Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0114 | 0.0729 | 0.0729 |
Trypanosoma brucei | NADH-dependent fumarate reductase, putative | 0.0114 | 0.0729 | 0.0729 |
Leishmania major | NADH-dependent fumarate reductase, putative | 0.0114 | 0.0729 | 0.0729 |
Leishmania major | reductase, putative | 0.0114 | 0.0729 | 0.0729 |
Loa Loa (eye worm) | cytochrome b5 reductase 4 | 0.0114 | 0.0729 | 0.0729 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.1006 | 1 | 1 |
Trypanosoma cruzi | nitrate reductase, putative | 0.0114 | 0.0729 | 0.0729 |
Trypanosoma cruzi | cytochrome-b5 reductase, putative | 0.0114 | 0.0729 | 0.0729 |
Plasmodium falciparum | NADH-cytochrome b5 reductase, putative | 0.0114 | 0.0729 | 0.0729 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0114 | 0.0729 | 0.0729 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.1006 | 1 | 1 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0114 | 0.0729 | 0.0729 |
Schistosoma mansoni | protein kinase | 0.0081 | 0.0384 | 0.0384 |
Brugia malayi | Casein kinase II, alpha chain | 0.0081 | 0.0384 | 0.0384 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.1006 | 1 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.1006 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.1006 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.1006 | 1 | 1 |
Trypanosoma brucei | NADH-dependent fumarate reductase | 0.0114 | 0.0729 | 0.0729 |
Echinococcus granulosus | methionine synthase reductase | 0.0621 | 0.5999 | 0.5999 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0892 | 0.8811 | 0.8811 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0081 | 0.0384 | 0.1085 |
Trypanosoma brucei | NADH-dependent fumarate reductase | 0.0114 | 0.0729 | 0.0729 |
Leishmania major | NADH-cytochrome b5 reductase, putative | 0.0114 | 0.0729 | 0.0729 |
Loa Loa (eye worm) | hypothetical protein | 0.1006 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0081 | 0.0384 | 0.0384 |
Plasmodium vivax | ferredoxin--NADP reductase, putative | 0.0114 | 0.0729 | 0.0729 |
Mycobacterium tuberculosis | Possible oxygenase | 0.0114 | 0.0729 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.1006 | 1 | 1 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0385 | 0.3541 | 0.3541 |
Leishmania major | cytochrome-b5 reductase, putative | 0.0114 | 0.0729 | 0.0729 |
Brugia malayi | Cytochrome b5-like Heme/Steroid binding domain containing protein | 0.0114 | 0.0729 | 0.0729 |
Echinococcus granulosus | cytochrome b5 reductase 4 | 0.0114 | 0.0729 | 0.0729 |
Plasmodium vivax | casein kinase 2, alpha subunit, putative | 0.0081 | 0.0384 | 0.0384 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.1006 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.1006 | 1 | 1 |
Brugia malayi | diaphorase | 0.0114 | 0.0729 | 0.0729 |
Schistosoma mansoni | NADH-cytochrome B5 reductase | 0.0114 | 0.0729 | 0.0729 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.1006 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.1006 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0621 | 0.5999 | 0.5999 |
Mycobacterium tuberculosis | Probable monooxygenase | 0.0114 | 0.0729 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.1006 | 1 | 1 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0114 | 0.0729 | 0.0729 |
Schistosoma mansoni | cytochrome B5 | 0.0114 | 0.0729 | 0.0729 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0621 | 0.5999 | 0.5999 |
Schistosoma mansoni | cytochrome P450 reductase | 0.1006 | 1 | 1 |
Plasmodium falciparum | NADPH--cytochrome P450 reductase, putative | 0.0385 | 0.3541 | 0.3541 |
Leishmania major | cytochrome-b5 reductase, putative | 0.0114 | 0.0729 | 0.0729 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0385 | 0.3541 | 0.3541 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0385 | 0.3541 | 0.3541 |
Plasmodium vivax | hypothetical protein, conserved | 0.0385 | 0.3541 | 0.3541 |
Trypanosoma cruzi | NADPH--cytochrome P450 reductase, putative | 0.0385 | 0.3541 | 0.3541 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0081 | 0.0384 | 0.0384 |
Echinococcus multilocularis | cytochrome b5 reductase 4 | 0.0114 | 0.0729 | 0.0729 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0114 | 0.0729 | 0.0729 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0385 | 0.3541 | 0.3541 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.1006 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0385 | 0.3541 | 1 |
Echinococcus multilocularis | methionine synthase reductase | 0.0621 | 0.5999 | 0.5999 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0114 | 0.0729 | 0.0729 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0385 | 0.3541 | 0.3541 |
Trichomonas vaginalis | sulfite reductase, putative | 0.1006 | 1 | 1 |
Mycobacterium tuberculosis | Hypothetical oxidoreductase | 0.0114 | 0.0729 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0385 | 0.3541 | 1 |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0114 | 0.0729 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0114 | 0.0729 | 0.5 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0114 | 0.0729 | 0.0729 |
Trypanosoma brucei | nitrate reductase, putative | 0.0114 | 0.0729 | 0.0729 |
Trypanosoma brucei | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0385 | 0.3541 | 0.3541 |
Giardia lamblia | Hypothetical protein | 0.0892 | 0.8811 | 1 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0114 | 0.0729 | 0.0729 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0081 | 0.0384 | 0.0384 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0081 | 0.0384 | 0.0384 |
