Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | tachykinin receptor 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | tachykinin peptides receptor 99D | Get druggable targets OG5_131969 | All targets in OG5_131969 |
Echinococcus multilocularis | tachykinin peptides receptor 99D | Get druggable targets OG5_131969 | All targets in OG5_131969 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | trypanothione reductase | 0.0193 | 0.3714 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0067 | 0.0169 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0193 | 0.3714 | 1 |
Chlamydia trachomatis | glutamine binding protein | 0.0096 | 0.0996 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0193 | 0.3714 | 0.3714 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0067 | 0.0169 | 0.5 |
Echinococcus granulosus | tachykinin peptides receptor 99D | 0.0369 | 0.8675 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0193 | 0.3714 | 0.3714 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0067 | 0.0169 | 0.0456 |
Brugia malayi | Thioredoxin reductase | 0.0193 | 0.3714 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0193 | 0.3714 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0134 | 0.2052 | 0.2365 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0067 | 0.0169 | 0.5 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0193 | 0.3714 | 0.4282 |
Plasmodium vivax | glutathione reductase, putative | 0.0193 | 0.3714 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0193 | 0.3714 | 0.4282 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0193 | 0.3714 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0193 | 0.3714 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0067 | 0.0169 | 0.5 |
Echinococcus multilocularis | tachykinin peptides receptor 99D | 0.0369 | 0.8675 | 1 |
Brugia malayi | glutathione reductase | 0.0193 | 0.3714 | 1 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0067 | 0.0169 | 0.0456 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0096 | 0.0996 | 1 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0067 | 0.0169 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0067 | 0.0169 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0096 | 0.0996 | 1 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0067 | 0.0169 | 0.0195 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0096 | 0.0996 | 1 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0134 | 0.2052 | 0.2365 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0193 | 0.3714 | 1 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0067 | 0.0169 | 0.0195 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0096 | 0.0996 | 0.2332 |
Trypanosoma brucei | trypanothione reductase | 0.0193 | 0.3714 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0416 | 1 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0193 | 0.3714 | 1 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0096 | 0.0996 | 1 |
Treponema pallidum | NADH oxidase | 0.0067 | 0.0169 | 0.1701 |
Onchocerca volvulus | 0.0061 | 0 | 0.5 | |
Echinococcus granulosus | nmda type glutamate receptor | 0.0134 | 0.2052 | 0.2365 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 493 nM | Inhibition of [125I]-MePhe7-Neurokinin B (NKB) binding in human Tachykinin receptor 3 of chinese hamster ovary (hNK-3-CHO) cell membranes. | ChEMBL. | 9191956 |
Ki (binding) | = 493 nM | Inhibition of [125I]-MePhe7-Neurokinin B (NKB) binding in human Tachykinin receptor 3 of chinese hamster ovary (hNK-3-CHO) cell membranes. | ChEMBL. | 9191956 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.