Detailed information for compound 74390

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 427.457 | Formula: C20H25N7O4
  • H donors: 1 H acceptors: 4 LogP: 2.41 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1nc(OC)nc(c1)N1CCN(CC1)c1nc(N)c2c(n1)cc(c(c2)OC)OC
  • InChi: 1S/C20H25N7O4/c1-28-14-9-12-13(10-15(14)29-2)22-19(25-18(12)21)27-7-5-26(6-8-27)16-11-17(30-3)24-20(23-16)31-4/h9-11H,5-8H2,1-4H3,(H2,21,22,25)
  • InChiKey: PTGBSMQDPBYDKC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Adrenergic receptor alpha-1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0225 0.022
Echinococcus multilocularis tar DNA binding protein 0.0128 0.1007 0.1002
Leishmania major mitochondrial DNA polymerase beta 0.03 0.251 0.2493
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0056 0.0379 0.0374
Brugia malayi N-terminal motif family protein 0.0367 0.3101 0.3097
Trypanosoma cruzi histone deacetylase, putative 0.0018 0.0054 0.0048
Schistosoma mansoni chromatin regulatory protein sir2 0.0171 0.1384 0.1384
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0111 0.0432
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0232 0.0227
Loa Loa (eye worm) hypothetical protein 0.0032 0.0169 0.0164
Echinococcus multilocularis nuclear receptor nhr 48 0.0026 0.0122 0.0117
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0056 0.0379 0.0379
Loa Loa (eye worm) hypothetical protein 0.0029 0.015 0.0144
Echinococcus granulosus histone deacetylase 3 0.0065 0.0457 0.0452
Trypanosoma cruzi histone deacetylase, putative 0.0018 0.0054 0.0048
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0111 0.0432
Brugia malayi TAR-binding protein 0.0128 0.1007 0.1002
Onchocerca volvulus 0.0056 0.0379 0.0823
Loa Loa (eye worm) hypothetical protein 0.0018 0.0054 0.0048
Loa Loa (eye worm) hypothetical protein 0.0026 0.0122 0.0117
Schistosoma mansoni z-protein (S1r protein) 0.0038 0.0221 0.0221
Echinococcus multilocularis histone deacetylase 8 0.0018 0.0054 0.0048
Toxoplasma gondii histone deacetylase HDAC3 0.0065 0.0457 0.3046
Giardia lamblia Histone deacetylase 0.0065 0.0457 0.0403
Loa Loa (eye worm) hypothetical protein 0.0026 0.0122 0.0117
Loa Loa (eye worm) hypothetical protein 0.0026 0.0122 0.0117
Echinococcus granulosus dnaJ subfamily B 0.0401 0.3395 0.3392
Onchocerca volvulus 0.0038 0.0225 0.0484
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.2181 0.2177
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.003 0.0024
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0026 0.0122 0.0257
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0056 0.0379 0.0374
Echinococcus multilocularis segment polarity protein dishevelled 0.0018 0.0051 0.0045
Trypanosoma brucei histone deacetylase, putative 0.0018 0.0054 0.0032
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0064 0.0075
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0063 0.0057
Leishmania major DNA polymerase kappa, putative 0.0021 0.008 0.0059
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0013 0.0006 0.0006
Leishmania major histone deacetylase, putative 0.0018 0.0054 0.0032
Brugia malayi beta-lactamase 0.0038 0.0225 0.022
Schistosoma mansoni polycystin 1-related 0.002 0.0064 0.0064
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.1157 1 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0056 0.0379 0.0374
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0022 0.0016
Brugia malayi tailless protein 0.0026 0.0122 0.0117
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0225 0.0204
Schistosoma mansoni cpg binding protein 0.003 0.0153 0.0153
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.1475 0.147
Trypanosoma brucei Silent information regulator 2 related protein 1 0.1157 1 1
Echinococcus granulosus GPCR family 2 0.0016 0.003 0.0024
Trypanosoma brucei histone deacetylase 1 0.0065 0.0457 0.0436
Loa Loa (eye worm) hypothetical protein 0.002 0.0064 0.0058
Onchocerca volvulus 0.002 0.0064 0.0128
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.003 0.0024
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0226 0.0204
Brugia malayi Nuclear hormone receptor-like 1 0.0056 0.0379 0.0374
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0063 0.0063
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0225 0.022
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0262 0.2181 0.2177
Loa Loa (eye worm) hypothetical protein 0.0015 0.0022 0.0016
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0063 0.0063
Loa Loa (eye worm) beta-lactamase 0.0038 0.0225 0.022
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0225 0.022
Echinococcus granulosus FTZ F1 alpha 0.0056 0.0379 0.0374
Brugia malayi RNA binding protein 0.0128 0.1007 0.1002
Leishmania major histone deacetylase, putative 0.0018 0.0054 0.0032
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0018 0.0051 0.0045
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.004 0.0019
Trichomonas vaginalis histone deacetylase, putative 0.0065 0.0457 0.0452
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0063 0.0057
Trypanosoma cruzi histone deacetylase 1, putative 0.0065 0.0457 0.0452
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0225 0.1021
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0063 0.0063
Loa Loa (eye worm) doublecortin family protein 0.002 0.0064 0.0058
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0056 0.0171
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.008 0.0294
Brugia malayi nuclear hormone receptor family member nhr-6 0.0026 0.0122 0.0117
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0063 0.0057
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.2181 0.2177
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0026 0.0122 0.0117
Loa Loa (eye worm) hypothetical protein 0.0038 0.0225 0.022
Echinococcus multilocularis RUN 0.002 0.0064 0.0058
