Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Gallus gallus | FK506 binding protein 12 | Starlite/ChEMBL | No references |
Homo sapiens | FK506 binding protein 1A, 12kDa | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.15 nM | Ability of the compound to promote neurite outgrowth against freshly isolated sensory neuronal cultures | ChEMBL. | No reference |
ED50 (functional) | = 0.15 nM | In Vitro neurotrophic effect was measured in cultured chick DRG sensory neurons. | ChEMBL. | 9857082 |
Ki (binding) | = 3 nM | Inhibition of binding to FKBP12 receptor | ChEMBL. | No reference |
Ki (binding) | = 3 nM | Compound was tested for its ability to inhibit FK506 binding protein 12 rotamase activity | ChEMBL. | 9857082 |
Ki (binding) | = 3 nM | Inhibition of binding to FKBP12 receptor | ChEMBL. | No reference |
Ki (binding) | = 3 nM | Compound was tested for its ability to inhibit FK506 binding protein 12 rotamase activity | ChEMBL. | 9857082 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.