Detailed information for compound 74462

Basic information

Technical information
  • TDR Targets ID: 74462
  • Name: 5-[3-fluoro-4-[3-(4-phenoxy-2-propylphenoxy)p ropoxy]phenyl]-1,3-thiazolidine-2,4-dione
  • MW: 495.562 | Formula: C27H26FNO5S
  • H donors: 1 H acceptors: 2 LogP: 6.73 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCc1cc(ccc1OCCCOc1ccc(cc1F)C1SC(=O)NC1=O)Oc1ccccc1
  • InChi: 1S/C27H26FNO5S/c1-2-7-18-16-21(34-20-8-4-3-5-9-20)11-13-23(18)32-14-6-15-33-24-12-10-19(17-22(24)28)25-26(30)29-27(31)35-25/h3-5,8-13,16-17,25H,2,6-7,14-15H2,1H3,(H,29,30,31)
  • InChiKey: JQTFXOHYNAIVNX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-[3-fluoro-4-[3-(4-phenoxy-2-propyl-phenoxy)propoxy]phenyl]thiazolidine-2,4-dione
  • 5-[3-fluoro-4-[3-(4-phenoxy-2-propylphenoxy)propoxy]phenyl]thiazolidine-2,4-dione
  • 5-[3-fluoro-4-[3-(4-phenoxy-2-propyl-phenoxy)propoxy]phenyl]-1,3-thiazolidine-2,4-dione
  • 5-[3-fluoro-4-[3-(4-phenoxy-2-propyl-phenoxy)propoxy]phenyl]thiazolidine-2,4-quinone
  • 5-[3-fluoro-4-[3-[4-(phenoxy)-2-propylphenoxy]propoxy]phenyl]-1,3-thiazolidine-2,4-dione
  • 5-[3-fluoro-4-[3-[4-(phenoxy)-2-propyl-phenoxy]propoxy]phenyl]thiazolidine-2,4-dione
  • 5-[3-fluoro-4-[3-[4-(phenoxy)-2-propylphenoxy]propoxy]phenyl]thiazolidine-2,4-dione
  • 5-[3-fluoro-4-[3-[4-(phenoxy)-2-propyl-phenoxy]propoxy]phenyl]thiazolidine-2,4-quinone
  • 5-[3-fluoro-4-[3-[4-(phenoxy)-2-propyl-phenoxy]propoxy]phenyl]-1,3-thiazolidine-2,4-dione

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens peroxisome proliferator-activated receptor alpha Starlite/ChEMBL References
Homo sapiens peroxisome proliferator-activated receptor gamma Starlite/ChEMBL References
Homo sapiens peroxisome proliferator-activated receptor delta Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni nuclear hormone receptor superfamily protein-related Get druggable targets OG5_137778 All targets in OG5_137778
Schistosoma japonicum IPR008946,Nuclear receptor, ligand-binding,domain-containing Get druggable targets OG5_137778 All targets in OG5_137778
Schistosoma japonicum ko:K08701 nuclear receptor, subfamily 1, invertebrate, putative Get druggable targets OG5_137778 All targets in OG5_137778
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi ecdysteroid receptor peroxisome proliferator-activated receptor delta 441 aa 369 aa 24.7 %
Brugia malayi ecdysteroid receptor peroxisome proliferator-activated receptor alpha 468 aa 397 aa 25.4 %
Echinococcus granulosus ecdysone induced protein 78C peroxisome proliferator-activated receptor gamma 477 aa 447 aa 28.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Putative organic anion transporter 0.0033 0.0239 0.0396
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0125 0.0125
Brugia malayi 6-phosphofructokinase 0.0127 0.1245 0.2674
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0125 0.0218
Echinococcus multilocularis lamin 0.0032 0.0222 0.0222
Brugia malayi nuclear hormone receptor family member odr-7 0.0027 0.017 0.0318
Onchocerca volvulus 0.0033 0.0239 0.0396
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0252 0.1863
Loa Loa (eye worm) nuclear hormone receptor 0.0027 0.017 0.0308
Onchocerca volvulus Cathepsin L homolog 0.002 0.0095 0.0128
Loa Loa (eye worm) hypothetical protein 0.0057 0.0489 0.0896
Trypanosoma brucei multidrug resistance-associated protein, putative 0.002 0.0103 0.0621
Onchocerca volvulus 0.002 0.0095 0.0128
Loa Loa (eye worm) fibroinase 0.002 0.0095 0.0168
Loa Loa (eye worm) hypothetical protein 0.0023 0.0127 0.0228
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0125 0.0125
Trichomonas vaginalis phosphofructokinase, putative 0.0127 0.1241 1
Trichomonas vaginalis abcb9, putative 0.0024 0.014 0.094
Brugia malayi hypothetical protein 0.003 0.0205 0.0393
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0027 0.017 0.017
Echinococcus multilocularis ecdysone induced protein 78C 0.0057 0.0489 0.0489
Echinococcus granulosus Regulator of G protein signaling 20 0.0022 0.0125 0.0272
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0125 0.0817
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0252 0.1863
Trypanosoma brucei p-glycoprotein 0.002 0.0103 0.0621
Loa Loa (eye worm) hypothetical protein 0.0027 0.017 0.0308
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0125 0.0216
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0057 0.0489 0.0489
Loa Loa (eye worm) hypothetical protein 0.0032 0.0222 0.0403
Onchocerca volvulus Cathepsin F homolog 0.002 0.0095 0.0128
Entamoeba histolytica P-glycoprotein-1 0.0024 0.014 0.094
Echinococcus granulosus ecdysone induced protein 78C 0.0057 0.0489 0.1067
Trypanosoma cruzi cruzipain precursor, putative 0.0075 0.0681 0.5489
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0681 0.5385
Loa Loa (eye worm) hypothetical protein 0.0109 0.1052 0.1934
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.014 0.094
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0681 0.5385
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0023 0.0127 0.0222
Onchocerca volvulus 0.002 0.0095 0.0128
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0057 0.0489 0.0896
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0152 0.1039
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0057 0.0489 0.0896
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0205 0.039
Brugia malayi Cathepsin L-like precursor 0.002 0.0095 0.0151
Loa Loa (eye worm) hypothetical protein 0.0027 0.017 0.0308
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.014 0.094
Mycobacterium tuberculosis Conserved protein 0.0042 0.0335 0.0746
