Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0081 | 0.5 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0081 | 0.5 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0081 | 0.5 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0081 | 0.5 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0081 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.5 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0081 | 0.5 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0081 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Cell cycle arrest in human LNCaP cells assessed as induction of G1 block at 100 uM by FACS flow cytometry | ChEMBL. | 15566290 |
Activity (functional) | = 0 % | Antiproliferative activity against androgen-sensitive human LNCaP cells at 100 uM after 72 hrs by MTT test | ChEMBL. | 15566290 |
Activity (functional) | = 4 % | Cell cycle arrest in human LNCaP cells by accumulation at subG1 phase at 10 uM after 72 hrs by FACS flow cytometry | ChEMBL. | 15566290 |
Activity (functional) | = 11.4 % | Cell cycle arrest in human LNCaP cells by accumulation at S phase at 10 uM after 72 hrs by FACS flow cytometry | ChEMBL. | 15566290 |
Activity (functional) | = 15 % | Antiproliferative activity against androgen-independent human PC3 cells at 100 uM after 72 hrs by MTT test | ChEMBL. | 15566290 |
Activity (functional) | = 15.2 % | Cell cycle arrest in human LNCaP cells by accumulation at G2M phase at 10 uM after 72 hrs by FACS flow cytometry | ChEMBL. | 15566290 |
Activity (functional) | = 69.4 % | Cell cycle arrest in human LNCaP cells by accumulation at G1 phase at 10 uM after 72 hrs by FACS flow cytometry | ChEMBL. | 15566290 |
IC50 (binding) | = 0.43 uM | In vitro inhibitory activity against prostaglandin G/H synthase 2 (COX-2) | ChEMBL. | 14584938 |
IC50 (binding) | = 1 uM | In vitro inhibitory activity against human whole blood Prostaglandin G/H synthase 2 | ChEMBL. | 10406640 |
IC50 (binding) | = 6.3 uM | In vitro inhibitory activity against human whole blood Prostaglandin G/H synthase 1 | ChEMBL. | 10406640 |
IC50 (binding) | > 500 uM | In vitro inhibitory activity against Prostaglandin G/H synthase 1 (COX-1) | ChEMBL. | 14584938 |
Ratio (binding) | = 6.3 | Ratio of IC50 values at Cyclooxygenase-1 and Cyclooxygenase-2 | ChEMBL. | 10406640 |
Selectivity index (binding) | > 1162 | Selectivity index of IC50 against COX-1 to the IC50 against COX-2 | ChEMBL. | 14584938 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.