Leishmania major | NADH-dependent fumarate reductase-like protein | 0.0114 | 0.0729 | 0.0729 |
Trypanosoma cruzi | p450 reductase, putative | 0.0114 | 0.0729 | 0.0729 |
Chlamydia trachomatis | sulfite reductase | 0.0621 | 0.5999 | 1 |
Leishmania major | NADH-cytochrome b5 reductase, putative | 0.0114 | 0.0729 | 0.0729 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0114 | 0.0729 | 0.0729 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0385 | 0.3541 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0081 | 0.0384 | 0.0384 |
Plasmodium falciparum | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0385 | 0.3541 | 0.3541 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0499 | 0.473 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.1006 | 1 | 1 |
Toxoplasma gondii | ferredoxin NADP+ oxidoreductase FNR | 0.0114 | 0.0729 | 0.1541 |
Echinococcus multilocularis | casein kinase ii subunit alpha | 0.0081 | 0.0384 | 0.0384 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0385 | 0.3541 | 1 |
Trypanosoma cruzi | casein kinase II, putative | 0.0081 | 0.0384 | 0.0384 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0114 | 0.0729 | 0.0729 |
Trypanosoma cruzi | oxidoreductase-protein, putative | 0.0114 | 0.0729 | 0.0729 |
Leishmania major | oxidoreductase-like protein | 0.0114 | 0.0729 | 0.0729 |
Trypanosoma brucei | NADH-cytochrome b5 reductase-like protein | 0.0114 | 0.0729 | 0.0729 |
Leishmania major | nitrate reductase, putative | 0.0114 | 0.0729 | 0.0729 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0114 | 0.0729 | 0.0729 |
Plasmodium vivax | oxidoreductase NAD-binding domain containing protein | 0.0114 | 0.0729 | 0.0729 |
Leishmania major | NADH-cytochrome b5 reductase, putative | 0.0114 | 0.0729 | 0.0729 |
Echinococcus granulosus | NADH cytochrome b5 reductase 3 | 0.0114 | 0.0729 | 0.0729 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.1006 | 1 | 1 |
Trypanosoma brucei | NADH-dependent fumarate reductase, putative | 0.0114 | 0.0729 | 0.0729 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.1006 | 1 | 1 |
Echinococcus multilocularis | NADH cytochrome b5 reductase 3 | 0.0114 | 0.0729 | 0.0729 |
Leishmania major | casein kinase II, putative | 0.0081 | 0.0384 | 0.0384 |
Onchocerca volvulus | 0.0114 | 0.0729 | 1 | |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.1006 | 1 | 1 |
Brugia malayi | flavodoxin family protein | 0.0385 | 0.3541 | 0.3541 |
Echinococcus granulosus | casein kinase ii subunit alpha | 0.0081 | 0.0384 | 0.0384 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0499 | 0.473 | 1 |
Loa Loa (eye worm) | diaphorase | 0.0114 | 0.0729 | 0.0729 |
Plasmodium falciparum | ferredoxin--NADP reductase | 0.0114 | 0.0729 | 0.0729 |
Toxoplasma gondii | CMGC kinase, CK2 family | 0.0081 | 0.0384 | 0.0813 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0892 | 0.8811 | 1 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0114 | 0.0729 | 0.0729 |
Leishmania major | hypothetical protein, conserved | 0.0385 | 0.3541 | 0.3541 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0385 | 0.3541 | 0.3541 |
Trypanosoma cruzi | reductase, putative | 0.0114 | 0.0729 | 0.0729 |
Echinococcus granulosus | cytochrome b5 reductase 4 | 0.0114 | 0.0729 | 0.0729 |
Giardia lamblia | Flavohemoprotein lateral transfer candidate | 0.0114 | 0.0729 | 0.0828 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0114 | 0.0729 | 0.0729 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.1006 | 1 | 1 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0114 | 0.0729 | 0.0729 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0114 | 0.0729 | 0.0729 |
Plasmodium falciparum | casein kinase 2, alpha subunit | 0.0081 | 0.0384 | 0.0384 |
Treponema pallidum | flavodoxin | 0.0385 | 0.3541 | 1 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0114 | 0.0729 | 0.0729 |
Loa Loa (eye worm) | flavodoxin family protein | 0.0385 | 0.3541 | 0.3541 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0081 | 0.0384 | 0.0384 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0621 | 0.5999 | 0.5999 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0081 | 0.0384 | 0.0384 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0507 | 0.481 | 0.481 |
Loa Loa (eye worm) | CMGC/CK2 protein kinase | 0.0081 | 0.0384 | 0.0384 |
Trypanosoma brucei | Casein kinase II | 0.0081 | 0.0384 | 0.0384 |
Leishmania major | cytochrome P450 reductase, putative | 0.0892 | 0.8811 | 0.8811 |
Trypanosoma brucei | oxidoreductase-protein, putative | 0.0114 | 0.0729 | 0.0729 |
Schistosoma mansoni | diflavin oxidoreductase | 0.0499 | 0.473 | 0.473 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0385 | 0.3541 | 1 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0892 | 0.8811 | 0.8811 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0114 | 0.0729 | 0.0729 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0114 | 0.0729 | 0.0729 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.1006 | 1 | 1 |
Trypanosoma cruzi | cytochrome-b5 reductase, putative | 0.0114 | 0.0729 | 0.0729 |
Plasmodium vivax | unspecified product | 0.0081 | 0.0384 | 0.0384 |
Toxoplasma gondii | NADH-cytochrome b5 reductase 1, putative | 0.0114 | 0.0729 | 0.1541 |
Entamoeba histolytica | casein kinase, putative | 0.0081 | 0.0384 | 0.1085 |
Giardia lamblia | Kinase, CMGC CK2 | 0.0081 | 0.0384 | 0.0436 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0114 | 0.0729 | 0.0729 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | ~ 1 p.p.m. | In vitro systemic flea efficacy using membrane feeding assay. | ChEMBL. | 12067553 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.