Detailed information for compound 74266

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 477.547 | Formula: C25H35NO8
  • H donors: 6 H acceptors: 8 LogP: -0.39 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(C(C(=O)O)O)C(=O)O.Oc1ccc2c(c1)[C@]13CCCC[C@]3([C@@H](C2)N(CC1)CC1CCC1)O
  • InChi: 1S/C21H29NO2.C4H6O6/c23-17-7-6-16-12-19-21(24)9-2-1-8-20(21,18(16)13-17)10-11-22(19)14-15-4-3-5-15;5-1(3(7)8)2(6)4(9)10/h6-7,13,15,19,23-24H,1-5,8-12,14H2;1-2,5-6H,(H,7,8)(H,9,10)/t19-,20+,21-;/m1./s1
  • InChiKey: GMTYREVWZXJPLF-SXWPHCFWSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0014 0.0055
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0048 0.0175
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0289 1
Echinococcus granulosus glutamate synthase 0.0009 0.001 0.0037
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0068 0.0289 0.1003
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0062 0.1187
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0035 0.0133 0.2803
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0108 0.2229
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0068 0.0289 0.1003
Brugia malayi MH1 domain containing protein 0.0017 0.0048 0.02
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0593 0.2794 0.3888
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0014 0.1175
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0014 0.0055
Leishmania major DNA polymerase eta, putative 0.0042 0.0165 0.3549
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0289 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0068 0.0289 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0014 0.0055
Giardia lamblia hypothetical protein 0.0068 0.0289 0.1068
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0014 0.0055
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0068 0.0289 0.1247
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0108 0.2229
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0068 0.0289 0.6367
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0172 0.3688
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0289 1
Schistosoma mansoni coup transcription factor 0.001 0.0014 0.0055
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0289 1
Echinococcus multilocularis geminin 0.0363 0.1697 0.6463
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0172 0.3688
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0062 0.1187
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0068 0.0289 0.1101
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0274 0.1044
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0172 0.3688
Toxoplasma gondii thioredoxin reductase 0.0101 0.0449 0.1576
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0042 0.0165 0.0559
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0031 0.0114 0.3719
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0068 0.0289 0.1003
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0068 0.0289 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0042 0.0161
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0009 0.001 0.0037
Plasmodium falciparum thioredoxin reductase 0.0101 0.0449 1
Schistosoma mansoni thyroid hormone receptor 0.001 0.0014 0.0055
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0274 0.1036
Echinococcus granulosus dna polymerase kappa 0.0043 0.0172 0.0653
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0068 0.0289 0.6367
Trypanosoma brucei chrX additional, unordered contigs 0.0013 0.0029 0.0446
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0068 0.0289 0.1093
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0031 0.0113 0.3694
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0172 0.0162
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0208 0.0785
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0014 0.0017
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0068 0.0289 0.1003
Brugia malayi glutathione reductase 0.0101 0.0449 0.194
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0009 0.001 0.0032
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0274 0.1044
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0068 0.0289 0.1101
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0014 0.0052
Schistosoma mansoni smad1 5 8 and 0.0017 0.0048 0.0184
Brugia malayi MH1 domain containing protein 0.0017 0.0048 0.02
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2105 1 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0035 0.0133 0.0505
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0062 0.1864
Brugia malayi polk-prov protein 0.0013 0.0029 0.0117
Trypanosoma brucei hypothetical protein, conserved 0.0068 0.0289 0.6367
Schistosoma mansoni Smad4 0.0008 0.0002 0.0009
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0043 0.0172 0.0653
Loa Loa (eye worm) hypothetical protein 0.0068 0.0289 0.1093
Brugia malayi ecdysteroid receptor 0.001 0.0014 0.0052
Plasmodium falciparum phosphodiesterase gamma, putative 0.0068 0.0289 0.6367
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0068 0.0289 1
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0009 0.001 0.0037
Brugia malayi MH2 domain containing protein 0.0017 0.0048 0.02
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0257 0.1191 0.1649
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0048 0.0184
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0231 0.1068 0.1477
