TDR Targets

Basic information

Technical information

TDR Targets ID: 739471
Name: 5-[(5-chloropyridin-2-yl)sulfamoyl]-2-methoxy -N-methylbenzamide
MW: 355.797 | Formula: C14H14ClN3O4S
H donors: 2 H acceptors: 4 LogP: 1.59 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CNC(=O)c1cc(ccc1OC)S(=O)(=O)Nc1ccc(cn1)Cl
InChi: 1S/C14H14ClN3O4S/c1-16-14(19)11-7-10(4-5-12(11)22-2)23(20,21)18-13-6-3-9(15)8-17-13/h3-8H,1-2H3,(H,16,19)(H,17,18)
InChiKey: WOZBVHKCPRTOFY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

5-[(5-chloro-2-pyridyl)sulfamoyl]-2-methoxy-N-methyl-benzamide
5-[(5-chloro-2-pyridyl)sulfamoyl]-2-methoxy-N-methylbenzamide
5-[(5-chloropyridin-2-yl)sulfamoyl]-2-methoxy-N-methyl-benzamide
ZINC06706823

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0009	0.0503	0.0503
Mycobacterium tuberculosis	Probable conserved transmembrane protein	0.0006	0	0.5
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0012	0.1205	0.1205
Entamoeba histolytica	hypothetical protein	0.001	0.0701	0.5
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0009	0.0503	0.082
Leishmania major	hypothetical protein, conserved	0.0006	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.001	0.0701	0.0701
Wolbachia endosymbiont of Brugia malayi	NAD-dependent DNA ligase, Lig	0.001	0.0701	0.5
Leishmania major	protein kinase A regulatory subunit, putative	0.0006	0	0.5
Chlamydia trachomatis	DNA ligase	0.001	0.0701	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.7174	0.7174
Loa Loa (eye worm)	hypothetical protein	0.0012	0.1205	0.1205
Echinococcus multilocularis	replication factor c subunit 1	0.001	0.0701	0.0701
Brugia malayi	TAR-binding protein	0.0062	1	1
Leishmania major	hypothetical protein, conserved	0.0006	0	0.5
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0006	0	0.5
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0009	0.0503	0.0503
Echinococcus granulosus	replication factor c subunit 1	0.001	0.0701	0.0701
Brugia malayi	Pax transcription activation domain interacting protein	0.001	0.0701	0.0701
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0009	0.0503	0.0503
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.7174	0.7174
Leishmania major	hypothetical protein, conserved	0.0006	0	0.5
Leishmania major	protein kinase, putative	0.0006	0	0.5
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0009	0.0503	0.082
Schistosoma mansoni	voltage-gated potassium channel	0.0012	0.1205	0.1205
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0701	0.1144
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0009	0.0503	0.0503
Onchocerca volvulus		0.001	0.0701	1
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0009	0.0503	0.0503
Mycobacterium tuberculosis	Conserved protein	0.0006	0	0.5
Mycobacterium tuberculosis	Probable transcriptional regulatory protein Cmr	0.0006	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.001	0.0701	0.0701
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0009	0.0503	0.0503
Schistosoma mansoni	voltage-gated potassium channel	0.0007	0.0196	0.0196
Schistosoma mansoni	tar DNA-binding protein	0.0062	1	1
Leishmania major	regulatory subunit of protein kinase a-like protein	0.0006	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0037	0.5626	0.5626
Schistosoma mansoni	DNA ligase IV	0.001	0.0701	0.0701
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.001	0.0701	0.1144
Mycobacterium leprae	PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+])	0.001	0.0701	1
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0009	0.0503	0.0503
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0009	0.0503	0.0503
Echinococcus multilocularis	nibrin	0.001	0.0701	0.0701
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0043	0.6636	0.6636
Trypanosoma cruzi	FHA domain containing protein, putative	0.001	0.0701	1
Echinococcus granulosus	hyperpolarization activated cyclic	0.0009	0.0503	0.0503
Brugia malayi	DKFZp564C0469 protein	0.001	0.0701	0.0701
Trypanosoma brucei	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.001	0.0701	1
Toxoplasma gondii	ATPase, AAA family protein	0.001	0.0701	1
Schistosoma mansoni	topbp1	0.001	0.0701	0.0701
Treponema pallidum	DNA ligase (lig)	0.001	0.0701	1
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0009	0.0503	0.0503
Schistosoma mansoni	tar DNA-binding protein	0.0062	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0701	0.1144
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	1	1
Schistosoma mansoni	voltage-gated potassium channel	0.0012	0.1205	0.1205
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0009	0.0503	0.0503
Leishmania major	hypothetical protein, unknown function	0.0006	0	0.5
Schistosoma mansoni	voltage-gated potassium channel	0.0047	0.7338	0.7338
