Detailed information for compound 74271

Basic information

Technical information
  • TDR Targets ID: 74271
  • Name: 9-bromo-7,12-dihydro-5H-indolo[3,2-d][1]benza zepine-6-thione
  • MW: 343.241 | Formula: C16H11BrN2S
  • H donors: 1 H acceptors: 0 LogP: 4.08 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc2c(c1)c1CC(=Nc3c(c1[nH]2)cccc3)S
  • InChi: 1S/C16H11BrN2S/c17-9-5-6-14-11(7-9)12-8-15(20)18-13-4-2-1-3-10(13)16(12)19-14/h1-7,19H,8H2,(H,18,20)
  • InChiKey: MHKWLZUWJABEIX-UHFFFAOYSA-N  

Network

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Synonyms

  • Paullone Analog 36

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cyclin-dependent kinase 3 Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 5 Starlite/ChEMBL References
Homo sapiens cyclin B3 Starlite/ChEMBL References
Homo sapiens glycogen synthase kinase 3 beta Starlite/ChEMBL References
Homo sapiens cyclin B2 Starlite/ChEMBL References
Homo sapiens cyclin B1 References
Homo sapiens cyclin-dependent kinase 5, regulatory subunit 1 (p35) References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Onchocerca volvulus Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania infantum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_134175 All targets in OG5_134175
Brugia malayi hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_134175 All targets in OG5_134175
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis mitotic cyclin-CYC2 Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin A, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum IPR002155,Thiolase,domain-containing Get druggable targets OG5_134175 All targets in OG5_134175
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus G2:mitotic specific cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cyclin 6,mitotic cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 Get druggable targets OG5_133447 All targets in OG5_133447
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum Cyclin-dependent kinase 5 activator 2 precursor, putative Get druggable targets OG5_133447 All targets in OG5_133447
Leishmania donovani cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense Cyclin, N-terminal domain/Cyclin, C-terminal domain containing protein, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis G2:mitotic specific cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Loa Loa (eye worm) cyclin domain-containing protein Get druggable targets OG5_134175 All targets in OG5_134175
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus cyclin dependent kinase 5 activator 1 Get druggable targets OG5_133447 All targets in OG5_133447
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans likely B-type cyclin similar to S. cerevisiae CLB4 (YLR210W) and CLB3 (YDL155W) involved in G1/S transition Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni cyclin-dependent kinase 5 activator Get druggable targets OG5_133447 All targets in OG5_133447
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania infantum CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia G2/mitotic-specific cyclin B Get druggable targets OG5_126649 All targets in OG5_126649

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 5 260 aa 307 aa 28.3 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0062 0.028
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0026 0.0113 0.0158
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.0104 0.0104
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0026 0.0113 0.0158
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0062 0.0295
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0026 0.0113 0.0539
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0051 0.03 0.1355
Trypanosoma brucei heat shock protein, putative 0.0032 0.0161 0.0769
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0051 0.03 0.0608
Brugia malayi Smad1 0.0016 0.0045 0.0204
Schistosoma mansoni coup transcription factor 0.0051 0.03 0.0608
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0015 0.0037 0.0052
Echinococcus multilocularis cyclin dependent kinase 5 0.0105 0.069 0.1187
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.0104 0.0104
Onchocerca volvulus 0.0026 0.0113 0.0495
Trichomonas vaginalis C-MYB, putative 0.002 0.0071 0.0336
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0027 0.0123 0.0249
Plasmodium vivax cyclin dependent kinase binding protein, putative 0.0016 0.0039 0.0518
Echinococcus granulosus Smad4 0.0016 0.0045 0.0092
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.002 0.0071 0.0244
Loa Loa (eye worm) hypothetical protein 0.0026 0.0113 0.0508
Loa Loa (eye worm) cyclin domain-containing protein 0.0016 0.0039 0.0174
Loa Loa (eye worm) brahma associated protein 0.0011 0.0003 0.0014
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0065 0.0311
Loa Loa (eye worm) hypothetical protein 0.0079 0.0505 0.228
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.069 0.1398
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0159 0.076
Onchocerca volvulus 0.0059 0.0357 0.1601
Brugia malayi Delta serrate ligand family protein 0.0026 0.0113 0.0508
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.0023 0.0296
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0309 0.218 0.442
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.023 0.1099
Entamoeba histolytica cell division protein kinase 2, putative 0.0105 0.069 0.3334
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0109 0.0492
Echinococcus granulosus X box binding protein 1 0.0287 0.2016 0.4087
Mycobacterium leprae Probable polyketide synthase Pks1 0.0026 0.0116 0.0162
Echinococcus granulosus heat shock protein 90 0.0032 0.0161 0.0327
Brugia malayi Cyclin, N-terminal domain containing protein 0.0016 0.0039 0.0173
Loa Loa (eye worm) hypothetical protein 0.0079 0.0505 0.228
Echinococcus granulosus cyclin dependent kinase 1 0.0105 0.069 0.1398
Brugia malayi MH2 domain containing protein 0.0016 0.0045 0.0204
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0045 0.0092
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0011 0.0005 0.0007
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0161 0.0769
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0024 0.0102 0.0176
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0232 0.1132
Loa Loa (eye worm) hypothetical protein 0.0043 0.0238 0.1073
Trypanosoma cruzi mitotic cyclin, putative 0.0016 0.0039 0.0183
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0159 0.0274
Loa Loa (eye worm) hypothetical protein 0.0098 0.064 0.289
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0051 0.03 0.0608
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0025 0.0109 0.0493
Loa Loa (eye worm) hypothetical protein 0.0026 0.0113 0.0508
Giardia lamblia Fructose-bisphosphate aldolase 0.0288 0.2025 1
Echinococcus multilocularis neurogenic locus notch protein 4 0.0026 0.0113 0.0194
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0102 0.0207
Loa Loa (eye worm) hypothetical protein 0.0051 0.03 0.1355
Echinococcus granulosus cpg binding protein 0.0031 0.0152 0.0309
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0065 0.0311
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0023 0.0084
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0051 0.03 0.1354
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0038 0.0201 0.0281
Schistosoma mansoni hypothetical protein 0.0041 0.0221 0.0447
Loa Loa (eye worm) hypothetical protein 0.0026 0.0113 0.0508
Loa Loa (eye worm) hypothetical protein 0.0024 0.0102 0.0461
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0045 0.0092
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0357 0.175
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0391 0.0792
Echinococcus granulosus FTZ F1 alpha 0.0051 0.03 0.0608
Leishmania major heat shock protein 83-1 0.0032 0.0161 0.0769
Trypanosoma brucei heat shock protein, putative 0.0032 0.0161 0.0769
Schistosoma mansoni retinoic acid receptor RXR 0.0051 0.03 0.0608
Schistosoma mansoni heat shock protein 0.0032 0.0161 0.0326
Onchocerca volvulus 0.0029 0.014 0.062
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0051 0.03 0.0608
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0161 0.0769
Loa Loa (eye worm) steroid hormone receptor 0.0051 0.03 0.1355
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0065 0.0308
Plasmodium vivax protein kinase Crk2 0.0105 0.069 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0039 0.0208 0.029
Toxoplasma gondii heat shock protein 75, putative 0.0013 0.0022 0.0079
Toxoplasma gondii Hsp90 domain-containing protein 0.0013 0.0022 0.0079
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0023 0.0111
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0288 0.2025 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0389 0.0788
Echinococcus granulosus cyclin dependent kinase 5 0.0105 0.069 0.1398
