Detailed information for compound 738181

Basic information

Technical information
  • TDR Targets ID: 738181
  • Name: 2-[[5-(5-bromo-1-benzofuran-2-yl)-4-ethyl-1,2 ,4-triazol-3-yl]sulfanyl]-N-(3-methylsulfanyl phenyl)acetamide
  • MW: 503.435 | Formula: C21H19BrN4O2S2
  • H donors: 1 H acceptors: 3 LogP: 4.78 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: CSc1cccc(c1)NC(=O)CSc1nnc(n1CC)c1cc2c(o1)ccc(c2)Br
  • InChi: 1S/C21H19BrN4O2S2/c1-3-26-20(18-10-13-9-14(22)7-8-17(13)28-18)24-25-21(26)30-12-19(27)23-15-5-4-6-16(11-15)29-2/h4-11H,3,12H2,1-2H3,(H,23,27)
  • InChiKey: GRWIMBLZJLVYRV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[[5-(5-bromobenzofuran-2-yl)-4-ethyl-1,2,4-triazol-3-yl]sulfanyl]-N-(3-methylsulfanylphenyl)acetamide
  • 2-[[5-(5-bromo-2-benzofuranyl)-4-ethyl-1,2,4-triazol-3-yl]thio]-N-[3-(methylthio)phenyl]acetamide
  • 2-[[5-(5-bromobenzofuran-2-yl)-4-ethyl-1,2,4-triazol-3-yl]thio]-N-[3-(methylthio)phenyl]acetamide
  • 2-[[5-(5-bromo-1-benzofuran-2-yl)-4-ethyl-1,2,4-triazol-3-yl]sulfanyl]-N-(3-methylsulfanylphenyl)ethanamide
  • CBKinase1_019468
  • ZINC02859311
  • STK151541
  • CBKinase1_007068

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum phd finger protein, putative 0.003 0.0085 0.1886
Loa Loa (eye worm) bromodomain containing protein 0.0026 0.0064 0.0115
Mycobacterium ulcerans hypothetical protein 0.0024 0.0053 0.048
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0046 0.0178 0.0318
Loa Loa (eye worm) TAR-binding protein 0.0528 0.3013 0.5377
Loa Loa (eye worm) transcription factor SMAD2 0.0969 0.5604 1
Entamoeba histolytica hypothetical protein 0.0255 0.141 1
Brugia malayi Pre-SET motif family protein 0.0842 0.4855 0.8663
Loa Loa (eye worm) MH2 domain-containing protein 0.0066 0.0298 0.0532
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0199 0.0354
Schistosoma mansoni survival motor neuron protein 0.0047 0.0189 0.023
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0098 0.0483 0.0483
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.033 0.033
Trypanosoma brucei hypothetical protein, conserved 0.0147 0.0773 1
Schistosoma mansoni ferritin 0.0034 0.0107 0.013
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0034 0.0107 0.0177
Schistosoma mansoni tar DNA-binding protein 0.0528 0.3013 0.3665
Toxoplasma gondii target of rapamycin (TOR), putative 0.0034 0.011 0.1047
Schistosoma mansoni smad1 5 8 and 0.0066 0.0298 0.0362
Leishmania major GTP-binding protein, putative 0.0021 0.0032 0.0415
Entamoeba histolytica hypothetical protein 0.0255 0.141 1
Brugia malayi MH2 domain containing protein 0.0066 0.0298 0.0532
Brugia malayi MH1 domain containing protein 0.0037 0.0125 0.0222
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0085 0.0085
Echinococcus granulosus beta LACTamase domain containing family member 0.0147 0.0773 0.0773
Mycobacterium ulcerans beta-lactamase 0.0147 0.0773 1
Loa Loa (eye worm) hypothetical protein 0.0201 0.1088 0.1942
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0031
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0056 0.0721
Brugia malayi beta-lactamase 0.0147 0.0773 0.1379
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0134 0.0239
Onchocerca volvulus 0.0027 0.0066 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0055 0.0099
Schistosoma mansoni tar DNA-binding protein 0.0528 0.3013 0.3665
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0199 0.0199
Schistosoma mansoni zinc finger protein 0.0016 0.0007 0.0008
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0032 0.0415
Trichomonas vaginalis D-aminoacylase, putative 0.0147 0.0773 0.1396
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0055 0.0099
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0123 0.0223
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0046 0.0178 0.2309
Brugia malayi Calcitonin receptor-like protein seb-1 0.0201 0.1088 0.1942
Brugia malayi Ets-domain containing protein 0.0071 0.0327 0.0583
Loa Loa (eye worm) hypothetical protein 0.0025 0.0056 0.0099
Schistosoma mansoni smad 0.003 0.0083 0.0101
Echinococcus multilocularis mothers against decapentaplegic 5 0.0066 0.0298 0.0298
Schistosoma mansoni ferritin 0.0034 0.0107 0.013
Echinococcus multilocularis ferritin 0.0034 0.0107 0.0107
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0066 0.0118
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.011 0.0198
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0297 0.1656 0.2014
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0056 0.0319
Loa Loa (eye worm) hypothetical protein 0.0053 0.0222 0.0397
Loa Loa (eye worm) hypothetical protein 0.0061 0.0266 0.0475
Loa Loa (eye worm) hypothetical protein 0.0041 0.0153 0.0273
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0076 0.0982
