TDR Targets

Basic information

Technical information

TDR Targets ID: 74434
Name: 2-[4-(7-chloro-8-methoxyquinoxalin-2-yl)oxyph enoxy]propanoic acid
MW: 374.775 | Formula: C18H15ClN2O5
H donors: 1 H acceptors: 4 LogP: 3.64 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1c(Cl)ccc2c1nc(cn2)Oc1ccc(cc1)OC(C(=O)O)C
InChi: 1S/C18H15ClN2O5/c1-10(18(22)23)25-11-3-5-12(6-4-11)26-15-9-20-14-8-7-13(19)17(24-2)16(14)21-15/h3-10H,1-2H3,(H,22,23)
InChiKey: URLWMQRMXHBGHM-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

2-[4-(7-chloro-8-methoxy-quinoxalin-2-yl)oxyphenoxy]propanoic acid
2-[4-[(7-chloro-8-methoxy-2-quinoxalinyl)oxy]phenoxy]propanoic acid
2-[4-(7-chloro-8-methoxy-quinoxalin-2-yl)oxyphenoxy]propionic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0022	0.0137	0.0189
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0031	0.0245	0.6947
Echinococcus multilocularis	FTZ F1 alpha	0.0022	0.0137	0.0137
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0022	0.0137	0.0189
Entamoeba histolytica	cysteine protease, putative	0.0018	0.0087	0.0568
Brugia malayi	hypothetical protein	0.003	0.0232	0.0321
Echinococcus granulosus	Solute carrier organic anion transporter family	0.003	0.0232	0.0321
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0087	0.0568
Schistosoma mansoni	follistatin	0.002	0.012	0.0165
Echinococcus granulosus	axis inhibition protein axin	0.002	0.0117	0.0162
Brugia malayi	PXA domain containing protein	0.002	0.0117	0.0162
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.002	0.0117	0.0162
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0022	0.0137	0.0137
Echinococcus multilocularis	musashi	0.0028	0.0215	0.0215
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0018	0.0087	0.0121
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0327	0.2543
Trichomonas vaginalis	DNA helicase recq, putative	0.0012	0.002	0.002
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0137	0.0189
Loa Loa (eye worm)	hypothetical protein	0.002	0.012	0.0165
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0022	0.0137	0.0189
Echinococcus multilocularis	6 phosphofructokinase	0.0115	0.1235	0.1235
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0087	0.0568
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0022	0.0137	0.0137
Leishmania major	cathepsin L-like protease	0.0018	0.0087	0.0549
Schistosoma mansoni	cathepsin F (C01 family)	0.0012	0.0018	0.0025
Loa Loa (eye worm)	hypothetical protein	0.003	0.0232	0.0321
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0087	0.0568
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0018	0.0087	0.0087
Brugia malayi	regulator of G-protein signaling rgs-7	0.002	0.0117	0.0162
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0022	0.0137	0.0189
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0014	0.0041	0.0056
Leishmania major	ATP-dependent phosphofructokinase	0.0115	0.1235	1
Echinococcus granulosus	intermediate filament protein	0.0028	0.0215	0.0297
Onchocerca volvulus		0.003	0.0232	0.0321
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.0117	0.0817
Onchocerca volvulus	Putative organic anion transporter	0.003	0.0232	0.0321
Leishmania major	cathepsin L-like protease	0.0067	0.0674	0.5385
Loa Loa (eye worm)	hypothetical protein	0.003	0.0232	0.0321
Echinococcus granulosus	geminin	0.0179	0.1993	0.276
Loa Loa (eye worm)	ctsf protein	0.0018	0.0087	0.0121
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0014	0.0041	0.0041
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0087	0.0121
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0022	0.0137	0.0189
Trichomonas vaginalis	phosphofructokinase, putative	0.0115	0.1235	1
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.002	0.0117	0.0162
Trypanosoma cruzi	cysteine peptidase, putative	0.0067	0.0674	0.5385
Schistosoma mansoni	nuclear hormone receptor	0.0022	0.0137	0.0189
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0215	0.0297
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.002	0.0117	0.0117
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0087	0.0568
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0034	0.0048
Brugia malayi	Papain family cysteine protease containing protein	0.0018	0.0087	0.0121
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0674	0.5385
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0087	0.0568
