Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.001 | 0.0999 | 0.2001 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0005 | 0.015 | 0.0041 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.001 | 0.0999 | 0.1875 |
Schistosoma mansoni | nuclear receptor | 0.0005 | 0.015 | 0.0041 |
Brugia malayi | CXXC zinc finger family protein | 0.0032 | 0.4393 | 1 |
Schistosoma mansoni | coup transcription factor | 0.001 | 0.0999 | 0.09 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0008 | 0.0634 | 0.1069 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0.0999 | 0.2001 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0008 | 0.0634 | 0.0531 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.001 | 0.0999 | 0.2001 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0005 | 0.0241 | 0.0133 |
Brugia malayi | hypothetical protein | 0.0005 | 0.0241 | 0.0214 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0525 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.001 | 0.0999 | 0.2001 |
Echinococcus granulosus | cpg binding protein | 0.0034 | 0.4678 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0005 | 0.015 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0241 | 0.0214 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0061 | 0.8867 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.001 | 0.0999 | 0.1875 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0034 | 0.4678 | 0.4619 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.001 | 0.092 | 0.1813 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0999 | 0.1875 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0008 | 0.0634 | 0.1069 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0999 | 0.2001 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.001 | 0.0939 | 0.1743 |
Loa Loa (eye worm) | steroid hormone receptor | 0.001 | 0.0999 | 0.2001 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0999 | 0.1875 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0999 | 0.2001 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0999 | 0.1875 |
Brugia malayi | nuclear receptor NHR-88 | 0.001 | 0.0999 | 0.2001 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0999 | 0.2001 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0999 | 0.1875 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.001 | 0.0999 | 0.2001 |
Schistosoma mansoni | nuclear receptor | 0.0005 | 0.015 | 0.0041 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0999 | 0.2001 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.001 | 0.0999 | 0.2001 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0005 | 0.0241 | 0.0214 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0999 | 0.2001 |
Schistosoma mansoni | nuclear hormone receptor | 0.0005 | 0.015 | 0.0041 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.001 | 0.0999 | 0.09 |
Brugia malayi | hypothetical protein | 0.0005 | 0.0241 | 0.0214 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.001 | 0.0999 | 0.1875 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0999 | 0.2001 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.001 | 0.0999 | 0.09 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0999 | 0.1875 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0999 | 0.2001 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0999 | 0.1875 |
Brugia malayi | nuclear hormone receptor | 0.001 | 0.0999 | 0.2001 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.001 | 0.0999 | 0.09 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.001 | 0.0999 | 0.2001 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.001 | 0.0999 | 0.2001 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0005 | 0.015 | 0.0041 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0005 | 0.0241 | 0.0201 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0999 | 0.2001 |
Echinococcus multilocularis | cpg binding protein | 0.0034 | 0.4678 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0005 | 0.0241 | 0.0201 |
Loa Loa (eye worm) | histone methyltransferase | 0.001 | 0.0939 | 0.186 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0.0999 | 0.2001 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0241 | 0.0214 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.001 | 0.0999 | 0.2001 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0005 | 0.0241 | 0.0133 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0005 | 0.0241 | 0.0214 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0008 | 0.0634 | 0.1069 |
Onchocerca volvulus | 0.0032 | 0.4393 | 1 | |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.001 | 0.0999 | 0.1875 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 0.0999 | 0.2001 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.001 | 0.0999 | 0.2001 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.001 | 0.0939 | 0.1743 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.001 | 0.0999 | 0.2001 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0005 | 0.015 | 0.0041 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0032 | 0.4393 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0005 | 0.0241 | 0.0214 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0008 | 0.0634 | 0.1069 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.001 | 0.0999 | 0.1875 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0999 | 0.1875 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0999 | 0.2001 |
Schistosoma mansoni | nuclear hormone receptor | 0.0005 | 0.015 | 0.0041 |
Echinococcus multilocularis | FTZ F1 alpha | 0.001 | 0.0999 | 0.1875 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0525 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0999 | 0.1875 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.001 | 0.0999 | 0.2001 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0999 | 0.09 |
Brugia malayi | ecdysteroid receptor | 0.001 | 0.0999 | 0.2001 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0999 | 0.2001 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0.0999 | 0.09 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.001 | 0.0999 | 0.2001 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0525 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.001 | 0.0999 | 0.2001 |
Onchocerca volvulus | 0.001 | 0.0999 | 0.2001 | |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0999 | 0.2001 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0999 | 0.2001 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0.0999 | 0.2001 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.001 | 0.0999 | 0.09 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.001 | 0.0999 | 0.1875 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.001 | 0.0999 | 0.09 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0005 | 0.0241 | 0.0214 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0999 | 0.1875 |
Schistosoma mansoni | cpg binding protein | 0.0034 | 0.4678 | 0.4619 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.001 | 0.0999 | 0.2001 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.001 | 0.0999 | 0.09 |
Schistosoma mansoni | cpg binding protein | 0.0032 | 0.4393 | 0.4331 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0999 | 0.2001 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0999 | 0.2001 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0241 | 0.0214 |
Trichomonas vaginalis | helicase, putative | 0.0007 | 0.0525 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.001 | 0.0999 | 0.1875 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0999 | 0.09 |
Brugia malayi | steroid hormone receptor | 0.001 | 0.0999 | 0.2001 |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 0.0999 | 0.09 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.001 | 0.0999 | 0.2001 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0241 | 0.0214 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0999 | 0.1875 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.001 | 0.0999 | 0.2001 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.001 | 0.0999 | 0.09 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0241 | 0.0214 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.001 | 0.0999 | 0.09 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0525 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.