Brugia malayi MH1 domain containing protein 0.0066 0.0298 0.0532
Echinococcus granulosus GPCR family 2 0.0063 0.0283 0.0283
Entamoeba histolytica hypothetical protein 0.0255 0.141 1
Schistosoma mansoni apoferritin-2 0.0034 0.0107 0.013
Schistosoma mansoni zinc finger protein 0.0028 0.0076 0.0093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.007 0.0127
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.0021 0.0278
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0053 0.048
Echinococcus granulosus histone lysine methyltransferase setb 0.0139 0.0727 0.0727
Loa Loa (eye worm) hypothetical protein 0.0233 0.1278 0.228
Brugia malayi Bromodomain containing protein 0.004 0.0142 0.0254
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0131 0.0678 0.0678
Echinococcus multilocularis peregrin 0.004 0.0142 0.0142
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0056 0.1072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0055 0.0099
Schistosoma mansoni transcription factor LCR-F1 0.0255 0.141 0.1714
Plasmodium vivax SET domain protein, putative 0.0121 0.0619 0.7967
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0084 0.0152
Mycobacterium ulcerans esterase/lipase LipP 0.0147 0.0773 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0137 0.0137
Giardia lamblia PHD finger protein 15 0.003 0.0085 0.1534
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0066 0.0118
Loa Loa (eye worm) hypothetical protein 0.0028 0.0076 0.0135
Mycobacterium ulcerans lipase LipD 0.0147 0.0773 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0147 0.0773 1
Loa Loa (eye worm) MH2 domain-containing protein 0.003 0.0083 0.0149
Echinococcus granulosus lamin 0.0027 0.0066 0.0066
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0056 0.0721
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0199 0.0242
Brugia malayi latrophilin 2 splice variant baaae 0.0137 0.0716 0.1277
Schistosoma mansoni gabp alpha 0.0071 0.0327 0.0397
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0076 0.0982
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0056 0.051
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0137 0.0137
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0053 0.0053
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0046 0.0178 0.2309
Mycobacterium leprae Probable lipase LipE 0.0147 0.0773 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0089 0.0434 0.0784
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0053 0.0154
Loa Loa (eye worm) hypothetical protein 0.0037 0.0125 0.0222
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0089 0.0434 0.5518
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0056 0.0721
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0139 0.0251
Entamoeba histolytica hypothetical protein 0.0023 0.0045 0.009
Echinococcus granulosus tar DNA binding protein 0.0528 0.3013 0.3013
Echinococcus multilocularis musashi 0.0027 0.0066 0.0066
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0053 0.0064
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0046 0.0178 0.1062
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0085 0.0152
Brugia malayi PHD-finger family protein 0.0034 0.011 0.0196
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0032 0.0198
Schistosoma mansoni ferritin light chain 0.0034 0.0107 0.013
Brugia malayi MH2 domain containing protein 0.0066 0.0298 0.0532
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0153 0.0153
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.007 0.0127
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0032 0.0415
Brugia malayi RNA recognition motif domain containing protein 0.0528 0.3013 0.5377
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0199 0.0242
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0031
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0089 0.0434 0.0784
Schistosoma mansoni tar DNA-binding protein 0.0528 0.3013 0.3665
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0121 0.0619 0.0753
Echinococcus multilocularis mothers against decapentaplegic 2 0.003 0.0083 0.0083
Schistosoma mansoni thyroid hormone receptor 0.0141 0.0739 0.0899
Brugia malayi PHD-finger family protein 0.003 0.0085 0.0152
Schistosoma mansoni ran 0.0021 0.0032 0.0039
Onchocerca volvulus Alhambra homolog 0.003 0.0085 0.0058
Schistosoma mansoni hypothetical protein 0.0255 0.141 0.1714
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0147 0.0773 0.094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0069 0.0124
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0031
Leishmania major hypothetical protein, conserved 0.0016 0.0007 0.0088
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0053 0.0078
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0053 0.0691
