TDR Targets

Basic information

Technical information

TDR Targets ID: 74595
Name: methyl 4-[(9,10-dioxophenanthren-1-yl)amino]- 4-oxobutanoate
MW: 337.326 | Formula: C19H15NO5
H donors: 1 H acceptors: 4 LogP: 2.1 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COC(=O)CCC(=O)Nc1cccc2c1C(=O)C(=O)c1c2cccc1
InChi: 1S/C19H15NO5/c1-25-16(22)10-9-15(21)20-14-8-4-7-12-11-5-2-3-6-13(11)18(23)19(24)17(12)14/h2-8H,9-10H2,1H3,(H,20,21)
InChiKey: IIEJKCICXMCYNS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

methyl 4-[(9,10-dioxo-1-phenanthryl)amino]-4-oxo-butanoate
4-[(9,10-dioxo-1-phenanthryl)amino]-4-oxobutanoic acid methyl ester
methyl 4-[(9,10-dioxophenanthren-1-yl)amino]-4-oxo-butanoate
4-[(9,10-diketo-1-phenanthryl)amino]-4-keto-butyric acid methyl ester

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	Starlite/ChEMBL	References
Homo sapiens	cathepsin B	Starlite/ChEMBL	References
Homo sapiens	protein tyrosine phosphatase, receptor type, C	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania donovani	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania infantum	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	SmCB2 peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	cathepsin B-like cysteine proteinase	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Neospora caninum	Cathepsin B-like protease (Precursor), related	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei gambiense	cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Ferm domain	Get druggable targets OG5_135820	All targets in OG5_135820
Schistosoma japonicum	ko:K01363 cathepsin B [EC3.4.22.1], putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Toxoplasma gondii	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_135820	All targets in OG5_135820
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_135820	All targets in OG5_135820

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	dipeptidyl aminopeptidase 1	cathepsin B	339 aa	368 aa	26.9 %
Mycobacterium tuberculosis	Methoxy mycolic acid synthase 2 MmaA2 (methyl mycolic acid synthase 2) (MMA2) (hydroxy mycolic acid synthase)	protein tyrosine phosphatase, receptor type, C	87 aa	85 aa	25.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Moesin/ezrin/radixin homolog 1	0.0008	0.0062	0.0151
Schistosoma mansoni	voltage-gated potassium channel	0.0042	0.0713	0.0713
Schistosoma mansoni	Radixin	0.0005	0.0008	0.0008
Schistosoma mansoni	netrin receptor unc5	0.0015	0.0191	0.0191
Schistosoma mansoni	voltage-gated potassium channel	0.0006	0.0019	0.0019
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0055	0.0967	0.235
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0105	0.0256
Mycobacterium ulcerans	beta-lactamase	0.0038	0.0635	1
Echinococcus multilocularis	voltage gated potassium channel	0.0011	0.0117	0.0117
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0105	0.0105
Onchocerca volvulus	Putative 4.1 G protein	0.0008	0.0062	0.0354
Echinococcus multilocularis	Pleckstrin y	0.0008	0.0062	0.0062
Brugia malayi	hypothetical protein	0.0008	0.0062	0.0151
Trypanosoma cruzi	histone deacetylase 1, putative	0.0216	0.4114	1
Echinococcus multilocularis	H17g protein, tegumental antigen	0.0008	0.0062	0.0062
Schistosoma mansoni	coup transcription factor	0.001	0.0105	0.0105
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0249	0.0606
Onchocerca volvulus	Protein ultraspiracle homolog	0.001	0.0105	0.0599
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0105	0.0256
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0105	0.0105
Schistosoma mansoni	zinc finger protein	0.002	0.0301	0.0301
Echinococcus multilocularis	zinc finger protein	0.002	0.0301	0.0301
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0008	0.0049	0.0049
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0036	0.0596	0.1449
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0018	0.0249	0.0249
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0038	0.0635	1
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0015	0.0191	0.0191
Loa Loa (eye worm)	hypothetical protein	0.001	0.0105	0.0256