Echinococcus granulosus thyroid hormone receptor alpha 0.0026 0.0122 0.0117
Schistosoma mansoni hypothetical protein 0.0513 0.4373 0.4373
Loa Loa (eye worm) hypothetical protein 0.0038 0.0225 0.022
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.1104 0.1099
Loa Loa (eye worm) hypothetical protein 0.0026 0.0122 0.0117
Plasmodium vivax hypothetical protein, conserved 0.0171 0.1384 1
Onchocerca volvulus 0.0026 0.0122 0.0257
Schistosoma mansoni nuclear hormone receptor 0.0026 0.0122 0.0122
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0225 0.1289
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0063 0.0057
Loa Loa (eye worm) hypothetical protein 0.0056 0.0379 0.0374
Echinococcus granulosus histone deacetylase 6 0.0018 0.0054 0.0048
Schistosoma mansoni hypothetical protein 0.0513 0.4373 0.4373
Schistosoma mansoni hypothetical protein 0.0016 0.003 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0063 0.0057
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.1104 0.1099
Schistosoma mansoni nuclear hormone receptor 0.0026 0.0122 0.0122
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0022 0.0016
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0063 0.0057
Echinococcus granulosus geminin 0.0513 0.4373 0.4369
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0432 0.2057
Schistosoma mansoni histone deacetylase 4 5 0.0018 0.0054 0.0054
Echinococcus multilocularis histone deacetylase 7 0.0018 0.0054 0.0048
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0056 0.005
Mycobacterium tuberculosis Conserved protein 0.0038 0.0225 0.1021
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0191 0.0847
Brugia malayi nuclear hormone receptor family member odr-7 0.0026 0.0122 0.0117
Loa Loa (eye worm) hypothetical protein 0.0026 0.0122 0.0117
Plasmodium vivax SET domain protein, putative 0.0061 0.0422 0.2767
Loa Loa (eye worm) hypothetical protein 0.0056 0.0379 0.0374
Schistosoma mansoni retinoic acid receptor RXR 0.0056 0.0379 0.0379
Brugia malayi Nuclear hormone receptor E75 0.0026 0.0122 0.0117
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0258 0.0237
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0064 0.0058
Entamoeba histolytica histone deacetylase, putative 0.0065 0.0457 0.0452
Brugia malayi Nuclear hormone receptor E75 0.0026 0.0122 0.0117
Schistosoma mansoni DNA polymerase eta 0.0015 0.0022 0.0022
Brugia malayi Doublecortin family protein 0.002 0.0064 0.0058
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0111 0.0106
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.004 0.0019
Onchocerca volvulus Glucosylceramidase homolog 0.0172 0.1394 0.3062
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0325 0.032
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0111 0.0454
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0258 0.0237
Schistosoma mansoni histone deacetylase 0.0065 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0026 0.0122 0.0117
Loa Loa (eye worm) histone deacetylase 1 0.0065 0.0457 0.0452
Schistosoma mansoni histone deacetylase 0.0065 0.0457 0.0457
Trichomonas vaginalis histone deacetylase, putative 0.0065 0.0457 0.0452
Loa Loa (eye worm) hypothetical protein 0.0026 0.0122 0.0117
Brugia malayi orphan nuclear receptor NR2E1 0.0026 0.0122 0.0117
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0015 0.0022 0.0016
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0139 0.1104 0.1099
Toxoplasma gondii ABC1 family protein 0.0038 0.0225 0.1308
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.1394 0.139
Leishmania major histone deacetylase, putative 0.0065 0.0457 0.0436
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0056 0.0379 0.0379
Plasmodium vivax NAD-dependent deacetylase, putative 0.0171 0.1384 1
Echinococcus multilocularis expressed protein 0.0379 0.32 0.3196
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.1131 0.1112
Loa Loa (eye worm) hypothetical protein 0.0367 0.3101 0.3097
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0225 0.022
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0056 0.0379 0.0374
Brugia malayi beta-lactamase family protein 0.0038 0.0225 0.022
Mycobacterium ulcerans Sir2-like regulatory protein 0.0171 0.1384 0.6099
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0056 0.0379 0.0374
Brugia malayi hypothetical protein 0.0018 0.0051 0.0045
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0144 0.1152 0.1147
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0063 0.0057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.1104 0.1104
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0419 0.3549 0.3545
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0258 0.0237
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0225 0.0778
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0258 0.0237
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0171 0.1384 0.1365
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0171 0.1384 0.1379
Loa Loa (eye worm) hypothetical protein 0.0029 0.015 0.0144
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0056 0.0379 0.0374
Loa Loa (eye worm) DR-78 0.0026 0.0122 0.0117
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0063 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0056 0.0379 0.0374
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0117 0.0915 0.091
Schistosoma mansoni inositol monophosphatase 0.0038 0.0226 0.0226
Brugia malayi hypothetical protein 0.0029 0.015 0.0144
Schistosoma mansoni RAR-like nuclear receptor 0.0056 0.0379 0.0379
Schistosoma mansoni dep domain containing protein 0.0018 0.0051 0.0051
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0056 0.005
Brugia malayi Pre-SET motif family protein 0.0419 0.3549 0.3545
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0432 0.0427
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0263 0.0258
Onchocerca volvulus 0.0038 0.0225 0.0484