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0245	0.1863
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0018	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0327	0.0453
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.002	0.0117	0.0162
Loa Loa (eye worm)	sodium-independent organic anion transporter	0.003	0.0232	0.0321
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0038	0.0327	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0087	0.0121
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0327	0.2529
Toxoplasma gondii	transporter, major facilitator family protein	0.003	0.0232	0.6472
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0022	0.0137	0.0189
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	0.0137	0.0189
Onchocerca volvulus		0.0038	0.0327	0.0453
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.002	0.012	0.0165
Schistosoma mansoni	regulator of G protein signaling	0.002	0.0117	0.0162
Echinococcus multilocularis	regulator of G protein signaling 3	0.002	0.0117	0.0117
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.002	0.0112	0.1587
Brugia malayi	phosphofructokinase	0.0115	0.1235	0.171
Brugia malayi	Regulator of G protein signaling domain containing protein	0.002	0.0117	0.0162
Schistosoma mansoni	sodium-bile acid cotransporter	0.0263	0.2992	0.4143
Schistosoma mansoni	6-phosphofructokinase	0.0115	0.1235	0.171
Plasmodium vivax	hypothetical protein, conserved	0.0038	0.0327	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0034	0.0048
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	0.0137	0.0189
Onchocerca volvulus	Bile acid receptor homolog	0.0022	0.0137	0.0189
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0674	0.5385
Leishmania major	cathepsin L-like protease	0.0018	0.0087	0.0549
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0674	0.5385
Echinococcus granulosus	regulator of G protein signaling 7	0.002	0.0117	0.0162
Echinococcus multilocularis	cysteine protease	0.0018	0.0087	0.0087
Schistosoma mansoni	regulator of G protein signaling	0.002	0.0117	0.0162
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.002	0.012	0.0165
Loa Loa (eye worm)	hypothetical protein	0.003	0.0232	0.0321
Loa Loa (eye worm)	RGS-3 protein	0.002	0.0117	0.0162
Schistosoma mansoni	regulator of G protein signaling	0.002	0.0117	0.0162
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0674	0.5385
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0022	0.0137	0.0189
Onchocerca volvulus		0.0038	0.0327	0.0453
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0215	0.0297
Brugia malayi	Regulator of G protein signaling domain containing protein	0.002	0.0117	0.0162
Entamoeba histolytica	phosphofructokinase, putative	0.0115	0.1235	1
Brugia malayi	cytoplasmic intermediate filament protein	0.0015	0.0058	0.0081
Echinococcus multilocularis	organic anion transporting polypeptide 30B	0.003	0.0232	0.0232
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0674	0.5385
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0137	0.0189
Schistosoma mansoni	organic anion transporter	0.003	0.0232	0.0321
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0031	0.0245	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0022	0.0137	0.0189
Brugia malayi	Cathepsin L-like precursor	0.0012	0.0018	0.0025
Brugia malayi	hypothetical protein	0.002	0.0117	0.0162
Loa Loa (eye worm)	hypothetical protein	0.002	0.0117	0.0162
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0012	0.0018	0.0025
Loa Loa (eye worm)	hypothetical protein	0.002	0.0117	0.0162
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0012	0.0015	0.0015
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0015	0.002
Brugia malayi	sodium-independent organic anion transporter family protein	0.003	0.0232	0.0321
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0087	0.0568
Onchocerca volvulus		0.003	0.0232	0.0321
Onchocerca volvulus		0.0038	0.0327	0.0453
Loa Loa (eye worm)	PXA domain-containing protein	0.002	0.0117	0.0162
Loa Loa (eye worm)	hypothetical protein	0.002	0.0117	0.0162
Echinococcus granulosus	agrin	0.002	0.012	0.0165
Echinococcus granulosus	cathepsin l1	0.0018	0.0087	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0137	0.0189
Echinococcus multilocularis	bloom syndrome protein	0.0022	0.0144	0.0144