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0105	0.0105
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0008	0.0062	0.0062
Onchocerca volvulus		0.0008	0.0062	0.0354
Toxoplasma gondii	histone deacetylase HDAC4	0.0075	0.1365	0.3318
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0038	0.0635	0.0635
Loa Loa (eye worm)	beta-lactamase	0.0038	0.0635	0.1544
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0009	0.0023
Plasmodium vivax	histone deacetylase 2, putative	0.0075	0.1365	0.3318
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0216	0.4114	1
Mycobacterium tuberculosis	Probable lipase LipD	0.0038	0.0635	0.1385
Loa Loa (eye worm)	hypothetical protein	0.001	0.0105	0.0256
Schistosoma mansoni	histone deacetylase 4 5	0.0075	0.1365	0.1365
Trichomonas vaginalis	esterase, putative	0.0038	0.0635	0.1544
Plasmodium vivax	histone deacetylase, putative	0.0075	0.1365	0.3318
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0024	0.0361	0.0361
Loa Loa (eye worm)	moesin	0.0008	0.0062	0.0151
Schistosoma mansoni	hypothetical protein	0.0006	0.0022	0.0022
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0055	0.0967	0.235
Toxoplasma gondii	ABC1 family protein	0.0038	0.0635	0.1544
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0038	0.0645	0.0645
Loa Loa (eye worm)	PHD-finger family protein	0.0022	0.0322	0.0783
Leishmania major	hypothetical protein, conserved	0.0038	0.0635	0.1544
Brugia malayi	cathepsin B-like cysteine proteinase	0.0166	0.3129	0.7605
Giardia lamblia	Cathepsin B precursor	0.0055	0.0967	0.235
Entamoeba histolytica	histone deacetylase, putative	0.0216	0.4114	0.5
Brugia malayi	TAR-binding protein	0.0066	0.1178	0.2863
Echinococcus granulosus	cathepsin b	0.0166	0.3129	0.3129
Schistosoma mansoni	merlin/moesin/ezrin/radixin	0.0005	0.0008	0.0008
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0105	0.0105
Brugia malayi	beta-lactamase family protein	0.0038	0.0635	0.1544
Plasmodium vivax	histone deacetylase 1, putative	0.0216	0.4114	1
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0105	0.0105
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0008	0.0049	0.0119
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0006	0.0009	0.0009
Brugia malayi	hypothetical protein	0.0006	0.0009	0.0023
Echinococcus granulosus	FERM domain containing protein 3	0.0005	0.0008	0.0008
Schistosoma mansoni	hypothetical protein	0.0022	0.0322	0.0322
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0006	0.0009	0.0023
Onchocerca volvulus		0.0038	0.0635	0.361
Echinococcus granulosus	hyperpolarization activated cyclic	0.0008	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0635	0.1544
Plasmodium vivax	histone deacetylase, putative	0.0075	0.1365	0.3318
Onchocerca volvulus		0.0038	0.0635	0.361
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0015	0.0191	0.0465
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0038	0.0634	0.0634
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0635	0.1544
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0635	0.1544
Loa Loa (eye worm)	hypothetical protein	0.0045	0.077	0.1873
Echinococcus granulosus	ezrin	0.0005	0.0008	0.0008
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.001	0.0105	0.0599
Plasmodium vivax	hypothetical protein, conserved	0.0038	0.0635	0.1544
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0105	0.0256
Loa Loa (eye worm)	hypothetical protein	0.0216	0.4114	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0105	0.0105
Trichomonas vaginalis	histone deacetylase, putative	0.0216	0.4114	1
Mycobacterium ulcerans	lipase LipD	0.0038	0.0635	1
Schistosoma mansoni	hypothetical protein	0.0519	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0105	0.0256
Brugia malayi	Histone deacetylase 1	0.0216	0.4114	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0105	0.0256
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0105	0.0105
Echinococcus multilocularis	protein tyrosine phosphatase, non receptor type	0.0005	0.0008	0.0008
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0105	0.0105
Brugia malayi	Nuclear hormone receptor-like 1	0.0006	0.0009	0.0023