Brugia malayi Cyclin C 0.0016 0.0039 0.0173
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0023 0.0047
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0065 0.0307
Brugia malayi Cyclin, N-terminal domain containing protein 0.0124 0.0832 0.3758
Onchocerca volvulus 0.0047 0.0268 0.1198
Loa Loa (eye worm) hypothetical protein 0.0026 0.0113 0.0508
Loa Loa (eye worm) cyclin domain-containing protein 0.0016 0.0039 0.0174
Leishmania major heat shock protein 83-1 0.0032 0.0161 0.0769
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0045 0.0091
Brugia malayi Cyclin, N-terminal domain containing protein 0.0016 0.0039 0.0173
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0214 0.1486 0.6713
Trichomonas vaginalis cyclins, putative 0.0124 0.0832 0.41
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0113 0.0545
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0135 0.0608
Echinococcus granulosus peroxidasin 0.0079 0.0505 0.1023
Onchocerca volvulus 0.0314 0.2214 1
Schistosoma mansoni hypothetical protein 0.0345 0.2441 0.4949
Trichomonas vaginalis cyclin B, putative 0.0124 0.0832 0.41
Loa Loa (eye worm) nuclear hormone receptor 0.0024 0.0102 0.0461
Echinococcus granulosus protein jagged 1 0.0026 0.0113 0.0228
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0051 0.03 0.0608
Schistosoma mansoni smad 0.0016 0.0045 0.0091
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0026 0.0116 0.0162
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0051 0.03 0.0608
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0051 0.03 0.0516
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.069 0.1398
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0013 0.0023 0.0023
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0105 0.069 0.1398
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0065 0.0295
Mycobacterium leprae Polyketide synthase Pks13 0.0038 0.0201 0.0281
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.0212 0.0365
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0016 0.0039 0.0518
Brugia malayi hypothetical protein 0.0079 0.0505 0.228
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.0016 0.0039 0.0174
Schistosoma mansoni hypothetical protein 0.0011 0.0003 0.0006
Brugia malayi MH2 domain containing protein 0.0016 0.0045 0.0204
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0159 0.076
Loa Loa (eye worm) animal heme peroxidase 0.0079 0.0505 0.228
Echinococcus granulosus nuclear receptor nhr 48 0.0024 0.0102 0.0207
Schistosoma mansoni smad1 5 8 and 0.0016 0.0045 0.0091
Trichomonas vaginalis C-MYB, putative 0.002 0.0071 0.0336
Toxoplasma gondii hypothetical protein 0.0049 0.0281 0.1017
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0065 0.0311
Echinococcus multilocularis GPCR, family 2 0.0032 0.0159 0.0274
Mycobacterium ulcerans heat shock protein 90 0.0026 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.0024 0.0102 0.0461
Toxoplasma gondii hypothetical protein 0.0016 0.0039 0.0139
Brugia malayi Pre-SET motif family protein 0.0214 0.1486 0.6712
Trichomonas vaginalis pc-MYB2, putative 0.002 0.0071 0.0336
Echinococcus granulosus cyclins 0.0064 0.0395 0.08
Loa Loa (eye worm) CYL-1 protein 0.0016 0.0039 0.0174
Loa Loa (eye worm) hypothetical protein 0.0026 0.0113 0.0508
Loa Loa (eye worm) hypothetical protein 0.0026 0.0113 0.0508
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0105 0.069 0.3116
Plasmodium falciparum cyclin 1 0.0016 0.0039 0.0518
Plasmodium vivax SET domain protein, putative 0.0031 0.0153 0.2187
Loa Loa (eye worm) cyclin domain-containing protein 0.0016 0.0039 0.0174
Brugia malayi EGF-like domain containing protein 0.0026 0.0113 0.0508
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0232 0.047
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.023 0.1099
Schistosoma mansoni cyclin d 0.0016 0.0039 0.0078
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0309 0.218 0.442
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.0208 0.0993
Giardia lamblia Grp94/Hsp90 0.0026 0.0113 0.0449
Echinococcus multilocularis neural cadherin 0.0026 0.0113 0.0194
Brugia malayi CXXC zinc finger family protein 0.0029 0.014 0.0632
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0389 0.2766 0.2763
Echinococcus granulosus cyclins 0.0064 0.0395 0.08
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0024 0.0102 0.0461
Trypanosoma brucei cdc2-related kinase 3 0.0105 0.069 0.3292
Giardia lamblia Kinase, CMGC CDK 0.0105 0.069 0.3329
Loa Loa (eye worm) hypothetical protein 0.0024 0.0102 0.0461
Echinococcus granulosus cyclin dependent kinase 0.0105 0.069 0.1398
Onchocerca volvulus Protein CNPPD1 homolog 0.0016 0.0039 0.0161
Schistosoma mansoni hypothetical protein 0.0032 0.0159 0.0322
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0159 0.076
Leishmania major DNA polymerase kappa, putative 0.0019 0.0065 0.0311
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0288 0.2025 1
Trypanosoma brucei heat shock protein, putative 0.0032 0.0161 0.0769
Treponema pallidum heat shock protein 90 0.0026 0.0113 0.009
Echinococcus multilocularis cyclin y 0.0016 0.0039 0.0066
Loa Loa (eye worm) hypothetical protein 0.0024 0.0102 0.0461
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0065 0.0295
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0072 0.0339
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0159 0.0274
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0023 0.0101
Onchocerca volvulus 0.0016 0.0039 0.0161
Schistosoma mansoni peroxidasin 0.0079 0.0505 0.1023
Brugia malayi hypothetical protein 0.0314 0.2214 1
Trichomonas vaginalis endoplasmin, putative 0.002 0.007 0.0331
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0011 0.0003 0.001
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0065 0.0065
Plasmodium falciparum heat shock protein 90, putative 0.0013 0.0022 0.0276
Echinococcus granulosus cyclins 0.0016 0.0039 0.0078
Echinococcus granulosus cyclin B 0.0124 0.0832 0.1687
Onchocerca volvulus Huntingtin homolog 0.0122 0.0814 0.367
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0019 0.0062 0.0062
Schistosoma mansoni hypothetical protein 0.0345 0.2441 0.4949
Mycobacterium tuberculosis Probable reductase 0.0088 0.057 0.0797
Trypanosoma brucei protein kinase, putative 0.0059 0.0357 0.1703
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0199 0.1375 0.2366
Trypanosoma cruzi heat shock protein, putative 0.0013 0.0022 0.0104
Leishmania major heat shock protein 83-1 0.0032 0.0161 0.0769
Trichomonas vaginalis cyclin B3, putative 0.0064 0.0395 0.1936
Plasmodium falciparum glycogen synthase kinase 3 0.0059 0.0357 0.5153
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0019 0.0065 0.0065
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.014 0.0633
Entamoeba histolytica cyclin, domain containing protein 0.0016 0.0039 0.0083
Plasmodium vivax cyclin 4, putative 0.0016 0.0039 0.0518
Leishmania major DNA polymerase eta, putative 0.0019 0.0065 0.0311
Echinococcus multilocularis cyclins 0.0064 0.0395 0.0679
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0161 0.0695
Onchocerca volvulus 0.0026 0.0113 0.0495
Onchocerca volvulus Peroxidase homolog 0.0079 0.0505 0.227
Entamoeba histolytica cyclin C, putative 0.0016 0.0039 0.0083
Onchocerca volvulus 0.0024 0.0102 0.0448
Echinococcus granulosus dna polymerase kappa 0.0019 0.0065 0.0133
Brugia malayi nuclear receptor RXR 0.0027 0.0123 0.0556
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0024 0.0102 0.0448
Schistosoma mansoni patched 1 0.0042 0.0232 0.047
Echinococcus multilocularis microtubule associated protein 2 0.0686 0.4933 0.8491
Schistosoma mansoni slit 0.0026 0.0113 0.0228
Onchocerca volvulus Chorion peroxidase homolog 0.0079 0.0505 0.227
Echinococcus granulosus neurogenic locus notch protein 4 0.0026 0.0113 0.0228
Loa Loa (eye worm) hypothetical protein 0.0079 0.0505 0.228
Echinococcus multilocularis cyclin B3 1 0.0064 0.0395 0.0679
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0051 0.03 0.1354
Echinococcus multilocularis Niemann Pick C1 protein 0.014 0.0946 0.1629
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0065 0.0308
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0051 0.03 0.0608
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.0651 0.1319
Brugia malayi Cytochrome P450 family protein 0.0029 0.0135 0.0608
Onchocerca volvulus Slit protein homolog 0.0026 0.0113 0.0495
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0051 0.03 0.0608
Onchocerca volvulus 0.0124 0.0832 0.375
Trypanosoma cruzi heat shock protein 90, putative 0.0026 0.0113 0.0539
Onchocerca volvulus Peroxidasin homolog 0.0079 0.0505 0.227
Toxoplasma gondii thioredoxin reductase 0.0039 0.0208 0.0752
Plasmodium falciparum cyclin dependent kinase binding protein, putative 0.0016 0.0039 0.0518
Loa Loa (eye worm) hypothetical protein 0.0024 0.0102 0.0461
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0023 0.0105