Schistosoma mansoni RAR-like nuclear receptor 0.0057 0.0489 0.101
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0057 0.0489 0.1017
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0095 0.0568
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0057 0.0489 0.1067
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0125 0.0216
Onchocerca volvulus Phospholipase A2 homolog 0.0519 0.5425 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0057 0.0489 0.101
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.012 0.1587
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0335 0.2543
Entamoeba histolytica hypothetical protein 0.0022 0.0125 0.0817
Brugia malayi steroid hormone receptor 0.0057 0.0489 0.1017
Schistosoma mansoni nuclear receptor 0.0027 0.017 0.0316
Entamoeba histolytica phosphofructokinase, putative 0.0127 0.1241 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0681 0.5385
Brugia malayi intermediate filament protein 0.0032 0.0222 0.0431
Brugia malayi hypothetical protein 0.0033 0.0239 0.0468
Loa Loa (eye worm) hypothetical protein 0.003 0.0205 0.0371
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.014 0.094
Leishmania major cathepsin L-like protease 0.002 0.0095 0.0549
Loa Loa (eye worm) hypothetical protein 0.0033 0.0239 0.0434
Brugia malayi tailless protein 0.0027 0.017 0.0318
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0022 0.0125 0.0218
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0096 0.0153
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0024 0.014 0.094
Brugia malayi nuclear receptor RXR 0.0027 0.017 0.0318
Loa Loa (eye worm) hypothetical protein 0.0022 0.0125 0.0224
Schistosoma mansoni lamin 0.0032 0.0222 0.0428
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0095 0.0568
Loa Loa (eye worm) hypothetical protein 0.0023 0.0127 0.0228
Schistosoma mansoni multidrug resistance protein 0.0024 0.014 0.0249
Echinococcus granulosus multidrug resistance protein 1 0.0024 0.014 0.0305
Schistosoma mansoni organic anion transporter 0.0033 0.0239 0.0465
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.0252 1
Brugia malayi nuclear hormone receptor 0.0027 0.017 0.0318
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0095 0.0568
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0033 0.0239 0.0239
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0057 0.0489 0.101
Brugia malayi regulator of G-protein signaling egl-10 0.0022 0.0125 0.0218
Schistosoma mansoni thyroid hormone receptor 0.0057 0.0489 0.101
Echinococcus granulosus agrin 0.0023 0.0127 0.0277
Loa Loa (eye worm) hypothetical protein 0.0042 0.0335 0.0611
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0057 0.0489 0.1017
Echinococcus granulosus FTZ F1 alpha 0.0057 0.0489 0.1067
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0071
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.014 0.094
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0095 0.0568
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0335 0.2697
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0252 0.1863
Loa Loa (eye worm) hypothetical protein 0.0013 0.0025 0.004
Schistosoma mansoni nuclear hormone receptor 0.0027 0.017 0.0316
Loa Loa (eye worm) hypothetical protein 0.0057 0.0489 0.0896
Toxoplasma gondii protease inhibitor PI2 0.0023 0.0127 0.2339
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0023 0.0127 0.0228
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0057 0.0489 0.101
Brugia malayi hypothetical protein 0.0027 0.017 0.0318
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.014 0.094
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.014 0.094
Brugia malayi hypothetical protein 0.0022 0.0125 0.0218
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.014 0.094
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0125 0.0216
Loa Loa (eye worm) hypothetical protein 0.0033 0.0239 0.0434
Onchocerca volvulus 0.002 0.0095 0.0128
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0057 0.0489 0.0489
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0095 0.0568
Schistosoma mansoni hypothetical protein 0.0198 0.1999 0.43
Echinococcus granulosus Nuclear hormone receptor HR96 0.0027 0.017 0.0371
Brugia malayi Cathepsin L-like precursor 0.002 0.0095 0.0151
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0024 0.014 0.014
Trichomonas vaginalis phosphofructokinase, putative 0.0127 0.1241 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.014 0.094
Onchocerca volvulus 0.0032 0.0222 0.0364
Loa Loa (eye worm) hypothetical protein 0.0023 0.0127 0.0228
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0095 0.0568
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.0252 0.6923
Mycobacterium tuberculosis Probable hydrolase 0.0042 0.0335 0.0746
Loa Loa (eye worm) ctsf protein 0.002 0.0095 0.0168
Leishmania major ATP-dependent phosphofructokinase 0.0127 0.1241 1
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0033 0.0239 0.0434
Brugia malayi ABC transporter family protein 0.0024 0.014 0.025
Mycobacterium tuberculosis Probable esterase LipL 0.0042 0.0335 0.0746
Onchocerca volvulus 0.0033 0.0239 0.0396
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0681 0.5385
Schistosoma mansoni multidrug resistance protein 0.0024 0.014 0.0249
Brugia malayi beta-lactamase family protein 0.0042 0.0335 0.0678
Loa Loa (eye worm) hypothetical protein 0.0027 0.017 0.0308
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0057 0.0489 0.0489
Schistosoma mansoni nuclear hormone receptor 0.0057 0.0489 0.101
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0095 0.0761
Toxoplasma gondii cathepsin CPL 0.002 0.0095 0.1143
