Detailed information for compound 74274

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 286.365 | Formula: C18H22O3
  • H donors: 0 H acceptors: 2 LogP: 4.55 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC(=O)c1ccc2c(c1CCC(C)C)oc(=O)cc2
  • InChi: 1S/C18H22O3/c1-4-5-16(19)14-10-7-13-8-11-17(20)21-18(13)15(14)9-6-12(2)3/h7-8,10-12H,4-6,9H2,1-3H3
  • InChiKey: GBYXDAUYOWDVLJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis ets variant gene 4 0.0013 0.0075 0.0028
Echinococcus granulosus replication factor c subunit 1 0.001 0.0047 0.000001725
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0017 0.012 0.0111
Echinococcus multilocularis netrin receptor unc 5 0.0017 0.0123 0.0076
Trypanosoma cruzi O-6 methyl-guanine alkyl transferase, putative 0.0211 0.2137 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0315 0.0269
Brugia malayi Pre-SET motif family protein 0.0036 0.0315 0.0966
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0315 0.1178
Mycobacterium ulcerans hydrolase 0.001 0.0051 0.0006
Schistosoma mansoni gabp alpha 0.0087 0.0842 0.3154
Loa Loa (eye worm) hypothetical protein 0.0058 0.0549 0.131
Brugia malayi Cytochrome P450 family protein 0.004 0.0356 0.1117
Loa Loa (eye worm) CYP4Cod1 0.0027 0.0229 0.0474
Entamoeba histolytica hypothetical protein 0.0107 0.1051 1
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0051 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0051 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0051 0.0013
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0051 0.0013
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0017 0.0123 0.0197
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0017 0.012 0.0111
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0011 0.0054 0.0032
Echinococcus granulosus lamin 0.0059 0.056 0.2568
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0249 0.2525 0.6468
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0315 0.1178
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0017 0.012 0.0111
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0017 0.012 0.0111
Echinococcus granulosus intermediate filament protein 0.0059 0.056 0.2568
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0107 0.1051 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0054 0.1703
Schistosoma mansoni cytochrome P450 0.0017 0.012 0.0449
Mycobacterium ulcerans methylated-DNA--protein-cysteine methyltransferase Ogt 0.0642 0.6608 1
Trichomonas vaginalis mucin-desulfating sulfatase, putative 0.001 0.0051 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0051 0.0013
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0011 0.0054 0.0017
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0017 0.012 0.0105
Schistosoma mansoni lamin 0.0059 0.056 0.2098
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0011 0.0054 0.0006
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0017 0.012 0.0105
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0054 0.0023
Echinococcus multilocularis ETS transcription factor Elf 2 0.0013 0.0075 0.0028
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0029 0.0242 0.0195
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0017 0.012 0.0105
Loa Loa (eye worm) hypothetical protein 0.0106 0.1045 0.2606
Giardia lamblia Hypothetical protein 0.001 0.0051 0.5673
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0051 0.0013
Echinococcus multilocularis geminin 0.0203 0.2046 0.2008
Echinococcus granulosus ETS transcription factor Elf 2 0.0013 0.0075 0.0137
Echinococcus multilocularis protein C ets 2 0.0013 0.0075 0.0028
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0017 0.012 0.0105
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.0123 0.2847
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0051 0.0013
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0011 0.0054 0.0006
Echinococcus granulosus death domain containing protein 0.0017 0.0123 0.0378
Loa Loa (eye worm) hypothetical protein 0.0013 0.0075 0.0072
Echinococcus multilocularis lamin 0.0059 0.056 0.0516
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0107 0.1051 0.262
Mycobacterium ulcerans arylsulfatase AtsD 0.001 0.0051 0.0006
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0017 0.012 0.0105
Mycobacterium leprae Conserved hypothetical protein 0.0017 0.012 0.0111
Brugia malayi Ets-domain containing protein 0.0087 0.0842 0.2872
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0153 0.0574
Echinococcus granulosus ETS transcription factor Elf 2 0.0013 0.0075 0.0137
Entamoeba histolytica hypothetical protein 0.001 0.0047 0.0448
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0017 0.0123 0.0076
Loa Loa (eye worm) hypothetical protein 0.0029 0.0242 0.0508
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0013 0.0075 0.0072
Onchocerca volvulus 0.0059 0.056 0.1809
Loa Loa (eye worm) hypothetical protein 0.001 0.0053 0.0015
Schistosoma mansoni ankyrin 23/unc44 0.0017 0.0123 0.0459