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0051 0.03 0.1354
Onchocerca volvulus Peroxidase homolog 0.0079 0.0505 0.227
Loa Loa (eye worm) hypothetical protein 0.0051 0.03 0.1355
Trypanosoma brucei mitotic cyclin 6 0.0124 0.0832 0.3971
Loa Loa (eye worm) hypothetical protein 0.0051 0.03 0.1355
Echinococcus multilocularis heat shock protein 90 0.0026 0.0113 0.0195
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0102 0.0176
Brugia malayi Animal haem peroxidase family protein 0.0079 0.0505 0.228
Echinococcus multilocularis cpg binding protein 0.0031 0.0152 0.0262
Schistosoma mansoni heat shock protein 0.0032 0.0161 0.0326
Leishmania major heat shock protein 83-1 0.0032 0.0161 0.0769
Loa Loa (eye worm) hypothetical protein 0.0051 0.03 0.1355
Leishmania major cyclin 0.0124 0.0832 0.3971
Toxoplasma gondii hypothetical protein 0.0048 0.0275 0.0995
Trypanosoma brucei unspecified product 0.0013 0.0022 0.0104
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0038 0.0201 0.0281
Loa Loa (eye worm) hypothetical protein 0.0148 0.1005 0.4539
Trypanosoma cruzi Heat shock protein 83, putative 0.0032 0.0161 0.0769
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0159 0.0575
Onchocerca volvulus 0.0249 0.1743 0.7871
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0051 0.03 0.0516
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0159 0.076
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.0991 0.716 1
Entamoeba histolytica cyclin, putative 0.0064 0.0395 0.186
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0297 0.1415
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0088 0.057 0.0797
Leishmania major heat shock protein 83-1 0.0032 0.0161 0.0769
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0015 0.0037 0.0037
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0065 0.0311
Toxoplasma gondii type I fatty acid synthase, putative 0.0019 0.0065 0.0236
Loa Loa (eye worm) hypothetical protein 0.0079 0.0505 0.228
Trypanosoma cruzi CYC2-like cyclin, putative 0.0124 0.0832 0.3971
Brugia malayi nuclear hormone receptor 0.0051 0.03 0.1354
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0023 0.0111
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0391 0.1864
Loa Loa (eye worm) hypothetical protein 0.0122 0.0814 0.3679
Trypanosoma brucei heat shock protein, putative 0.0032 0.0161 0.0769
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0023 0.004
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0232 0.047
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0092 0.0186
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0019 0.0065 0.0091
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0013 0.0023 0.0032
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.0023 0.0296
Schistosoma mansoni notch 0.0026 0.0113 0.0228
Giardia lamblia Hypothetical protein 0.0016 0.0039 0.0076
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0024 0.0102 0.0206
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0297 0.1415
Echinococcus multilocularis FTZ F1 alpha 0.0051 0.03 0.0516
Brugia malayi nuclear receptor NHR-67 0.0024 0.0102 0.046
Leishmania major cyclin 9, putative 0.0016 0.0039 0.0183
Echinococcus granulosus geminin 0.0345 0.2441 0.4949
Echinococcus granulosus ecdysone induced protein 78C 0.0051 0.03 0.0608
Schistosoma mansoni g1/s-specific cyclin C 0.0016 0.0039 0.0078
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0065 0.0132
Brugia malayi intracellular kinase 0.0059 0.0357 0.1611
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0297 0.4276
Schistosoma mansoni hypothetical protein 0.0026 0.0113 0.0228
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0051 0.03 0.0608
Loa Loa (eye worm) animal heme peroxidase 0.0079 0.0505 0.228
Entamoeba histolytica cyclin, domain containing protein 0.0016 0.0039 0.0083
Loa Loa (eye worm) animal heme peroxidase 0.0079 0.0505 0.228
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0024 0.0102 0.046
Loa Loa (eye worm) hypothetical protein 0.0026 0.0113 0.0508
Onchocerca volvulus Cyclin L homolog 0.0016 0.0039 0.0161
Brugia malayi Cyclin, N-terminal domain containing protein 0.0016 0.0039 0.0173
Loa Loa (eye worm) hypothetical protein 0.0027 0.0123 0.0557
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0391 0.184
Trichomonas vaginalis cyclins, putative 0.0124 0.0832 0.41
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.2025 1
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.0357 0.1672
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0025 0.0109 0.0152
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.002 0.0071 0.0244
Brugia malayi Animal haem peroxidase family protein 0.0079 0.0505 0.228
Echinococcus multilocularis slit 2 protein 0.0026 0.0113 0.0194
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0013 0.0022 0.0086
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0023 0.0047
Schistosoma mansoni Cyclin fold protein 0.0016 0.0039 0.0078
Brugia malayi Pre-SET motif family protein 0.0031 0.0153 0.0691
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0664 0.2998
Loa Loa (eye worm) cyclin C 0.0016 0.0039 0.0174
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.0023 0.0296
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0026 0.0113 0.0495
Schistosoma mansoni hypothetical protein 0.0026 0.0113 0.0228
Schistosoma mansoni hypothetical protein 0.0016 0.0039 0.0078
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0065 0.0295
Loa Loa (eye worm) hypothetical protein 0.0042 0.0232 0.1048
Echinococcus granulosus neurogenic locus notch protein 0.0026 0.0113 0.0228
Brugia malayi MH2 domain containing protein 0.0241 0.1686 0.7615
Echinococcus multilocularis protein kinase shaggy 0.0059 0.0357 0.0614
Trichomonas vaginalis cyclins, putative 0.0124 0.0832 0.41
Loa Loa (eye worm) hypothetical protein 0.0079 0.0505 0.228
Loa Loa (eye worm) cytochrome P450 0.001 0 0.0001
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0141 0.0951 0.0951
Echinococcus granulosus fibropellin Ia 0.0026 0.0113 0.0228
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0011 0.0003 0.001
Brugia malayi Cadherin domain containing protein 0.0026 0.0113 0.0508
Brugia malayi hypothetical protein 0.0016 0.0039 0.0173
Brugia malayi Endoplasmin precursor 0.0032 0.0161 0.0727
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0159 0.0717
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0159 0.0274
Leishmania major heat shock protein 83-1 0.0032 0.0161 0.0769
Leishmania major heat shock protein 83-1 0.0032 0.0161 0.0769
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0019 0.0065 0.0065
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1381 1 1
Plasmodium vivax cyclin homologue, putative 0.0016 0.0039 0.0518
Echinococcus multilocularis tumor protein p63 0.035 0.2477 0.4264
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0161 0.0769
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0105 0.069 0.3116
Plasmodium falciparum glutathione reductase 0.0013 0.0023 0.0296
Echinococcus multilocularis neurogenic locus protein delta 0.0026 0.0113 0.0194
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0013 0.0023 0.0023
Entamoeba histolytica protein kinase, putative 0.0059 0.0357 0.1672
Mycobacterium ulcerans hypothetical protein 0.0157 0.1068 0.1068
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0026 0.0116 0.0162
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0065 0.0311
Loa Loa (eye worm) hypothetical protein 0.0024 0.0102 0.0461
Onchocerca volvulus 0.0079 0.0505 0.227
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0199 0.1375 0.2787
Echinococcus granulosus cyclin G2 0.0016 0.0039 0.0078
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.2025 1
Echinococcus granulosus protein jagged 2 0.0026 0.0113 0.0228
Trichomonas vaginalis MYB, putative 0.002 0.0072 0.0339
Onchocerca volvulus 0.0024 0.0102 0.0448
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0141 0.0951 0.1328
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0102 0.0176
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.0123 0.0249
Brugia malayi tailless protein 0.0024 0.0102 0.046
Echinococcus multilocularis smad 0.0016 0.0045 0.0078
Plasmodium vivax heat shock protein 90, putative 0.0013 0.0022 0.0276
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.0113 0.0539
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.0357 0.1672
Brugia malayi EGF-like domain containing protein 0.0026 0.0113 0.0508
Loa Loa (eye worm) cyclin domain-containing protein 0.0199 0.1375 0.621
Echinococcus multilocularis cyclin G2 0.0016 0.0039 0.0066
Loa Loa (eye worm) hypothetical protein 0.0069 0.043 0.1943
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0051 0.03 0.1343
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0102 0.046
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0051 0.03 0.0608