Schistosoma mansoni hypothetical protein 0.0022 0.0041 0.0049
Loa Loa (eye worm) hypothetical protein 0.0147 0.0773 0.1379
Onchocerca volvulus 0.0047 0.0189 0.0247
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0046 0.0178 0.0178
Schistosoma mansoni microtubule-associated protein tau 0.1415 0.8223 1
Toxoplasma gondii ABC1 family protein 0.0147 0.0773 1
Echinococcus multilocularis survival motor neuron protein 1 0.0233 0.1278 0.1278
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0032 0.0415
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0053 0.0154
Leishmania major hypothetical protein, conserved 0.0147 0.0773 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0063 0.0283 0.0283
Brugia malayi Bromodomain containing protein 0.0048 0.0195 0.0348
Schistosoma mansoni jumonji domain containing protein 0.0078 0.0365 0.0444
Echinococcus granulosus mothers against decapentaplegic 2 0.003 0.0083 0.0083
Leishmania major hypothetical protein, conserved 0.0025 0.0056 0.0721
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0147 0.0773 0.1407
Brugia malayi jmjC domain containing protein 0.0038 0.0134 0.0239
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0053 0.0053
Echinococcus multilocularis tar DNA binding protein 0.0528 0.3013 0.3013
Brugia malayi RNA, U transporter 1 0.008 0.0382 0.0681
Brugia malayi Importin beta-1 subunit 0.0028 0.0076 0.0135
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0046 0.0178 0.2309
Trichomonas vaginalis D-aminoacylase, putative 0.0147 0.0773 0.1396
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0121 0.0619 0.7926
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0046 0.0178 0.2309
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0095
Loa Loa (eye worm) hypothetical protein 0.0147 0.0773 0.1379
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.011 0.0198
Trypanosoma cruzi ISWI complex protein 0.0016 0.0007 0.0088
Brugia malayi beta-lactamase family protein 0.0147 0.0773 0.1379
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0056 0.1072
Loa Loa (eye worm) hypothetical protein 0.0139 0.0727 0.1298
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.0124 0.1601
Trypanosoma cruzi ISWI complex protein 0.0016 0.0007 0.0088
Brugia malayi Pre-SET motif family protein 0.0121 0.0619 0.1105
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0018 0.0022
Mycobacterium tuberculosis Probable lipase LipE 0.0147 0.0773 0.1407
Schistosoma mansoni Smad4 0.003 0.0083 0.0101
Loa Loa (eye worm) fli-1 protein 0.0215 0.1175 0.2097
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0201 0.1088 0.1942
Schistosoma mansoni hypothetical protein 0.0016 0.0007 0.0008
Echinococcus multilocularis Smad4 0.0066 0.0298 0.0298
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0123 0.0223
Echinococcus granulosus peregrin 0.004 0.0142 0.0142
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0053 0.0095
Loa Loa (eye worm) hypothetical protein 0.0147 0.0773 0.1379
Mycobacterium tuberculosis Probable esterase LipL 0.0147 0.0773 0.1407
Onchocerca volvulus 0.0251 0.1387 0.2431
Mycobacterium ulcerans hypothetical protein 0.0147 0.0773 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0046 0.0178 0.0217
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0055 0.0099
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0055 0.0099
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0939 0.5423 1
Loa Loa (eye worm) hypothetical protein 0.0251 0.1387 0.2475
Trichomonas vaginalis ran, putative 0.0021 0.0032 0.0058
Schistosoma mansoni ferritin light chain 0.0034 0.0107 0.013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.011 0.0198
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0199 0.0199
Echinococcus multilocularis zinc finger protein 0.0028 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0147 0.0773 0.1379
Trichomonas vaginalis set domain proteins, putative 0.0958 0.5538 1
Schistosoma mansoni intermediate filament proteins 0.0027 0.0066 0.008
Echinococcus multilocularis GA binding protein alpha chain 0.0071 0.0327 0.0327
Schistosoma mansoni smad 0.0066 0.0298 0.0362
Onchocerca volvulus 0.0027 0.0066 0.0023
Loa Loa (eye worm) hypothetical protein 0.0076 0.0358 0.0638
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.011 0.0198
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0271 0.0484
Loa Loa (eye worm) latrophilin receptor protein 2 0.0063 0.0283 0.0505
Loa Loa (eye worm) hypothetical protein 0.003 0.0083 0.0149
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0031
Schistosoma mansoni hypothetical protein 0.003 0.0085 0.0103
Loa Loa (eye worm) hypothetical protein 0.0027 0.0066 0.0118
Mycobacterium tuberculosis Probable lipase LipD 0.0147 0.0773 0.1407
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0034 0.0107 0.0749