Schistosoma mansoni topbp1 0.001 0.0047 0.0176
Schistosoma mansoni hypothetical protein 0.0017 0.0123 0.0459
Echinococcus granulosus geminin 0.0203 0.2046 1
Brugia malayi Bloom's syndrome protein homolog 0.0026 0.0209 0.0584
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0017 0.012 0.0105
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0277 0.2816 0.7228
Entamoeba histolytica recQ family helicase, putative 0.0014 0.0086 0.0815
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0315 0.1178
Schistosoma mansoni hypothetical protein 0.0203 0.2046 0.766
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0017 0.012 0.0111
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0107 0.1051 0.4805
Plasmodium vivax SET domain protein, putative 0.0036 0.0315 1
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0017 0.0123 0.0378
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0315 1
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0011 0.0054 0.0032
Echinococcus multilocularis musashi 0.0059 0.056 0.0516
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0047 0.00000034637
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0017 0.012 0.0111
Trichomonas vaginalis DNA helicase recq, putative 0.0026 0.0209 0.0571
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0051 0.0013
Echinococcus multilocularis GA binding protein alpha chain 0.0087 0.0842 0.0799
Schistosoma mansoni DNA ligase IV 0.001 0.0047 0.0176
Schistosoma mansoni lamin 0.0059 0.056 0.2098
Loa Loa (eye worm) hypothetical protein 0.0036 0.0315 0.0698
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0017 0.012 0.0348
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0047 0.0000012162
Entamoeba histolytica protein kinase domain containing protein 0.0107 0.1051 1
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0051 0.0013
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0027 0.0229 0.0277
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0017 0.012 0.0111
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0011 0.0054 0.0497
Echinococcus multilocularis lamin dm0 0.0059 0.056 0.0516
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0229 0.0868
Schistosoma mansoni netrin receptor unc5 0.0017 0.0123 0.0459
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0051 0.0013
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0017 0.012 0.0105
Echinococcus granulosus bloom syndrome protein 0.0026 0.0209 0.081
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0047 0.1498
Schistosoma mansoni hypothetical protein 0.0013 0.0075 0.0279
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0051 0.0013
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0017 0.012 0.0348
Loa Loa (eye worm) hypothetical protein 0.0074 0.0712 0.1736
Loa Loa (eye worm) hypothetical protein 0.0017 0.0124 0.0201
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0051 0.0013
Leishmania major hypothetical protein, conserved 0.0211 0.2137 1
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0051 0.0013
Brugia malayi Cytochrome P450 family protein 0.0017 0.012 0.0263
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0013 0.0075 0.0072
Brugia malayi Sulfatase family protein 0.001 0.0051 0.0013
Trichomonas vaginalis set domain proteins, putative 0.0283 0.2882 1
Brugia malayi Death domain containing protein 0.0017 0.0123 0.0273
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0051 0.0013
Mycobacterium ulcerans arylsulfatase, AslA 0.001 0.0051 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0051 0.0013
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.001 0.0051 0.0013
Brugia malayi Ets-domain containing protein 0.0087 0.0842 0.2872
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0047 0.0176
Onchocerca volvulus Netrin receptor homolog 0.0017 0.0123 0.0266
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0229 0.0868
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0013 0.0075 0.0279
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0017 0.012 0.0105
Loa Loa (eye worm) hypothetical protein 0.0106 0.1045 0.2606
Loa Loa (eye worm) hypothetical protein 0.001 0.0051 0.001
Brugia malayi Intermediate filament tail domain containing protein 0.0059 0.056 0.1853
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0047 0.0448
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0017 0.0124 0.0465
Echinococcus granulosus netrin receptor unc 5 0.0017 0.0123 0.0378
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.0301 0.127
Trichomonas vaginalis Phosphoglycerol transferase I, putative 0.001 0.0051 0.0013
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.001 0.0047 0.1498
Echinococcus granulosus dual specificity 0.0107 0.1051 0.5023
Trypanosoma cruzi O-6 methyl-guanine alkyl transferase, putative 0.0211 0.2137 1
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0047 0.0000012162
Loa Loa (eye worm) hypothetical protein 0.0028 0.023 0.0478
Brugia malayi follicle stimulating hormone receptor 0.0277 0.2816 1