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0022	0.0137	0.0189
Brugia malayi	photoreceptor-specific nuclear receptor	0.0022	0.0137	0.0189
Brugia malayi	sodium-independent organic anion transporter family protein	0.003	0.0232	0.0321
Entamoeba histolytica	hypothetical protein	0.002	0.0117	0.0817
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.002	0.012	0.2339
Echinococcus multilocularis	expressed protein	0.002	0.012	0.012
Mycobacterium ulcerans	6-phosphofructokinase	0.0115	0.1235	1
Echinococcus multilocularis	regulator of G protein signaling 3	0.002	0.0117	0.0117
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0031	0.0245	1
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.002	0.0117	0.0162
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0115	0.1235	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0018	0.0087	0.0549
Echinococcus granulosus	cathepsin l1	0.0012	0.0018	0.0025
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0022	0.0137	0.0189
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0245	0.1863
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0022	0.0137	0.0189
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0674	0.5385
Echinococcus granulosus	lamin	0.0028	0.0215	0.0297
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0087	0.0568
Echinococcus granulosus	sodium bile acid cotransporter	0.062	0.7222	1
Echinococcus multilocularis	sodium bile acid cotransporter	0.062	0.7222	0.7222
Echinococcus multilocularis	cysteine protease	0.0018	0.0087	0.0087
Loa Loa (eye worm)	hypothetical protein	0.002	0.0117	0.0162
Onchocerca volvulus		0.0018	0.0087	0.0121
Onchocerca volvulus	Cathepsin L homolog	0.0018	0.0087	0.0121
Schistosoma mansoni	RAR-like nuclear receptor	0.0022	0.0137	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0015	0.002
Trypanosoma cruzi	MFS transporter, putative	0.003	0.0232	0.174
Trypanosoma cruzi	major cysteine proteinase, putative	0.0053	0.0504	0.3982
Plasmodium vivax	6-phosphofructokinase, putative	0.0031	0.0245	0.6923
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0018	0.0087	0.0568
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0087	0.0568
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0022	0.0137	0.0189
Brugia malayi	Nuclear hormone receptor-like 1	0.0022	0.0137	0.0189
Leishmania major	cathepsin L-like protease	0.0018	0.0087	0.0549
Echinococcus granulosus	axis inhibition protein axin	0.002	0.0117	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0209	0.0289
Brugia malayi	nuclear receptor NHR-88	0.0022	0.0137	0.0189
Trichomonas vaginalis	phosphofructokinase, putative	0.0115	0.1235	1
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0115	0.1235	1
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0012	0.0015	0.002
Echinococcus granulosus	organic anion transporting polypeptide 30B	0.003	0.0232	0.0321
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0137	0.0189
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0022	0.0137	0.0189
Trichomonas vaginalis	esterase, putative	0.0038	0.0327	0.2543
Leishmania major	cysteine peptidase A (CPA)	0.0018	0.0087	0.0549
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0087	0.0568
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.002	0.0117	0.0162
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.002	0.012	0.0165
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0018	0.0087	0.0568
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0087	0.0568
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0038	0.0327	0.0453
Brugia malayi	cathepsin L-like precursor	0.0012	0.0018	0.0025
Brugia malayi	PXA domain containing protein	0.002	0.0117	0.0162
Echinococcus multilocularis	lamin	0.0028	0.0215	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0327	0.0453
Loa Loa (eye worm)	hypothetical protein	0.002	0.012	0.0165
Schistosoma mansoni	coup transcription factor	0.0022	0.0137	0.0189
Brugia malayi	Phospholipase A2 family protein	0.0099	0.1045	0.1447
Loa Loa (eye worm)	hypothetical protein	0.002	0.0117	0.0162
Onchocerca volvulus	Cathepsin L homolog	0.0018	0.0087	0.0121
Entamoeba histolytica	hypothetical protein	0.002	0.0117	0.0817
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0022	0.0137	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0018	0.0025
Entamoeba histolytica	phosphofructokinase, putative	0.0115	0.1235	1
