Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0008 | 0.0628 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 187A4 Cyp187A4 | 0.0008 | 0.0628 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.042 | 0.5 |
Echinococcus multilocularis | musashi | 0.0061 | 0.9418 | 1 |
Onchocerca volvulus | 0.0061 | 0.9418 | 1 | |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.7731 | 0.8102 |
Onchocerca volvulus | 0.0061 | 0.9418 | 1 | |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0008 | 0.0628 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.042 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.042 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0061 | 0.9418 | 1 |
Schistosoma mansoni | cytochrome P450 | 0.0008 | 0.0628 | 0.0628 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0061 | 0.9418 | 1 |
Mycobacterium ulcerans | cytochrome P450 191A3 Cyp191A3 | 0.0008 | 0.0628 | 0.5 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0033 | 0.4708 | 0.4642 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0029 | 0.4095 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0008 | 0.0628 | 0.5 |
Schistosoma mansoni | cpg binding protein | 0.0032 | 0.4619 | 0.4619 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0008 | 0.0628 | 0.5 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0839 | 0.0347 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.4095 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0061 | 0.9418 | 1 |
Mycobacterium ulcerans | cytochrome P450 123A3 Cyp123A3 | 0.0008 | 0.0628 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0008 | 0.0628 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.042 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.3984 | 0.3818 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.417 | 0.4029 |
Mycobacterium ulcerans | cytochrome P450 125A7 Cyp125A7 | 0.0008 | 0.0628 | 0.5 |
Brugia malayi | CXXC zinc finger family protein | 0.003 | 0.4331 | 0.4213 |
Schistosoma mansoni | hypothetical protein | 0.0013 | 0.1437 | 0.1437 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0008 | 0.0628 | 0.011 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0061 | 0.9418 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0839 | 0.0347 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.4095 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.3984 | 0.3818 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.042 | 0.5 |
Mycobacterium ulcerans | cytochrome p450 150 cyp150 | 0.0008 | 0.0628 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 144A4 Cyp144A4 | 0.0008 | 0.0628 | 0.5 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0029 | 0.417 | 0.4095 |
Mycobacterium ulcerans | cytochrome P450 150A6 Cyp150A6 | 0.0008 | 0.0628 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.4095 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0032 | 0.4619 | 0.4619 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.4331 | 0.4331 |
Echinococcus multilocularis | lamin dm0 | 0.0061 | 0.9418 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.042 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.7731 | 0.7731 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0029 | 0.4095 | 0.4215 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0033 | 0.4708 | 0.4642 |
Loa Loa (eye worm) | histone methyltransferase | 0.0009 | 0.0839 | 0.024 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.003 | 0.4331 | 0.4213 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.042 | 0.5 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0013 | 0.1437 | 0.1019 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.7731 | 0.7731 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0008 | 0.0628 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.4095 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 126A3 Cyp126A3 | 0.0008 | 0.0628 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0029 | 0.4095 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0008 | 0.0628 | 0.5 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0008 | 0.0531 | 0.0531 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0008 | 0.0628 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.7731 | 0.8102 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.042 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0008 | 0.0628 | 0.5 |
Echinococcus multilocularis | lamin | 0.0061 | 0.9418 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.042 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 143A4 Cyp143A4 | 0.0008 | 0.0628 | 0.5 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0029 | 0.417 | 0.4095 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0051 | 0.7731 | 0.8081 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0009 | 0.0819 | 0.0217 |
Mycobacterium ulcerans | cytochrome P450 187A5 Cyp187A5 | 0.0008 | 0.0628 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 105Q4 Cyp105Q4 | 0.0008 | 0.0628 | 0.5 |
Echinococcus granulosus | cpg binding protein | 0.0032 | 0.4619 | 0.4601 |
Mycobacterium ulcerans | cytochrome P450 143A3 Cyp143A3 | 0.0008 | 0.0628 | 0.5 |
Trichomonas vaginalis | helicase, putative | 0.0007 | 0.042 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0008 | 0.0628 | 0.5 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0008 | 0.0628 | 0.5 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0008 | 0.0628 | 0.5 |
Echinococcus multilocularis | 0.0008 | 0.0628 | 0.011 | |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0008 | 0.0628 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 51B1 Cyp51B1 | 0.0008 | 0.0628 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0029 | 0.4095 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.9418 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0008 | 0.0628 | 0.5 |
Brugia malayi | hypothetical protein | 0.0019 | 0.2387 | 0.2001 |
Mycobacterium ulcerans | cytochrome P450 108B4 Cyp108B4 | 0.0008 | 0.0628 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.042 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0008 | 0.0628 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.003 | 0.4277 | 0.4152 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.042 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0008 | 0.0628 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.7731 | 0.8102 |
Brugia malayi | intermediate filament protein | 0.0061 | 0.9418 | 1 |
Echinococcus granulosus | lamin | 0.0061 | 0.9418 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.042 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0061 | 0.9418 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0061 | 0.9418 | 0.9418 |
Schistosoma mansoni | lamin | 0.0061 | 0.9418 | 0.9418 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0013 | 0.1437 | 0.1019 |
Mycobacterium ulcerans | cytochrome P450 124A1, Cyp124A1 | 0.0008 | 0.0628 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0008 | 0.0628 | 0.5 |
Echinococcus multilocularis | cpg binding protein | 0.0032 | 0.4619 | 0.4601 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0051 | 0.7731 | 0.8081 |
Mycobacterium leprae | putative cytochrome p450 | 0.0008 | 0.0628 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0008 | 0.0628 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0008 | 0.0628 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0008 | 0.0628 | 0.5 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.042 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0008 | 0.0628 | 0.0628 |
Mycobacterium ulcerans | cytochrome P450 189A7 Cyp189A7 | 0.0008 | 0.0628 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 188A3 Cyp188A3 | 0.0008 | 0.0628 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.042 | 0.5 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0008 | 0.0628 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.7731 | 0.7731 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0057 | 0.8854 | 1 |
Mycobacterium ulcerans | cytochrome P450 142A3 Cyp142A3 | 0.0008 | 0.0628 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 136A2 Cyp136A2 | 0.0008 | 0.0628 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.9232 | 0.9789 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.042 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0008 | 0.0628 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 140A5 Cyp140A5 | 0.0008 | 0.0628 | 0.5 |
Schistosoma mansoni | lamin | 0.0061 | 0.9418 | 0.9418 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.042 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.7731 | 0.8102 |
Brugia malayi | hypothetical protein | 0.0029 | 0.4095 | 0.3945 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.4095 | 0.3945 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.042 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.003 | 0.4277 | 0.4152 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.