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0195 0.0395
Entamoeba histolytica cyclin family protein 0.0064 0.0395 0.186
Echinococcus multilocularis peroxidasin 0.0079 0.0505 0.0869
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0153 0.031
Schistosoma mansoni nuclear hormone receptor 0.0051 0.03 0.0608
Echinococcus granulosus cyclins 0.0064 0.0395 0.08
Loa Loa (eye worm) hypothetical protein 0.0026 0.0113 0.0508
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0297 0.1418
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0065 0.0311
Echinococcus multilocularis cyclins 0.0064 0.0395 0.0679
Giardia lamblia Kinase, CMGC CDK 0.0105 0.069 0.3329
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0045 0.0205
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1381 1 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0051 0.03 0.0516
Leishmania major hypothetical protein, conserved 0.0051 0.0297 0.1415
Brugia malayi Hsp90 protein 0.0013 0.0022 0.0099
Echinococcus multilocularis Smad4 0.0016 0.0045 0.0078
Schistosoma mansoni hypothetical protein 0.0011 0.0003 0.0006
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0391 0.0672
Mycobacterium tuberculosis Probable oxidoreductase 0.0098 0.0642 0.0897
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0153 0.0553
Echinococcus granulosus Cyclin L1 0.0016 0.0039 0.0078
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0065 0.0113
Echinococcus granulosus G1:S specific cyclin D1 0.0016 0.0039 0.0078
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0013 0.0023 0.0111
Brugia malayi Cyclin, N-terminal domain containing protein 0.0016 0.0039 0.0173
Schistosoma mansoni cyclin B 0.0124 0.0832 0.1686
Echinococcus granulosus smad 0.0016 0.0045 0.0092
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0159 0.0323
Schistosoma mansoni cyclins 0.0064 0.0395 0.0799
Echinococcus granulosus heat shock protein 90 0.0026 0.0113 0.0229
Loa Loa (eye worm) hypothetical protein 0.0026 0.0113 0.0508
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0039 0.0176
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0065 0.0311
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0071 0.0336
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0024 0.0102 0.0206
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0011 0.0003 0.0006
Onchocerca volvulus 0.0031 0.0153 0.0679
Echinococcus granulosus cyclin y 0.0016 0.0039 0.0078
Schistosoma mansoni cyclin l 0.0016 0.0039 0.0078
Entamoeba histolytica cyclin family protein 0.0064 0.0395 0.186
Loa Loa (eye worm) hypothetical protein 0.0309 0.218 0.9849
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0088 0.057 0.0797
Giardia lamblia Heat shock protein HSP 90-alpha 0.0032 0.0161 0.0689
Trypanosoma brucei mitotic cyclin 0.0016 0.0039 0.0183
Loa Loa (eye worm) transcription factor SMAD2 0.0241 0.1686 0.7615
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0059 0.0357 0.1703
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0026 0.0113 0.0229
Trichomonas vaginalis cyclin B, putative 0.0124 0.0832 0.41
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0051 0.03 0.0516
Brugia malayi Cadherin domain containing protein 0.0026 0.0113 0.0508
Echinococcus multilocularis cyclin dependent kinase 0.0105 0.069 0.1187
Mycobacterium tuberculosis Probable thioesterase TesA 0.0022 0.0089 0.0124
Loa Loa (eye worm) hypothetical protein 0.0026 0.0113 0.0508
Giardia lamblia G2/mitotic-specific cyclin B 0.0124 0.0832 0.404
Echinococcus granulosus protein kinase shaggy 0.0059 0.0357 0.0724
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0102 0.0207
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0051 0.03 0.0608
Leishmania major heat shock protein 83-1 0.0032 0.0161 0.0769
Entamoeba histolytica cell division protein kinase 2, putative 0.0105 0.069 0.3334
Schistosoma mansoni heat shock protein 0.0013 0.0022 0.0044
Loa Loa (eye worm) hypothetical protein 0.0079 0.0505 0.228
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0023 0.0111
Brugia malayi Cyclin, N-terminal domain containing protein 0.0199 0.1375 0.621
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.0016 0.0039 0.0066
Loa Loa (eye worm) hypothetical protein 0.0101 0.0664 0.2998
Echinococcus granulosus cyclin y 0.0016 0.0039 0.0078
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0159 0.0718
Brugia malayi nuclear receptor RXR 0.0024 0.0102 0.046
Trypanosoma cruzi cyclin 6, putative 0.0124 0.0832 0.3971
Loa Loa (eye worm) hypothetical protein 0.0051 0.0297 0.134
Brugia malayi nuclear receptor NHR-88 0.0051 0.03 0.1354
Onchocerca volvulus Protein ultraspiracle homolog 0.0051 0.03 0.1343
Loa Loa (eye worm) hypothetical protein 0.0024 0.0102 0.0461
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0105 0.069 0.2494
Toxoplasma gondii heat shock protein 90, putative 0.0032 0.0161 0.0582
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0806 0.581 1
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0025 0.0089
Leishmania major trypanothione reductase 0.0039 0.0208 0.0993
Onchocerca volvulus Neurogenic locus notch homolog 0.0026 0.0113 0.0495
Loa Loa (eye worm) hypothetical protein 0.0079 0.0505 0.228
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0051 0.03 0.1355
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0159 0.0274
Brugia malayi Animal haem peroxidase family protein 0.0079 0.0505 0.228
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0049 0.028 0.1264
Leishmania major mitochondrial DNA polymerase beta 0.0297 0.2095 1
Loa Loa (eye worm) notch protein 0.0026 0.0113 0.0508
Schistosoma mansoni hypothetical protein 0.0016 0.0039 0.0078
Schistosoma mansoni hypothetical protein 0.0069 0.043 0.0871
Trichomonas vaginalis set domain proteins, putative 0.0243 0.1701 0.8397
Loa Loa (eye worm) hypothetical protein 0.0019 0.0065 0.0295
Echinococcus multilocularis SWI:SNF matrix associated 0.0011 0.0003 0.0005
Trypanosoma brucei cytochrome P450, putative 0.0019 0.0062 0.0295
Schistosoma mansoni notch 0.0026 0.0113 0.0228
Echinococcus granulosus cyclins 0.0064 0.0395 0.08
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0065 0.0311
Trypanosoma cruzi heat shock protein 90, putative 0.0032 0.0161 0.0769
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0024 0.0104 0.0145
Loa Loa (eye worm) hypothetical protein 0.0024 0.0102 0.0461
Brugia malayi GCC2 and GCC3 family protein 0.0026 0.0113 0.0508
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0159 0.0322
Trichomonas vaginalis cyclin B3, putative 0.0016 0.0039 0.0176
Trichomonas vaginalis cyclins, putative 0.0016 0.0039 0.0176
Loa Loa (eye worm) hypothetical protein 0.0026 0.0113 0.0508
Schistosoma mansoni cpg binding protein 0.0029 0.014 0.0284
Loa Loa (eye worm) hypothetical protein 0.0026 0.0113 0.0508
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0059 0.0357 0.1612
Brugia malayi EGF-like domain containing protein 0.0026 0.0113 0.0508
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0664 0.2997
Echinococcus multilocularis cyclin dependent kinase 1 0.0105 0.069 0.1187
Loa Loa (eye worm) hypothetical protein 0.0079 0.0505 0.228
Brugia malayi nuclear hormone receptor 0.0024 0.0102 0.046
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.2025 1
Onchocerca volvulus 0.0026 0.0113 0.0495
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0027 0.0123 0.025
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0065 0.0113
Echinococcus multilocularis cyclins 0.0064 0.0395 0.0679
Onchocerca volvulus 0.0025 0.0109 0.048
Schistosoma mansoni steroid hormone receptor ad4bp 0.0051 0.03 0.0608
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0065 0.0132
Trichomonas vaginalis pc-MYB2, putative 0.002 0.0071 0.0336
Echinococcus granulosus protein jagged 1 0.0026 0.0113 0.0228
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0065 0.0311
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0059 0.0357 0.0723
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0159 0.0274
Plasmodium falciparum glutathione reductase 0.0039 0.0208 0.2987
Loa Loa (eye worm) hypothetical protein 0.0026 0.0113 0.0508
Loa Loa (eye worm) thioredoxin reductase 0.0039 0.0208 0.094
Leishmania major mitotic cyclin, putative 0.0016 0.0039 0.0183
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0071 0.0336
Schistosoma mansoni brg-1 associated factor 0.0011 0.0003 0.0006
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.064 0.1101
Mycobacterium ulcerans polyketide synthase Pks13 0.0038 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.0051 0.03 0.1355
Loa Loa (eye worm) cyclin domain-containing protein 0.0016 0.0039 0.0174
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.2025 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0023 0.0111
Echinococcus granulosus Niemann Pick C1 protein 0.014 0.0946 0.1918
Echinococcus multilocularis neurogenic locus notch protein 0.0026 0.0113 0.0194