Echinococcus multilocularis	follistatin	0.002	0.012	0.012
Trichomonas vaginalis	penicillin-binding protein, putative	0.0038	0.0327	0.2543
Echinococcus multilocularis	sodium bile acid cotransporter	0.062	0.7222	0.7222
Echinococcus granulosus	beta-adrenergic receptor kinase	0.002	0.0117	0.0162
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0038	0.0327	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0041	0.0056
Echinococcus multilocularis	regulator of G protein signaling 7	0.002	0.0117	0.0117
Entamoeba histolytica	cysteine proteinase, putative	0.0018	0.0087	0.0568
Onchocerca volvulus		0.0012	0.0018	0.0025
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	0.0137	0.0137
Entamoeba histolytica	hypothetical protein	0.002	0.0117	0.0817
Echinococcus multilocularis	regulator of G protein signaling 7	0.002	0.0117	0.0117
Schistosoma mansoni	regulator of G protein signaling	0.002	0.0117	0.0162
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0022	0.0137	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0215	0.0297
Schistosoma mansoni	lamin	0.0028	0.0215	0.0297
Schistosoma mansoni	organic anion transporter	0.003	0.0232	0.0321
Echinococcus multilocularis	Solute carrier organic anion transporter family	0.003	0.0232	0.0232
Onchocerca volvulus		0.003	0.0232	0.0321
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0215	0.0297
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0087	0.0121
Echinococcus granulosus	regulator of G protein signaling 3	0.002	0.0117	0.0162
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0245	0.1863
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.002	0.0117	0.0162
Loa Loa (eye worm)	agrin synaptic family protein	0.002	0.012	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0468	0.5421	0.7507
Loa Loa (eye worm)	steroid hormone receptor	0.0022	0.0137	0.0189
Schistosoma mansoni	retinoic acid receptor RXR	0.0022	0.0137	0.0189
Echinococcus multilocularis	Regulator of G protein signaling 20	0.002	0.0117	0.0117
Loa Loa (eye worm)	hypothetical protein	0.003	0.0232	0.0321
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0038	0.0327	0.0327
Echinococcus granulosus	beta LACTamase domain containing family member	0.0038	0.0327	0.0453
Echinococcus granulosus	sodium bile acid cotransporter	0.062	0.7222	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0674	0.5385
Schistosoma mansoni	sodium-bile acid cotransporter related	0.0357	0.4108	0.5689
Echinococcus multilocularis	axis inhibition protein axin	0.002	0.0117	0.0117
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0087	0.0568
Brugia malayi	ecdysteroid receptor	0.0022	0.0137	0.0189
Brugia malayi	Sodium Bile acid symporter family protein	0.062	0.7222	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0087	0.0568
Onchocerca volvulus	Putative organic anion transporter	0.003	0.0232	0.0321
Loa Loa (eye worm)	hypothetical protein	0.003	0.0232	0.0321
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0087	0.0568
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0087	0.0121
Leishmania major	cathepsin L-like protease	0.0067	0.0674	0.5385
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0115	0.1235	0.3747
Schistosoma mansoni	hypothetical protein	0.0179	0.1993	0.276
Echinococcus multilocularis	beta adrenergic receptor kinase	0.002	0.0117	0.0117
Onchocerca volvulus		0.003	0.0232	0.0321
Brugia malayi	Steroid receptor seven-up type 2	0.0022	0.0137	0.0189
Brugia malayi	A-kinase anchor protein 10, precursor	0.002	0.0117	0.0162
Loa Loa (eye worm)	beta-lactamase	0.0038	0.0327	0.0453
Entamoeba histolytica	phosphofructokinase, putative	0.0115	0.1235	1
Trichomonas vaginalis	DNA helicase recq1, putative	0.0022	0.0144	0.1039
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0087	0.0121
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0087	0.0121
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0022	0.0137	0.0137
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.0117	0.0817
Onchocerca volvulus		0.0018	0.0087	0.0121
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0022	0.0137	0.0189
Echinococcus multilocularis	ecdysone induced protein 78C	0.0022	0.0137	0.0137
Plasmodium vivax	vivapain-2	0.0018	0.0087	0.1073
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0022	0.0137	0.0189
Schistosoma mansoni	agrin	0.002	0.012	0.0165