Echinococcus granulosus lamin 0.0032 0.0222 0.0484
Onchocerca volvulus 0.0027 0.017 0.0268
Entamoeba histolytica P-glycoprotein 5, putative 0.0024 0.014 0.094
Loa Loa (eye worm) hypothetical protein 0.0033 0.0239 0.0434
Echinococcus multilocularis sodium bile acid cotransporter 0.0441 0.4586 0.4586
Entamoeba histolytica ATP-binding cassette protein, putative 0.002 0.0103 0.0639
Echinococcus multilocularis expressed protein 0.0436 0.4541 0.4541
Loa Loa (eye worm) PXA domain-containing protein 0.0022 0.0125 0.0224
Brugia malayi photoreceptor-specific nuclear receptor 0.0057 0.0489 0.1017
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.014 0.094
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0057 0.0489 0.1017
Loa Loa (eye worm) hypothetical protein 0.0023 0.0136 0.0244
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.0222 0.0403
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.017 0.0371
Echinococcus multilocularis agrin 0.0023 0.0127 0.0127
Onchocerca volvulus 0.0023 0.0127 0.0188
Toxoplasma gondii ABC1 family protein 0.0042 0.0335 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0335 0.0674
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0057 0.0489 0.1017
Brugia malayi ecdysteroid receptor 0.0057 0.0489 0.1017
Brugia malayi beta-lactamase family protein 0.0042 0.0335 0.0678
Onchocerca volvulus Cathepsin L homolog 0.002 0.0095 0.0128
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.0252 0.6923
Echinococcus granulosus sodium bile acid cotransporter 0.0441 0.4586 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.017 0.0308
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0095 0.0568
Brugia malayi conserved hypotetical protein 0.0027 0.017 0.0318
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0125 0.0218
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.014 0.094
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0057 0.0489 0.1067
Brugia malayi A-kinase anchor protein 10, precursor 0.0022 0.0125 0.0218
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.002 0.0103 0.0621
Trichomonas vaginalis ABC transporter, putative 0.0024 0.014 0.094
Schistosoma mansoni coup transcription factor 0.0057 0.0489 0.101
Echinococcus granulosus nuclear receptor nhr 48 0.0027 0.017 0.0371
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0057 0.0489 0.1017
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0057 0.0489 0.0489
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0027 0.017 0.0316
Brugia malayi PXA domain containing protein 0.0022 0.0125 0.0218
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.003 0.0205 0.039
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0127 0.1241 1
Echinococcus granulosus sodium bile acid cotransporter 0.0441 0.4586 1
Entamoeba histolytica P-glycoprotein-2 0.0024 0.014 0.094
Trypanosoma cruzi cysteine peptidase, putative 0.0075 0.0681 0.5489
Loa Loa (eye worm) hypothetical protein 0.0033 0.0239 0.0434
Loa Loa (eye worm) hypothetical protein 0.0057 0.0489 0.0896
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0443 0.4615 1
Mycobacterium tuberculosis Probable lipase LipE 0.0042 0.0335 0.0746
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0335 1
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0125 0.0272
Loa Loa (eye worm) hypothetical protein 0.0033 0.0239 0.0434
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0023 0.0136 0.0297
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0335 0.2543
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0095 0.0568
Entamoeba histolytica P-glycoprotein-2, putative 0.0024 0.014 0.094
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.014 0.094
Echinococcus granulosus cathepsin l1 0.0013 0.0025 0.0056
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0095 0.0568
Loa Loa (eye worm) hypothetical protein 0.002 0.0103 0.0184
Echinococcus granulosus multidrug resistance protein 1 0.0024 0.014 0.0305
Trypanosoma cruzi major cysteine proteinase, putative 0.0059 0.0511 0.4117
Entamoeba histolytica ATP-binding cassette protein, putative 0.002 0.0103 0.0639
Echinococcus multilocularis FTZ F1 alpha 0.0057 0.0489 0.0489
Brugia malayi phosphofructokinase 0.0127 0.1241 0.2666
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0095 0.015
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.0252 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0027 0.017 0.0371
Loa Loa (eye worm) hypothetical protein 0.002 0.01 0.0177
Loa Loa (eye worm) hypothetical protein 0.0042 0.0335 0.0611
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0335 0.2697
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0057 0.0489 0.1067
Loa Loa (eye worm) hypothetical protein 0.003 0.0205 0.0371
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0127 0.1241 1
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0125 0.0817
Loa Loa (eye worm) hypothetical protein 0.003 0.0205 0.0371
Brugia malayi nuclear receptor RXR 0.003 0.0205 0.0393
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0335 0.2543
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0125 0.0272
Trypanosoma brucei multidrug resistance-associated protein, putative 0.002 0.0103 0.0621
Brugia malayi PXA domain containing protein 0.0022 0.0125 0.0218
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0024 0.014 0.094
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0095 0.0568
Brugia malayi hypothetical protein 0.0027 0.017 0.0318
Onchocerca volvulus 0.0057 0.0489 0.0859
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0057 0.0489 0.1017
Schistosoma mansoni agrin 0.0023 0.0127 0.0221