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0261 0.0256
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0063 0.0057
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0432 0.1727
Schistosoma mansoni tar DNA-binding protein 0.0128 0.1007 0.1007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0056 0.0379 0.0374
Loa Loa (eye worm) hypothetical protein 0.0029 0.015 0.0144
Brugia malayi hypothetical protein 0.0016 0.0034 0.0028
Onchocerca volvulus 0.002 0.0064 0.0128
Brugia malayi nuclear receptor RXR 0.0026 0.0122 0.0117
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0064 0.0058
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0029 0.015 0.015
Schistosoma mansoni ets-related 0.0218 0.1798 0.1798
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0225 0.1021
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0056 0.5
Schistosoma mansoni chromatin regulatory protein sir2 0.0171 0.1384 0.1384
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0258 0.0253
Onchocerca volvulus 0.0018 0.0051 0.01
Brugia malayi RNA recognition motif domain containing protein 0.0128 0.1007 0.1002
Brugia malayi nuclear receptor RXR 0.0029 0.015 0.0144
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0056 0.0379 0.0374
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0225 0.022
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0063 0.0057
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0232 0.0177
Schistosoma mansoni lipoxygenase 0.0082 0.0607 0.0607
Echinococcus granulosus GA binding protein alpha chain 0.0072 0.052 0.0515
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0225 0.022
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.1157 1 1
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0063 0.0057
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0171 0.1384 0.1379
Loa Loa (eye worm) histone deacetylase 7A 0.0018 0.0054 0.0048
Brugia malayi nuclear receptor NHR-67 0.0026 0.0122 0.0117
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0258 0.0253
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0064 0.0058
Schistosoma mansoni cpg binding protein 0.003 0.0153 0.0153
Echinococcus granulosus dna polymerase kappa 0.0042 0.0258 0.0253
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0065 0.0457 0.0452
Schistosoma mansoni tar DNA-binding protein 0.0128 0.1007 0.1007
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0225 0.022
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0056 0.0379 0.0374
Mycobacterium ulcerans glutaminase 0.0268 0.2234 1
Loa Loa (eye worm) transcriptional regulator 0.0171 0.1384 0.1379
Schistosoma mansoni chromatin regulatory protein sir2 0.0171 0.1384 0.1384
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0056 0.0379 0.0379
Onchocerca volvulus Bile acid receptor homolog 0.0056 0.0379 0.0823
Brugia malayi nuclear receptor NHR-88 0.0056 0.0379 0.0374
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0056 0.0379 0.0374
Loa Loa (eye worm) glutaminase 0.0268 0.2234 0.2229
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0018 0.0051 0.0051
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0171 0.1384 0.1379
Loa Loa (eye worm) hypothetical protein 0.0049 0.0325 0.032
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0063 0.0057
Loa Loa (eye worm) hypothetical protein 0.0019 0.0063 0.0057
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0026 0.0122 0.0117
Loa Loa (eye worm) hypothetical protein 0.0026 0.0122 0.0117
Echinococcus granulosus histone deacetylase 7 0.0018 0.0054 0.0048
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.1104 0.1099
Echinococcus granulosus cpg binding protein 0.003 0.0153 0.0147
Leishmania major silent information regulator 2, putative 0.1157 1 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0258 0.0253
Loa Loa (eye worm) hypothetical protein 0.0018 0.0051 0.0045
Loa Loa (eye worm) hypothetical protein 0.0026 0.0122 0.0117
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.03 0.251 0.2506
Brugia malayi Latrophilin receptor protein 2 0.0016 0.003 0.0024
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0263 0.1593
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0063 0.0057
Brugia malayi Inositol-1 0.0038 0.0226 0.022
Leishmania major hypothetical protein, conserved 0.0038 0.0225 0.0204
Leishmania major hypothetical protein, conserved 0.0025 0.0111 0.009
Brugia malayi nuclear hormone receptor 0.0503 0.4284 0.4281
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0056 0.0379 0.0374
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0225 0.1021
Onchocerca volvulus Protein ultraspiracle homolog 0.0056 0.0379 0.0823
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0056 0.0379 0.0374
Brugia malayi Ets-domain containing protein 0.0072 0.052 0.0515
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0422 0.0422
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.0422 0.0422
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.0122 0.0117
Loa Loa (eye worm) TAR-binding protein 0.0128 0.1007 0.1002
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0056 0.005
Echinococcus multilocularis GPCR, family 2 0.0016 0.003 0.0024
Brugia malayi histone deacetylase 1 (HD1) 0.0065 0.0457 0.0452
Trypanosoma brucei DNA polymerase IV, putative 0.0035 0.02 0.0178
Schistosoma mansoni coup transcription factor 0.0056 0.0379 0.0379
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0042 0.0258 0.0253
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0226 0.0779
Loa Loa (eye worm) nuclear hormone receptor 0.0026 0.0122 0.0117
Loa Loa (eye worm) fli-1 protein 0.0218 0.1798 0.1793
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0056 0.0379 0.0374
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0063 0.0063
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0063 0.0057
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0056 0.0379 0.0374