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0115	0.1235	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0137	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0137	0.0189
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0674	0.5385
Schistosoma mansoni	lamin	0.0028	0.0215	0.0297
Echinococcus granulosus	ecdysone induced protein 78C	0.0022	0.0137	0.0189
Onchocerca volvulus		0.0018	0.0087	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0137	0.0189
Schistosoma mansoni	thyroid hormone receptor	0.0022	0.0137	0.0189
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.0117	0.0817
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0061	0.0605	0.4816
Onchocerca volvulus		0.0022	0.0137	0.0189
Schistosoma mansoni	cathepsin F (C01 family)	0.0018	0.0087	0.0121
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0327	0.2543
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0087	0.0568
Leishmania major	hypothetical protein, conserved	0.0038	0.0327	0.2529
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0087	0.0121
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0115	0.1235	1
Loa Loa (eye worm)	kazal-type serine protease inhibitor domain-containing protein	0.002	0.012	0.0165
Loa Loa (eye worm)	phosphofructokinase	0.0115	0.1235	0.171
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.0117	0.0817
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.0117	0.0817
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0022	0.0137	0.0189
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0243	0.2749	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0012	0.0015	0.002
Schistosoma mansoni	regulator of G protein signaling	0.002	0.0117	0.0162
Brugia malayi	steroid hormone receptor	0.0022	0.0137	0.0189
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0031	0.0245	0.1863
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0015	0.002
Trypanosoma cruzi	cysteine peptidase, putative	0.0067	0.0674	0.5385
Brugia malayi	nuclear receptor RXR	0.0012	0.0015	0.002
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0087	0.0568
Echinococcus multilocularis	cathepsin L cysteine protease	0.0018	0.0087	0.0087
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0022	0.0137	0.0189
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0087	0.0568
Onchocerca volvulus		0.003	0.0232	0.0321
Brugia malayi	hypothetical protein	0.002	0.0117	0.0162
Schistosoma mansoni	hypothetical protein	0.0179	0.1993	0.276
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.002	0.012	0.2339
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0022	0.0137	0.0189
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.002	0.0117	0.0162
Brugia malayi	sodium-independent organic anion transporter family protein	0.003	0.0232	0.0321
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0022	0.0137	0.0189
Trypanosoma brucei	hypothetical protein, conserved	0.0038	0.0327	0.2529
Echinococcus granulosus	follistatin	0.002	0.012	0.0165
Echinococcus granulosus	Regulator of G protein signaling 20	0.002	0.0117	0.0162
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0022	0.0137	0.0189
Loa Loa (eye worm)	cysteine protease	0.0018	0.0087	0.0121
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0022	0.0137	0.0137
Onchocerca volvulus		0.0018	0.0087	0.0121
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0015	0.002
Schistosoma mansoni	axis inhibition protein axin	0.002	0.0117	0.0162
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0245	0.1863
Onchocerca volvulus	Protein ultraspiracle homolog	0.0022	0.0137	0.0189
Loa Loa (eye worm)	hypothetical protein	0.003	0.0232	0.0321
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0327	0.0453
Plasmodium vivax	6-phosphofructokinase, putative	0.0031	0.0245	0.6923
Echinococcus granulosus	regulator of G protein signaling 7	0.002	0.0117	0.0162
Brugia malayi	hypothetical protein	0.003	0.0232	0.0321
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0091	0.0125
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0245	0.1863
Schistosoma mansoni	thyroid hormone receptor	0.0022	0.0137	0.0189
Onchocerca volvulus		0.0018	0.0087	0.0121
Brugia malayi	Bloom's syndrome protein homolog	0.0022	0.0144	0.02
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0137	0.0189
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0087	0.0568