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0095 0.0095
Brugia malayi nuclear receptor NHR-67 0.0027 0.017 0.0318
Loa Loa (eye worm) hypothetical protein 0.0015 0.0042 0.0071
Loa Loa (eye worm) hypothetical protein 0.0027 0.017 0.0308
Loa Loa (eye worm) hypothetical protein 0.0057 0.0489 0.0896
Brugia malayi nuclear hormone receptor family member nhr-6 0.0027 0.017 0.0318
Loa Loa (eye worm) intermediate filament protein 0.0032 0.0222 0.0403
Brugia malayi Intermediate filament tail domain containing protein 0.0032 0.0222 0.0431
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0022 0.0125 0.0817
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0335 0.2529
Brugia malayi hypothetical protein 0.0022 0.0125 0.0218
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.014 0.094
Onchocerca volvulus Protein ultraspiracle homolog 0.0057 0.0489 0.0859
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0023 0.0127 0.2339
Loa Loa (eye worm) steroid hormone receptor 0.0057 0.0489 0.0896
Brugia malayi nuclear hormone receptor 0.0057 0.0489 0.1017
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0057 0.0489 0.101
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0057 0.0489 0.101
Loa Loa (eye worm) hypothetical protein 0.0057 0.0489 0.0896
Loa Loa (eye worm) hypothetical protein 0.002 0.0098 0.0174
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0034 0.0252 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0042 0.0335 0.0746
Schistosoma mansoni follistatin 0.0023 0.0127 0.0221
Onchocerca volvulus 0.0033 0.0239 0.0396
Onchocerca volvulus 0.002 0.0095 0.0128
Echinococcus multilocularis nuclear receptor nhr 48 0.0027 0.017 0.017
Loa Loa (eye worm) nuclear receptor NHR-67 0.0027 0.017 0.0308
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0022 0.0125 0.0224
Entamoeba histolytica ATP-binding cassette protein, putative 0.002 0.0103 0.0639
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0095 0.0095
Echinococcus multilocularis bloom syndrome protein 0.0025 0.0152 0.0152
Entamoeba histolytica ABC transporter, putative 0.002 0.0103 0.0639
Brugia malayi secreted modular calcium-binding protein 1 0.0023 0.0127 0.0222
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.014 0.094
Giardia lamblia ABC transporter, putative 0.002 0.0103 0.0236
Leishmania major ABC-thiol transporter 0.002 0.0103 0.0621
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0095 0.0168
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.002 0.0103 0.0184
Echinococcus multilocularis expressed protein 0.0023 0.0127 0.0127
Loa Loa (eye worm) 6-phosphofructokinase 0.0127 0.1241 0.2283
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0095 0.0568
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0057 0.0489 0.0489
Echinococcus granulosus Nuclear hormone receptor HR96 0.0027 0.017 0.0371
Echinococcus multilocularis geminin 0.0198 0.1999 0.1999
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0681 0.5385
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0034 0.0252 0.6947
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0023 0.0127 0.0222
Brugia malayi Cathepsin L-like precursor 0.002 0.0095 0.0151
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0681 0.5385
Brugia malayi hypothetical protein 0.0033 0.0239 0.0468
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0023 0.0127 0.0222
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0125 0.0125
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0057 0.0489 0.0896
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0057 0.0489 0.0489
Loa Loa (eye worm) hypothetical protein 0.0027 0.017 0.0308
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.003 0.0205 0.0205
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0335 0.0674
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0022 0.0125 0.0224
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.017 0.017
Brugia malayi Cathepsin L-like precursor 0.002 0.0095 0.0151
Loa Loa (eye worm) hypothetical protein 0.0027 0.017 0.0308
Echinococcus multilocularis 6 phosphofructokinase 0.0127 0.1241 0.1241
Loa Loa (eye worm) hypothetical protein 0.0022 0.0125 0.0224
Echinococcus granulosus geminin 0.0198 0.1999 0.4359
Echinococcus multilocularis cysteine protease 0.002 0.0095 0.0095
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0024 0.014 0.0305
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0095 0.0568
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.0335 0.0611
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0022 0.0125 0.0216
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0057 0.0489 0.0896
Echinococcus granulosus sodium bile acid cotransporter 0.0441 0.4586 1
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0125 0.0817
Leishmania major cysteine peptidase A (CPA) 0.002 0.0095 0.0549
Schistosoma mansoni multidrug resistance protein 0.002 0.0103 0.0169
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0057 0.0489 0.0896
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0335 0.2543
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0027 0.017 0.0308
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0095 0.0206
Schistosoma mansoni 6-phosphofructokinase 0.0127 0.1241 0.2649
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0125 0.0216
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0681 0.5385
Echinococcus multilocularis multidrug resistance protein 1 0.0024 0.014 0.014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0681 0.5385
Schistosoma mansoni multidrug resistance protein 0.0024 0.014 0.0249
Schistosoma mansoni smdr2 0.0024 0.014 0.0249