Trypanosoma brucei unspecified product 0.003 0.0108 0.2229
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0042 0.0173
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0289 1
Leishmania major cAMP-specific phosphodiesterase, putative 0.0068 0.0289 0.6367
Schistosoma mansoni smad1 5 8 and 0.0017 0.0048 0.0184
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0068 0.0289 0.1101
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0068 0.0289 0.1101
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0172 0.3688
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0013 0.0048
Echinococcus multilocularis smad 0.0017 0.0048 0.0184
Trichomonas vaginalis DNA polymerase eta, putative 0.0043 0.0172 0.5793
Plasmodium falciparum glutathione reductase 0.0101 0.0449 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0257 0.1191 0.1649
Brugia malayi TAR-binding protein 0.0065 0.0274 0.1182
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0133 0.2803
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0014 0.0055
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0172 0.3688
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0014 0.0108
Schistosoma mansoni thyroid hormone receptor 0.001 0.0014 0.0055
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0172 0.3688
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0068 0.0289 0.1101
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0009 0.0032
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0593 0.2794 0.2787
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0035 0.0133 0.2803
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0014 0.0055
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0035 0.0133 0.0505
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0068 0.0289 0.1003
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0014 0.1175
Trypanosoma cruzi DNA polymerase eta, putative 0.0042 0.0165 0.3549
Brugia malayi MH1 domain containing protein 0.001 0.0011 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0289 1
Schistosoma mansoni glutamate synthase 0.0009 0.001 0.0037
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0009 0.001 0.0037
Entamoeba histolytica hypothetical protein 0.0037 0.0141 0.8092
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0046
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0046
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0068 0.0289 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0231 0.1068 0.1477
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0068 0.0289 0.6367
Brugia malayi hypothetical protein 0.0037 0.0141 0.0601
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0068 0.0289 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0068 0.0289 1
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0009 0.001 0.0037
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0062 0.0258
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0068 0.0289 0.6367
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0289 1
Onchocerca volvulus 0.001 0.0014 0.1175
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0274 0.1044
Brugia malayi MH2 domain containing protein 0.0017 0.0048 0.02
Entamoeba histolytica recQ family DNA helicase 0.001 0.0014 0.0293
Schistosoma mansoni smad1 5 8 and 0.0017 0.0048 0.0184
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0558 0.2626 1
Schistosoma mansoni hypothetical protein 0.0363 0.1697 0.6463
Loa Loa (eye worm) hypothetical protein 0.002 0.0062 0.0226
Schistosoma mansoni smad 0.0008 0.0002 0.0009
Brugia malayi Thioredoxin reductase 0.0101 0.0449 0.194
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0029 0.0446
Echinococcus multilocularis mothers against decapentaplegic 6 0.0008 0.0002 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0172 0.3688
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0014 0.0108
Trypanosoma brucei DNA damage repair protein, putative 0.0013 0.0029 0.0446
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0068 0.0289 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0014 0.0055
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0131 0.0561
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0048 0.0184
Echinococcus granulosus smad 0.0017 0.0048 0.0184
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0014 0.0046
Trichomonas vaginalis mercuric reductase, putative 0.0035 0.0133 0.4403
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0068 0.0289 0.6367
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0068 0.0289 0.1101
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0035 0.0133 0.2803
Loa Loa (eye worm) thioredoxin reductase 0.0101 0.0449 0.1701
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.049 0.2302 0.8766
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0068 0.0289 0.1003
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0035 0.0133 0.0505
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0068 0.0289 0.6367
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0062 0.0226
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0035 0.0133 0.2803
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0062 0.1187
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0068 0.0289 1
Trypanosoma cruzi hypothetical protein, conserved 0.0068 0.0289 0.6367
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0231 0.1068 0.1477
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0172 0.3688
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0068 0.0289 0.1003