Loa Loa (eye worm) D-ets-2 protein 0.0013 0.0075 0.0072
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0107 0.1051 0.4805
Loa Loa (eye worm) RecQ helicase 0.0026 0.0209 0.0422
Brugia malayi intermediate filament protein 0.0059 0.056 0.1853
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0051 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0051 0.0013
Mycobacterium leprae putative cytochrome p450 0.0017 0.012 0.0111
Brugia malayi Immunoglobulin I-set domain containing protein 0.0017 0.0123 0.0273
Loa Loa (eye worm) hypothetical protein 0.0059 0.056 0.1339
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0017 0.012 0.0105
Brugia malayi Protein kinase domain containing protein 0.0018 0.0128 0.0293
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0017 0.012 0.0348
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0086 0.0185
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0017 0.012 0.0105
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0017 0.012 0.0111
Treponema pallidum methylated-DNA-protein-cysteine S-methyltransferase (dat) 0.0211 0.2137 1
Onchocerca volvulus 0.0036 0.0315 0.0943
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0086 0.0384
Schistosoma mansoni elf1 0.0013 0.0075 0.0279
Schistosoma mansoni hypothetical protein 0.0013 0.0075 0.0279
Echinococcus multilocularis ETS transcription factor Elf 5 0.0013 0.0075 0.0028
Brugia malayi hypothetical protein 0.001 0.0051 0.0013
Brugia malayi Fli-1 protein 0.0263 0.2671 0.9474
Echinococcus granulosus ETS domain containing protein Elk 1 0.0013 0.0075 0.0137
Echinococcus granulosus Ankyrin 0.0017 0.0124 0.0385
Loa Loa (eye worm) cytochrome P450 0.0017 0.012 0.019
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0017 0.012 0.0111
Onchocerca volvulus 0.0283 0.2883 1
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0051 0.0013
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0087 0.0842 0.2076
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0032 0.0274 0.0593
Schistosoma mansoni DNA helicase recq1 0.0011 0.0054 0.0201
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0054 0.1703
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0051 0.0013
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0017 0.012 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0051 0.0013
Brugia malayi cytochrome P450 0.0017 0.012 0.0263
Mycobacterium ulcerans arylsulfatase AtsD 0.001 0.0051 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0051 0.0013
Echinococcus granulosus protein C ets 2 0.0013 0.0075 0.0137
Brugia malayi Uncoordinated protein 44 0.0017 0.0123 0.0273
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0229 0.0474
Entamoeba histolytica protein kinase, putative 0.0107 0.1051 1
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0017 0.012 0.0111
Brugia malayi Cytochrome P450 family protein 0.0027 0.0229 0.0655
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0017 0.012 0.0105
Mycobacterium tuberculosis Methylated-DNA--protein-cysteine methyltransferase Ogt (6-O-methylguanine-DNA methyltransferase) (O-6-methylguanine-DNA-alkyltra 0.0642 0.6608 1
Brugia malayi Cytochrome P450 family protein 0.0027 0.0229 0.0655
Echinococcus multilocularis ETS transcription factor Elf 2 0.0013 0.0075 0.0028
Echinococcus multilocularis 0.0017 0.012 0.0073
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0017 0.012 0.0105
Loa Loa (eye worm) intermediate filament protein 0.0059 0.056 0.1339
Loa Loa (eye worm) hypothetical protein 0.0028 0.023 0.0478
Schistosoma mansoni topbp1 0.001 0.0047 0.0176
Trichomonas vaginalis methylated-DNA--protein-cysteine methyltransferase, putative 0.0211 0.2137 0.7371
Loa Loa (eye worm) fli-1 protein 0.0263 0.2671 0.6848
Loa Loa (eye worm) hypothetical protein 0.002 0.0155 0.0283
Schistosoma mansoni intermediate filament proteins 0.0059 0.056 0.2098
Echinococcus granulosus ETS transcription factor Elf 1 0.0013 0.0075 0.0137
Brugia malayi DNA-binding protein D-ETS-3 0.0013 0.0075 0.0099
Loa Loa (eye worm) hypothetical protein 0.0013 0.0075 0.0072
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0017 0.012 0.0167
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0107 0.1051 0.4707
Brugia malayi Pre-SET motif family protein 0.0249 0.2525 0.8948
Echinococcus granulosus ETS transcription factor Elf 5 0.0013 0.0075 0.0137
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0121 0.3851
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0051 0.0013
Schistosoma mansoni hypothetical protein 0.0203 0.2046 0.766
Leishmania major cytochrome p450-like protein 0.0027 0.0229 0.0696
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0177 1
Mycobacterium leprae PROBABLE METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE OGT (6-O-methylguanine-DNA methyltransferase) (O-6-methylguanine-DNA 0.0642 0.6608 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0229 0.0474
Brugia malayi Ets-domain containing protein 0.0013 0.0075 0.0099
Loa Loa (eye worm) hypothetical protein 0.0017 0.0123 0.0197