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.002 0.0103 0.0621
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0125 0.0272
Trichomonas vaginalis abcb9, putative 0.0024 0.014 0.094
Entamoeba histolytica phosphofructokinase, putative 0.0127 0.1241 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0095 0.0568
Loa Loa (eye worm) 6-phosphofructokinase 0.0127 0.1241 0.2283
Loa Loa (eye worm) hypothetical protein 0.0031 0.0216 0.0392
Onchocerca volvulus 0.0024 0.014 0.0212
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0057 0.0489 0.1017
Echinococcus multilocularis multidrug resistance protein 1 0.0024 0.014 0.014
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0095 0.0568
Echinococcus multilocularis sodium bile acid cotransporter 0.0441 0.4586 0.4586
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0095 0.0568
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0125 0.0125
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0095 0.0568
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0034 0.0252 0.1863
Loa Loa (eye worm) hypothetical protein 0.003 0.0205 0.0371
Onchocerca volvulus Putative organic anion transporter 0.0033 0.0239 0.0396
Echinococcus multilocularis thyroid hormone receptor alpha 0.0057 0.0489 0.0489
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.002 0.0103 0.0832
Toxoplasma gondii phosphofructokinase PFKII 0.0034 0.0252 0.6947
Mycobacterium tuberculosis Probable lipase LipD 0.0042 0.0335 0.0746
Onchocerca volvulus Putative organic anion transporter 0.0033 0.0239 0.0396
Schistosoma mansoni sodium-bile acid cotransporter related 0.0441 0.4586 0.9937
Echinococcus granulosus beta-adrenergic receptor kinase 0.0022 0.0125 0.0272
Echinococcus multilocularis Regulator of G protein signaling 20 0.0022 0.0125 0.0125
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0205 0.0393
Loa Loa (eye worm) RGS-3 protein 0.0022 0.0125 0.0224
Loa Loa (eye worm) hypothetical protein 0.0042 0.0335 0.0611
Echinococcus granulosus thyroid hormone receptor alpha 0.0027 0.017 0.0371
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.002 0.0103 0.0621
Brugia malayi ABC transporter transmembrane region family protein 0.002 0.0103 0.017
Trichomonas vaginalis abcb9, putative 0.0024 0.014 0.094
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0057 0.0489 0.1017
Echinococcus granulosus expressed protein 0.0436 0.4541 0.9902
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0034 0.0252 0.1863
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0095 0.0568
Echinococcus multilocularis ATP binding cassette sub family B 0.0023 0.0136 0.0136
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0022 0.0125 0.0125
Schistosoma mansoni steroid hormone receptor ad4bp 0.0057 0.0489 0.101
Onchocerca volvulus 0.0042 0.0335 0.0573
Giardia lamblia Multidrug resistance-associated protein 1 0.002 0.0103 0.0236
Brugia malayi Nuclear hormone receptor E75 0.0027 0.017 0.0318
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.002 0.0103 0.0832
Loa Loa (eye worm) hypothetical protein 0.0027 0.017 0.0308
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.0335 0.0678
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0048 0.0048
Schistosoma mansoni multidrug resistance protein 0.002 0.0103 0.0169
Brugia malayi multidrug resistance protein 3 0.0024 0.014 0.025
Loa Loa (eye worm) hypothetical protein 0.0024 0.014 0.0251
Echinococcus granulosus multidrug resistance protein 1 0.0024 0.014 0.0305
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0095 0.0206
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0095 0.0168
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0095 0.0568
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0057 0.0489 0.1067
Brugia malayi Nuclear hormone receptor-like 1 0.0057 0.0489 0.1017
Loa Loa (eye worm) hypothetical protein 0.0441 0.4586 0.8453
Echinococcus granulosus multidrug resistance associated protein 7 0.002 0.0103 0.0225
Schistosoma mansoni sodium-bile acid cotransporter 0.0145 0.1429 0.3058
Schistosoma mansoni multidrug resistance protein 0.002 0.0103 0.0169
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0014 0.004 0.012
Loa Loa (eye worm) hypothetical protein 0.0027 0.017 0.0308
Entamoeba histolytica phosphofructokinase, putative 0.0127 0.1241 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0024 0.014 0.0305
Loa Loa (eye worm) hypothetical protein 0.0042 0.0335 0.0611
Echinococcus multilocularis sodium bile acid cotransporter 0.0441 0.4586 0.4586
Schistosoma mansoni z-protein (S1r protein) 0.0022 0.0125 0.0216
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0024 0.014 0.014
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.002 0.0103 0.0621
Onchocerca volvulus 0.002 0.0095 0.0128
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0125 0.0216
Loa Loa (eye worm) phosphofructokinase 0.0127 0.1241 0.2283
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0125 0.0817
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0125 0.0272
Loa Loa (eye worm) hypothetical protein 0.0022 0.0125 0.0224
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.0152 0.0277
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0024 0.014 0.0305
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0095 0.0568
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.014 0.094
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0024 0.014 0.094
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0125 0.0216
Loa Loa (eye worm) cysteine protease 0.002 0.0095 0.0168
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0057 0.0489 0.1067
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0027 0.017 0.0318