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0011	0.0117	0.0117
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0635	0.1544
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0166	0.3129	0.3129
Echinococcus multilocularis	Ankyrin	0.0015	0.0194	0.0194
Toxoplasma gondii	histone deacetylase HDAC3	0.0216	0.4114	1
Mycobacterium tuberculosis	Probable hydrolase	0.0038	0.0635	0.1385
Schistosoma mansoni	histone deacetylase 4 5	0.0075	0.1365	0.1365
Onchocerca volvulus		0.0008	0.0062	0.0354
Echinococcus multilocularis	radixin	0.0005	0.0008	0.0008
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0105	0.0105
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0038	0.0634	0.0634
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0008	0.0049	0.0049
Brugia malayi	Ferm domain	0.0095	0.1759	0.4276
Onchocerca volvulus	Netrin receptor homolog	0.0015	0.0191	0.1088
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.1178	0.1178
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0038	0.0645	0.1567
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0036	0.0596	0.1449
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0015	0.0194	0.0194
Mycobacterium tuberculosis	Probable esterase LipL	0.0038	0.0635	0.1385
Brugia malayi	beta-lactamase	0.0038	0.0635	0.1544
Echinococcus multilocularis	geminin	0.0519	1	1
Echinococcus multilocularis	cathepsin b	0.0166	0.3129	0.3129
Schistosoma mansoni	bromodomain containing protein	0.0066	0.119	0.119
Loa Loa (eye worm)	histone deacetylase 7A	0.0075	0.1365	0.3318
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0008	0.0062	0.0062
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0018	0.0249	0.0249
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0008	0.0049	0.0119
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0105	0.0105
Loa Loa (eye worm)	cathepsin B	0.0055	0.0967	0.235
Brugia malayi	Protein kinase domain containing protein	0.0015	0.0191	0.0465
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0008	0.0019
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0105	0.0256
Onchocerca volvulus		0.0095	0.1759	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0105	0.0256
Echinococcus granulosus	histone deacetylase 6	0.0075	0.1365	0.1365
Trypanosoma cruzi	histone deacetylase, putative	0.0075	0.1365	0.3318
Onchocerca volvulus		0.001	0.0105	0.0599
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0055	0.0967	0.235
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.1178	0.1178
Brugia malayi	neurofibromatosis homolog protein 1	0.0008	0.0062	0.0151
Leishmania major	histone deacetylase, putative	0.0075	0.1365	0.3318
Trypanosoma brucei	histone deacetylase 2	0.0075	0.1365	0.3318
Trichomonas vaginalis	histone deacetylase, putative	0.0216	0.4114	1
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.1178	0.1178
Trichomonas vaginalis	histone deacetylase, putative	0.0216	0.4114	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0006	0.0009	0.0023
Schistosoma mansoni	hypothetical protein	0.0008	0.0062	0.0062
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0105	0.0256
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0105	0.0105
Brugia malayi	RNA recognition motif domain containing protein	0.0066	0.1178	0.2863
Schistosoma mansoni	ankyrin 23/unc44	0.0015	0.0191	0.0191
Brugia malayi	ecdysteroid receptor	0.001	0.0105	0.0256
Trypanosoma brucei	histone deacetylase, putative	0.0075	0.1365	0.3318
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0008	0.0049	0.0049
Toxoplasma gondii	histone deacetylase HDAC5	0.0075	0.1367	0.3324
Trichomonas vaginalis	penicillin-binding protein, putative	0.0038	0.0635	0.1544
Echinococcus granulosus	protein 4.1	0.0008	0.0062	0.0062
Chlamydia trachomatis	cAMP-dependent protein kinase regulatory subunit	0.0005	0	0.5
Trypanosoma brucei	histone deacetylase 1	0.0216	0.4114	1
Echinococcus multilocularis	histone deacetylase 6	0.0075	0.1365	0.1365
Mycobacterium leprae	Probable lipase LipE	0.0038	0.0635	1
Echinococcus granulosus	merlin:moesin:ezrin:radixin	0.0008	0.0062	0.0062
Brugia malayi	RNA binding protein	0.0066	0.1178	0.2863