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.0112
Brugia malayi hypothetical protein 0.0255 0.141 0.2516
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0121 0.0619 0.0753
Brugia malayi acetyltransferase, GNAT family protein 0.0297 0.1656 0.2956
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0139 0.0727 0.0884
Loa Loa (eye worm) phosphatidylinositol 3 0.0046 0.0178 0.0318
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0031
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0134 0.0163
Echinococcus granulosus lamin dm0 0.0027 0.0066 0.0066
Schistosoma mansoni Smad4 0.003 0.0083 0.0101
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0302 0.1681 0.3001
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0098 0.0483 0.0483
Onchocerca volvulus 0.0121 0.0619 0.1032
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0116 0.0593 0.0593
Echinococcus granulosus expressed protein 0.0034 0.0107 0.0107
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0147 0.0773 0.1407
Mycobacterium ulcerans bacterioferritin BfrA 0.0034 0.0107 0.1193
Mycobacterium leprae conserved hypothetical protein 0.0147 0.0773 1
Mycobacterium tuberculosis Conserved protein 0.0147 0.0773 0.1407
Echinococcus granulosus TGF beta signal transducer SmadC 0.0066 0.0298 0.0298
Plasmodium vivax hypothetical protein, conserved 0.003 0.0085 0.0898
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0063 0.0283 0.0283
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0045 0.0576
Brugia malayi Latrophilin receptor protein 2 0.0063 0.0283 0.0505
Schistosoma mansoni hypothetical protein 0.0063 0.0283 0.0344
Schistosoma mansoni hypothetical protein 0.0063 0.0283 0.0344
Plasmodium vivax hypothetical protein, conserved 0.0147 0.0773 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0066 0.0298 0.0298
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0053 0.0691
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0066 0.0118
Schistosoma mansoni Smad4 0.0066 0.0298 0.0362
Echinococcus granulosus microtubule associated protein 2 0.1415 0.8223 0.8223
Brugia malayi jmjC domain containing protein 0.0098 0.0483 0.0862
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0041 0.0072
Loa Loa (eye worm) beta-lactamase 0.0147 0.0773 0.1379
Loa Loa (eye worm) Smad1 0.0066 0.0298 0.0532
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0147 0.0773 0.094
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0199 0.0242
Echinococcus granulosus snurportin 1 0.0302 0.1681 0.1681
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0842 0.4855 0.8663
Schistosoma mansoni tar DNA-binding protein 0.0528 0.3013 0.3665
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0066 0.0298 0.0362
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0153 0.0153
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0017 0.5
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.0037 0.0478
Onchocerca volvulus 0.0147 0.0773 0.1312
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0046 0.0178 0.0178
Loa Loa (eye worm) MH2 domain-containing protein 0.0969 0.5604 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.021 0.0375
Entamoeba histolytica acetyltransferase, GNAT family 0.0079 0.0377 0.2501
Schistosoma mansoni ets-related 0.0215 0.1175 0.1429
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0199 0.0199
Schistosoma mansoni importin beta-1 0.0028 0.0076 0.0092
Brugia malayi TAR-binding protein 0.0528 0.3013 0.5377
Echinococcus multilocularis GPCR, family 2 0.0063 0.0283 0.0283
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0045 0.008
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0076 0.0076
Brugia malayi F/Y-rich N-terminus family protein 0.0016 0.0005 0.001
Loa Loa (eye worm) hypothetical protein 0.003 0.0085 0.0152
Trypanosoma brucei ISWI complex protein 0.0016 0.0007 0.0088
Trichomonas vaginalis D-aminoacylase, putative 0.0147 0.0773 0.1396
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0147 0.0773 0.1379
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0139 0.0727 0.0884
Echinococcus granulosus importin subunit beta 1 0.0028 0.0076 0.0076
Echinococcus granulosus GA binding protein alpha chain 0.0071 0.0327 0.0327
Brugia malayi Smad1 0.0066 0.0298 0.0532
Mycobacterium ulcerans bacterioferritin BfrB 0.0034 0.0107 0.1193
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0032 0.0032
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0045 0.008
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0051 0.021 0.0375
Brugia malayi RNA binding protein 0.0528 0.3013 0.5377
Schistosoma mansoni hypothetical protein 0.0131 0.0678 0.0824
Echinococcus multilocularis thyroid hormone receptor alpha 0.0141 0.0739 0.0739
Loa Loa (eye worm) acetyltransferase 0.0297 0.1656 0.2956