Toxoplasma gondii cytochrome p450 superfamily protein 0.0017 0.012 0.3811
Brugia malayi transcription factor E74 isoform 0.0013 0.0075 0.0099
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0054 0.0023
Trichomonas vaginalis DNA helicase recq, putative 0.0014 0.0086 0.0136
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0017 0.012 0.0105
Schistosoma mansoni DNA helicase recq5 0.0011 0.0054 0.0201
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0017 0.012 0.0111
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0017 0.012 0.0105
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0315 0.0269
Loa Loa (eye worm) hypothetical protein 0.0379 0.3878 1
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0017 0.012 0.0105
Entamoeba histolytica protein kinase, putative 0.0107 0.1051 1
Echinococcus granulosus lamin dm0 0.0059 0.056 0.2568
Leishmania major cytochrome p450-like protein 0.0017 0.012 0.0167
Schistosoma mansoni ets-related 0.0263 0.2671 1
Echinococcus multilocularis ewsr:fli fusion protein type 0.0013 0.0075 0.0028
Leishmania major cytochrome p450-like protein 0.0017 0.012 0.0167
Schistosoma mansoni serine/threonine protein kinase 0.0107 0.1051 0.3936
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0017 0.012 0.0105
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.0356 0.0808
Schistosoma mansoni hypothetical protein 0.0017 0.012 0.0449
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0051 0.0013
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0013 0.0075 0.0028
Trypanosoma brucei hypothetical protein, conserved 0.0086 0.0836 0.7856
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0017 0.012 0.0105
Trichomonas vaginalis DNA helicase recq1, putative 0.0026 0.0209 0.0571
Brugia malayi cytoplasmic intermediate filament protein 0.0032 0.0274 0.082
Mycobacterium ulcerans DNA-methyltransferase (modification methylase) 0.0086 0.0836 0.1202
Echinococcus granulosus nuclear factor of activated T cells 5 0.0088 0.0858 0.4055
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0017 0.012 0.0105
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0059 0.056 0.1339
Brugia malayi hypothetical protein 0.0146 0.1454 0.508
Schistosoma mansoni ets 0.0013 0.0075 0.0279
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0017 0.012 0.0105
Mycobacterium ulcerans arylsulfatase AtsB 0.001 0.0051 0.0006
Giardia lamblia Hypothetical protein 0.001 0.0051 0.5673
Loa Loa (eye worm) hypothetical protein 0.001 0.0051 0.001
Mycobacterium ulcerans sulfatase 0.001 0.0051 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0051 0.0013
Giardia lamblia Sgs1 DNA helicase, putative 0.0011 0.0054 1
Schistosoma mansoni ets-related 0.0013 0.0075 0.0279
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0029 0.0242 0.0973
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0017 0.012 0.0111
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0017 0.012 0.0111
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0017 0.012 0.0111
Echinococcus multilocularis ETS transcription factor Elf 1 0.0013 0.0075 0.0028
Loa Loa (eye worm) ets-domain-containing protein 0.0013 0.0075 0.0072
Trypanosoma brucei cytochrome P450, putative 0.0027 0.0229 0.1807
Echinococcus granulosus GA binding protein alpha chain 0.0087 0.0842 0.3979
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0047 0.0000012162
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0017 0.012 0.0725
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0017 0.012 0.0111
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0315 0.1178
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0017 0.012 0.0111
Chlamydia trachomatis methylated-DNA protein-cysteine methyltransferase 0.0211 0.2137 1
Echinococcus multilocularis bloom syndrome protein 0.0026 0.0209 0.0163
Echinococcus multilocularis Ankyrin 0.0017 0.0124 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0051 0.0013
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0017 0.012 0.0111
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0017 0.012 0.0111
Echinococcus granulosus ewsr:fli fusion protein type 0.0013 0.0075 0.0137
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0088 0.0858 0.0814
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0017 0.012 0.0105
Onchocerca volvulus 0.0059 0.056 0.1809
Echinococcus multilocularis dual specificity 0.0107 0.1051 0.1009
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0315 0.1338
Echinococcus granulosus cytochrome P450 2K1 0.0017 0.012 0.0364
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0017 0.012 0.0111
Brugia malayi Protein kinase domain containing protein 0.0107 0.1051 0.3625
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0051 0.0013
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.001 0.0047 0.5

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 58 uM Cytotoxicity against V-79 cells ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

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