Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Replicative DNA helicase | 0.2767 | 1 | 1 |
Mycobacterium tuberculosis | Probable replicative DNA helicase DnaB | 0.2767 | 1 | 1 |
Echinococcus granulosus | Receptor type tyrosine protein phosphatase O | 0.0604 | 0.0906 | 0.2252 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.1143 | 0.3169 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | replicative DNA helicase | 0.2767 | 1 | 1 |
Mycobacterium ulcerans | replicative DNA helicase DnaB | 0.2767 | 1 | 1 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.1143 | 0.3169 | 0.5 |
Treponema pallidum | replicative DNA helicase (dnaB) | 0.2767 | 1 | 0.5 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.1143 | 0.3169 | 0.5 |
Echinococcus multilocularis | EGFP:Bcl2 fusion protein | 0.1346 | 0.4023 | 1 |
Mycobacterium leprae | PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase | 0.2767 | 1 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.1143 | 0.3169 | 0.5 |
Echinococcus granulosus | EGFP:Bcl2 fusion protein | 0.1346 | 0.4023 | 1 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0389 | 0 | 0.5 |
Loa Loa (eye worm) | twinkle helicase | 0.0791 | 0.169 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.