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0018	0.0087	0.0121
Onchocerca volvulus	Phospholipase A2 homolog	0.0468	0.5421	0.7507
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0031	0.0245	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0022	0.0137	0.0189
Echinococcus granulosus	6 phosphofructokinase	0.0115	0.1235	0.171
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0022	0.0137	0.0189
Echinococcus multilocularis	expressed protein	0.0394	0.4537	0.4537
Trichomonas vaginalis	penicillin-binding protein, putative	0.0038	0.0327	0.2543
Loa Loa (eye worm)	6-phosphofructokinase	0.0115	0.1235	0.171
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0674	0.5385
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.002	0.0117	0.0817
Brugia malayi	beta-lactamase family protein	0.0038	0.0327	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0015	0.002
Echinococcus multilocularis	lamin dm0	0.0028	0.0215	0.0215
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	0.0137	0.0137
Echinococcus granulosus	lamin dm0	0.0028	0.0215	0.0297
Leishmania major	cathepsin L-like protease	0.0018	0.0087	0.0549
Trichomonas vaginalis	phosphofructokinase, putative	0.0115	0.1235	1
Loa Loa (eye worm)	hypothetical protein	0.062	0.7222	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0087	0.0568
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0022	0.0137	0.0137
Onchocerca volvulus		0.002	0.012	0.0165
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.002	0.0117	0.0162
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0012	0.0015	0.002
Schistosoma mansoni	z-protein (S1r protein)	0.002	0.0117	0.0162
Onchocerca volvulus		0.0018	0.0087	0.0121
Schistosoma mansoni	6-phosphofructokinase	0.0115	0.1235	0.171
Schistosoma mansoni	serine/threonine protein kinase	0.002	0.0117	0.0162
Brugia malayi	regulator of G-protein signaling egl-10	0.002	0.0117	0.0162
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0022	0.0137	0.0189
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0058	0.0081
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0018	0.0087	0.0087
Leishmania major	cathepsin L-like protease	0.0018	0.0087	0.0549
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.002	0.012	0.2339
Schistosoma mansoni	serine/threonine protein kinase	0.002	0.0117	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0015	0.002
Brugia malayi	prostaglandin transporter	0.003	0.0232	0.0321
Onchocerca volvulus	Cathepsin F homolog	0.0018	0.0087	0.0121
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0012	0.0015	0.002
Trypanosoma cruzi	cysteine peptidase, putative	0.0067	0.0674	0.5385
Brugia malayi	Cathepsin L-like precursor	0.0012	0.0018	0.0025
Onchocerca volvulus		0.062	0.7222	1
Echinococcus multilocularis	axis inhibition protein axin	0.002	0.0117	0.0117
Loa Loa (eye worm)	hypothetical protein	0.002	0.0117	0.0162
Onchocerca volvulus		0.0028	0.0215	0.0297
Toxoplasma gondii	6-phosphofructokinase	0.0031	0.0245	0.6947
Echinococcus granulosus	expressed protein	0.0394	0.4537	0.6282
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0022	0.0137	0.0189
Trichomonas vaginalis	conserved hypothetical protein	0.002	0.0117	0.0817
Loa Loa (eye worm)	fibroinase	0.0018	0.0087	0.0121
Loa Loa (eye worm)	hypothetical protein	0.003	0.0232	0.0321
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0031	0.0245	0.5
Brugia malayi	beta-lactamase	0.0038	0.0327	0.0453
Onchocerca volvulus		0.0028	0.0215	0.0297
Brugia malayi	nuclear hormone receptor	0.0022	0.0137	0.0189
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.002	0.012	0.2339
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0031	0.0245	0.1863
Brugia malayi	SPARC precursor	0.002	0.012	0.0165
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0087	0.0568
Schistosoma mansoni	axis inhibition protein axin	0.002	0.0117	0.0162
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0327	0.2543
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0038	0.0327	0.0453
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0327	0.2529
Echinococcus multilocularis	cathepsin L cysteine protease	0.0018	0.0087	0.0087
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0087	0.0568
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0327	0.0453
Schistosoma mansoni	blooms syndrome DNA helicase	0.0018	0.0088	0.0122
Brugia malayi	hypothetical protein	0.0012	0.0015	0.002