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0274 0.1044
Onchocerca volvulus 0.0009 0.001 0.071
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0014 0.0055
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0068 0.0289 0.6367
Trypanosoma brucei unspecified product 0.0043 0.0172 0.3688
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0208 0.0895
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0068 0.0289 0.6367
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0141 0.0536
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0031 0.0113 0.3694
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0558 0.2626 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0289 1
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0031 0.0113 0.6376
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0289 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.049 0.2302 1
Trichomonas vaginalis MYB3r3, putative 0.0031 0.0113 0.3694
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0068 0.0289 0.1247
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0172 0.3688
Trypanosoma cruzi hypothetical protein, conserved 0.0068 0.0289 0.6367
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0031 0.0113 0.3694
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0014 0.0052
Giardia lamblia NADH oxidase lateral transfer candidate 0.0035 0.0133 0.047
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0068 0.0289 0.6367
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0008 0.0024
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0068 0.0289 1
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0062 0.1864
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0068 0.0289 0.1101
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0042 0.0161
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0231 0.1068 0.1477
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0035 0.0133 0.2803
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0062 0.0235
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0133 0.2803
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0035 0.0133 0.2803
Trichomonas vaginalis pc-MYB2, putative 0.0031 0.0113 0.3694
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0133 0.2803
Echinococcus multilocularis bloom syndrome protein 0.002 0.0062 0.0235
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0274 0.1036
Brugia malayi ImpB/MucB/SamB family protein 0.0072 0.0308 0.1328
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0046
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0068 0.0289 0.1003
Echinococcus granulosus geminin 0.0363 0.1697 0.6463
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0035 0.0133 0.2803
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0068 0.0289 0.1247
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0014 0.0055
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0172 0.3688
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0068 0.0289 0.6367
Schistosoma mansoni hypothetical protein 0.0016 0.0042 0.0161
Loa Loa (eye worm) hypothetical protein 0.0051 0.0208 0.0785
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0133 0.2803
Loa Loa (eye worm) hypothetical protein 0.0068 0.0289 0.1093
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0262 0.0998
Echinococcus multilocularis dna polymerase kappa 0.0043 0.0172 0.0653
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0289 1
Toxoplasma gondii NADPH-glutathione reductase 0.0035 0.0133 0.0442
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0014 0.0046
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1512 0.7171 1
Trypanosoma cruzi DNA damage repair protein, putative 0.0013 0.0029 0.0446
Loa Loa (eye worm) hypothetical protein 0.0009 0.001 0.0028
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0068 0.0289 0.1101
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0068 0.0289 1
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0009 0.001 0.0028
Schistosoma mansoni disulfide oxidoreductase 0.0009 0.001 0.0037
Entamoeba histolytica hypothetical protein 0.0037 0.0141 0.8092
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0048 0.0184
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0035 0.0133 0.0442
Loa Loa (eye worm) Smad1 0.0017 0.0048 0.0175
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0068 0.0289 0.6367
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0068 0.0289 1
Trypanosoma brucei DNA polymerase eta, putative 0.0072 0.0308 0.6791
Schistosoma mansoni hypothetical protein 0.0016 0.0042 0.0161
Entamoeba histolytica hypothetical protein 0.0037 0.0141 0.8092
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0289 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0042 0.0152
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0031 0.0113 0.3694
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0068 0.0289 0.6367
Leishmania major DNA polymerase eta, putative 0.0072 0.0308 0.6791
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0031 0.0113 0.3694
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0014 0.0052
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0231 0.1068 0.1477
Loa Loa (eye worm) hypothetical protein 0.001 0.0011 0.0034
Echinococcus multilocularis glutamate synthase 0.0009 0.001 0.0037
Giardia lamblia DNA damage repair protein 0.0013 0.0029 0.0075
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0014 0.0055
