Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Dihydrofolate reductase | 0.0216 | 0.3899 | 0.4528 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0217 | 0.3931 | 1 |
Onchocerca volvulus | 0.0107 | 0.1223 | 0.1216 | |
Echinococcus multilocularis | dihydrofolate reductase | 0.0216 | 0.3899 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0107 | 0.1223 | 0.3138 |
Echinococcus multilocularis | thymidylate synthase | 0.0107 | 0.1223 | 0.3138 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0058 | 0.0008 | 0.0021 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.2618 | 0.5131 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0058 | 0.0008 | 0.0016 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0058 | 0.0008 | 0.0021 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0058 | 0.0008 | 0.0016 |
Brugia malayi | dihydrofolate reductase family protein | 0.0216 | 0.3899 | 0.4528 |
Trichomonas vaginalis | set domain proteins, putative | 0.0463 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0216 | 0.3899 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0216 | 0.3899 | 0.7642 |
Echinococcus multilocularis | geminin | 0.0164 | 0.2618 | 0.6715 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0216 | 0.3899 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0216 | 0.3899 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.0058 | 0.0008 | 0.0009 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0216 | 0.3899 | 0.6898 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0107 | 0.1223 | 0.2398 |
Brugia malayi | thymidylate synthase | 0.0107 | 0.1223 | 0.1421 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0217 | 0.3931 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0008 | 0.0009 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.2618 | 0.5131 |
Brugia malayi | Pre-SET motif family protein | 0.0406 | 0.8612 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0217 | 0.3931 | 0.5 |
Echinococcus granulosus | geminin | 0.0164 | 0.2618 | 0.6715 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0217 | 0.3931 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0217 | 0.3931 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0216 | 0.3899 | 0.4528 |
Loa Loa (eye worm) | thymidylate synthase | 0.0107 | 0.1223 | 0.1421 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0406 | 0.8612 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0217 | 0.3931 | 1 |
Brugia malayi | glutaminase DH11.1 | 0.0264 | 0.5102 | 0.5925 |
Mycobacterium ulcerans | glutaminase | 0.0264 | 0.5102 | 1 |
Schistosoma mansoni | glutaminase | 0.0264 | 0.5102 | 1 |
Loa Loa (eye worm) | glutaminase 2 | 0.0264 | 0.5102 | 0.5925 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0058 | 0.0008 | 0.0016 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0058 | 0.0008 | 0.0016 |
Echinococcus granulosus | dihydrofolate reductase | 0.0216 | 0.3899 | 1 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0058 | 0.0008 | 0.0021 |
Loa Loa (eye worm) | glutaminase | 0.0264 | 0.5102 | 0.5925 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.