Detailed information for compound 74195

Basic information

Technical information
  • TDR Targets ID: 74195
  • Name: 9-[(3-fluorophenyl)methyl]-N,N-dimethyl-2-(tr ifluoromethyl)purin-6-amine
  • MW: 339.291 | Formula: C15H13F4N5
  • H donors: 0 H acceptors: 3 LogP: 3.12 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1cccc(c1)Cn1cnc2c1nc(nc2N(C)C)C(F)(F)F
  • InChi: 1S/C15H13F4N5/c1-23(2)12-11-13(22-14(21-12)15(17,18)19)24(8-20-11)7-9-4-3-5-10(16)6-9/h3-6,8H,7H2,1-2H3
  • InChiKey: CKDHMZNJDLJJAS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 9-[(3-fluorophenyl)methyl]-N,N-dimethyl-2-(trifluoromethyl)-6-purinamine
  • [9-(3-fluorobenzyl)-2-(trifluoromethyl)purin-6-yl]-dimethyl-amine
  • AIDS-209455
  • AIDS209455
  • [9-(3-Fluoro-benzyl)-2-trifluoromethyl-9H-purin-6-yl]-dimethyl-amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0121 0.0777 0.4711
Schistosoma mansoni hypothetical protein 0.0031 0.0113 0.0229
Loa Loa (eye worm) hypothetical protein 0.0121 0.0777 0.4711
Brugia malayi ecdysteroid receptor 0.002 0.003 0.0179
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0119 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0066 0.4521
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0119 0.1676
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.003 0.006
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0031 0.0113 0.9342
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.003 0.0179
Trypanosoma brucei heat shock protein, putative 0.0032 0.0119 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.019 0.0327
Plasmodium vivax endoplasmin, putative 0.0032 0.0119 1
Trichomonas vaginalis endoplasmin, putative 0.002 0.0027 0.0309
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0022 0.0046
Onchocerca volvulus 0.015 0.0992 0.5938
Leishmania major heat shock protein 83-1 0.0032 0.0119 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0031 0.0113 0.0229
Loa Loa (eye worm) hypothetical protein 0.0027 0.0079 0.048
Brugia malayi Steroid receptor seven-up type 2 0.002 0.003 0.0179
Onchocerca volvulus Dual oxidase homolog 0.0027 0.0079 0.0306
Loa Loa (eye worm) hypothetical protein 0.0027 0.0079 0.048
Onchocerca volvulus 0.0027 0.0079 0.0306
Trypanosoma brucei heat shock protein, putative 0.0032 0.0119 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0079 0.048
Schistosoma mansoni hypothetical protein 0.004 0.0179 0.0364
Echinococcus multilocularis peroxidasin 0.0027 0.0079 0.0136
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0031 0.0113 0.9374
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1365 1 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0079 0.048
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.003 0.0179
Loa Loa (eye worm) MH2 domain-containing protein 0.0235 0.1622 0.9835
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0113 0.9379
Echinococcus granulosus heat shock protein 90 0.0032 0.0119 0.0242
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0079 0.048
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0079 0.048
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0385 0.2734 0.3763
Loa Loa (eye worm) hypothetical protein 0.015 0.0992 0.6011
Echinococcus multilocularis tumor protein p63 0.0335 0.2364 0.4069
Schistosoma mansoni DNA polymerase eta 0.0019 0.0022 0.0046
Echinococcus granulosus dna polymerase kappa 0.0019 0.0022 0.0046
Schistosoma mansoni peroxidasin 0.0027 0.0079 0.0161
Brugia malayi isocitrate dehydrogenase 0.0031 0.0113 0.0685
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0079 0.048
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.08 0.581 1
Loa Loa (eye worm) heat shock protein 90 0.0032 0.0119 0.0721
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.003 0.0179
Giardia lamblia Heat shock protein HSP 90-alpha 0.0026 0.0071 0.4987
Loa Loa (eye worm) hypothetical protein 0.0067 0.0381 0.2309
Trypanosoma cruzi Heat shock protein 83, putative 0.0032 0.0119 1
Trypanosoma brucei heat shock protein, putative 0.0032 0.0119 1
Echinococcus multilocularis heat shock protein 0.0032 0.0119 0.0205
Loa Loa (eye worm) hypothetical protein 0.002 0.003 0.0179
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.003 0.006
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0031 0.0113 0.8866
Loa Loa (eye worm) hypothetical protein 0.0027 0.0079 0.048
Plasmodium falciparum heat shock protein 90 0.0032 0.0119 1
Leishmania major heat shock protein 83-1 0.0032 0.0119 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0113 0.9374
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.091 0.1847
Trichomonas vaginalis MYB, putative 0.0019 0.0023 0.004
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0079 0.048
Loa Loa (eye worm) pax transcription factor protein 2 0.0239 0.165 1
Mycobacterium ulcerans heat shock protein 90 0.0026 0.0071 0.0048
