Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | beta-site APP-cleaving enzyme 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | memapsin-2 (A01 family) | Get druggable targets OG5_135830 | All targets in OG5_135830 |
Schistosoma japonicum | ko:K07747 beta-site APP-cleaving enzyme 2 (memapsin 1) [EC3.4.23.45], putative | Get druggable targets OG5_135830 | All targets in OG5_135830 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | plasmepsin VII | beta-site APP-cleaving enzyme 1 | 401 aa | 352 aa | 21.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | fructose-bisphosphate aldolase 1 | 0.0268 | 0.3647 | 0.4045 |
Toxoplasma gondii | fructose-bisphosphate aldolase, putative | 0.0268 | 0.3647 | 0.5 |
Echinococcus granulosus | fructose 16 bisphosphate aldolase | 0.0268 | 0.3647 | 1 |
Trypanosoma cruzi | fructose-bisphosphate aldolase, glycosomal, putative | 0.0268 | 0.3647 | 1 |
Echinococcus multilocularis | fructose bisphosphate aldolase class I | 0.0268 | 0.3647 | 1 |
Loa Loa (eye worm) | fructose-bisphosphate aldolase 1 | 0.0268 | 0.3647 | 1 |
Schistosoma mansoni | ryanodine receptor related | 0.0221 | 0.2463 | 0.1204 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0274 | 0.3813 | 0.2779 |
Plasmodium falciparum | fructose-bisphosphate aldolase | 0.0268 | 0.3647 | 0.5 |
Echinococcus multilocularis | fructose 1,6 bisphosphate aldolase | 0.0268 | 0.3647 | 1 |
Toxoplasma gondii | fructose-1,6-bisphosphate aldolase | 0.0268 | 0.3647 | 0.5 |
Echinococcus granulosus | fructose bisphosphate aldolase class I | 0.0268 | 0.3647 | 1 |
Echinococcus granulosus | fructose 16 bisphosphate aldolase | 0.0268 | 0.3647 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0211 | 0.2217 | 0.4819 |
Schistosoma mansoni | fructose 16-bisphosphate aldolase | 0.0268 | 0.3647 | 0.2585 |
Leishmania major | fructose-1,6-bisphosphate aldolase | 0.0268 | 0.3647 | 1 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0158 | 0.0887 | 0.2431 |
Echinococcus multilocularis | fructose 1,6 bisphosphate aldolase | 0.0268 | 0.3647 | 1 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0158 | 0.0887 | 0.2431 |
Echinococcus granulosus | fructose 16 bisphosphate aldolase | 0.0268 | 0.3647 | 1 |
Trypanosoma cruzi | fructose-bisphosphate aldolase, glycosomal, putative | 0.0268 | 0.3647 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.1432 | 0.1976 |
Plasmodium vivax | fructose 1,6-bisphosphate aldolase, putative | 0.0268 | 0.3647 | 0.5 |
Trypanosoma cruzi | fructose-bisphosphate aldolase, glycosomal, putative | 0.0268 | 0.3647 | 1 |
Toxoplasma gondii | fructose-1,6-bisphosphate aldolase | 0.0268 | 0.3647 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0215 | 0.2319 | 0.5188 |
Brugia malayi | fructose-bisphosphate aldolase 2 | 0.0268 | 0.3647 | 0.4045 |
Loa Loa (eye worm) | fructose-bisphosphate aldolase 2 | 0.0268 | 0.3647 | 1 |
Trypanosoma brucei | fructose-bisphosphate aldolase, glycosomal, putative | 0.0268 | 0.3647 | 1 |
Brugia malayi | cation channel family protein | 0.0337 | 0.539 | 1 |
Trypanosoma cruzi | fructose-bisphosphate aldolase, glycosomal, putative | 0.0268 | 0.3647 | 1 |
Echinococcus multilocularis | fructose 1,6 bisphosphate aldolase | 0.0268 | 0.3647 | 1 |
Schistosoma mansoni | fructose 16-bisphosphate aldolase | 0.0268 | 0.3647 | 0.2585 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.