Echinococcus granulosus histone acetyltransferase KAT2B 0.0089 0.0434 0.0434
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.009 0.0163
Schistosoma mansoni lamin 0.0027 0.0066 0.008
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0134 0.0163
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0046 0.0178 0.2309
Giardia lamblia Histone acetyltransferase GCN5 0.0079 0.0377 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0085 0.0103
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.0124 0.1601
Schistosoma mansoni thyroid hormone receptor 0.0141 0.0739 0.0899
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0076 0.0591
Schistosoma mansoni hypothetical protein 0.0063 0.0283 0.0344
Brugia malayi MH2 domain containing protein 0.003 0.0083 0.0149
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0089 0.0434 0.5428
Loa Loa (eye worm) RNA binding protein 0.0528 0.3013 0.5377
Plasmodium vivax importin-beta 2, putative 0.0028 0.0076 0.0778
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0123 0.0223
Brugia malayi MH1 domain containing protein 0.0037 0.0125 0.0222
Echinococcus multilocularis lamin dm0 0.0027 0.0066 0.0066
Echinococcus multilocularis tumor protein p63 0.1718 1 1
Schistosoma mansoni hypothetical protein 0.0137 0.0716 0.087
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0122 0.0122
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0199 0.0354
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0053 0.048
Schistosoma mansoni ran 0.0021 0.0032 0.0039
Loa Loa (eye worm) hypothetical protein 0.0063 0.0283 0.0505
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0034 0.0107 0.0177
Schistosoma mansoni hypothetical protein 0.0063 0.0283 0.0344
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0053 0.048
Echinococcus multilocularis snurportin 1 0.0302 0.1681 0.1681
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0085 0.0714
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0178 0.0322
Schistosoma mansoni ferritin 0.0034 0.0107 0.013
Echinococcus granulosus histone acetyltransferase KAT2B 0.0287 0.1593 0.1593
Schistosoma mansoni smad1 5 8 and 0.0066 0.0298 0.0362
Loa Loa (eye worm) hypothetical protein 0.0137 0.0716 0.1277
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0066 0.0298 0.0298
Echinococcus multilocularis mothers against decapentaplegic 6 0.003 0.0083 0.0083
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0139 0.0727 0.0727
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.011 0.0198
Echinococcus granulosus mothers against decapentaplegic 6 0.003 0.0083 0.0083
Mycobacterium tuberculosis Conserved protein 0.0147 0.0773 0.1407
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0053 0.0078
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0053 0.048
Onchocerca volvulus 0.0147 0.0773 0.1312
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0089 0.0434 0.5428
Schistosoma mansoni hypothetical protein 0.0302 0.1681 0.2045
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0034 0.0107 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0055 0.0099
Echinococcus multilocularis lamin 0.0027 0.0066 0.0066
Brugia malayi MH1 domain containing protein 0.0066 0.0298 0.0532
Schistosoma mansoni apoferritin-2 0.0034 0.0107 0.013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.007 0.0127
Schistosoma mansoni cellular tumor antigen P53 0.0251 0.1387 0.1686
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0131 0.0678 0.0678
Schistosoma mansoni hypothetical protein 0.0047 0.0189 0.023
Brugia malayi Fli-1 protein 0.0215 0.1175 0.2097
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0178 0.0322
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0055 0.0099
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0032 0.0057
Echinococcus granulosus smad 0.0066 0.0298 0.0298
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0147 0.0773 0.1407
Echinococcus granulosus intermediate filament protein 0.0027 0.0066 0.0066
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0124 0.1601
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0063 0.0283 0.0283
Onchocerca volvulus 0.0147 0.0773 0.1312
Onchocerca volvulus 0.0958 0.5538 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0147 0.0773 0.0773
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0053 0.048
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0046 0.0178 0.2309
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0017 0.0011
Schistosoma mansoni tar DNA-binding protein 0.0528 0.3013 0.3665
Brugia malayi MH2 domain containing protein 0.0969 0.5604 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0053 0.0154
Echinococcus multilocularis expressed protein 0.0034 0.0107 0.0107
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0201 0.1088 0.1942