Loa Loa (eye worm) hypothetical protein 0.0026 0.0113 0.0508
Schistosoma mansoni hypothetical protein 0.0041 0.0221 0.0447
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0045 0.0078
Trichomonas vaginalis cyclin A, putative 0.0016 0.0039 0.0176
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.0952 0.4545
Echinococcus multilocularis notch 0.0026 0.0113 0.0194
Loa Loa (eye worm) hypothetical protein 0.006 0.0363 0.1639
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0123 0.0556
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0062 0.028
Brugia malayi Cyclin, N-terminal domain containing protein 0.0016 0.0039 0.0173
Brugia malayi hypothetical protein 0.0027 0.0123 0.0556
Onchocerca volvulus 0.0243 0.1701 0.7681
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0391 0.1864
Echinococcus multilocularis thyroid hormone receptor alpha 0.0051 0.03 0.0516
Trypanosoma brucei trypanothione reductase 0.0039 0.0208 0.0993
Trypanosoma brucei heat shock protein, putative 0.0032 0.0161 0.0769
Echinococcus multilocularis protein dispatched 1 0.0048 0.0275 0.0474
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0159 0.0323
Trypanosoma brucei heat shock protein, putative 0.0032 0.0161 0.0769
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.0023 0.0296
Loa Loa (eye worm) hypothetical protein 0.0079 0.0505 0.228
Trichomonas vaginalis cyclin A, putative 0.0124 0.0832 0.41
Echinococcus multilocularis cyclins 0.0064 0.0395 0.0679
Brugia malayi brahma associated protein 60 kDa 0.0011 0.0003 0.0013
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.002 0.0068 0.0095
Leishmania major cytochrome p450-like protein 0.0019 0.0062 0.0295
Brugia malayi brahma associated protein 60 kDa 0.0011 0.0003 0.0013
Toxoplasma gondii cyclin, N-terminal domain-containing protein 0.0016 0.0039 0.0139
Loa Loa (eye worm) hypothetical protein 0.0051 0.0301 0.1359
Loa Loa (eye worm) hypothetical protein 0.0051 0.03 0.1355
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0297 0.2095 1
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0022 0.0089 0.0124
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0051 0.03 0.1354
Leishmania major heat shock protein 83-1 0.0032 0.0161 0.0769
Leishmania major heat shock protein 83-1 0.0032 0.0161 0.0769
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0297 0.1072
Schistosoma mansoni endoplasmin 0.0032 0.0161 0.0326
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0027 0.0123 0.0557
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0391 0.1864
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0051 0.03 0.0608
Trichomonas vaginalis MYB72, putative 0.002 0.0071 0.0336
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0102 0.0206
Leishmania major heat shock protein 83-1 0.0032 0.0161 0.0769
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0051 0.03 0.0516
Loa Loa (eye worm) hypothetical protein 0.0024 0.0102 0.0461
Brugia malayi hypothetical protein 0.0016 0.0039 0.0173
Echinococcus multilocularis heat shock protein 0.0032 0.0161 0.0277
Echinococcus granulosus endoplasmin 0.0026 0.0113 0.0229
Loa Loa (eye worm) DR-78 0.0024 0.0102 0.0461
Leishmania major heat shock protein 83-1 0.0032 0.0161 0.0769
Brugia malayi Calcium binding EGF domain containing protein 0.0026 0.0113 0.0508
Loa Loa (eye worm) hypothetical protein 0.0079 0.0505 0.228
Loa Loa (eye worm) nuclear receptor NHR-67 0.0024 0.0102 0.0461
Mycobacterium ulcerans polyketide synthase 0.0026 0.0116 0.0116
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0159 0.0717
Mycobacterium ulcerans Type I modular polyketide synthase 0.0024 0.0104 0.0104
Schistosoma mansoni hypothetical protein 0.0032 0.0159 0.0322
Echinococcus multilocularis protein jagged 1 0.0026 0.0113 0.0194
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0024 0.0102 0.0176
Brugia malayi SWIB/MDM2 domain containing protein 0.0011 0.0003 0.0013
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0065 0.0311
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0065 0.0311
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0015 0.0037 0.0052
Echinococcus granulosus cyclin B3 1 0.0064 0.0395 0.08
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0059 0.0357 0.1612
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0024 0.0104 0.0145
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0159 0.2276
Echinococcus multilocularis cyclins 0.0064 0.0395 0.0679
Schistosoma mansoni hypothetical protein 0.0023 0.0092 0.0186
Leishmania major heat shock protein, putative 0.0013 0.0022 0.0104
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0019 0.0067 0.0093
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.014 0.0284
Loa Loa (eye worm) hypothetical protein 0.0024 0.0102 0.0461
Onchocerca volvulus 0.0026 0.0113 0.0495
Schistosoma mansoni hypothetical protein 0.0032 0.0159 0.0322
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0023 0.0111
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0159 0.0719
Brugia malayi orphan nuclear receptor NR2E1 0.0024 0.0102 0.046
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1381 1 1
Onchocerca volvulus Cyclin L homolog 0.0016 0.0039 0.0161
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0153 0.0311
Loa Loa (eye worm) hypothetical protein 0.0122 0.0814 0.3679
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.2025 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0051 0.03 0.1354
Loa Loa (eye worm) fatty acid synthase 0.0027 0.0119 0.054
Giardia lamblia Kinase, CMGC GSK 0.0059 0.0357 0.1666
Loa Loa (eye worm) hypothetical protein 0.0026 0.0113 0.0508
Schistosoma mansoni endoplasmin 0.0032 0.0161 0.0326
Plasmodium falciparum thioredoxin reductase 0.0013 0.0023 0.0296
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.0116 0.0116
Echinococcus multilocularis nuclear receptor nhr 48 0.0024 0.0102 0.0176
Loa Loa (eye worm) blistered cuticle protein 3 0.0079 0.0505 0.228
Plasmodium vivax heat shock protein, putative 0.0013 0.0022 0.0276
Echinococcus granulosus thyroid hormone receptor alpha 0.0024 0.0102 0.0207
Brugia malayi hypothetical protein 0.0033 0.0165 0.0745
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0065 0.0217
Brugia malayi Steroid receptor seven-up type 2 0.0051 0.03 0.1354
Echinococcus granulosus protein jagged 2 0.0026 0.0113 0.0228
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0023 0.0111
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0071 0.0336
Loa Loa (eye worm) pax transcription factor protein 2 0.0249 0.1743 0.7874
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0153 0.031
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0102 0.046
Trichomonas vaginalis cyclin B, putative 0.0124 0.0832 0.41
Schistosoma mansoni notch 0.0026 0.0113 0.0228
Loa Loa (eye worm) hypothetical protein 0.0024 0.0102 0.0461
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0023 0.0111
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0013 0.0023 0.0023
Trypanosoma brucei cdc2-related kinase 1 0.0105 0.069 0.3292
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0102 0.0207
Brugia malayi hypothetical protein 0.0148 0.1005 0.4539
Loa Loa (eye worm) hypothetical protein 0.0026 0.0113 0.0508
Schistosoma mansoni hypothetical protein 0.0026 0.0113 0.0228
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0161 0.0695
Echinococcus granulosus notch 0.0026 0.0113 0.0228
Brugia malayi Blistered cuticle protein 3 0.0079 0.0505 0.228
Giardia lamblia Cyclin A 0.0064 0.0395 0.1854
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0024 0.0102 0.0207
Loa Loa (eye worm) hypothetical protein 0.0051 0.0299 0.135
Schistosoma mansoni microtubule-associated protein tau 0.0686 0.4933 1
Brugia malayi Animal haem peroxidase family protein 0.0079 0.0505 0.228
Plasmodium vivax heat shock protein 86, putative 0.0032 0.0161 0.2303
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0013 0.0023 0.0111
Loa Loa (eye worm) endoplasmin 0.0032 0.0161 0.0728
Schistosoma mansoni notch 0.0026 0.0113 0.0228
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0051 0.03 0.1355
Echinococcus multilocularis protein jagged 1 0.0026 0.0113 0.0194
Echinococcus multilocularis expressed conserved protein 0.0092 0.0596 0.1027
Trypanosoma brucei heat shock protein, putative 0.0032 0.0161 0.0769
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0092 0.0158
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0153 0.0264
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0297 0.4276
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0051 0.03 0.1354
Brugia malayi hypothetical protein 0.0024 0.0102 0.046
Trichomonas vaginalis CMGC family protein kinase 0.0059 0.0357 0.175
Brugia malayi Pax transcription factor protein 2 0.0249 0.1743 0.7874
Mycobacterium ulcerans polyketide synthase 0.0024 0.0104 0.0104
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0059 0.0357 0.1703