Entamoeba histolytica hypothetical protein 0.002 0.0103 0.0639
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0057 0.0489 0.1067
Entamoeba histolytica hypothetical protein 0.0022 0.0125 0.0817
Leishmania major cathepsin L-like protease 0.002 0.0095 0.0549
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0027 0.017 0.0268
Echinococcus multilocularis beta adrenergic receptor kinase 0.0022 0.0125 0.0125
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0095 0.0568
Schistosoma mansoni retinoic acid receptor RXR 0.0057 0.0489 0.101
Onchocerca volvulus 0.0441 0.4586 0.8447
Trypanosoma cruzi multidrug resistance protein E, putative 0.002 0.0103 0.0832
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0033 0.0239 0.0521
Plasmodium falciparum multidrug resistance protein 1 0.0024 0.014 0.2871
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0028 0.002
Loa Loa (eye worm) hypothetical protein 0.0033 0.0239 0.0434
Entamoeba histolytica P-glycoprotein-2 0.0024 0.014 0.094
Loa Loa (eye worm) DR-78 0.0027 0.017 0.0308
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.014 0.094
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0127 0.1241 0.4213
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0057 0.0489 0.1067
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0127 0.1241 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0125 0.0224
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0125 0.0817
Echinococcus multilocularis multidrug resistance associated protein 1 0.002 0.0103 0.0103
Onchocerca volvulus 0.0033 0.0239 0.0396
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0269 0.2755 1
Brugia malayi sodium-independent organic anion transporter family protein 0.0033 0.0239 0.0468
Loa Loa (eye worm) agrin synaptic family protein 0.0023 0.0127 0.0228
Loa Loa (eye worm) hypothetical protein 0.0033 0.0239 0.0434
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0125 0.0272
Leishmania major cathepsin L-like protease 0.0075 0.0681 0.5385
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0024 0.014 0.014
Schistosoma mansoni intermediate filament proteins 0.0032 0.0222 0.0428
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0057 0.0489 0.0859
Loa Loa (eye worm) hypothetical protein 0.003 0.0205 0.0371
Loa Loa (eye worm) hypothetical protein 0.0022 0.0125 0.0224
Onchocerca volvulus 0.0033 0.0239 0.0396
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0027 0.017 0.017
Brugia malayi Steroid receptor seven-up type 2 0.0057 0.0489 0.1017
Schistosoma mansoni organic anion transporter 0.0033 0.0239 0.0465
Entamoeba histolytica P-glycoprotein-5 0.0024 0.014 0.094
Schistosoma mansoni lamin 0.0032 0.0222 0.0428
Giardia lamblia Multidrug resistance-associated protein 1 0.002 0.0103 0.0236
Echinococcus granulosus bloom syndrome protein 0.0025 0.0152 0.0331
Mycobacterium tuberculosis Conserved protein 0.0042 0.0335 0.0746
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0681 0.5385
Trichomonas vaginalis ABC transporter, putative 0.0024 0.014 0.094
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0125 0.0216
Brugia malayi sodium-independent organic anion transporter family protein 0.0033 0.0239 0.0468
Entamoeba histolytica multidrug resistance protein, putative 0.002 0.0103 0.0639
Schistosoma mansoni nuclear receptor 0.0027 0.017 0.0316
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0066 0.0089
Loa Loa (eye worm) hypothetical protein 0.0057 0.0489 0.0896
Brugia malayi Sodium Bile acid symporter family protein 0.0441 0.4586 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0095 0.0568
Leishmania major cathepsin L-like protease 0.0075 0.0681 0.5385
Onchocerca volvulus Bile acid receptor homolog 0.0057 0.0489 0.0859
Plasmodium vivax vivapain-2 0.002 0.0095 0.1073
Loa Loa (eye worm) hypothetical protein 0.002 0.0095 0.0168
Echinococcus granulosus cathepsin l1 0.002 0.0095 0.0206
Loa Loa (eye worm) hypothetical protein 0.0013 0.0025 0.004
Schistosoma mansoni hypothetical protein 0.0198 0.1999 0.43
Loa Loa (eye worm) hypothetical protein 0.0027 0.017 0.0308
Mycobacterium tuberculosis Conserved protein 0.0042 0.0335 0.0746
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0028 0.002
Trichomonas vaginalis ABC transporter, putative 0.0024 0.014 0.094
Echinococcus granulosus multidrug resistance protein 1 0.0014 0.004 0.0087
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0095 0.0568
Schistosoma mansoni 6-phosphofructokinase 0.0127 0.1241 0.2649
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0681 0.5385
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0095 0.0095
Brugia malayi multidrug resistance related protein 1 0.002 0.0103 0.017
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0028 0.0225
Brugia malayi sodium-independent organic anion transporter family protein 0.0033 0.0239 0.0468
Echinococcus multilocularis cysteine protease 0.002 0.0095 0.0095
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0125 0.0216
Brugia malayi nuclear receptor NHR-88 0.0027 0.017 0.0318
Echinococcus granulosus intermediate filament protein 0.0032 0.0222 0.0484
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0024 0.014 0.0251
Schistosoma mansoni zinc finger protein 0.0027 0.017 0.0316
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0057 0.0489 0.1017
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0013 0.0025 0.004
Onchocerca volvulus 0.002 0.0095 0.0128
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0095 0.0568
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0057 0.0489 0.0896
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0027 0.017 0.0268