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.003 0.0051
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.003 0.006
Loa Loa (eye worm) hypothetical protein 0.0027 0.0079 0.048
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0022 0.0136
Brugia malayi Endoplasmin precursor 0.0032 0.0119 0.0721
Schistosoma mansoni thyroid hormone receptor 0.002 0.003 0.006
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0113 0.9374
Schistosoma mansoni hypothetical protein 0.0031 0.0113 0.0229
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.003 0.0051
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.003 0.006
Echinococcus multilocularis heat shock protein 90 0.0026 0.0071 0.0122
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0119 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.003 0.0179
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1365 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.003 0.0179
Brugia malayi Pax transcription factor protein 2 0.0239 0.165 1
Brugia malayi hypothetical protein 0.0016 0 0.0002
Brugia malayi nuclear receptor NHR-88 0.002 0.003 0.0179
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0022 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.003 0.0179
Brugia malayi hypothetical protein 0.0025 0.0066 0.0398
Onchocerca volvulus Peroxidasin homolog 0.0027 0.0079 0.0306
Onchocerca volvulus Peroxidase homolog 0.0027 0.0079 0.0306
Echinococcus granulosus geminin 0.0167 0.112 0.2274
Loa Loa (eye worm) hypothetical protein 0.002 0.003 0.0179
Leishmania major heat shock protein 83-1 0.0032 0.0119 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0079 0.048
Onchocerca volvulus Huntingtin homolog 0.0121 0.0777 0.4614
Trypanosoma cruzi heat shock protein 90, putative 0.0032 0.0119 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.003 0.0051
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0019 0.0023 0.004
Loa Loa (eye worm) hypothetical protein 0.0027 0.0079 0.048
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0113 0.0229
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.019 1
Echinococcus multilocularis dna polymerase eta 0.0019 0.0022 0.0039
Loa Loa (eye worm) endoplasmin 0.0032 0.0119 0.0721
Onchocerca volvulus Chorion peroxidase homolog 0.0027 0.0079 0.0306
Schistosoma mansoni hypothetical protein 0.0167 0.112 0.2274
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.003 0.006
Leishmania major hypothetical protein, conserved 0.0025 0.0066 0.4474
Schistosoma mansoni hypothetical protein 0.0067 0.0381 0.0773
Leishmania major heat shock protein 83-1 0.0032 0.0119 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0601 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.003 0.0179
Trypanosoma cruzi heat shock protein 90, putative 0.0026 0.0071 0.503
Trypanosoma brucei heat shock protein, putative 0.0032 0.0119 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.003 0.0051
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0031 0.0113 0.9379
Brugia malayi CHE-14 protein 0.0042 0.019 0.1153
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0071 0.2891
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0079 0.048
Schistosoma mansoni microtubule-associated protein tau 0.0681 0.4927 1
Toxoplasma gondii heat shock protein 90, putative 0.0032 0.0119 0.0356
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.003 0.0179
Onchocerca volvulus 0.0049 0.0245 0.1328
Echinococcus multilocularis microtubule associated protein 2 0.0681 0.4927 0.848
Brugia malayi MH2 domain containing protein 0.0235 0.1622 0.9835
Giardia lamblia Grp94/Hsp90 0.0026 0.0071 0.4987
Loa Loa (eye worm) hypothetical protein 0.0031 0.0113 0.0683
Echinococcus granulosus expressed conserved protein 0.0091 0.0558 0.1132
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.003 0.006
Onchocerca volvulus 0.0027 0.0079 0.0306
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0113 0.0194
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.003 0.0179
Echinococcus multilocularis X box binding protein 1 0.0284 0.1988 0.3421
Leishmania major heat shock protein 83-1 0.0032 0.0119 1
Onchocerca volvulus 0.0027 0.0079 0.0306
Echinococcus multilocularis GPCR, family 2 0.0031 0.0113 0.0194
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0071 0.2891
Loa Loa (eye worm) hypothetical protein 0.0027 0.0079 0.048
Loa Loa (eye worm) hypothetical protein 0.002 0.003 0.0179
Trypanosoma brucei heat shock protein, putative 0.0032 0.0119 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0079 0.048
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0113 0.0194
Echinococcus granulosus heat shock protein 0.0032 0.0119 0.0242
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.003 0.006
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0079 0.048
