (eye worm)	PHD-finger family protein	0.0044	0.0053	0.0075
Brugia malayi	glutathione reductase	0.0052	0.0113	0.0022
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0108	0.0504	0.0877
Onchocerca volvulus		0.0156	0.0838	0.1122
Trypanosoma cruzi	PAB1-binding protein , putative	0.0054	0.0124	0.0152
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0097	0.0424	0.0712
Schistosoma mansoni	transcription factor LCR-F1	0.0078	0.0296	0.0296
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0125	0.0622	0.0622
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0097	0.0424	0.0424
Brugia malayi	latrophilin 2 splice variant baaae	0.0144	0.0753	0.1139
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0211	0.1218	0.1949
Trypanosoma cruzi	trypanothione reductase, putative	0.0052	0.0113	0.0099
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0075	0.0269	0.0255
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0048	0.0081	0.0081
Trypanosoma brucei	trypanothione reductase	0.0052	0.0113	0.0427
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0051	0.0102	0.0001
Mycobacterium tuberculosis	Conserved protein	0.0108	0.0504	0.0877
Plasmodium falciparum	ataxin-2 like protein, putative	0.0054	0.0124	1
Brugia malayi	beta-lactamase	0.0108	0.0504	0.0704
Brugia malayi	hypothetical protein	0.0157	0.0845	0.1298
Brugia malayi	RNA binding protein	0.0535	0.3479	0.5891
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0161	0.0873	0.0873
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0132	0.0673	1
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0132	0.0673	0.1254
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0504	0.085
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.035	0.2191	1
Echinococcus granulosus	polycomb protein SCMH1	0.005	0.01	0.01
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0214	0.0351
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0104	0.0476	0.0655
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0075	0.0269	0.0255
Echinococcus multilocularis	tar DNA binding protein	0.0535	0.3479	0.3479
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0125	0.0622	1
Brugia malayi	Pre-SET motif family protein	0.0125	0.0622	0.0909
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0125	0.0622	0.0622
Brugia malayi	Thioredoxin reductase	0.0052	0.0113	0.0022
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0119	0.058	0.1046
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0873	0.5836	1
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0057	0.0149	0.0149
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.035	0.2191	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0108	0.0504	0.1963
Schistosoma mansoni	thyroid hormone receptor	0.0141	0.0729	0.0729
Loa Loa (eye worm)	mbt repeat family protein	0.005	0.01	0.0156
Loa Loa (eye worm)	hypothetical protein	0.0157	0.0845	0.1434
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0075	0.0269	0.0255
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0076	0.0278	0.0278
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0121	0.059	0.059
Echinococcus granulosus	thioredoxin glutathione reductase	0.0052	0.0113	0.0113
Schistosoma mansoni	hypothetical protein	0.0306	0.1885	0.1885
Schistosoma mansoni	tar DNA-binding protein	0.0535	0.3479	0.3479
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0166	0.0905	0.3871
Trichomonas vaginalis	D-aminoacylase, putative	0.0108	0.0504	0.0613
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0097	0.0424	0.0424
Loa Loa (eye worm)	MBCTL1	0.0057	0.0149	0.024
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0199	0.1134	0.1134
Brugia malayi	beta-lactamase family protein	0.0108	0.0504	0.0704
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0044	0.0058	0.0173
Echinococcus granulosus	fetal alzheimer antigen falz	0.0048	0.0081	0.0081
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0057	0.0149	0.0149
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0097	0.0424	0.0424
Trichomonas vaginalis	set domain proteins, putative	0.0994	0.6677	1
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0094	0.0403	0.1761
Schistosoma mansoni	sex comb on midleg homolog	0.005	0.01	0.01
Echinococcus multilocularis	polycomb protein SCMH1	0.005	0.01	0.01
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0055	0.0136	0.0052
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0094	0.0403	0.0458
Echinococcus granulosus	histone lysine methyltransferase setb	0.0161	0.0873	0.0873
Onchocerca volvulus		0.0108	0.0504	0.0614
Schistosoma mansoni	zinc finger protein	0.0041	0.0037	0.0037
Brugia malayi	RNA recognition motif domain containing protein	0.0535	0.3479	0.5891
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0094	0.0403	0.0403
Mycobacterium tuberculosis	Probable oxidoreductase	0.0132	0.0673	0.1254
Onchocerca volvulus		0.0125	0.0622	0.0793
Loa Loa (eye worm)	MH2 domain-containing protein	0.0491	0.3175	0.5433
Trichomonas vaginalis	D-aminoacylase, putative	0.0108	0.0504	0.0613
Schistosoma mansoni	survival motor neuron protein	0.0104	0.0476	0.0476
Trypanosoma cruzi	PAB1-binding protein , putative	0.0054	0.0124	0.0152
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0141	0.0729	0.0729
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0504	0.085
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0075	0.0269	0.0255
Toxoplasma gondii	target of rapamycin (TOR), putative	0.007	0.0235	0.2399
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0504	0.085
Echinococcus granulosus	zinc finger protein	0.0041	0.0037	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0156	0.0838	0.1423
Trypanosoma brucei	PAB1-binding protein , putative	0.0054	0.0124	0.0478
Trichomonas vaginalis	PIKK family atypical protein kinase	0.008	0.0307	0.0313
Trichomonas vaginalis	penicillin-binding protein, putative	0.0108	0.0504	0.0613
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0051	0.0102	0.0001
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0166	0.0905	0.4074
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0094	0.0403	1
Brugia malayi	Pre-SET motif family protein	0.0873	0.5836	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.007	0.0235	0.0203
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0125	0.0622	0.0622
Echinococcus granulosus	survival motor neuron protein 1	0.0511	0.3315	0.3315
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0076	0.0278	0.0278
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.035	0.2191	1
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0126	0.0628	0.0628
Trichomonas vaginalis	PIKK family atypical protein kinase	0.007	0.0235	0.0203
Schistosoma mansoni	hypothetical protein	0.013	0.0656	0.0656

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 738147