Echinococcus multilocularis	sodium bile acid cotransporter	0.062	0.7222	0.7222
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0031	0.0245	0.5
Toxoplasma gondii	cathepsin CPL	0.0018	0.0087	0.1143
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0015	0.002
Loa Loa (eye worm)	6-phosphofructokinase	0.0115	0.1235	0.171
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0018	0.0025
Loa Loa (eye worm)	hypothetical protein	0.002	0.012	0.0165
Echinococcus multilocularis	regulator of G protein signaling	0.002	0.0117	0.0117
Plasmodium vivax	vivapain-2	0.0018	0.0087	0.1073
Brugia malayi	secreted modular calcium-binding protein 1	0.002	0.012	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0327	0.0453
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0087	0.0568
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0087	0.0568
Echinococcus granulosus	regulator of G protein signaling 3	0.002	0.0117	0.0162
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0022	0.0137	0.0189
Brugia malayi	6-phosphofructokinase	0.0115	0.1235	0.171
Onchocerca volvulus	Phospholipase A2 homolog	0.0099	0.1045	0.1447
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0022	0.0137	0.0189
Onchocerca volvulus	Putative organic anion transporter	0.003	0.0232	0.0321
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0022	0.0137	0.0189
Loa Loa (eye worm)	hypothetical protein	0.002	0.012	0.0165
Echinococcus granulosus	bloom syndrome protein	0.0022	0.0144	0.02
Brugia malayi	hypothetical protein	0.0012	0.0015	0.002
Echinococcus granulosus	sodium bile acid cotransporter	0.062	0.7222	1
Schistosoma mansoni	serine/threonine protein kinase	0.002	0.0117	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1045	0.1447
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0022	0.0137	0.0189
Schistosoma mansoni	intermediate filament proteins	0.0028	0.0215	0.0297
Leishmania major	cathepsin L-like protease	0.0067	0.0674	0.5385
Onchocerca volvulus		0.0018	0.0087	0.0121
Toxoplasma gondii	ABC1 family protein	0.0038	0.0327	1
Trichomonas vaginalis	DNA helicase recq, putative	0.0022	0.0144	0.1039
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0245	0.1863
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0674	0.5385
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0022	0.0137	0.0189
Entamoeba histolytica	recQ family helicase, putative	0.0012	0.002	0.002
Toxoplasma gondii	phosphofructokinase PFKII	0.0031	0.0245	0.6947
Loa Loa (eye worm)	RecQ helicase	0.0022	0.0144	0.02
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0018	0.0087	0.0121
Echinococcus multilocularis	geminin	0.0179	0.1993	0.1993
Trichomonas vaginalis	phosphofructokinase, putative	0.0115	0.1235	1
Schistosoma mansoni	sodium-bile acid cotransporter related	0.062	0.7222	1
Echinococcus granulosus	FTZ F1 alpha	0.0022	0.0137	0.0189
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.002	0.012	0.0165
Echinococcus multilocularis	agrin	0.002	0.012	0.012
Brugia malayi	6-phosphofructokinase	0.0115	0.1235	0.171
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0327	0.0453
Toxoplasma gondii	protease inhibitor PI2	0.002	0.012	0.2339
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0022	0.0137	0.0189
Brugia malayi	beta-lactamase family protein	0.0038	0.0327	0.0453
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0022	0.0137	0.0189
Brugia malayi	intermediate filament protein	0.0028	0.0215	0.0297
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0087	0.0568
Entamoeba histolytica	cysteine proteinase, putative	0.0018	0.0087	0.0568
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0018	0.0087	0.0121
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.0674	0.5385
Schistosoma mansoni	cathepsin F (C01 family)	0.0018	0.0087	0.0121
Trypanosoma cruzi	cruzipain precursor, putative	0.0067	0.0674	0.5385

Activities

Activity type	Activity value	Assay description	Source	Reference
Body weight loss (functional)	= -16.4 %	In vivo activity tested against C3H mice bearing mammary adenocarcinoma -17/ADR tumor measured as body weight loss at 162 mg/kg (po)	ChEMBL.	11356111
Body weight loss (functional)	= -16.4 %	In vivo activity tested against C3H mice bearing mammary adenocarcinoma -17/ADR tumor measured as body weight loss at 162 mg/kg (po)	ChEMBL.	11356111