Trichomonas vaginalis heat shock protein, putative 0.002 0.0027 0.0309
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.019 0.1153
Loa Loa (eye worm) blistered cuticle protein 3 0.0027 0.0079 0.048
Echinococcus multilocularis FTZ F1 alpha 0.002 0.003 0.0051
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0612 0.3711
Schistosoma mansoni hypothetical protein 0.0031 0.0113 0.0229
Schistosoma mansoni heat shock protein 0.0032 0.0119 0.0242
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0022 0.0032
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0066 0.4193
Onchocerca volvulus Huntingtin homolog 0.0121 0.0777 0.4614
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0113 0.0194
Schistosoma mansoni endoplasmin 0.0032 0.0119 0.0242
Leishmania major heat shock protein 83-1 0.0032 0.0119 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.003 0.0179
Brugia malayi Blistered cuticle protein 3 0.0027 0.0079 0.048
Schistosoma mansoni heat shock protein 0.0032 0.0119 0.0242
Loa Loa (eye worm) steroid hormone receptor 0.002 0.003 0.0179
Schistosoma mansoni coup transcription factor 0.002 0.003 0.006
Leishmania major heat shock protein 83-1 0.0032 0.0119 1
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.019 0.0386
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0601 0.1035
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.098 0.7147 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0066 0.0398
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0119 1
Echinococcus granulosus dna polymerase eta 0.0019 0.0022 0.0046
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.003 0.0051
Brugia malayi hypothetical protein 0.015 0.0992 0.6011
Trypanosoma brucei Heat shock protein 83, putative 0.0032 0.0119 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.003 0.006
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0381 0.2309
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.003 0.006
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0385 0.2734 1
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0079 0.048
Brugia malayi Peroxidasin 0.0027 0.0079 0.048
Loa Loa (eye worm) hypothetical protein 0.0099 0.0612 0.3711
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.098 0.7147 1
Onchocerca volvulus 0.0239 0.165 1
Echinococcus granulosus endoplasmin 0.0026 0.0071 0.0143
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0019 0.0023 0.004
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0066 0.4474
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.003 0.0179
Loa Loa (eye worm) hypothetical protein 0.0042 0.019 0.1153
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0113 0.0194
Echinococcus granulosus GPCR family 2 0.0031 0.0113 0.0229
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.0612 0.1243
Schistosoma mansoni thyroid hormone receptor 0.002 0.003 0.006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.003 0.0179
Onchocerca volvulus Peroxidasin homolog 0.0027 0.0079 0.0306
Schistosoma mansoni hypothetical protein 0.0284 0.1988 0.4035
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0245 0.0497
Leishmania major heat shock protein 83-1 0.0032 0.0119 1
Brugia malayi nuclear hormone receptor 0.002 0.003 0.0179
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0022 0.0086
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0031 0.0113 0.0194
Schistosoma mansoni hypothetical protein 0.004 0.0179 0.0364
Echinococcus multilocularis geminin 0.0167 0.112 0.1928
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0079 0.048
Leishmania major heat shock protein 83-1 0.0032 0.0119 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.003 0.0051
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0113 0.0333
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0022 0.0086
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.003 0.0051
Schistosoma mansoni endoplasmin 0.0032 0.0119 0.0242
Loa Loa (eye worm) hypothetical protein 0.0049 0.0245 0.1484
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0066 0.0159
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.003 0.0179
Onchocerca volvulus Peroxidase homolog 0.0027 0.0079 0.0306
Loa Loa (eye worm) hypothetical protein 0.002 0.003 0.0179
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.003 0.006
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0079 0.048
Brugia malayi hypothetical protein 0.0027 0.0079 0.048
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.091 0.1566
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0022 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.003 0.0179
Loa Loa (eye worm) hypothetical protein 0.0027 0.0079 0.048
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0612 0.3711
Echinococcus multilocularis isocitrate dehydrogenase 0.0031 0.0113 0.0194