Brugia malayi	PHD-finger family protein	0.0026	0.0409	0.0995
Plasmodium falciparum	histone deacetylase 1	0.0216	0.4114	1
Trichomonas vaginalis	histone deacetylase, putative	0.0216	0.4114	1
Mycobacterium tuberculosis	Conserved protein	0.0038	0.0635	0.1385
Brugia malayi	Ferm domain	0.0008	0.0062	0.0151
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0105	0.0256
Schistosoma mansoni	histone deacetylase	0.0216	0.4114	0.4114
Echinococcus multilocularis	merlin:moesin:ezrin:radixin	0.0008	0.0062	0.0062
Loa Loa (eye worm)	RNA binding protein	0.0066	0.1178	0.2863
Schistosoma mansoni	hypothetical protein	0.0005	0.0008	0.0008
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0008	0.0062	0.0062
Echinococcus granulosus	histone deacetylase 3	0.0216	0.4114	0.4114
Schistosoma mansoni	voltage-gated potassium channel	0.0008	0.0049	0.0049
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0105	0.0105
Echinococcus granulosus	hyperpolarization activated cyclic	0.0008	0.0049	0.0049
Echinococcus multilocularis	histone deacetylase 1	0.0216	0.4114	0.4114
Trypanosoma brucei	ISWI complex protein	0.0016	0.0213	0.0519
Echinococcus granulosus	histone deacetylase	0.0075	0.1365	0.1365
Echinococcus granulosus	Ezrin radixin moesin ERM	0.0008	0.0062	0.0062
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0008	0.0049	0.0119
Schistosoma mansoni	zinc finger protein	0.0016	0.0213	0.0213
Echinococcus granulosus	FERM domain containing protein 5	0.0008	0.0062	0.0062
Echinococcus granulosus	FERM central domain	0.0005	0.0008	0.0008
Echinococcus granulosus	SPRY domain containing protein	0.0008	0.0062	0.0062
Loa Loa (eye worm)	hypothetical protein	0.001	0.0105	0.0256
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0062	0.0151
Echinococcus multilocularis		0.0008	0.0062	0.0062
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0062	0.1118	0.1118
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0635	0.1544
Giardia lamblia	Cathepsin B precursor	0.0055	0.0967	0.235
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0166	0.3129	0.3129
Echinococcus multilocularis	FERM domain containing protein 5	0.0005	0.0008	0.0008
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0166	0.3129	0.3129
Toxoplasma gondii	cathepsin B	0.0055	0.0967	0.235
Schistosoma mansoni	hypothetical protein	0.0008	0.0062	0.0062
Brugia malayi	beta-lactamase family protein	0.0038	0.0635	0.1544
Brugia malayi	steroid hormone receptor	0.001	0.0105	0.0256
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0062	0.0151
Trypanosoma cruzi	histone deacetylase, putative	0.0075	0.1365	0.3318
Echinococcus granulosus	histone deacetylase 6	0.0075	0.1365	0.1365
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0105	0.0256
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0038	0.0635	0.1385
Echinococcus granulosus	tar DNA binding protein	0.0066	0.1178	0.1178
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0117	0.0285
Brugia malayi	Ferm domain (protein4.1-ezrin-radixin-moesin) family protein 4-like	0.0005	0.0008	0.0019
Brugia malayi	histone deacetylase 1 (HD1)	0.0216	0.4114	1
Brugia malayi	Histone deacetylase family protein	0.0075	0.1365	0.3318
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0018	0.0249	0.0249
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0038	0.0645	0.1567
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0105	0.0256
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0105	0.0256
Trypanosoma cruzi	histone deacetylase, putative	0.0075	0.1365	0.3318
Brugia malayi	histone deacetylase 3 (HD3)	0.0216	0.4114	1
Schistosoma mansoni	Band 4.1-like protein	0.0008	0.0062	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0194	0.0471
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0008	0.0062	0.0062
Echinococcus granulosus	fetal alzheimer antigen falz	0.0024	0.0361	0.0361
Schistosoma mansoni	histone deacetylase hda2	0.0075	0.1365	0.1365
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0008	0.0049	0.0049
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0105	0.0256
Echinococcus granulosus	cathepsin b	0.0166	0.3129	0.3129
