Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | inositol-1 | 0.0037 | 0.3132 | 0.3255 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0023 | 0.0535 | 0.0679 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.4163 | 0.4395 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.006 | 0.724 | 1 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0023 | 0.0535 | 0.0739 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.9228 | 1 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0037 | 0.3132 | 0.5 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0033 | 0.2434 | 0.5 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0037 | 0.3132 | 0.5 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0037 | 0.3132 | 0.4326 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0191 | 0.0242 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0037 | 0.3132 | 0.5 |
Brugia malayi | Inositol-1 | 0.0037 | 0.3132 | 0.2401 |
Schistosoma mansoni | inositol monophosphatase | 0.0037 | 0.3132 | 0.3972 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.3132 | 0.5 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0033 | 0.2434 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.5463 | 0.4979 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0037 | 0.3132 | 0.4326 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.3391 | 0.3541 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.2617 | 0.183 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0036 | 0.2951 | 0.4076 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0023 | 0.0535 | 0.0739 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.2617 | 0.2684 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0037 | 0.3132 | 0.5 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0037 | 0.3132 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.5463 | 0.4979 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0036 | 0.2951 | 0.4076 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.5463 | 0.5833 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.3818 | 0.4014 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.006 | 0.724 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.2617 | 0.3318 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0037 | 0.3132 | 0.5 |
Schistosoma mansoni | bromodomain containing protein | 0.0063 | 0.7886 | 1 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0037 | 0.3132 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.5463 | 0.5833 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.3132 | 0.5 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.3132 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0038 | 0.3378 | 0.2673 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.3132 | 0.5 |
Schistosoma mansoni | inositol monophosphatase | 0.0037 | 0.3132 | 0.3972 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.