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.2181 0.2177
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0171 0.1384 0.1379
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0169 0.0148
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.1131 0.1127
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0056 0.0379 0.0374
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0015 0.0022 0.0016
Schistosoma mansoni gabp alpha 0.0072 0.052 0.052
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0056 0.005
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0258 0.0237
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0063 0.0057
Schistosoma mansoni ap endonuclease 0.0019 0.0056 0.0056
Brugia malayi ecdysteroid receptor 0.0056 0.0379 0.0374
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0063 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0056 0.0379 0.0374
Loa Loa (eye worm) hypothetical protein 0.0038 0.0225 0.022
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0226 0.022
Entamoeba histolytica hypothetical protein 0.0019 0.0063 0.0057
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0258 0.0237
Brugia malayi hypothetical protein 0.0018 0.0051 0.0045
Schistosoma mansoni histone deacetylase hda2 0.0018 0.0054 0.0054
Schistosoma mansoni cpg binding protein 0.0028 0.0139 0.0139
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.1104 0.1104
Schistosoma mansoni tar DNA-binding protein 0.0128 0.1007 0.1007
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0261 0.024
Echinococcus multilocularis segment polarity protein dishevelled 0.0018 0.0051 0.0045
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0013 0.0006 0.0006
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0325 0.032
Schistosoma mansoni thyroid hormone receptor 0.0056 0.0379 0.0379
Leishmania major sir2-family protein-like protein 0.0171 0.1384 0.1365
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0225 1
Schistosoma mansoni hypothetical protein 0.0016 0.003 0.003
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0056 0.005
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0056 0.0379 0.0374
Brugia malayi hypothetical protein 0.0019 0.0063 0.0057
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0063 0.0057
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0056 0.0379 0.0374
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0063 0.0057
Entamoeba histolytica hypothetical protein 0.0019 0.0063 0.0057
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0225 0.022
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0243 0.2016 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0015 0.0022 0.0016
Echinococcus multilocularis histone deacetylase 6 0.0018 0.0054 0.0048
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0261 0.0256
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.008 0.0059
Plasmodium vivax histone deacetylase 1, putative 0.0065 0.0457 0.3031
Trichomonas vaginalis glutaminase, putative 0.0268 0.2234 0.2229
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0432 0.2858
Echinococcus granulosus segment polarity protein dishevelled 0.0018 0.0051 0.0045
Schistosoma mansoni chromatin regulatory protein sir2 0.1157 1 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0397 0.0392
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0225 0.1021
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0056 0.0034
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0263 0.0258
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0013 0.0006 0.0006
Brugia malayi Fli-1 protein 0.0218 0.1798 0.1793
Schistosoma mansoni nuclear hormone receptor 0.0056 0.0379 0.0379
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.1104 0.1104
Echinococcus granulosus Nuclear hormone receptor HR96 0.0026 0.0122 0.0117
Loa Loa (eye worm) hypothetical protein 0.0019 0.0063 0.0057
Trichomonas vaginalis esterase, putative 0.0038 0.0225 0.022
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0056 0.0379 0.0374
Trichomonas vaginalis histone deacetylase, putative 0.0065 0.0457 0.0452
Onchocerca volvulus 0.0026 0.0122 0.0257
Loa Loa (eye worm) hypothetical protein 0.0065 0.0457 0.0452
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0434 0.0434
Schistosoma mansoni histone deacetylase hda2 0.0018 0.0054 0.0054
Echinococcus multilocularis dnaJ subfamily B 0.0401 0.3395 0.3392
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0063 0.0063
Brugia malayi Nuclear hormone receptor-like 1 0.0029 0.015 0.0144
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0432 0.1727
Loa Loa (eye worm) hypothetical protein 0.0477 0.4055 0.4052
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0063 0.0057
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0226 0.022
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0171 0.1384 0.1379
Brugia malayi Histone deacetylase family protein 0.0018 0.0054 0.0048
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0117 0.0915 0.091
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.003 0.0024
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.2181 0.2177
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0409 0.2686
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0056 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0063 0.0057
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0226 0.022
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0018 0.0051 0.01
Schistosoma mansoni hypothetical protein 0.0034 0.0188 0.0188
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0056 0.0379 0.0374
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0111 0.009
Schistosoma mansoni nuclear receptor 0.0026 0.0122 0.0122
Toxoplasma gondii hypothetical protein 0.0048 0.0315 0.1981
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0171 0.1384 0.6831
Giardia lamblia Sirtuin type 2 0.0171 0.1384 0.1336