Onchocerca volvulus 0.0027 0.017 0.0268
Brugia malayi Cathepsin L-like precursor 0.002 0.0095 0.0151
Leishmania major cathepsin L-like protease 0.002 0.0095 0.0549
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0125 0.0125
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0023 0.0127 0.2339
Brugia malayi Phospholipase A2 family protein 0.0109 0.1052 0.225
Toxoplasma gondii transporter, major facilitator family protein 0.0033 0.0239 0.6472
Loa Loa (eye worm) hypothetical protein 0.0027 0.017 0.0308
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0023 0.0127 0.2339
Brugia malayi beta-lactamase 0.0042 0.0335 0.0678
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0024 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.002 0.0103 0.0184
Echinococcus granulosus lamin dm0 0.0032 0.0222 0.0484
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0095 0.0568
Loa Loa (eye worm) hypothetical protein 0.0519 0.5425 1
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0095 0.0151
Loa Loa (eye worm) hypothetical protein 0.0022 0.0125 0.0224
Loa Loa (eye worm) hypothetical protein 0.0027 0.017 0.0308
Loa Loa (eye worm) hypothetical protein 0.0023 0.0127 0.0228
Brugia malayi regulator of G-protein signaling rgs-7 0.0022 0.0125 0.0218
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0125 0.0216
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0042 0.0335 0.0746
Plasmodium vivax multidrug resistance protein 1, putative 0.0024 0.014 0.2753
Loa Loa (eye worm) multidrug resistance protein 3 0.0024 0.014 0.0251
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0125 0.0272
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.003 0.0205 0.0371
Leishmania major cathepsin L-like protease 0.002 0.0095 0.0549
Echinococcus granulosus multidrug resistance protein 1 0.0014 0.004 0.0087
Loa Loa (eye worm) hypothetical protein 0.0024 0.014 0.0251
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0068 0.0612 0.4933
Leishmania major p-glycoprotein e 0.002 0.0103 0.0621
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0022 0.0125 0.0272
Brugia malayi SPARC precursor 0.0023 0.0127 0.0222
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0095 0.015
Loa Loa (eye worm) hypothetical protein 0.0015 0.0048 0.0082
Toxoplasma gondii 6-phosphofructokinase 0.0034 0.0252 0.6947
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.0335 0.073
Schistosoma mansoni nuclear hormone receptor 0.0027 0.017 0.0316
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0057 0.0489 0.0896
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0125 0.0216
Loa Loa (eye worm) hypothetical protein 0.0042 0.0335 0.0611
Echinococcus granulosus Solute carrier organic anion transporter family 0.0033 0.0239 0.0521
Loa Loa (eye worm) beta-lactamase 0.0042 0.0335 0.0611
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0125 0.0216
Brugia malayi 6-phosphofructokinase 0.0127 0.1241 0.2666
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0033 0.0239 0.0239
Leishmania major hypothetical protein, conserved 0.0042 0.0335 0.2529
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0125 0.0817
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0022 0.0125 0.0224
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.014 0.094
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0125 0.0216
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0027 0.017 0.017
Entamoeba histolytica ATP-binding cassette protein, putative 0.002 0.0103 0.0639
Onchocerca volvulus 0.002 0.0095 0.0128
Mycobacterium ulcerans 6-phosphofructokinase 0.0127 0.1241 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0095 0.0568
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0024 0.014 0.281
Giardia lamblia MRP-like ABC transporter 0.002 0.0103 0.0236
Loa Loa (eye worm) hypothetical protein 0.0057 0.0489 0.0896
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.0335 0.0335
Echinococcus granulosus 6 phosphofructokinase 0.0127 0.1241 0.2707
Echinococcus multilocularis musashi 0.0032 0.0222 0.0222
Leishmania major cathepsin L-like protease 0.0075 0.0681 0.5385
Leishmania major pentamidine resistance protein 1 0.002 0.0103 0.0621
Trypanosoma cruzi cysteine peptidase, putative 0.0075 0.0681 0.5489
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.0252 1
Entamoeba histolytica hypothetical protein 0.0022 0.0125 0.0817
Schistosoma mansoni thyroid hormone receptor 0.0057 0.0489 0.101
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.0252 1
Echinococcus multilocularis regulator of G protein signaling 0.0022 0.0125 0.0125
Leishmania major cathepsin L-like protease 0.002 0.0095 0.0549
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0023 0.0127 0.0222
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0205 0.0393
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0048 0.0105
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0335 0.2543
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0125 0.0125
Loa Loa (eye worm) RecQ helicase 0.0025 0.0152 0.0273
Brugia malayi orphan nuclear receptor NR2E1 0.0027 0.017 0.0318
Echinococcus multilocularis multidrug resistance protein 1 0.0014 0.004 0.004
Trichomonas vaginalis phosphofructokinase, putative 0.0127 0.1241 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0057 0.0489 0.1017
Onchocerca volvulus 0.0032 0.0222 0.0364
Trichomonas vaginalis ABC transporter, putative 0.0024 0.014 0.094
Schistosoma mansoni nuclear receptor nhr-48 0.0027 0.017 0.0316
Schistosoma mansoni sodium-bile acid cotransporter related 0.0296 0.3043 0.6575
Brugia malayi hypothetical protein 0.003 0.0205 0.0393