Mycobacterium ulcerans hypothetical protein 0.0013 0.0029 0.002
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0014 0.0055
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0013 0.001
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0062 0.0235
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0068 0.0289 0.1003
Brugia malayi nuclear hormone receptor 0.001 0.0014 0.0052
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2105 1 1
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0009 0.001 0.0037
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0014 0.0052
Schistosoma mansoni terminal deoxycytidyl transferase 0.0043 0.0172 0.0653
Echinococcus granulosus GPCR family 2 0.0016 0.0042 0.0161
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0558 0.2626 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0043 0.0172 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0289 1
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0029 0.0446
Brugia malayi glutamate synthase 0.0009 0.001 0.0032
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0014 0.0055
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0014 0.0055
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.049 0.2302 0.8767
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0068 0.0289 0.6367
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0009 0.001 0.0037
Mycobacterium tuberculosis Conserved hypothetical protein 0.0043 0.0172 0.0226
Schistosoma mansoni DNA polymerase eta 0.0072 0.0308 0.1172
Schistosoma mansoni glutamate synthase 0.0009 0.001 0.0037
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0274 0.1044
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0068 0.0289 0.6367
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.049 0.2302 0.8767
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0014 0.0055
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0014 0.0055
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0558 0.2626 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0068 0.0289 0.1003
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0046
Trypanosoma cruzi DNA polymerase eta, putative 0.0072 0.0308 0.6791
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0172 0.3688
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0289 1
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0558 0.2626 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0068 0.0289 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0043 0.0172 0.0226
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0043 0.0172 0.3688
Leishmania major DNA damage repair protein, putative 0.0013 0.0029 0.0446
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0035 0.0133 0.2803
Schistosoma mansoni sulfide quinone reductase 0.0009 0.001 0.0037
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0068 0.0289 0.1101
Echinococcus multilocularis Smad4 0.0017 0.0048 0.0184
Mycobacterium tuberculosis Probable reductase 0.0231 0.1068 0.1477
Loa Loa (eye worm) glutathione reductase 0.0101 0.0449 0.1701
Plasmodium falciparum phosphodiesterase delta, putative 0.0068 0.0289 0.6367
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0068 0.0289 0.1101
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0031 0.0113 0.6376
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0068 0.0289 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0014 0.0052
Mycobacterium tuberculosis Probable oxidoreductase 0.0257 0.1191 0.1649
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0048 0.0184
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0014 0.0055
Schistosoma mansoni nuclear hormone receptor 0.001 0.0014 0.0055
Brugia malayi RNA binding protein 0.0065 0.0274 0.1182
Trypanosoma cruzi trypanothione reductase, putative 0.0035 0.0133 0.2803
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0035 0.0133 0.0123
Plasmodium vivax glutathione reductase, putative 0.0101 0.0449 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0014 0.0052
Schistosoma mansoni hypothetical protein 0.0418 0.1958 0.7455
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0062 0.0235
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0062 0.0187
Schistosoma mansoni sulfide quinone reductase 0.0009 0.001 0.0037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0014 0.0046
Schistosoma mansoni Smad4 0.0017 0.0048 0.0184
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0013 0.0029 0.007
Loa Loa (eye worm) hypothetical protein 0.0068 0.0289 0.1093
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0208 0.0895
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0068 0.0289 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0558 0.2626 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0131 0.0492
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0068 0.0289 0.1101
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0043 0.0172 0.0653
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0068 0.0289 0.6367
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.0172 0.0736
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0068 0.0289 0.1101
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0274 0.1182
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0035 0.0133 0.0123
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0046
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0068 0.0289 1
Plasmodium falciparum thioredoxin reductase 0.0035 0.0133 0.2803