Toxoplasma gondii cyclin domain protein, cyclin H family protein 0.0016 0.0039 0.0139
Brugia malayi Cytochrome P450 family protein 0.0019 0.0062 0.0279
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0022 0.0104
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0017 0.0053 0.0191
Echinococcus multilocularis X box binding protein 1 0.0287 0.2016 0.347
Loa Loa (eye worm) hypothetical protein 0.0026 0.0113 0.0508
Leishmania major heat shock protein 83-1 0.0032 0.0161 0.0769
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0051 0.03 0.1354
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0065 0.0065
Loa Loa (eye worm) MH2 domain-containing protein 0.0241 0.1686 0.7615
Brugia malayi Calcium binding EGF domain containing protein 0.0026 0.0113 0.0508
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.2025 1
Plasmodium falciparum thioredoxin reductase 0.0039 0.0208 0.2987
Trypanosoma cruzi cyclin, putative 0.0124 0.0832 0.3971
Loa Loa (eye worm) hypothetical protein 0.0051 0.03 0.1355
Trichomonas vaginalis cyclins, putative 0.0016 0.0039 0.0176
Loa Loa (eye worm) hypothetical protein 0.0079 0.0505 0.228
Brugia malayi Cyclin, N-terminal domain containing protein 0.0016 0.0039 0.0173
Schistosoma mansoni hypothetical protein 0.0041 0.0221 0.0447
Trichomonas vaginalis CMGC family protein kinase 0.0105 0.069 0.3396
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0102 0.0176
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0051 0.03 0.1354
Brugia malayi ecdysteroid receptor 0.0051 0.03 0.1354
Onchocerca volvulus 0.0079 0.0505 0.227
Echinococcus granulosus tumor protein p63 0.035 0.2477 0.5022
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0161 0.0782
Echinococcus granulosus cyclin A3 4 0.0016 0.0039 0.0078
Schistosoma mansoni hypothetical protein 0.0026 0.0113 0.0228
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0123 0.0556
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0051 0.03 0.0608
Leishmania major heat shock protein 83-1 0.0032 0.0161 0.0769
Echinococcus granulosus neurogenic locus protein delta 0.0026 0.0113 0.0228
Trichomonas vaginalis cyclin B, putative 0.0064 0.0395 0.1936
Echinococcus granulosus expressed conserved protein 0.0092 0.0596 0.1209
Loa Loa (eye worm) hypothetical protein 0.0027 0.0123 0.0557
Brugia malayi conserved hypotetical protein 0.0024 0.0102 0.046
Brugia malayi MH1 domain containing protein 0.0016 0.0045 0.0204
Schistosoma mansoni hypothetical protein 0.0026 0.0113 0.0228
Brugia malayi Peroxidasin 0.0079 0.0505 0.228
Brugia malayi EGF-like domain containing protein 0.0026 0.0113 0.0508
Echinococcus granulosus cyclin G2 0.0016 0.0039 0.0078
Trypanosoma cruzi mitotic cyclin, putative 0.0016 0.0039 0.0183
Echinococcus multilocularis geminin 0.0345 0.2441 0.4202
Echinococcus multilocularis protein jagged 2 0.0026 0.0113 0.0194
Trichomonas vaginalis heat shock protein, putative 0.002 0.007 0.0331
Loa Loa (eye worm) hypothetical protein 0.0027 0.0123 0.0557
Schistosoma mansoni laminin gamma-3 chain 0.0026 0.0113 0.0228
Loa Loa (eye worm) hypothetical protein 0.0148 0.1005 0.4539
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.064 0.1297
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0297 0.4276
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.064 0.3084
Brugia malayi Cytochrome P450 family protein 0.0019 0.0062 0.0279
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0395 0.1936
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.023 0.1099
Onchocerca volvulus Huntingtin homolog 0.0122 0.0814 0.367
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0159 0.072
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0027 0.0123 0.0212
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.0016 0.0039 0.0078
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0105 0.069 0.3292
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0098 0.0642 0.0897
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.2025 1
Onchocerca volvulus 0.0079 0.0505 0.227
Schistosoma mansoni Smad4 0.0016 0.0045 0.0091
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0026 0.0113 0.0508
Loa Loa (eye worm) hypothetical protein 0.0024 0.0102 0.0461
Onchocerca volvulus 0.0026 0.0113 0.0495
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0232 0.0399
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0105 0.069 0.3116
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0023 0.0111
Trichomonas vaginalis CMGC family protein kinase 0.0105 0.069 0.3396
Echinococcus multilocularis SWI:SNF matrix associated 0.0011 0.0003 0.0005
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.034 0.123
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0051 0.03 0.1355
Brugia malayi nuclear hormone receptor family member nhr-6 0.0024 0.0102 0.046
Onchocerca volvulus 0.0051 0.03 0.1343
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0051 0.03 0.1354
Trichomonas vaginalis cyclin B, putative 0.0124 0.0832 0.41
Trypanosoma cruzi trypanothione reductase, putative 0.0013 0.0023 0.0111
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0153 0.0264
Brugia malayi heat shock protein 90 0.0032 0.0161 0.0727
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.2095 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.1068 0.1492
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0098 0.0642 0.0897
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0116 0.0162
Trichomonas vaginalis cyclin B, putative 0.0016 0.0039 0.0176
Loa Loa (eye worm) hypothetical protein 0.0016 0.0039 0.0174
Schistosoma mansoni smad1 5 8 and 0.0016 0.0045 0.0091
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0389 0.2766 0.2765
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0088 0.057 0.0797
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.023 0.1099
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0088 0.057 0.0797
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0051 0.03 0.1355
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.043 0.1942
Brugia malayi Muscle positioning protein 4 0.0026 0.0113 0.0508
Trypanosoma cruzi cdc2-related kinase 1 0.0105 0.069 0.3292
Echinococcus multilocularis ecdysone induced protein 78C 0.0051 0.03 0.0516
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0016 0.0039 0.0066
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0141 0.0951 0.1328
Loa Loa (eye worm) hypothetical protein 0.0051 0.03 0.1355
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0159 0.076
Echinococcus multilocularis cyclins 0.0064 0.0395 0.0679
Trichomonas vaginalis cyclin D, putative 0.0064 0.0395 0.1936
Echinococcus multilocularis Cyclin L1 0.0016 0.0039 0.0066
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0664 0.2997
Loa Loa (eye worm) hypothetical protein 0.0031 0.0153 0.0692
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0051 0.03 0.1354
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0071 0.0336
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0026 0.0116 0.0162
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0159 0.0222
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0065 0.0311
Schistosoma mansoni cell polarity protein 0.0026 0.0113 0.0228
Loa Loa (eye worm) cyclin domain-containing protein 0.0016 0.0039 0.0174
Brugia malayi EGF-like domain containing protein 0.0026 0.0113 0.0508
Schistosoma mansoni smad1 5 8 and 0.0016 0.0045 0.0091
Trichomonas vaginalis heat shock protein, putative 0.0013 0.0022 0.0094
Schistosoma mansoni DNA polymerase eta 0.0019 0.0065 0.0132
Echinococcus granulosus cyclins 0.0064 0.0395 0.08
Trypanosoma brucei unspecified product 0.0013 0.0022 0.0104
Loa Loa (eye worm) hypothetical protein 0.0103 0.0678 0.3061
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0023 0.0101
Echinococcus multilocularis fat cadherin tumor suppressor 0.0026 0.0113 0.0194
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0026 0.0113 0.009
Echinococcus multilocularis fibropellin Ia 0.0026 0.0113 0.0194
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0952 0.4545
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0013 0.0023 0.002
Onchocerca volvulus Fatty acid synthase homolog 0.0049 0.028 0.1253
Echinococcus multilocularis G1:S specific cyclin D1 0.0016 0.0039 0.0066
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.2025 1
Plasmodium falciparum heat shock protein 90 0.0032 0.0161 0.2303
Brugia malayi Nuclear hormone receptor-like 1 0.0051 0.03 0.1354
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0051 0.03 0.1354
Echinococcus granulosus slit 2 protein 0.0026 0.0113 0.0228
Trypanosoma cruzi cdc2-related kinase 3 0.0105 0.069 0.3292
Echinococcus multilocularis cyclin y 0.0016 0.0039 0.0066
Brugia malayi cell division control protein 2 homolog 0.0105 0.069 0.3115
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0389 0.2766 0.3862
Schistosoma mansoni nuclear receptor 0.0024 0.0102 0.0206
Loa Loa (eye worm) animal heme peroxidase 0.0079 0.0505 0.228