Brugia malayi hypothetical protein 0.0233 0.1278 0.228
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0071 0.0327 0.0583
Loa Loa (eye worm) MH1 domain-containing protein 0.0066 0.0298 0.0532
Loa Loa (eye worm) MH1 domain-containing protein 0.003 0.0083 0.0149
Schistosoma mansoni lamin 0.0027 0.0066 0.008
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0189 0.0337
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0528 0.3013 0.5377
Loa Loa (eye worm) hypothetical protein 0.0147 0.0773 0.1379
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0063 0.0283 0.0505
Brugia malayi Bromodomain containing protein 0.0088 0.0427 0.0762
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0053 0.0691
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.033 0.033
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0053 0.048
Loa Loa (eye worm) nuclear factor I 0.0037 0.0125 0.0222
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0032 0.0416
Trichomonas vaginalis esterase, putative 0.0147 0.0773 0.1396
Echinococcus granulosus ferritin 0.0034 0.0107 0.0107
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0045 0.008
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0046 0.0178 0.1062
Schistosoma mansoni smad1 5 8 and 0.0066 0.0298 0.0362
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0053 0.0095
Schistosoma mansoni bromodomain containing protein 0.0075 0.0353 0.0429
Mycobacterium tuberculosis Probable hydrolase 0.0147 0.0773 0.1407
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0063 0.0283 0.0283
Echinococcus granulosus zinc finger protein 0.0028 0.0076 0.0076
Brugia malayi beta-lactamase family protein 0.0147 0.0773 0.1379
Echinococcus multilocularis smad 0.0066 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0095
Treponema pallidum bacterioferrin (TpF1) 0.0034 0.0107 0.5
Echinococcus granulosus Smad4 0.0066 0.0298 0.0298
Trichomonas vaginalis ferritin, putative 0.0034 0.0107 0.0194
Trichomonas vaginalis penicillin-binding protein, putative 0.0147 0.0773 0.1396
Onchocerca volvulus Mothers against decapentaplegic homolog 0.003 0.0083 0.0055
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0255 0.141 0.141
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0032 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0178 0.0322
Plasmodium falciparum histone acetyltransferase GCN5 0.0079 0.0377 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0123 0.0223
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0255 0.141 0.141
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0053 0.048
Brugia malayi hypothetical protein 0.0016 0.0004 0.0007
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0199 0.0199
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0123 0.0223
Brugia malayi Ets-domain containing protein 0.0071 0.0327 0.0583
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0018 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0069 0.0124
Trypanosoma cruzi hypothetical protein, conserved 0.0147 0.0773 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0147 0.0773 0.1396
Loa Loa (eye worm) hypothetical protein 0.0147 0.0773 0.1379
Schistosoma mansoni ferritin 0.0034 0.0107 0.013
Entamoeba histolytica hypothetical protein 0.0255 0.141 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0053 0.0095
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0147 0.0773 0.1379
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.011 0.0198
Mycobacterium tuberculosis Conserved protein 0.0147 0.0773 0.1407
Giardia lamblia GTOR 0.0046 0.0178 0.4245
Echinococcus multilocularis microtubule associated protein 2 0.1415 0.8223 0.8223
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0134 0.0134
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0085 0.0714
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0053 0.0095
Trypanosoma cruzi hypothetical protein, conserved 0.0147 0.0773 1
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0018 0.0018
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0018 0.0018
Brugia malayi mothers against decapentaplegic homolog 3 0.003 0.0083 0.0149
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0032 0.0032
Echinococcus granulosus survival motor neuron protein 1 0.0233 0.1278 0.1278
Plasmodium falciparum importin beta, putative 0.0028 0.0076 0.1635
Brugia malayi intermediate filament protein 0.0027 0.0066 0.0118
Brugia malayi hypothetical protein 0.0025 0.0056 0.0099
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0121 0.0619 0.0619
Leishmania major importin beta-1 subunit, putative 0.0023 0.0045 0.0576
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0297 0.1656 0.1656
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.011 0.0198

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.