Schistosoma mansoni lipoxygenase 0.0117 0.0915 0.0915
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0432 0.0411
Loa Loa (eye worm) transcriptional regulator 0.0171 0.1384 0.1379
Loa Loa (eye worm) hypothetical protein 0.0018 0.0051 0.0045
Echinococcus granulosus regulator of G protein signaling 7 0.0038 0.0221 0.0215
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0063 0.0057
Schistosoma mansoni steroid hormone receptor ad4bp 0.0056 0.0379 0.0379
Brugia malayi hypothetical protein 0.0025 0.0111 0.0106
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.1394 0.139
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0258 0.0929
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0142 0.1131 0.1112
Trypanosoma cruzi histone deacetylase, putative 0.0018 0.0054 0.0048
Loa Loa (eye worm) hypothetical protein 0.0019 0.0063 0.0057
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0263 0.0258
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0226 0.022
Echinococcus multilocularis dna polymerase kappa 0.0042 0.0258 0.0253
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0225 0.022
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0063 0.0063
Loa Loa (eye worm) steroid hormone receptor 0.0056 0.0379 0.0374
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0139 0.0133
Loa Loa (eye worm) hypothetical protein 0.002 0.0064 0.0058
Schistosoma mansoni hypothetical protein 0.0016 0.003 0.003
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0171 0.1384 0.1379
Brugia malayi Steroid receptor seven-up type 2 0.0056 0.0379 0.0374
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.1394 0.139
Schistosoma mansoni glutaminase 0.0268 0.2234 0.2234
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0225 0.0225
Loa Loa (eye worm) hypothetical protein 0.0056 0.0379 0.0374
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0171 0.1384 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0169 0.0148
Echinococcus multilocularis cpg binding protein 0.003 0.0153 0.0147
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0171 0.1384 0.1336
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0258 0.0929
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0056 0.0379 0.0374
Trypanosoma brucei histone deacetylase 2 0.0018 0.0054 0.0032
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0422 0.0417
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0225 0.0225
Echinococcus granulosus segment polarity protein dishevelled 0.0018 0.0051 0.0045
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0171 0.1384 0.1379
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0072 0.052 0.0515
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0056 0.005
Loa Loa (eye worm) hypothetical protein 0.0061 0.0429 0.0424
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0221 0.0221
Schistosoma mansoni ap endonuclease 0.0019 0.0056 0.0056
Schistosoma mansoni rab6-interacting 0.002 0.0064 0.0064
Toxoplasma gondii histone deacetylase SIR2 0.0171 0.1384 1
Trypanosoma cruzi histone deacetylase 1, putative 0.0065 0.0457 0.0452
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0063 0.0057
Schistosoma mansoni hypothetical protein 0.0016 0.003 0.003
Mycobacterium ulcerans hypothetical protein 0.0038 0.0225 0.0778
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.003 0.0024
Trypanosoma cruzi histone deacetylase, putative 0.0018 0.0054 0.0048
Onchocerca volvulus 0.0476 0.4053 0.8924
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0063 0.0063
Echinococcus multilocularis thyroid hormone receptor alpha 0.0056 0.0379 0.0374
Loa Loa (eye worm) hypothetical protein 0.0026 0.0122 0.0117
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0422 0.0417
Brugia malayi glutaminase DH11.1 0.0268 0.2234 0.2229
Mycobacterium ulcerans hypothetical protein 0.0158 0.1271 0.5581
Echinococcus multilocularis ecdysone induced protein 78C 0.0056 0.0379 0.0374
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0026 0.0122 0.0117
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0226 0.022
Schistosoma mansoni tar DNA-binding protein 0.0128 0.1007 0.1007
Echinococcus multilocularis histone deacetylase 0.0018 0.0054 0.0048
Onchocerca volvulus Histone deacetylase 10 homolog 0.0018 0.0054 0.0107
Echinococcus multilocularis chromatin regulatory protein sir2 0.1157 1 1
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0171 0.1384 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0026 0.0122 0.0122
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0422 0.2783
Brugia malayi nuclear hormone receptor 0.0056 0.0379 0.0374
Brugia malayi hypothetical protein 0.0026 0.0122 0.0117
Loa Loa (eye worm) hypothetical protein 0.0034 0.0188 0.0183
Entamoeba histolytica hypothetical protein, conserved 0.0171 0.1384 0.1379
Trypanosoma brucei histone deacetylase 4 0.0018 0.0054 0.0032
Echinococcus granulosus histone deacetylase 8 0.0018 0.0054 0.0048
Loa Loa (eye worm) hypothetical protein 0.0056 0.0379 0.0374
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0029 0.015 0.0144
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.1157 1 1
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0018 0.0051 0.0045
Loa Loa (eye worm) hypothetical protein 0.0061 0.0422 0.0417
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0056 0.0379 0.0374
Trichomonas vaginalis histone deacetylase, putative 0.0065 0.0457 0.0452
Loa Loa (eye worm) RNA binding protein 0.0128 0.1007 0.1002
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.2181 0.2177
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0341 0.0336
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0065 0.0457 0.0452
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0258 0.0237
Brugia malayi photoreceptor-specific nuclear receptor 0.0056 0.0379 0.0374
Loa Loa (eye worm) cytochrome P450 family protein 0.0049 0.0325 0.032
