Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0814 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0037 | 0.0814 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0037 | 0.0814 | 0.0814 |
Loa Loa (eye worm) | TAR-binding protein | 0.0131 | 0.5108 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.5108 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0131 | 0.5108 | 1 |
Brugia malayi | TAR-binding protein | 0.0131 | 0.5108 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.5108 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0037 | 0.0814 | 0.1594 |
Brugia malayi | hypothetical protein | 0.0037 | 0.0813 | 0.1592 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0131 | 0.5108 | 1 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0037 | 0.0814 | 0.0814 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0813 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0037 | 0.0814 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0814 | 0.1594 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0037 | 0.0814 | 0.1594 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0813 | 0.1592 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0814 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0037 | 0.0814 | 0.1594 |
Brugia malayi | beta-lactamase | 0.0037 | 0.0814 | 0.1594 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0037 | 0.0814 | 0.1594 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.0814 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0037 | 0.0814 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.5108 | 1 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0037 | 0.0814 | 0.0814 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.0814 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0814 | 0.1594 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0037 | 0.0814 | 0.0814 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0037 | 0.0814 | 0.0814 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0814 | 0.1594 |
Echinococcus multilocularis | tar DNA binding protein | 0.0131 | 0.5108 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0131 | 0.5108 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.0814 | 0.0814 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0814 | 0.1594 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0813 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0037 | 0.0814 | 1 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0037 | 0.0814 | 0.0814 |
Loa Loa (eye worm) | RNA binding protein | 0.0131 | 0.5108 | 1 |
Onchocerca volvulus | 0.0037 | 0.0814 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0814 | 0.1594 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.0813 | 0.1592 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0814 | 0.1594 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0037 | 0.0814 | 0.1594 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0813 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0814 | 0.1594 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0814 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.5108 | 1 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0037 | 0.0814 | 0.0814 |
Schistosoma mansoni | tar DNA-binding protein | 0.0131 | 0.5108 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0814 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0 | 0.5 |
Toxoplasma gondii | ABC1 family protein | 0.0037 | 0.0814 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0814 | 0.1594 |
Mycobacterium leprae | Probable lipase LipE | 0.0037 | 0.0814 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.0814 | 0.0814 |
Mycobacterium leprae | conserved hypothetical protein | 0.0037 | 0.0814 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.0814 | 0.0814 |
Trichomonas vaginalis | esterase, putative | 0.0037 | 0.0814 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0037 | 0.0814 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0813 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0814 | 0.1594 |
Onchocerca volvulus | 0.0037 | 0.0814 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0814 | 0.1594 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.0813 | 0.1592 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.0813 | 0.1592 |
Brugia malayi | RNA binding protein | 0.0131 | 0.5108 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0037 | 0.0814 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0037 | 0.0814 | 1 |
Onchocerca volvulus | 0.0037 | 0.0814 | 0.5 | |
Leishmania major | hypothetical protein, conserved | 0.0037 | 0.0814 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0814 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.