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0127 0.1241 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0027 0.017 0.017
Trypanosoma brucei multidrug resistance protein E 0.002 0.0103 0.0621
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0057 0.0489 0.1017
Echinococcus multilocularis multidrug resistance associated protein 7 0.002 0.0103 0.0103
Brugia malayi ecdysone receptor 0.0027 0.017 0.0318
Trypanosoma cruzi cysteine peptidase, putative 0.0075 0.0681 0.5489
Echinococcus multilocularis follistatin 0.0023 0.0127 0.0127
Onchocerca volvulus Phospholipase A2 homolog 0.0109 0.1052 0.1901
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0024 0.014 0.094
Trypanosoma cruzi MFS transporter, putative 0.0033 0.0239 0.1926
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.002 0.0103 0.1464
Trichomonas vaginalis taga, putative 0.0024 0.014 0.094
Onchocerca volvulus 0.0042 0.0335 0.0573
Brugia malayi nuclear receptor NHR-88 0.0057 0.0489 0.1017
Brugia malayi Nuclear hormone receptor E75 0.0027 0.017 0.0318
Trichomonas vaginalis esterase, putative 0.0042 0.0335 0.2543
Brugia malayi Cathepsin L-like precursor 0.002 0.0095 0.0151
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0024 0.014 0.281
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0095 0.0568
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.014 0.094
Loa Loa (eye worm) hypothetical protein 0.0027 0.017 0.0308
Plasmodium vivax vivapain-2 0.002 0.0095 0.1073
Trichomonas vaginalis phosphofructokinase, putative 0.0127 0.1241 1
Entamoeba histolytica P-glyco protein 6, putative 0.0024 0.014 0.094
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0057 0.0489 0.1017
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0057 0.0489 0.1017
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0024 0.014 0.014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0095 0.0568
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0057 0.0489 0.101
Leishmania major p-glycoprotein 0.0024 0.014 0.0922
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0681 0.5385
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.014 0.094
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.003 0.0205 0.0446
Echinococcus granulosus follistatin 0.0023 0.0127 0.0277
Onchocerca volvulus 0.0042 0.0335 0.0573
Brugia malayi prostaglandin transporter 0.0033 0.0239 0.0468
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0252 0.1863
Echinococcus granulosus multidrug resistance associated protein 1 0.002 0.0103 0.0225
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0024 0.014 0.0922
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0252 0.1863
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0066 0.0115
Entamoeba histolytica cysteine protease, putative 0.002 0.0095 0.0568
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.0152 0.1039
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0024 0.014 0.0305
Loa Loa (eye worm) hypothetical protein 0.0042 0.0335 0.0611
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0042 0.0335 0.0746
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0023 0.0127 0.2339
Echinococcus multilocularis lamin dm0 0.0032 0.0222 0.0222
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0252 0.1863
Schistosoma mansoni multidrug resistance protein 0.002 0.0103 0.0169
Loa Loa (eye worm) hypothetical protein 0.0057 0.0489 0.0896

Activities

Activity type Activity value Assay description Source Reference
AUC (ADMET) = 7.43 uM hr Dose-normalized AUC was determined in rat after peroral administration of the compound (2 mg/kg) ChEMBL. 12729668
Clp (ADMET) = 2.9 ml min-1 kg-1 Plasma clearance was determined in rat after intravenous administion of the compound (0.5 mg/kg) ChEMBL. 12729668
EC50 (functional) = 0.3 uM In vitro agonist activity tested for transactivation in human PPAR gamma-Gal4 chimeric COS-1 cells ChEMBL. 12729668
EC50 (functional) = 0.3 uM In vitro agonist activity tested for transactivation in human PPAR gamma-Gal4 chimeric COS-1 cells ChEMBL. 12729668
EC50 (binding) = 0.3 uM Transactivation activity at Homo sapiens (human) PPARgamma ChEMBL. No reference
EC50 (functional) > 3 uM In vitro agonist activity tested for transactivation in human PPAR alpha-Gal4 chimeric COS-1 cells ChEMBL. 12729668
EC50 (functional) > 3 uM In vitro agonist activity tested for transactivation in human PPAR delta-GAL4 chimeric COS-1 cells ChEMBL. 12729668
EC50 (functional) > 3 uM In vitro agonist activity tested for transactivation in human PPAR alpha-Gal4 chimeric COS-1 cells ChEMBL. 12729668
EC50 (functional) > 3 uM In vitro agonist activity tested for transactivation in human PPAR delta-GAL4 chimeric COS-1 cells ChEMBL. 12729668
F (ADMET) = 63 % Oral bioavailability in rat (dose 2 mg/kg) ChEMBL. 12729668
Glucose correction (functional) = 43 % In vivo glucose correction was determined in male db/db mice after administration at 10 mg/kg ChEMBL. 12729668
IC50 (binding) = 2 uM In vitro binding affinity against human PPAR delta (peroxisome proliferator-activated delta receptor) ChEMBL. 12729668
IC50 (binding) = 2 uM In vitro binding affinity against human PPAR delta (peroxisome proliferator-activated delta receptor) ChEMBL. 12729668
T1/2 (ADMET) = 1.7 hr Half-life was determined in rat after intravenous administion of the compound (0.5 mg/kg) ChEMBL. 12729668
Triglyceride correction (functional) = 50 % In vivo triglyceride correction was determined in male db/db mice after administration at 10 mg/kg ChEMBL. 12729668

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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