Schistosoma mansoni tar DNA-binding protein 0.0128 0.1007 0.1007
Schistosoma mansoni inositol monophosphatase 0.0038 0.0226 0.0226
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0171 0.1384 0.1379
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0432 0.0427
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.1157 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0258 0.0237
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0056 0.0379 0.0374
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0063 0.0057
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0056 0.0379 0.0379
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0258 0.0253
Entamoeba histolytica hypothetical protein 0.0019 0.0063 0.0057
Schistosoma mansoni zinc finger protein 0.0026 0.0122 0.0122
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0029 0.015 0.0144
Schistosoma mansoni hypothetical protein 0.0401 0.3395 0.3395
Echinococcus granulosus Pleckstrin G protein interacting region 0.0018 0.0051 0.0045
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0171 0.1384 0.1379
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0144 0.1152 0.1152
Schistosoma mansoni histone deacetylase 1 2 3 0.0018 0.0054 0.0054
Brugia malayi Cytochrome P450 family protein 0.0049 0.0325 0.032
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0056 0.0379 0.0374
Echinococcus multilocularis histone deacetylase 6 0.0018 0.0054 0.0048
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0226 1
Brugia malayi PXA domain containing protein 0.0019 0.0063 0.0057
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0171 0.1384 0.1379
Echinococcus granulosus nuclear receptor nhr 48 0.0026 0.0122 0.0117
Toxoplasma gondii histone deacetylase HDAC1 0.0018 0.0054 0.0023
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.1104 0.1099
Brugia malayi NAD-dependent deacetylase SIRT1 0.0171 0.1384 0.1379
Brugia malayi beta-lactamase family protein 0.0038 0.0225 0.022
Mycobacterium leprae Probable lipase LipE 0.0038 0.0225 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0056 0.0379 0.0374
Echinococcus multilocularis FTZ F1 alpha 0.0056 0.0379 0.0374
Loa Loa (eye worm) hypothetical protein 0.0038 0.0221 0.0215
Trichomonas vaginalis set domain proteins, putative 0.0476 0.4053 0.405
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0056 0.0379 0.0374
Schistosoma mansoni nuclear receptor nhr-48 0.0026 0.0122 0.0122
Brugia malayi nuclear receptor NHR-88 0.0026 0.0122 0.0117
Echinococcus granulosus histone deacetylase 1 0.0065 0.0457 0.0452
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0171 0.1384 0.1379
Loa Loa (eye worm) histone deacetylase 11 0.0018 0.0054 0.0048
Brugia malayi PXA domain containing protein 0.0019 0.0063 0.0057
Leishmania major histone deacetylase, putative 0.0065 0.0457 0.0436
Echinococcus granulosus expressed protein 0.0379 0.32 0.3196
Loa Loa (eye worm) hypothetical protein 0.0026 0.0122 0.0117
Echinococcus granulosus regulator of G protein signaling 7 0.0038 0.0221 0.0215
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0064 0.0075
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0056 0.0379 0.0379
Echinococcus multilocularis histone deacetylase 1 0.0065 0.0457 0.0452
Trypanosoma brucei SIR2-like protein 4, putative 0.0171 0.1384 0.1365
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0225 0.1021
Loa Loa (eye worm) hypothetical protein 0.0019 0.0063 0.0057
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.1157 1 1
Plasmodium falciparum histone deacetylase 1 0.0065 0.0457 0.3031
Brugia malayi hypothetical protein 0.0026 0.0122 0.0117
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0232 0.1342
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0026 0.0122 0.0122
Brugia malayi histone deacetylase 3 (HD3) 0.0065 0.0457 0.0452
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0026 0.0122 0.0117
Brugia malayi polk-prov protein 0.0032 0.0169 0.0164
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0056 0.0379 0.0374
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0056 0.0015
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0063 0.0057
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0171 0.1384 0.1379
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.1394 0.139
Mycobacterium ulcerans NAD-dependent deacetylase 0.0171 0.1384 0.6099
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0056 0.0379 0.0374
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0139 0.1104 0.1099
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0015 0.0022 0.0022
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0018 0.0051 0.0045
Schistosoma mansoni chromatin regulatory protein sir2 0.0171 0.1384 0.1384
Schistosoma mansoni ras GTP exchange factor 0.0013 0.0006 0.0006
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0029 0.015 0.0144
Brugia malayi Histone deacetylase family protein 0.0018 0.0054 0.0048
Trichomonas vaginalis histone deacetylase, putative 0.0065 0.0457 0.0452
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0026 0.0122 0.0117
Loa Loa (eye worm) hypothetical protein 0.0026 0.0122 0.0117
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0503 0.4284 0.4281
Schistosoma mansoni nuclear receptor 0.0026 0.0122 0.0122
Brugia malayi Ets-domain containing protein 0.0072 0.052 0.0515
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.0122 0.0117
Giardia lamblia Hypothetical protein 0.1157 1 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.003 0.0024
Toxoplasma gondii histone deacetylase SIR2-like 0.0171 0.1384 1
Trichomonas vaginalis histone deacetylase, putative 0.0065 0.0457 0.0452
Loa Loa (eye worm) histone deacetylase 3 0.0065 0.0457 0.0452
Echinococcus granulosus chromatin regulatory protein sir2 0.1157 1 1
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0262 0.2181 0.2177
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0432 0.1727
