Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | calcium channel, voltage-dependent, N type, alpha 1B subunit | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0289 | 0.1444 | 0.1444 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0289 | 0.1444 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0289 | 0.1444 | 0.1085 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1712 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.1444 | 0.1085 |
Loa Loa (eye worm) | hypothetical protein | 0.1712 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0289 | 0.1444 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0289 | 0.1444 | 0.1085 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0289 | 0.1444 | 0.1444 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0289 | 0.1444 | 0.1085 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0289 | 0.1444 | 0.5 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0116 | 0.0402 | 0.0402 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0116 | 0.0402 | 0.0402 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.1444 | 0.1085 |
Loa Loa (eye worm) | carboxylesterase | 0.0289 | 0.1444 | 0.1085 |
Onchocerca volvulus | 0.0289 | 0.1444 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0289 | 0.1444 | 0.1085 |
Echinococcus granulosus | carboxylesterase 5A | 0.1712 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.1712 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0289 | 0.1444 | 0.5 |
Echinococcus granulosus | voltage dependent L type calcium channel subunit|voltage dependent calcium channel | 0.0116 | 0.0402 | 0.0402 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0116 | 0.0402 | 0.0402 |
Onchocerca volvulus | 0.0289 | 0.1444 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.1712 | 1 | 1 |
Onchocerca volvulus | 0.0289 | 0.1444 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.1712 | 1 | 1 |
Onchocerca volvulus | 0.0289 | 0.1444 | 0.5 | |
Echinococcus multilocularis | neuroligin | 0.0289 | 0.1444 | 0.1444 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0116 | 0.0402 | 0.0402 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1712 | 1 | 1 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0289 | 0.1444 | 0.1444 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0289 | 0.1444 | 0.1085 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0116 | 0.0402 | 0.0402 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.1444 | 0.1085 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 | 0.0116 | 0.0402 | 0.0402 |
Loa Loa (eye worm) | hypothetical protein | 0.1712 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.1444 | 0.1085 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0289 | 0.1444 | 0.1444 |
Loa Loa (eye worm) | carboxylesterase | 0.0289 | 0.1444 | 0.1085 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.1444 | 0.1085 |
Onchocerca volvulus | 0.0289 | 0.1444 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.1444 | 0.1085 |
Brugia malayi | hypothetical protein | 0.0289 | 0.1444 | 0.1085 |
Trypanosoma cruzi | Voltage-dependent calcium channel subunit, putative | 0.0071 | 0.0129 | 0.5 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0289 | 0.1444 | 0.1085 |
Echinococcus granulosus | neuroligin | 0.0289 | 0.1444 | 0.1444 |
Brugia malayi | Carboxylesterase family protein | 0.0289 | 0.1444 | 0.1085 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu | 0.0116 | 0.0402 | 0.0402 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.1444 | 0.1085 |
Brugia malayi | Carboxylesterase family protein | 0.0289 | 0.1444 | 0.1085 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0116 | 0.0402 | 0.0402 |
Brugia malayi | Carboxylesterase family protein | 0.1712 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0289 | 0.1444 | 0.5 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0289 | 0.1444 | 0.1444 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0289 | 0.1444 | 0.1085 |
Loa Loa (eye worm) | carboxylesterase | 0.1712 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.1712 | 1 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.0289 | 0.1444 | 0.1085 |
Schistosoma mansoni | gliotactin | 0.0289 | 0.1444 | 0.1085 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0289 | 0.1444 | 0.1444 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1712 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0289 | 0.1444 | 0.5 |
Trypanosoma brucei | Voltage-dependent calcium channel subunit, putative | 0.0071 | 0.0129 | 0.5 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0116 | 0.0402 | 0.0402 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1 uM | In vitro antagonism of N-type voltage sensitive calcium channel in IMR-32 assay using fluorescent [Ca2+] indicator Indo-11 in the presence of 5 microM nitrendipine | ChEMBL. | 10406647 |
IC50 (functional) | = 1 uM | In vitro antagonism of N-type voltage sensitive calcium channel in IMR-32 assay using fluorescent [Ca2+] indicator Indo-11 in the presence of 5 microM nitrendipine | ChEMBL. | 10406647 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.