Mycobacterium tuberculosis	Conserved protein	0.0038	0.0635	0.1385
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0105	0.0256
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0105	0.0105
Mycobacterium ulcerans	esterase/lipase LipP	0.0038	0.0635	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0105	0.0105
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0008	0.0049	0.0049
Brugia malayi	GRP1 binding protein	0.0008	0.0062	0.0151
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0635	0.1544
Echinococcus multilocularis	histone deacetylase	0.0075	0.1365	0.1365
Schistosoma mansoni	60S ribosomal protein L21	0.0006	0.0019	0.0019
Trypanosoma cruzi	ISWI complex protein	0.0016	0.0213	0.0519
Brugia malayi	FERM domain	0.0008	0.0062	0.0151
Trypanosoma brucei	histone deacetylase 4	0.0075	0.1365	0.3318
Brugia malayi	hypothetical protein	0.0005	0.0008	0.0019
Trypanosoma brucei	hypothetical protein, conserved	0.0038	0.0635	0.1544
Brugia malayi	Death domain containing protein	0.0015	0.0191	0.0465
Echinococcus multilocularis	tar DNA binding protein	0.0066	0.1178	0.1178
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0009	0.0023
Echinococcus multilocularis	cathepsin b	0.0166	0.3129	0.3129
Echinococcus granulosus	SPRY domain containing protein	0.0008	0.0062	0.0062
Trypanosoma cruzi	histone deacetylase, putative	0.0075	0.1365	0.3318
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0105	0.0105
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0006	0.0009	0.0009
Treponema pallidum	catabolite gene activator	0.0005	0	0.5
Echinococcus multilocularis	SPRY domain containing protein	0.0008	0.0062	0.0062
Onchocerca volvulus		0.0038	0.0635	0.361
Echinococcus granulosus	histone deacetylase 6	0.0075	0.1365	0.1365
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0105	0.0105
Trypanosoma cruzi	histone deacetylase 1, putative	0.0216	0.4114	1
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0008	0.0049	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0635	0.1544
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0024	0.0361	0.0361
Loa Loa (eye worm)	TAR-binding protein	0.0066	0.1178	0.2863
Echinococcus granulosus	voltage gated potassium channel	0.0011	0.0117	0.0117
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0635	0.1544
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.1178	0.1178
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0105	0.0256
Echinococcus granulosus	histone deacetylase 7	0.0075	0.1365	0.1365
Trypanosoma cruzi	histone deacetylase, putative	0.0075	0.1365	0.3318
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.1178	0.1178
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0105	0.0105
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0066	0.1178	0.2863
Toxoplasma gondii	histone deacetylase HDAC1	0.0075	0.1365	0.3318
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0105	0.0256
Echinococcus multilocularis	FERM central domain	0.0005	0.0008	0.0008
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0105	0.0256
Loa Loa (eye worm)	histone deacetylase 3	0.0216	0.4114	1
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0008	0.0062	0.0062
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0038	0.0635	0.1385
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0105	0.0105
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0008	0.0049	0.0049
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0015	0.0191	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0075	0.1365	0.3318
Loa Loa (eye worm)	histone deacetylase 11	0.0075	0.1365	0.3318
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0008	0.0049	0.0049
Echinococcus multilocularis	SPRY domain containing protein	0.0008	0.0062	0.0062
Echinococcus granulosus	histone deacetylase 8	0.0075	0.1365	0.1365
Brugia malayi	nuclear receptor RXR	0.0006	0.0009	0.0023
Giardia lamblia	Histone deacetylase	0.0216	0.4114	1
Loa Loa (eye worm)	GRP1 binding protein	0.0006	0.0022	0.0054
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0011	0.0117	0.0285
Echinococcus granulosus	SPRY domain containing protein	0.0008	0.0062	0.0062