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.001 0.0013 0.0066
Schistosoma mansoni hypothetical protein 0.0009 0.001 0.0037
Echinococcus multilocularis GPCR, family 2 0.0016 0.0042 0.0161
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0043 0.0172 0.0645
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0009 0.001 0.0037
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0062 0.0258
Schistosoma mansoni hypothetical protein 0.0016 0.0042 0.0161
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0068 0.0289 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0062 0.1187
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0009 0.001 0.0037
Echinococcus multilocularis dna polymerase eta 0.0072 0.0308 0.1172
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0014 0.0052
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0257 0.1191 0.1649
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0026 0.0088 0.0373
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0013 0.0029 0.007
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0068 0.0289 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0101 0.0449 0.0613
Schistosoma mansoni DNA helicase recq1 0.002 0.0062 0.0235
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0289 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0014 0.0052
Loa Loa (eye worm) hypothetical protein 0.0558 0.2626 1
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0029 0.0446
Loa Loa (eye worm) hypothetical protein 0.0072 0.0308 0.1164
Brugia malayi CXXC zinc finger family protein 0.0029 0.0105 0.0447
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0035 0.0133 0.2803
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0068 0.0289 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0009 0.001 0.0032
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0043 0.0172 0.5793
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1512 0.7171 1
Trichomonas vaginalis C-MYB, putative 0.0031 0.0113 0.3694
Loa Loa (eye worm) RNA binding protein 0.0065 0.0274 0.1036
Onchocerca volvulus 0.0029 0.0105 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0042 0.0161
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0068 0.0289 0.1101
Trypanosoma brucei DNA damage repair protein, putative 0.0013 0.0029 0.0446
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0068 0.0289 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0048 0.0175
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0048 0.0184
Trypanosoma cruzi hypothetical protein, conserved 0.0068 0.0289 0.6367
Trypanosoma cruzi hypothetical protein, conserved 0.0068 0.0289 0.6367
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0035 0.0133 0.0172
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0068 0.0289 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0068 0.0289 0.1101
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0062 0.0235
Plasmodium falciparum glutathione reductase 0.0035 0.0133 0.2803
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0014 0.0046
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0031 0.0113 0.3694
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0068 0.0289 0.6367
Trichomonas vaginalis glutathione reductase, putative 0.0035 0.0133 0.4403
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0068 0.0289 1
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.0031 0.0114 0.0373
Trichomonas vaginalis C-MYB, putative 0.0031 0.0113 0.3694
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0068 0.0289 0.1101
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0068 0.0289 0.1101
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0014 0.0046
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0105 0.0392
Trypanosoma cruzi DNA damage repair protein, putative 0.0013 0.0029 0.0446
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0014 0.0055
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0062 0.0187
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0172 0.3688
Giardia lamblia Hypothetical protein 0.0068 0.0289 0.1068
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0062 0.0199
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0035 0.0133 0.0123
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0068 0.0289 0.6367
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0014 0.0046
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0009 0.001 0.0037
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0068 0.0289 0.6367
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0014 0.0052
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0593 0.2794 1
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0068 0.0289 0.1101
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0068 0.0289 1
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0014 0.0046
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0289 1
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0031 0.0113 0.6376
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0035 0.0133 0.0123
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0068 0.0289 0.1101
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0289 1
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0172 0.0162
Leishmania major hypothetical protein, conserved 0.0068 0.0289 0.6367
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0009 0.001 0.0032
Echinococcus granulosus mothers against decapentaplegic 2 0.0008 0.0002 0.0009