Body weight loss (functional)	= -15 %	In vivo activity tested against C3H mice bearing panc-03 murine tumor measured as body weight loss at 324 mg/kg (po)	ChEMBL.	11356111
Body weight loss (functional)	= -15 %	In vivo activity tested against C3H mice bearing panc-03 murine tumor measured as body weight loss at 324 mg/kg (po)	ChEMBL.	11356111
Body weight loss (functional)	= -6.2 %	In vivo activity tested against C3H mice bearing mammary adenocarcinoma -16c/ADR tumor measured as body weight loss at 164 mg/kg (po)	ChEMBL.	11356111
Body weight loss (functional)	= -6.2 %	In vivo activity tested against C3H mice bearing mammary adenocarcinoma -16c/ADR tumor measured as body weight loss at 164 mg/kg (po)	ChEMBL.	11356111
Body weight loss (functional)	= -1.5 %	In vivo activity tested against C3H mice bearing mammary adenocarcinoma -17/ADR tumor measured as body weight loss at 99 mg/kg (po)	ChEMBL.	11356111
Body weight loss (functional)	= -1.5 %	In vivo activity tested against C3H mice bearing mammary adenocarcinoma -17/ADR tumor measured as body weight loss at 99 mg/kg (po)	ChEMBL.	11356111
Body weight loss (functional)	= 5 %	In vivo activity tested against C3H mice bearing panc-03 murine tumor measured as body weight loss at 180 mg/kg (po)	ChEMBL.	11356111
Body weight loss (functional)	= 5 %	In vivo activity tested against C3H mice bearing panc-03 murine tumor measured as body weight loss at 180 mg/kg (po)	ChEMBL.	11356111
Log kill (functional)	= 0.64	In vivo activity tested against C3H mice bearing panc-03 murine tumor measured as log Kill value was based on tumors that grew at 180 mg/kg (po)	ChEMBL.	11356111
Log kill (functional)	= 1.2	In vivo activity tested against C3H mice bearing mammary adenocarcinoma -17/ADR tumor measured as log Kill value was based on tumors that grew at 99 mg/kg (po)	ChEMBL.	11356111
Log kill (functional)	= 1.5	In vivo activity tested against C3H mice bearing mammary adenocarcinoma -17/ADR tumor measured as log Kill value was based on tumors that grew at 162 mg/kg (po)	ChEMBL.	11356111
Log kill (functional)	= 1.7	In vivo activity tested against C3H mice bearing mammary adenocarcinoma -16c/ADR tumor measured as log Kill value was based on tumors that grew at 164 mg/kg (po)	ChEMBL.	11356111
Log kill (functional)	= 3	In vivo activity tested against C3H mice bearing panc-03 murine tumor measured as log Kill value was based on tumors that grew at 324 mg/kg (po)	ChEMBL.	11356111
T/C (functional)	= 0 %	In vivo activity tested against C3H mice bearing panc-03 murine tumor measured as % treated/control calculated at 324 mg/kg (po)	ChEMBL.	11356111
T/C (functional)	= 0 %	In vivo activity tested against C3H mice bearing panc-03 murine tumor measured as % treated/control calculated at 324 mg/kg (po)	ChEMBL.	11356111
T/C (functional)	= 7 %	In vivo activity tested against C3H mice bearing mammary adenocarcinoma -17/ADR tumor measured as % treated/control calculated at 162 mg/kg (po)	ChEMBL.	11356111
T/C (functional)	= 7 %	In vivo activity tested against C3H mice bearing mammary adenocarcinoma -17/ADR tumor measured as % treated/control calculated at 162 mg/kg (po)	ChEMBL.	11356111
T/C (functional)	= 7.5 %	In vivo activity tested against C3H mice bearing mammary adenocarcinoma -16c/ADR tumor measured as % treated/control calculated at 164 mg/kg (po)	ChEMBL.	11356111
T/C (functional)	= 7.5 %	In vivo activity tested against C3H mice bearing mammary adenocarcinoma -16c/ADR tumor measured as % treated/control calculated at 164 mg/kg (po)	ChEMBL.	11356111
T/C (functional)	= 13 %	In vivo activity tested against C3H mice bearing mammary adenocarcinoma -17/ADR tumor measured as % treated/control calculated at 99 mg/kg (po)	ChEMBL.	11356111
T/C (functional)	= 13 %	In vivo activity tested against C3H mice bearing mammary adenocarcinoma -17/ADR tumor measured as % treated/control calculated at 99 mg/kg (po)	ChEMBL.	11356111
T/C (functional)	= 33 %	In vivo activity tested against C3H mice bearing panc-03 murine tumor measured as % treated/control calculated at 180 mg/kg (po)	ChEMBL.	11356111
T/C (functional)	= 33 %	In vivo activity tested against C3H mice bearing panc-03 murine tumor measured as % treated/control calculated at 180 mg/kg (po)	ChEMBL.	11356111

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL52062
PubChem: 11793840

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 74434