Brugia malayi	hypothetical protein	0.0006	0.0009	0.0023
Echinococcus granulosus	Pleckstrin y	0.0008	0.0062	0.0062
Loa Loa (eye worm)	hypothetical protein	0.001	0.0105	0.0256
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0009	0.0023
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0105	0.0256
Echinococcus multilocularis	FERM domain containing protein 5	0.0008	0.0062	0.0062
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0105	0.0105
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0009	0.0023
Echinococcus multilocularis	histone deacetylase 7	0.0075	0.1365	0.1365
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0062	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0191	0.0465
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0105	0.0256
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0241	0.4586	1
Brugia malayi	nuclear receptor NHR-88	0.001	0.0105	0.0256
Loa Loa (eye worm)	histone deacetylase 1	0.0216	0.4114	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0105	0.0105
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0105	0.0256
Echinococcus multilocularis	histone deacetylase 6	0.0075	0.1365	0.1365
Echinococcus multilocularis	netrin receptor unc 5	0.0015	0.0191	0.0191
Brugia malayi	histone deacetylase 11	0.0075	0.1365	0.3318
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0008	0.0049	0.0049
Brugia malayi	protein-tyrosine-phosphatase	0.0005	0.0008	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0731	0.1778
Echinococcus granulosus	FERM domain containing protein 3	0.0008	0.0062	0.0062
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0055	0.0967	0.235
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0547	0.1329
Schistosoma mansoni	voltage-gated potassium channel	0.0011	0.0117	0.0117
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0038	0.0635	0.0635
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0008	0.0049	0.0049
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0216	0.4114	1
Schistosoma mansoni	hypothetical protein	0.0008	0.0062	0.0062
Mycobacterium leprae	conserved hypothetical protein	0.0038	0.0635	1
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0076	0.1385	0.1385
Leishmania major	histone deacetylase, putative	0.0075	0.1365	0.3318
Plasmodium falciparum	histone deacetylase 2	0.0075	0.1365	0.3318
Brugia malayi	nuclear hormone receptor	0.001	0.0105	0.0256
Echinococcus multilocularis	FERM domain containing protein 3	0.0005	0.0008	0.0008
Trichomonas vaginalis	histone deacetylase, putative	0.0216	0.4114	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0166	0.3129	0.7605
Trypanosoma cruzi	ISWI complex protein	0.0016	0.0213	0.0519
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0105	0.0256
Loa Loa (eye worm)	bromodomain containing protein	0.0018	0.0262	0.0636
Echinococcus multilocularis	Ezrin radixin moesin ERM	0.0008	0.0062	0.0062
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0635	0.1544
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0018	0.0249	0.0249
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0055	0.0967	0.0967
Loa Loa (eye worm)	hypothetical protein	0.001	0.0105	0.0256
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0635	0.1544
Plasmodium falciparum	histone deacetylase, putative	0.0075	0.1365	0.3318
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0105	0.0105
Echinococcus multilocularis	histone deacetylase 3	0.0216	0.4114	0.4114
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0105	0.0105
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0105	0.0105
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0076	0.1385	0.1385
Brugia malayi	Histone deacetylase family protein	0.0075	0.1365	0.3318
Treponema pallidum	catabolite gene activator (Crp)	0.0005	0	0.5
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0105	0.0105
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0635	0.1544
Loa Loa (eye worm)	hypothetical protein	0.0074	0.1342	0.3262
Echinococcus granulosus	histone lysine methyltransferase setb	0.0018	0.0249	0.0249
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0166	0.3129	0.3129