Brugia malayi transcriptional regulator, Sir2 family protein 0.0171 0.1384 0.1379
Schistosoma mansoni chromatin regulatory protein sir2 0.1157 1 1
Onchocerca volvulus 0.0028 0.0139 0.0294
Loa Loa (eye worm) hypothetical protein 0.0056 0.0379 0.0374
Loa Loa (eye worm) hypothetical protein 0.0171 0.1384 0.1379
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.008 0.0059
Echinococcus granulosus histone acetyltransferase KAT2B 0.014 0.1117 0.1112
Echinococcus granulosus RUN 0.002 0.0064 0.0058
Echinococcus multilocularis histone deacetylase 3 0.0065 0.0457 0.0452
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.2181 0.2177
Trypanosoma brucei histone deacetylase 3 0.0018 0.0054 0.0032
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0171 0.1384 0.1379
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0063 0.0063
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0422 0.0422
Echinococcus granulosus histone deacetylase 0.0018 0.0054 0.0048
Brugia malayi acetyltransferase, GNAT family protein 0.0144 0.1152 0.1147
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0056 0.0379 0.0379
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0063 0.0063
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0171 0.1384 0.1379
Trypanosoma cruzi DNA polymerase eta, putative 0.0015 0.0022 0.0016
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0171 0.1384 0.1365
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.004 0.0019
Brugia malayi steroid hormone receptor 0.0056 0.0379 0.0374
Brugia malayi Nuclear hormone receptor-like 1 0.0029 0.015 0.0144
Trypanosoma cruzi histone deacetylase, putative 0.0018 0.0054 0.0048
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0026 0.0122 0.0117
Brugia malayi Pre-SET motif family protein 0.0061 0.0422 0.0417
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0325 0.032
Brugia malayi CXXC zinc finger family protein 0.0028 0.0139 0.0133
Loa Loa (eye worm) histone deacetylase 0.0018 0.0054 0.0048
Brugia malayi Histone deacetylase 1 0.0065 0.0457 0.0452
Loa Loa (eye worm) hypothetical protein 0.0056 0.0379 0.0374
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0226 0.022
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.1394 0.139
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0063 0.0057
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0038 0.0221 0.0215
Trypanosoma brucei unspecified product 0.0035 0.02 0.0178
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.1157 1 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0056 0.005
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0064 0.0058
Loa Loa (eye worm) acetyltransferase 0.0144 0.1152 0.1147
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.003 0.0024
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.003 0.0024
Echinococcus multilocularis geminin 0.0513 0.4373 0.4369
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0432 0.0432
Loa Loa (eye worm) sirtuin 4 0.0171 0.1384 0.1379
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0258 0.0237
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0188 0.0183
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0056 0.005
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0064 0.0058
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0038 0.0225 0.022
Mycobacterium ulcerans lipase LipD 0.0038 0.0225 0.0778
Loa Loa (eye worm) hypothetical protein 0.0038 0.0225 0.022
Loa Loa (eye worm) DIX domain-containing protein 0.0018 0.0051 0.0045
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0015 0.0022 0.0016
Brugia malayi hypothetical protein 0.002 0.0064 0.0058
Schistosoma mansoni thyroid hormone receptor 0.0056 0.0379 0.0379
Loa Loa (eye worm) inositol-1 0.0038 0.0226 0.022
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0263 0.1593
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0063 0.0057
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.1394 0.139
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0226 0.022
Loa Loa (eye worm) glutaminase 2 0.0268 0.2234 0.2229
Brugia malayi DIX domain containing protein 0.0018 0.0051 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0063 0.0057
Loa Loa (eye worm) transcriptional regulator 0.1157 1 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0226 0.131
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0171 0.1384 0.1379
Toxoplasma gondii histone deacetylase HDAC5 0.0018 0.0054 0.0023
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0225 0.0778
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0225 0.1021
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0064 0.0058
Brugia malayi hypothetical protein 0.0019 0.0063 0.0057
Schistosoma mansoni loxhd1 0.002 0.0064 0.0064
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0226 0.0204
Echinococcus granulosus Nuclear hormone receptor HR96 0.0026 0.0122 0.0117
Brugia malayi hypothetical protein 0.0029 0.015 0.0144
Loa Loa (eye worm) hypothetical protein 0.0029 0.015 0.0144
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.1157 1 1
Brugia malayi conserved hypotetical protein 0.0026 0.0122 0.0117
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0422 0.0417
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0171 0.1384 0.1379
Mycobacterium tuberculosis Conserved hypothetical protein 0.0158 0.1271 0.6266
Toxoplasma gondii exonuclease III APE 0.0019 0.0056 0.0038
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0013 0.0006 0.0006
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0226 0.022
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0225 0.022
Trichomonas vaginalis DNA polymerase eta, putative 0.0042 0.0258 0.0253
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0367 0.3101 0.6826
Loa Loa (eye worm) hypothetical protein 0.0025 0.0111 0.0106
Echinococcus multilocularis regulator of G protein signaling 7 0.0038 0.0221 0.0215