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0068 0.0289 0.1003
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0068 0.0289 0.1247
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0031 0.0114 0.3719
Loa Loa (eye worm) MH2 domain-containing protein 0.0256 0.1186 0.451
Echinococcus granulosus FTZ F1 alpha 0.001 0.0014 0.0055
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0062 0.0258
Trichomonas vaginalis MYB, putative 0.0031 0.0114 0.3719
Brugia malayi MH2 domain containing protein 0.0256 0.1186 0.5145
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0141 0.0536
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0172 0.3688
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0068 0.0289 1
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0031 0.0113 0.6376
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0046
Schistosoma mansoni hypothetical protein 0.0016 0.0042 0.0161
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0133 0.2803
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0046
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0014 0.0055
Brugia malayi Smad1 0.0017 0.0048 0.02
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0172 0.3688
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0035 0.0133 0.2803
Echinococcus granulosus mothers against decapentaplegic 6 0.0008 0.0002 0.0009
Echinococcus granulosus thioredoxin glutathione reductase 0.0101 0.0449 0.1708
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0274 0.1044
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0009 0.001 0.0037
Entamoeba histolytica recQ family helicase, putative 0.001 0.0013 0.0178
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0068 0.0289 0.1101
Trypanosoma cruzi hypothetical protein, conserved 0.0068 0.0289 0.6367
Schistosoma mansoni cpg binding protein 0.0029 0.0105 0.04
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0029 0.0446
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0014 0.0108
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0068 0.0289 0.1247
Schistosoma mansoni Smad4 0.0008 0.0002 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0029 0.0446
Schistosoma mansoni DNA helicase recq5 0.002 0.0062 0.0235
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0014 0.0052
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0014 0.0055
Leishmania major DNA polymerase kappa, putative 0.0013 0.0029 0.0446
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0068 0.0289 0.6367
Giardia lamblia DINP protein human, muc B family 0.0043 0.0172 0.0619
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0068 0.0289 0.1003
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0035 0.0133 0.0123
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0029 0.0446
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0068 0.0289 0.1101
Schistosoma mansoni hypothetical protein 0.0363 0.1697 0.6463
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0108 0.2229
Schistosoma mansoni cpg binding protein 0.0031 0.0113 0.0431
Echinococcus granulosus dnaJ subfamily B 0.0418 0.1958 0.7455
Schistosoma mansoni glutamate synthase 0.0009 0.001 0.0037
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0014 0.0055
Loa Loa (eye worm) PDE1B protein 0.0068 0.0289 0.1093
Entamoeba histolytica recQ family helicase, putative 0.002 0.0062 0.3218
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0035 0.0133 0.2803
Plasmodium falciparum DNA repair protein REV1, putative 0.0013 0.0029 0.0446
Schistosoma mansoni DNA polymerase IV / kappa 0.0013 0.0029 0.0112
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0035 0.0133 0.0567
Echinococcus granulosus cpg binding protein 0.0031 0.0113 0.0431
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0014 0.0052
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0009 0.0023
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0009 0.0032
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0068 0.0289 0.1003
Echinococcus multilocularis mothers against decapentaplegic 2 0.0008 0.0002 0.0009
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0046
Echinococcus multilocularis thioredoxin glutathione reductase 0.0101 0.0449 0.1708
Echinococcus granulosus tar DNA binding protein 0.0065 0.0274 0.1044
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0031 0.0113 0.6376
Schistosoma mansoni cpg binding protein 0.0031 0.0113 0.0431
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0172 0.3688
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0014 0.0046
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0014 0.0055
Loa Loa (eye worm) programmed cell death 8 0.0009 0.001 0.0028
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0062 0.1187
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0014 0.0052
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0062 0.1864
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0289 1
Schistosoma mansoni smad 0.0017 0.0048 0.0184
Leishmania major hypothetical protein, conserved 0.0068 0.0289 0.6367
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0014 0.0052
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0014 0.0055
Trypanosoma cruzi hypothetical protein, conserved 0.0068 0.0289 0.6367
Brugia malayi nuclear receptor NHR-88 0.001 0.0014 0.0052
Brugia malayi MH1 domain containing protein 0.001 0.0011 0.0038
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0289 1
Loa Loa (eye worm) RecQ helicase 0.002 0.0062 0.0226