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.002 0.0072 0.0258
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0023 0.0084
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0159 0.0274
Brugia malayi nuclear hormone receptor family member odr-7 0.0024 0.0102 0.046
Echinococcus multilocularis SWI:SNF matrix associated 0.0011 0.0003 0.0005
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0299 0.0606
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0013 0.0022 0.0045
Brugia malayi Animal haem peroxidase family protein 0.0079 0.0505 0.228
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0088 0.057 0.0797
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0051 0.03 0.0516
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0024 0.0104 0.0468
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0159 0.0322
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0391 0.1764
Schistosoma mansoni notch 0.0026 0.0113 0.0228
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0065 0.0311
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0065 0.0311
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0013 0.0022 0.0038
Echinococcus granulosus cyclin b3 0.0064 0.0395 0.08
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0039 0.0176
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0391 0.1765
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.064 0.2889
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0051 0.03 0.1355
Echinococcus multilocularis cyclin 0.0016 0.0039 0.0066
Mycobacterium ulcerans polyketide synthase Pks9 0.0015 0.0037 0.0037
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0023 0.0111
Leishmania major heat shock protein 83-1 0.0032 0.0161 0.0769
Loa Loa (eye worm) hypothetical protein 0.0024 0.0102 0.0461
Echinococcus granulosus dna polymerase eta 0.0019 0.0065 0.0133
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0016 0.0039 0.0078
Plasmodium vivax hypothetical protein, conserved 0.0016 0.0039 0.0518
Echinococcus granulosus GPCR family 2 0.0032 0.0159 0.0322
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0065 0.0311
Brugia malayi nuclear receptor NHR-88 0.0024 0.0102 0.046
Schistosoma mansoni cpg binding protein 0.0031 0.0152 0.0308
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0065 0.0311
Plasmodium vivax glutathione reductase, putative 0.0039 0.0208 0.2987
Brugia malayi hypothetical protein 0.0051 0.0297 0.134
Entamoeba histolytica cyclin, putative 0.0124 0.0832 0.4044
Loa Loa (eye worm) hypothetical protein 0.0314 0.2214 1
Echinococcus multilocularis cyclin G2 0.0016 0.0039 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0051 0.03 0.1354
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0065 0.0091
Schistosoma mansoni hypothetical protein 0.0011 0.0003 0.0006
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0059 0.0357 0.0614
Onchocerca volvulus 0.0051 0.0299 0.1338
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0016 0.0039 0.0078
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0045 0.0205
Brugia malayi steroid hormone receptor 0.0051 0.03 0.1354
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0039 0.0183
Loa Loa (eye worm) cyclin domain-containing protein 0.0016 0.0039 0.0174
Loa Loa (eye worm) hypothetical protein 0.0026 0.0113 0.0508
Toxoplasma gondii cyclin 4, putative 0.0016 0.0039 0.0139
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0072 0.0339
Trypanosoma brucei heat shock protein, putative 0.0032 0.0161 0.0769
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0071 0.0336
Loa Loa (eye worm) hypothetical protein 0.0027 0.0123 0.0557
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0113 0.0545
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0062 0.028
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0161 0.0769
Brugia malayi Cyclin, N-terminal domain containing protein 0.0124 0.0832 0.3758
Onchocerca volvulus Bile acid receptor homolog 0.0051 0.03 0.1343
Echinococcus multilocularis neurogenic locus protein delta 0.0026 0.0113 0.0194
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0024 0.0104 0.0145
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0059 0.0357 0.129
Schistosoma mansoni septate junction protein 0.0026 0.0113 0.0228
Loa Loa (eye worm) Smad1 0.0016 0.0045 0.0205
Giardia lamblia Cyclin B-like protein 0.0016 0.0039 0.0076
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0013 0.0023 0.0111
Plasmodium falciparum heat shock protein 90, putative 0.0013 0.0022 0.0276
Brugia malayi hypothetical protein 0.0122 0.0814 0.3678
Plasmodium vivax thioredoxin reductase, putative 0.0039 0.0208 0.2987
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0098 0.0642 0.0897
Echinococcus multilocularis dna polymerase eta 0.0019 0.0065 0.0113
Giardia lamblia Myb 1-like protein 0.002 0.0072 0.0241
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0065 0.0311
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0195 0.0335
Trypanosoma brucei cyclin 9 0.0016 0.0039 0.0183
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0051 0.03 0.0608
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0051 0.03 0.1355
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0159 0.2276
Echinococcus granulosus cyclin k 0.0016 0.0039 0.0078
Schistosoma mansoni nuclear receptor nhr-48 0.0024 0.0102 0.0206
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.002 0.0071 0.0244
Toxoplasma gondii heat shock protein HSP90 0.0032 0.0161 0.0582
Schistosoma mansoni cyclin k 0.0016 0.0039 0.0078
Echinococcus granulosus cyclin 0.0016 0.0039 0.0078
Schistosoma mansoni hypothetical protein 0.0032 0.0159 0.0322
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.0991 0.716 1
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0105 0.069 0.3292
Leishmania major heat shock protein 83-1 0.0032 0.0161 0.0769
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0026 0.0116 0.0162
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.002 0.0071 0.0244
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0024 0.0104 0.0145
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0297 0.1415
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0232 0.1048
Trypanosoma brucei cyclin 3 0.0016 0.0039 0.0183
Trypanosoma brucei cyclin dependent kinase-binding protein, putative 0.0016 0.0039 0.0183
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0116 0.0116
Brugia malayi photoreceptor-specific nuclear receptor 0.0051 0.03 0.1354
Schistosoma mansoni notch 0.0026 0.0113 0.0228
Loa Loa (eye worm) hypothetical protein 0.0026 0.0113 0.0508
Echinococcus multilocularis cyclin A3 4 0.0016 0.0039 0.0066
Echinococcus multilocularis cyclin B 0.0124 0.0832 0.1432
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0153 0.031
Schistosoma mansoni thyroid hormone receptor 0.0051 0.03 0.0608
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0309 0.218 0.3753
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.0952 0.4545
Trichomonas vaginalis cyclin B, putative 0.0016 0.0039 0.0176
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0159 0.0575
Brugia malayi Protein kinase domain containing protein 0.0105 0.069 0.3115
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0102 0.0206
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0391 0.0792
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0045 0.0078
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0022 0.0104
Echinococcus multilocularis endoplasmin 0.0026 0.0113 0.0195
Leishmania major heat shock protein 83-1 0.0032 0.0161 0.0769
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0024 0.0102 0.0448
Giardia lamblia Cyclin fold protein 1, putative 0.0016 0.0039 0.0076
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0024 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0013 0.0017 0.0078
Echinococcus multilocularis protein patched 0.0042 0.0232 0.0399
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.002 0.0071 0.0336
Trichomonas vaginalis CMGC family protein kinase 0.0105 0.069 0.3396
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0026 0.0116 0.0162
Brugia malayi MH1 domain containing protein 0.0016 0.0045 0.0204
Loa Loa (eye worm) hypothetical protein 0.0079 0.0505 0.228
Brugia malayi EGF-like domain containing protein 0.0026 0.0113 0.0508
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0065 0.0311
Loa Loa (eye worm) hypothetical protein 0.0079 0.0505 0.228
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0023 0.0111
Brugia malayi Cyclin, N-terminal domain containing protein 0.0016 0.0039 0.0173
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0023 0.0111
Schistosoma mansoni hypothetical protein 0.0287 0.2016 0.4087
Brugia malayi Calcium binding EGF domain containing protein 0.0026 0.0113 0.0508
Trypanosoma cruzi cyclin, putative 0.0124 0.0832 0.3971
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0065 0.0311