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.7174	0.7174
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.7174	0.7174
Mycobacterium tuberculosis	Probable conserved transmembrane transport protein	0.0006	0	0.5
Schistosoma mansoni	topbp1	0.001	0.0701	0.0701
Echinococcus granulosus	nibrin	0.001	0.0701	0.0701
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0009	0.0503	0.0503
Plasmodium vivax	replication factor C subunit 1, putative	0.001	0.0701	1
Brugia malayi	hypothetical protein	0.001	0.0701	0.0701
Trypanosoma cruzi	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.001	0.0701	1
Echinococcus granulosus	tar DNA binding protein	0.0062	1	1
Schistosoma mansoni	tar DNA-binding protein	0.0062	1	1
Echinococcus granulosus	voltage gated potassium channel	0.0012	0.1205	0.1205
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0701	0.1144
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0009	0.0503	0.0503
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.001	0.0701	1
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0009	0.0503	0.0503
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.001	0.0701	0.1144
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0043	0.6636	0.6636
Schistosoma mansoni	chromosome transmission fidelity factor	0.001	0.0701	0.0701
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0043	0.6636	0.6636
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0012	0.1205	0.1205
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.7174	0.7174
Brugia malayi	RNA recognition motif domain containing protein	0.0062	1	1
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0012	0.1205	0.1205
Leishmania major	protein kinase, putative	0.0006	0	0.5
Echinococcus multilocularis	tar DNA binding protein	0.0062	1	1
Entamoeba histolytica	Activator 1 140 kDa subunit, putative	0.001	0.0701	0.5
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0009	0.0503	0.0503
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.004	0.6133	1
Mycobacterium ulcerans	NAD-dependent DNA ligase LigA	0.001	0.0701	1
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0006	0	0.5
Leishmania major	cyclic nucleotide-binding protein-like protein	0.0006	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.001	0.0701	0.0701
Trichomonas vaginalis	replication factor C large subunit, putative	0.001	0.0701	0.1144
Mycobacterium tuberculosis	Probable glutamine-transport ATP-binding protein ABC transporter GlnQ	0.0006	0	0.5
Plasmodium falciparum	replication factor C subunit 1, putative	0.001	0.0701	1
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.001	0.0701	0.1144
Giardia lamblia	Replication factor C, subunit 1	0.001	0.0701	1
Echinococcus granulosus	hyperpolarization activated cyclic	0.0009	0.0503	0.0503
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.7174	0.7174
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0009	0.0503	0.0503
Loa Loa (eye worm)	hypothetical protein	0.001	0.0701	0.0701
Trypanosoma cruzi	hypothetical protein, conserved	0.001	0.0701	1
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0009	0.0503	0.0503
Schistosoma mansoni	60S ribosomal protein L21	0.0007	0.0196	0.0196
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0009	0.0503	0.0503
Brugia malayi	topoisomerase	0.001	0.0701	0.0701
Echinococcus multilocularis	voltage gated potassium channel	0.0012	0.1205	0.1205
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.7174	0.7174
Schistosoma mansoni	voltage-gated potassium channel	0.0009	0.0503	0.0503
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.7174	0.7174
Loa Loa (eye worm)	RNA binding protein	0.0062	1	1
Trypanosoma cruzi	hypothetical protein, conserved	0.001	0.0701	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.004	0.6133	1
Schistosoma mansoni	tar DNA-binding protein	0.0062	1	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.7174	0.7174
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0701	0.1144
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0043	0.6636	0.6636
Brugia malayi	ATP dependent DNA ligase C terminal region family protein	0.001	0.0701	0.0701
Loa Loa (eye worm)	hypothetical protein	0.001	0.0701	0.0701
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0503	0.0503
Brugia malayi	hypothetical protein	0.001	0.0701	0.0701
Schistosoma mansoni	tar DNA-binding protein	0.0062	1	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0701	0.0701
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0701	0.1144
Schistosoma mansoni	voltage-gated potassium channel	0.0047	0.7338	0.7338
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.001	0.0701	0.1144
Loa Loa (eye worm)	TAR-binding protein	0.0062	1	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 739471