Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.068 | 0.3813 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0013 | 0.0027 | 0.0032 |
Onchocerca volvulus | 0.002 | 0.0065 | 0.0591 | |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0012 | 0.0014 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0076 | 0.0382 | 0.0978 |
Onchocerca volvulus | Cathepsin L homolog | 0.002 | 0.0065 | 0.0591 |
Brugia malayi | Cathepsin L-like precursor | 0.002 | 0.0065 | 0.0144 |
Onchocerca volvulus | 0.002 | 0.0065 | 0.0591 | |
Onchocerca volvulus | 0.002 | 0.0065 | 0.0591 | |
Schistosoma mansoni | amine oxidase | 0.0125 | 0.0659 | 0.0762 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0125 | 0.0659 | 0.1708 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0265 | 0.1459 | 1 |
Echinococcus multilocularis | 0.0125 | 0.0659 | 0.0762 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0065 | 0.0378 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.001 | 0.001 | 0.0012 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0312 | 0.1725 | 0.451 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0072 | 0.0363 | 0.0419 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.002 | 0.0065 | 0.0378 |
Brugia malayi | Cathepsin L-like precursor | 0.002 | 0.0065 | 0.0144 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.002 | 0.0065 | 0.0144 |
Echinococcus granulosus | dnaJ subfamily B | 0.0486 | 0.271 | 0.3131 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0065 | 0.0378 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0125 | 0.0659 | 0.0762 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0265 | 0.1459 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.002 | 0.0065 | 0.0075 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.002 | 0.0065 | 0.0378 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0027 | 0.0242 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0265 | 0.1459 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.002 | 0.0065 | 0.0378 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0013 | 0.0027 | 0.012 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0065 | 0.0378 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.1645 | 0.9292 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0013 | 0.0027 | 0.0046 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0069 | 0.0345 | 0.088 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.002 | 0.0065 | 0.0075 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0044 | 0.0201 | 0.0503 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0148 | 0.0791 | 0.2054 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0125 | 0.0659 | 0.0762 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0013 | 0.0027 | 0.0046 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0076 | 0.0382 | 0.0978 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.0659 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0036 | 0.0157 | 0.0181 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0054 | 0.0256 | 0.0646 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0148 | 0.0791 | 0.2054 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0148 | 0.0791 | 0.1938 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0044 | 0.0201 | 0.0503 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0065 | 0.0378 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0076 | 0.0382 | 0.0978 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.0659 | 1 |
Onchocerca volvulus | 0.002 | 0.0065 | 0.0591 | |
Leishmania major | mitochondrial DNA polymerase beta | 0.0312 | 0.1725 | 0.4429 |
Onchocerca volvulus | 0.0125 | 0.0659 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0027 | 0.0242 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.002 | 0.0065 | 0.0075 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0076 | 0.0382 | 0.0978 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.1769 | 1 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0127 | 0.0671 | 0.1618 |
Loa Loa (eye worm) | fibroinase | 0.002 | 0.0065 | 0.0818 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.002 | 0.0065 | 0.0075 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0265 | 0.1459 | 0.1686 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.0659 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.068 | 0.3813 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.002 | 0.0065 | 0.0144 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0125 | 0.0659 | 0.1708 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0065 | 0.0378 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.068 | 0.3813 | 0.5 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.006 | 0.029 | 0.0736 |
Entamoeba histolytica | cysteine proteinase, putative | 0.002 | 0.0065 | 0.0378 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0044 | 0.0201 | 0.0503 |
Loa Loa (eye worm) | ctsf protein | 0.002 | 0.0065 | 0.0818 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0076 | 0.0382 | 0.0978 |
Brugia malayi | CXXC zinc finger family protein | 0.0034 | 0.0146 | 0.0356 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0076 | 0.0382 | 0.0978 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0076 | 0.0382 | 0.0978 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.002 | 0.0065 | 0.0378 |
Plasmodium vivax | vivapain-2 | 0.002 | 0.0065 | 0.0144 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0044 | 0.0201 | 0.0503 |
Entamoeba histolytica | cysteine protease, putative | 0.002 | 0.0065 | 0.0378 |
Onchocerca volvulus | 0.002 | 0.0065 | 0.0591 | |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.068 | 0.3813 | 1 |
Echinococcus multilocularis | cysteine protease | 0.002 | 0.0065 | 0.0075 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0065 | 0.0378 |
Plasmodium vivax | hypothetical protein, conserved | 0.0125 | 0.0659 | 0.1708 |
Brugia malayi | Cathepsin L-like precursor | 0.0013 | 0.0027 | 0.0046 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0265 | 0.1459 | 0.3812 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0027 | 0.0242 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0065 | 0.0378 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.002 | 0.0065 | 0.0075 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0012 | 0.0014 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.001 | 0.0011 | 0.0003 |
Leishmania major | cathepsin L-like protease | 0.0076 | 0.0382 | 0.0847 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0065 | 0.0319 | 0.0678 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0125 | 0.0659 | 0.1708 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.002 | 0.0065 | 0.0818 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0125 | 0.0659 | 0.0762 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.002 | 0.0065 | 0.0378 |
Echinococcus granulosus | cpg binding protein | 0.0036 | 0.0157 | 0.0181 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.002 | 0.0065 | 0.0818 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.002 | 0.0065 | 0.0075 |
Leishmania major | cathepsin L-like protease | 0.0076 | 0.0382 | 0.0847 |
Schistosoma mansoni | cpg binding protein | 0.0034 | 0.0146 | 0.0168 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0265 | 0.1459 | 1 |