Giardia lamblia Heat shock protein HSP 90-alpha 0.0026 0.0113 0.0449
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0391 0.1864
Giardia lamblia DINP protein human, muc B family 0.0019 0.0065 0.021
Loa Loa (eye worm) glutathione reductase 0.0039 0.0208 0.094
Schistosoma mansoni cyclin G 0.0016 0.0039 0.0078
Entamoeba histolytica hypothetical protein 0.0016 0.0039 0.0083
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0113 0.0545
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0065 0.0311
Mycobacterium tuberculosis Probable dehydrogenase 0.0088 0.057 0.0797
Leishmania major mitotic cyclin, putative 0.0016 0.0039 0.0183
Echinococcus multilocularis cyclin t1 0.0016 0.0039 0.0066
Trichomonas vaginalis cyclins, putative 0.0075 0.0476 0.2339
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0065 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0039 0.0176
Trypanosoma brucei Heat shock protein 83, putative 0.0032 0.0161 0.0769
Schistosoma mansoni thyroid hormone receptor 0.0051 0.03 0.0608
Echinococcus multilocularis cyclin b3 0.0064 0.0395 0.0679
Trypanosoma brucei unspecified product 0.0019 0.0065 0.0311
Loa Loa (eye worm) heat shock protein 75 0.0013 0.0022 0.0099
Giardia lamblia Hypothetical protein 0.0064 0.0395 0.1854
Onchocerca volvulus Peroxidasin homolog 0.0079 0.0505 0.227
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0011 0.0003 0.0005
Schistosoma mansoni cpg binding protein 0.0031 0.0152 0.0308
Loa Loa (eye worm) hypothetical protein 0.0027 0.0123 0.0557
Trypanosoma brucei heat shock protein 84, putative 0.0013 0.0022 0.0104
Plasmodium falciparum endoplasmin, putative 0.002 0.007 0.0976
Schistosoma mansoni zinc finger protein 0.0024 0.0102 0.0206
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.0212 0.043
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0039 0.0176
Mycobacterium ulcerans thioesterase 0.0022 0.0089 0.0089
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0124 0.0832 0.3971
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0013 0.0023 0.0111
Echinococcus granulosus SWI:SNF matrix associated 0.0011 0.0003 0.0006
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0059 0.0357 0.0724
Onchocerca volvulus Putative cubilin 0.0026 0.0113 0.0495
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0153 0.031
Echinococcus granulosus neurogenic locus notch protein 0.0026 0.0113 0.0228
Loa Loa (eye worm) acyl carrier protein 0.0012 0.0016 0.0072
Echinococcus multilocularis cyclins 0.0064 0.0395 0.0679
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0023 0.0111
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0065 0.0133
Loa Loa (eye worm) hypothetical protein 0.0079 0.0505 0.228
Echinococcus granulosus heat shock protein 0.0032 0.0161 0.0327
Trypanosoma cruzi cdc2-related kinase 3 0.0105 0.069 0.3292
Plasmodium falciparum protein kinase 5 0.0105 0.069 1
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0011 0.0003 0.0014
Schistosoma mansoni peroxidasin 0.0079 0.0505 0.1023
Schistosoma mansoni nuclear receptor 0.0024 0.0102 0.0206
Brugia malayi Thioredoxin reductase 0.0039 0.0208 0.094
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0062 0.0295
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0389 0.2766 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0113 0.0508
Echinococcus multilocularis heat shock protein 90 0.0032 0.0161 0.0277
Schistosoma mansoni hypothetical protein 0.0041 0.0221 0.0447
Brugia malayi isocitrate dehydrogenase 0.0032 0.0159 0.0719
Brugia malayi EGF-like domain containing protein 0.0026 0.0113 0.0508
Mycobacterium ulcerans thioesterase TesA 0.0022 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0026 0.0113 0.0508
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0024 0.0104 0.0145
Toxoplasma gondii cyclin dependent kinase binding protein 0.0016 0.0039 0.0139
Brugia malayi ecdysone receptor 0.0024 0.0102 0.046
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0026 0.0116 0.0162
Schistosoma mansoni hypothetical protein 0.0026 0.0113 0.0228
Loa Loa (eye worm) hypothetical protein 0.0026 0.0113 0.0508
Echinococcus multilocularis cyclin dependent kinase 1 0.0105 0.069 0.1187
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.002 0.0071 0.0244
Trypanosoma cruzi cdc2-related kinase 1 0.0105 0.069 0.3292
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0161 0.0769
Schistosoma mansoni hypothetical protein 0.0026 0.0113 0.0228
Giardia lamblia Kinase, CMGC GSK 0.0059 0.0357 0.1666
Brugia malayi cyclin fold protein 1 variant b 0.0016 0.0039 0.0173
Brugia malayi CHE-14 protein 0.0042 0.0232 0.1047
Giardia lamblia Hypothetical protein 0.0016 0.0039 0.0076
Echinococcus multilocularis neurogenic locus notch protein 0.0026 0.0113 0.0194
Toxoplasma gondii EGF family domain-containing protein 0.0026 0.0113 0.0406
Plasmodium vivax glycogen synthase kinase 3, putative 0.0059 0.0357 0.5153
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0159 0.0274
Loa Loa (eye worm) heat shock protein 90 0.0032 0.0161 0.0728
Echinococcus granulosus delta-like protein 1 0.0026 0.0113 0.0228
Trichomonas vaginalis cyclin D, putative 0.0016 0.0039 0.0176
Brugia malayi hypothetical protein 0.0027 0.0123 0.0556
Giardia lamblia High cysteine protein 0.0026 0.0113 0.0446
Plasmodium falciparum cyclin 0.0064 0.0395 0.57
Loa Loa (eye worm) Notch2 0.0026 0.0113 0.0508
Brugia malayi notch-like transmembrane receptor 0.0026 0.0113 0.0508
Trichomonas vaginalis cyclins, putative 0.0124 0.0832 0.41
Brugia malayi hypothetical protein 0.0024 0.0102 0.046
Echinococcus granulosus neural cadherin 0.0026 0.0113 0.0228
Echinococcus granulosus microtubule associated protein 2 0.0686 0.4933 1
Plasmodium vivax endoplasmin, putative 0.0032 0.0161 0.2303
Loa Loa (eye worm) hypothetical protein 0.0124 0.0832 0.3759
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0051 0.03 0.1354
Trichomonas vaginalis cyclin B3, putative 0.0016 0.0039 0.0176
Schistosoma mansoni RAR-like nuclear receptor 0.0051 0.03 0.0608
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0297 0.2095 1
Brugia malayi glutathione reductase 0.0039 0.0208 0.094
Onchocerca volvulus Dual oxidase homolog 0.0079 0.0505 0.227
Echinococcus multilocularis cyclin k 0.0016 0.0039 0.0066
Schistosoma mansoni cyclin G2 0.0016 0.0039 0.0078
Echinococcus granulosus cyclin t1 0.0016 0.0039 0.0078
Trichomonas vaginalis cyclin D, putative 0.0064 0.0395 0.1936
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0022 0.0104
Toxoplasma gondii type I fatty acid synthase, putative 0.0026 0.0116 0.0419
Loa Loa (eye worm) hypothetical protein 0.0124 0.0832 0.3759
Loa Loa (eye worm) hypothetical protein 0.0016 0.0039 0.0174
Treponema pallidum fructose-bisphosphate aldolase 0.0288 0.2025 0.2007
Trichomonas vaginalis MYB3r3, putative 0.002 0.0071 0.0336
Schistosoma mansoni cyclin B3 0.0199 0.1375 0.2787
Trypanosoma cruzi cyclin 9, putative 0.0016 0.0039 0.0183
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0026 0.0113 0.0228
Loa Loa (eye worm) hypothetical protein 0.0032 0.0159 0.0718
Trichomonas vaginalis cyclins, putative 0.0064 0.0395 0.1936

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 5.097 Inhibitory activity against cyclin-dependent kinase 5/p25 ChEMBL. 14695817
IC50 (binding) = 5.638 Inhibitory activity against cyclin dependent kinase 1-cyclinB extracted from M phase starfish (Marthasterias glacialis) oocytes ChEMBL. 14695817
IC50 (binding) = 5.699 Inhibitory activity against glycogen synthase kinase-3 beta purified from insect sf9 cells ChEMBL. 14695817
IC50 (binding) = 2.3 uM In vitro inhibitory activity against cyclin-dependent kinase 1-cyclin B (Cyclin-Dependent Kinase) harvested from starfish oocytes. ChEMBL. 10425100
IC50 (binding) = 2.3 uM In vitro inhibitory activity against cyclin-dependent kinase 1-cyclin B (Cyclin-Dependent Kinase) harvested from starfish oocytes. ChEMBL. 10425100
ID50 (binding) = 2.3 uM Inhibition of Cyclin-dependent kinase 1-cyclin B ChEMBL. 10633033
ID50 (binding) = 2.3 uM Inhibition of Cyclin-dependent kinase 1-cyclin B ChEMBL. 10633033
Log GI50 (functional) 0 The logarithmic molar concentration of the compound inhibiting 50% net cell growth was measured on HCT-116(M)colon cancer cell lines; not available ChEMBL. 10425100
Log GI50 (functional) 0 Antitumor activity of the compound was reported for each out of 60 human tumor cell line; result omitted because of irregular shape of the dose-response curve. ChEMBL. 10425100
Log IC50 (binding) = 5.097 Inhibitory activity against cyclin-dependent kinase 5/p25 ChEMBL. 14695817
Log IC50 (binding) = 5.638 Inhibitory activity against cyclin dependent kinase 1-cyclinB extracted from M phase starfish (Marthasterias glacialis) oocytes ChEMBL. 14695817
Log IC50 (binding) = 5.699 Inhibitory activity against glycogen synthase kinase-3 beta purified from insect sf9 cells ChEMBL. 14695817

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.