Loa Loa (eye worm) hypothetical protein 0.0038 0.0225 0.022
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.03 0.251 0.2506
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0065 0.0457 0.0452
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0056 0.0015
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0056 0.0379 0.0374
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0258 0.0237
Loa Loa (eye worm) hypothetical protein 0.0019 0.0063 0.0057
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0026 0.0122 0.0257
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0111 0.0432
Schistosoma mansoni hypothetical protein 0.002 0.0064 0.0064
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0128 0.1007 0.1002
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0171 0.1384 0.1379
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0432 0.0432
Loa Loa (eye worm) hypothetical protein 0.0026 0.0122 0.0117
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0056 0.0379 0.0374
Mycobacterium tuberculosis Conserved protein 0.0038 0.0225 0.1021
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.1475 0.147
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0056 0.005
Schistosoma mansoni histone deacetylase 4 5 0.0018 0.0054 0.0054
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0063 0.0063
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0422 0.0422
Giardia lamblia Transcriptional regulator, Sir2 family 0.0171 0.1384 0.1336
Schistosoma mansoni rab6-interacting 0.002 0.0064 0.0064
Brugia malayi transcriptional regulator, Sir2 family protein 0.0171 0.1384 0.1379
Mycobacterium ulcerans beta-lactamase 0.0038 0.0225 0.0778
Giardia lamblia DINP protein human, muc B family 0.0021 0.008 0.0025
Schistosoma mansoni terminal deoxycytidyl transferase 0.0015 0.0022 0.0022
Brugia malayi ecdysone receptor 0.0026 0.0122 0.0117
Echinococcus multilocularis regulator of G protein signaling 7 0.0038 0.0221 0.0215
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0258 0.0237
Trypanosoma brucei mitochondrial DNA polymerase beta 0.03 0.251 0.2493
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0063 0.0057
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0225 0.1021
Toxoplasma gondii histone deacetylase HDAC2 0.0065 0.0457 0.3046
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.1157 1 1
Schistosoma mansoni dishevelled 0.0018 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0029 0.015 0.0144
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0063 0.0057
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0171 0.1384 0.1379
Schistosoma mansoni dishevelled 0.0018 0.0051 0.0051
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0111 0.0106
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.1394 0.139
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0056 0.0379 0.0374
Echinococcus granulosus histone deacetylase 6 0.0018 0.0054 0.0048
Echinococcus multilocularis GA binding protein alpha chain 0.0072 0.052 0.0515
Onchocerca volvulus 0.0061 0.0422 0.0918
Schistosoma mansoni chromatin regulatory protein sir2 0.1157 1 1
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0063 0.0057
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0532 0.4541 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0029 0.015 0.015
Mycobacterium tuberculosis Conserved protein 0.0038 0.0225 0.1021
Echinococcus granulosus tar DNA binding protein 0.0128 0.1007 0.1002
Echinococcus multilocularis histone deacetylase 6 0.0018 0.0054 0.0048
Loa Loa (eye worm) nuclear receptor NHR-67 0.0026 0.0122 0.0117
Echinococcus granulosus dna polymerase eta 0.0015 0.0022 0.0016
Echinococcus granulosus ecdysone induced protein 78C 0.0056 0.0379 0.0374
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0056 0.0379 0.0374
Brugia malayi hypothetical protein 0.002 0.0064 0.0058
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0225 0.022
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0063 0.0057
Brugia malayi histone deacetylase 11 0.0018 0.0054 0.0048
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0263 0.1574
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0056 0.0379 0.0374
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0261 0.0256
Echinococcus multilocularis dna polymerase eta 0.0015 0.0022 0.0016
Brugia malayi regulator of G-protein signaling egl-10 0.0038 0.0221 0.0215
Echinococcus granulosus histone deacetylase 6 0.0018 0.0054 0.0048
Onchocerca volvulus 0.0038 0.0225 0.0484
Toxoplasma gondii histone deacetylase HDAC4 0.0018 0.0054 0.0023
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0171 0.1384 0.1379
Loa Loa (eye worm) hypothetical protein 0.0056 0.0379 0.0374

Activities

Activity type Activity value Assay description Source Reference
Displacement (binding) = 54.2 % Percent displacement of [3H]-clonidine to alpha2-adrenoceptor was determined in rat brain homogenates at 10E-6 M ChEMBL. 2888896
Displacement (binding) = 54.2 % Percent displacement of [3H]-clonidine to alpha2-adrenoceptor was determined in rat brain homogenates at 10E-6 M ChEMBL. 2888896
Ki (binding) = 0.16 nM Binding affinity against alpha1-adrenoceptor in rat brain homogenates [3H]-prazosin displacement. ChEMBL. 2888896
Ki (binding) = 0.16 nM Binding affinity against alpha1-adrenoceptor in rat brain homogenates [3H]-prazosin displacement. ChEMBL. 2888896
Reduction (functional) = 20 % Antihypertensive activity was determined by percent reduction in blood pressure after 6 hr upon per oral administration of 5 mg/kg dose in spontaneously hypertensive rats(SHR). ChEMBL. 2888896
Reduction (functional) = 22 % Antihypertensive activity was determined by percent reduction in blood pressure after 1 hr upon per oral administration of 5 mg/kg dose in spontaneously hypertensive rats(SHR). ChEMBL. 2888896

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.