Plasmodium vivax | vivapain-2 | 0.002 | 0.0065 | 0.0144 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0125 | 0.0659 | 0.1708 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.001 | 0.001 | 0.0012 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.002 | 0.0065 | 0.0378 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0312 | 0.1725 | 0.451 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0265 | 0.1459 | 0.1686 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0265 | 0.1459 | 1 |
Echinococcus multilocularis | cysteine protease | 0.002 | 0.0065 | 0.0075 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.068 | 0.3813 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0076 | 0.0382 | 0.0978 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0125 | 0.0659 | 0.1708 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.002 | 0.0065 | 0.0378 |
Leishmania major | UDP-galactopyranose mutase | 0.0125 | 0.0659 | 0.1587 |
Plasmodium vivax | hypothetical protein, conserved | 0.0125 | 0.0659 | 0.1708 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0125 | 0.0659 | 0.1708 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0076 | 0.0382 | 0.0978 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0065 | 0.0378 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0065 | 0.0378 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0013 | 0.0027 | 0.0032 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0125 | 0.0659 | 0.0762 |
Onchocerca volvulus | 0.002 | 0.0065 | 0.0591 | |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.0659 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.002 | 0.0065 | 0.0144 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0076 | 0.0382 | 0.0978 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.002 | 0.0065 | 0.0144 |
Mycobacterium ulcerans | hypothetical protein | 0.0164 | 0.0886 | 0.0242 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.002 | 0.0065 | 0.0378 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.002 | 0.0065 | 0.0144 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.068 | 0.3813 | 0.3653 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0265 | 0.1459 | 0.1686 |
Schistosoma mansoni | amine oxidase | 0.0125 | 0.0659 | 0.0762 |
Brugia malayi | Cathepsin L-like precursor | 0.002 | 0.0065 | 0.0144 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0125 | 0.0659 | 0.1587 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.1533 | 0.8657 | 1 |
Brugia malayi | hypothetical protein | 0.0125 | 0.0659 | 0.1708 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0065 | 0.0378 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0164 | 0.0886 | 0.0262 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.068 | 0.3813 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0076 | 0.0382 | 0.0978 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0265 | 0.1459 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.002 | 0.0065 | 0.0144 |
Echinococcus granulosus | microtubule associated protein 2 | 0.1533 | 0.8657 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0076 | 0.0382 | 0.0978 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0125 | 0.0659 | 0.0762 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0265 | 0.1459 | 0.3812 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.0659 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.002 | 0.0065 | 0.0378 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.068 | 0.3813 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.002 | 0.0065 | 0.0075 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.068 | 0.3813 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0065 | 0.0378 |
Onchocerca volvulus | Cathepsin F homolog | 0.002 | 0.0065 | 0.0591 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.068 | 0.3813 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0265 | 0.1459 | 0.1686 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0486 | 0.271 | 0.3131 |
Onchocerca volvulus | 0.002 | 0.0065 | 0.0591 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0065 | 0.0378 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.001 | 0.001 | 0.0012 |
Schistosoma mansoni | hypothetical protein | 0.0486 | 0.271 | 0.3131 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.002 | 0.0065 | 0.0075 |
Loa Loa (eye worm) | cysteine protease | 0.002 | 0.0065 | 0.0818 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0034 | 0.0146 | 0.2065 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0125 | 0.0659 | 0.1708 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0013 | 0.0027 | 0.012 |
Echinococcus multilocularis | cathepsin L | 0.001 | 0.001 | 0.0012 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0076 | 0.0382 | 0.0978 |
Echinococcus multilocularis | cpg binding protein | 0.0036 | 0.0157 | 0.0181 |
Entamoeba histolytica | cysteine proteinase, putative | 0.002 | 0.0065 | 0.0378 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.002 | 0.0065 | 0.0378 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.001 | 0.001 | 0.0012 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.0659 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0265 | 0.1459 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0312 | 0.1725 | 0.451 |
Brugia malayi | Cathepsin L-like precursor | 0.002 | 0.0065 | 0.0144 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0065 | 0.0818 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.068 | 0.3813 | 1 |
Leishmania major | dihydroorotate dehydrogenase | 0.068 | 0.3813 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.1533 | 0.8657 | 1 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.068 | 0.3813 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0013 | 0.0027 | 0.012 |
Echinococcus granulosus | cysteine protease | 0.001 | 0.001 | 0.0012 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0076 | 0.0382 | 0.0978 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0125 | 0.0659 | 0.5 |
Onchocerca volvulus | 0.0034 | 0.0146 | 0.1869 | |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.068 | 0.3813 | 0.4404 |
Schistosoma mansoni | cpg binding protein | 0.0036 | 0.0157 | 0.0181 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0065 | 0.0378 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.002 | 0.0065 | 0.0378 |
Onchocerca volvulus | Cathepsin L homolog | 0.002 | 0.0065 | 0.0591 |
Echinococcus granulosus | cathepsin L | 0.001 | 0.001 | 0.0012 |
Toxoplasma gondii | hypothetical protein | 0.005 | 0.0238 | 0.0462 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0125 | 0.0659 | 0.0762 |
Brugia malayi | SWIRM domain containing protein | 0.0125 | 0.0659 | 0.1708 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.068 | 0.3813 | 0.3376 |
Echinococcus granulosus | cathepsin l1 | 0.002 | 0.0065 | 0.0075 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0125 | 0.0659 | 0.1708 |
Brugia malayi | cathepsin L-like precursor | 0.0013 | 0.0027 | 0.0046 |
Leishmania major | cathepsin L-like protease | 0.0076 | 0.0382 | 0.0847 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0076 | 0.0382 | 0.0978 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0065 | 0.0378 |
Brugia malayi | Cathepsin L-like precursor | 0.002 | 0.0065 | 0.0144 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.