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.003 0.006
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0022 0.0039
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.003 0.0179
Echinococcus multilocularis expressed conserved protein 0.0091 0.0558 0.096
Leishmania major heat shock protein 83-1 0.0032 0.0119 1
Leishmania major heat shock protein 83-1 0.0032 0.0119 1
Leishmania major heat shock protein 83-1 0.0032 0.0119 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0022 0.0136
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.003 0.0179
Brugia malayi hypothetical protein 0.0121 0.0777 0.4711
Trypanosoma brucei heat shock protein, putative 0.0032 0.0119 1
Trypanosoma brucei heat shock protein, putative 0.0032 0.0119 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0022 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.003 0.0179
Leishmania major heat shock protein 83-1 0.0032 0.0119 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.003 0.006
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0022 0.0086
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0022 0.0046
Loa Loa (eye worm) hypothetical protein 0.002 0.003 0.0179
Schistosoma mansoni peroxidasin 0.0027 0.0079 0.0161
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0113 0.0683
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0119 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0113 0.0229
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.003 0.0179
Brugia malayi Isocitrate dehydrogenase 0.0031 0.0113 0.0685
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.0071 0.503
Schistosoma mansoni patched 1 0.0042 0.019 0.0386
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.003 0.0179
Schistosoma mansoni hypothetical protein 0.0167 0.112 0.2274
Loa Loa (eye worm) hypothetical protein 0.002 0.003 0.0179
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.003 0.006
Echinococcus granulosus FTZ F1 alpha 0.002 0.003 0.006
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0113 0.0333
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0071 0.2891
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0022 0.0086
Leishmania major heat shock protein 83-1 0.0032 0.0119 1
Loa Loa (eye worm) hypothetical protein 0.002 0.003 0.0179
Loa Loa (eye worm) transcription factor SMAD2 0.0235 0.1622 0.9835
Brugia malayi heat shock protein 90 0.0032 0.0119 0.0721
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0031 0.0113 0.0229
Echinococcus granulosus tumor protein p63 0.0335 0.2364 0.4798
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0026 0.0071 0.4987
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0612 0.3711
Schistosoma mansoni hypothetical protein 0.004 0.0179 0.0364
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0022 0.0039
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0022 0.0086
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0066 0.4193
Echinococcus granulosus Protein patched homolog 1 0.0042 0.019 0.0386
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1365 1 1
Trypanosoma brucei heat shock protein, putative 0.0032 0.0119 1
Echinococcus multilocularis endoplasmin 0.0026 0.0071 0.0122
Echinococcus multilocularis protein patched 0.0042 0.019 0.0327
Loa Loa (eye worm) hypothetical protein 0.0097 0.0601 0.3644
Echinococcus granulosus heat shock protein 90 0.0026 0.0071 0.0143
Loa Loa (eye worm) isocitrate dehydrogenase 0.0031 0.0113 0.0685
Loa Loa (eye worm) hypothetical protein 0.0027 0.0079 0.048
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.003 0.0051
Echinococcus granulosus X box binding protein 1 0.0284 0.1988 0.4035
Giardia lamblia Myb 1-like protein 0.0019 0.0023 0.0012
Giardia lamblia Heat shock protein HSP 90-alpha 0.0032 0.0119 1
Echinococcus multilocularis heat shock protein 90 0.0032 0.0119 0.0205
Leishmania major heat shock protein 83-1 0.0032 0.0119 1
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0026 0.0071 0.0068
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0113 0.0683
Leishmania major heat shock protein 83-1 0.0032 0.0119 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0066 0.4521
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0119 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.003 0.0179
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.003 0.006
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0119 0.1676
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0031 0.0113 0.0127
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0119 0.5766
Schistosoma mansoni nuclear hormone receptor 0.002 0.003 0.006
Loa Loa (eye worm) hypothetical protein 0.0051 0.026 0.1575
Loa Loa (eye worm) hypothetical protein 0.0027 0.0079 0.048
Echinococcus multilocularis protein dispatched 1 0.0048 0.0234 0.0403
Toxoplasma gondii heat shock protein HSP90 0.0032 0.0119 0.0356