Entamoeba histolytica hypothetical protein 0.0037 0.0141 0.8092
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0035 0.0133 0.2803
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0035 0.0133 0.2803
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0172 0.3688
Treponema pallidum ATP-dependent DNA helicase 0.001 0.0014 0.0005
Plasmodium vivax thioredoxin reductase, putative 0.0101 0.0449 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0289 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0172 0.3688
Trypanosoma brucei trypanothione reductase 0.0101 0.0449 1
Giardia lamblia Myb 1-like protein 0.0031 0.0114 0.0397
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0014 0.0052
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0558 0.2626 0.9396
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0068 0.0289 0.1003
Echinococcus multilocularis dnaJ subfamily B 0.0418 0.1958 0.7455
Echinococcus granulosus dna polymerase eta 0.0072 0.0308 0.1172
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0026 0.0088 0.0373
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0035 0.0133 0.2803
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0009 0.001 0.0037
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0068 0.0289 0.1247
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0068 0.0289 0.1101
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0014 0.0052
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0068 0.0289 0.6367
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0593 0.2794 0.2787
Trypanosoma brucei unspecified product 0.003 0.0108 0.2229
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0068 0.0289 1
Leishmania major DNA polymerase kappa, putative 0.0043 0.0172 0.3688
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0289 1
Trichomonas vaginalis MYB72, putative 0.0031 0.0113 0.3694
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0042 0.0173
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0014 0.0055
Loa Loa (eye worm) hypothetical protein 0.0016 0.0042 0.0152
Schistosoma mansoni hypothetical protein 0.0035 0.0131 0.05
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0042 0.0161
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0068 0.0289 0.1101
Echinococcus granulosus bloom syndrome protein 0.002 0.0062 0.0235
Loa Loa (eye worm) hypothetical protein 0.0013 0.0029 0.0102
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0014 0.0055
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0068 0.0289 0.1003
Trypanosoma cruzi trypanothione reductase, putative 0.0101 0.0449 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0068 0.0289 0.1003
Leishmania major trypanothione reductase 0.0101 0.0449 1
Plasmodium vivax phosphodiesterase gamma, putative 0.0068 0.0289 0.6367
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0068 0.0289 0.6367
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0068 0.0289 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0046
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0014 0.1175
Trichomonas vaginalis pc-MYB2, putative 0.0031 0.0113 0.3694
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0043 0.0172 0.0653
Schistosoma mansoni hypothetical protein 0.0037 0.0141 0.0536
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0046
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0035 0.0133 0.0123
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0035 0.0133 0.2803
Mycobacterium tuberculosis Probable dehydrogenase 0.0231 0.1068 0.1477
Loa Loa (eye worm) nuclear factor I 0.001 0.0011 0.0034
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0068 0.0289 0.1003
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0014 0.0055
Treponema pallidum NADH oxidase 0.0035 0.0133 0.0123
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0014 0.0055
Brugia malayi steroid hormone receptor 0.001 0.0014 0.0052
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2105 1 1
Plasmodium vivax DNA repair protein REV1, putative 0.0013 0.0029 0.0446
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0014 0.0055
Echinococcus multilocularis cpg binding protein 0.0031 0.0113 0.0431
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0141 0.0536
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0014 0.0052
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0009 0.001 0.0037
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.023 0.0792
Loa Loa (eye worm) transcription factor SMAD2 0.0256 0.1186 0.451
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0068 0.0289 0.6367
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0068 0.0289 1
Echinococcus granulosus Smad4 0.0017 0.0048 0.0184

Activities

Activity type Activity value Assay description Source Reference
Change (functional) = -6.6 % The %change in weight from day 0 to day1 after administering the compound at dose of 40 (mg/kg)/day in rat ChEMBL. 6767032
Change (functional) = -3.1 % The %change in weight from day 0 to day 2 after administering the compound at dose of 40 (mg/kg)/day in rat ChEMBL. 6767032
Change (functional) = 0.9 % The %change in weight from day 0 to day 3 after administering the compound at dose of 40 (mg/kg)/day in rat ChEMBL. 6767032
Change (functional) = 2.2 % The %change in weight from day 0 to day 4 after administering the compound at dose of 40 (mg/kg)/day in rat ChEMBL. 6767032

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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