Leishmania major heat shock protein 83-1 0.0032 0.0119 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.003 0.006
Schistosoma mansoni hypothetical protein 0.004 0.0179 0.0364
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0601 0.122
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.003 0.0179
Brugia malayi steroid hormone receptor 0.002 0.003 0.0179
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.003 0.006
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.003 0.0179
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0601 0.3644
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0385 0.2734 0.2718
Echinococcus granulosus microtubule associated protein 2 0.0681 0.4927 1
Plasmodium vivax heat shock protein 86, putative 0.0032 0.0119 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0113 0.0683
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0113 0.0194
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0026 0.0071 0.0143
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0022 0.0136
Loa Loa (eye worm) hypothetical protein 0.0027 0.0079 0.048
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0022 0.0136
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.003 0.0179
Echinococcus granulosus peroxidasin 0.0027 0.0079 0.0161
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.003 0.006
Schistosoma mansoni hypothetical protein 0.0031 0.0113 0.0229

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.03 uM Antiviral activity against rhinoviral-1B serotype in a plaque inhibition assay using monolayers of M-HeLa cells ChEMBL. 2547069
IC50 (functional) = 0.3 uM Antiviral activity against rhinoviral 9 serotype in a plaque inhibition assay using monolayers of M-HeLa cells ChEMBL. 2547069
IC50 (functional) = 0.57 uM Antiviral activity against rhinoviral-1A serotype in a plaque inhibition assay using monolayers of M-HeLa cells ChEMBL. 2547069
IC50 (functional) = 0.8 uM Antiviral activity against rhinoviral 16 serotype in a plaque inhibition assay using monolayers of M-HeLa cells ChEMBL. 2547069
IC50 (functional) = 2.3 uM Antiviral activity against rhinoviral 12 serotype in a plaque inhibition assay using monolayers of M-HeLa cells ChEMBL. 2547069
IC50 (functional) = 2.7 uM Antiviral activity against rhinoviral 29 serotype in a plaque inhibition assay using monolayers of M-HeLa cells ChEMBL. 2547069
IC50 (functional) = 3.2 uM Antiviral activity against rhinoviral 15 serotype in a plaque inhibition assay using monolayers of M-HeLa cells ChEMBL. 2547069
IC50 (functional) = 7.1 uM Antiviral activity against rhinoviral 14 serotype in a plaque inhibition assay using monolayers of M-HeLa cells ChEMBL. 2547069
IC50 (functional) = 8 uM Antiviral activity against rhinoviral-18 serotype in a plaque inhibition assay using monolayers of M-HeLa cells ChEMBL. 2547069
IC50 (functional) = 10 uM Antiviral activity against rhinoviral 21 serotype in a plaque inhibition assay using monolayers of M-HeLa cells ChEMBL. 2547069
IC50 (functional) = 15 uM Antiviral activity against rhinoviral 2 serotype in a plaque inhibition assay using monolayers of M-HeLa cells ChEMBL. 2547069
Inhibition (functional) = 28 uM Percent inhibitory activity of the compound at 8 uM against rhinoviral 19s erotype in a plaque inhibition assay using monolayers of M-HeLa cells ChEMBL. 2547069
Inhibition (functional) = 28 uM Percent inhibitory activity of the compound at 8 uM against rhinoviral 30 serotype in a plaque inhibition assay using monolayers of M-HeLa cells ChEMBL. 2547069
Inhibition (functional) = 30 uM Percent inhibitory activity of the compound at 8 uM against rhinoviral 13 serotype in a plaque inhibition assay using monolayers of M-HeLa cells ChEMBL. 2547069
Inhibition (functional) = 34 uM Percent inhibitory activity of the compound at 8 uM against rhinoviral 4 serotype in a plaque inhibition assay using monolayers of M-HeLa cells ChEMBL. 2547069
Inhibition (functional) = 34 uM Percent inhibitory activity of the compound at 8 uM against rhinoviral 5 serotype in a plaque inhibition assay using monolayers of M-HeLa cells ChEMBL. 2547069
Inhibition (functional) = 35 uM Percent inhibitory activity of the compound at 8 uM against rhinoviral 3 serotype in a plaque inhibition assay using monolayers of M-HeLa cells ChEMBL. 2547069
Inhibition (functional) = 43 uM Percent inhibitory activity of the compound at 8 uM against rhinoviral 31 serotype in a plaque inhibition assay using monolayers of M-HeLa cells ChEMBL. 2547069
Inhibition (functional) = 45 uM Percent inhibitory activity of the compound at 8 uM against rhinoviral 8 serotype in a plaque inhibition assay using monolayers of M-HeLa cells ChEMBL. 2547069

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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