Schistosoma mansoni	voltage-gated potassium channel	0.0042	0.0713	0.0713
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0008	0.0062	0.0062
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0038	0.0635	0.0635
Trichomonas vaginalis	histone deacetylase, putative	0.0216	0.4114	1
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0038	0.0635	0.1385
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0105	0.0105
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0038	0.0645	0.0645
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0018	0.0249	0.0249
Mycobacterium tuberculosis	Conserved protein	0.0038	0.0635	0.1385
Leishmania major	histone deacetylase, putative	0.0216	0.4114	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0105	0.0256
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0008	0.0049	0.0119
Toxoplasma gondii	histone deacetylase HDAC2	0.0216	0.4114	1
Echinococcus multilocularis	histone deacetylase 6	0.0075	0.1365	0.1365
Echinococcus granulosus	death domain containing protein	0.0015	0.0191	0.0191
Brugia malayi	Bromodomain containing protein	0.004	0.0682	0.1657
Echinococcus granulosus	netrin receptor unc 5	0.0015	0.0191	0.0191
Trypanosoma brucei	histone deacetylase 3	0.0075	0.1365	0.3318
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0049	0.0119
Echinococcus granulosus	radixin	0.0005	0.0008	0.0008
Echinococcus granulosus	beta LACTamase domain containing family member	0.0038	0.0635	0.0635
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0008	0.0049	0.0049
Schistosoma mansoni	voltage-gated potassium channel	0.0011	0.0117	0.0117
Schistosoma mansoni	histone deacetylase hda2	0.0075	0.1365	0.1365
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0105	0.0256
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0105	0.0256
Echinococcus multilocularis	FERM domain containing protein 3	0.0008	0.0062	0.0062
Echinococcus granulosus	zinc finger protein	0.002	0.0301	0.0301
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0105	0.0105
Loa Loa (eye worm)	hypothetical protein	0.001	0.0105	0.0256
Onchocerca volvulus	Bile acid receptor homolog	0.001	0.0105	0.0599
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0038	0.0635	0.1544
Schistosoma mansoni	hypothetical protein	0.0016	0.0213	0.0213
Schistosoma mansoni	merlin/moesin/ezrin/radixin	0.0008	0.0062	0.0062
Echinococcus granulosus	histone deacetylase 1	0.0216	0.4114	0.4114
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0018	0.0249	0.0249
Echinococcus granulosus	protein tyrosine phosphatase non receptor type	0.0005	0.0008	0.0008
Onchocerca volvulus	4.1 G protein, putative homolog	0.0008	0.0056	0.0319
Echinococcus granulosus	H17g protein tegumental antigen	0.0008	0.0062	0.0062
Echinococcus multilocularis	ezrin	0.0005	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0062	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0166	0.3129	0.7605
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0018	0.0249	0.0249
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0216	0.4114	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0683	0.1661
Echinococcus granulosus	Ankyrin	0.0015	0.0194	0.0194
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0105	0.0105
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0008	0.0049	0.0049
Schistosoma mansoni	merlin/moesin/ezrin/radixin	0.0008	0.0062	0.0062
Brugia malayi	Uncoordinated protein 44	0.0015	0.0191	0.0465
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0105	0.0105
Schistosoma mansoni	hypothetical protein	0.0015	0.0191	0.0191
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0006	0.0009	0.0009
Schistosoma mansoni	histone deacetylase 1 2 3	0.0075	0.1365	0.1365
Echinococcus multilocularis	histone deacetylase 8	0.0075	0.1365	0.1365
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0062	0.1118	0.1118
Echinococcus granulosus	FERM domain containing protein 5	0.0005	0.0008	0.0008
Schistosoma mansoni	hypothetical protein	0.0519	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0105	0.0256
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0015	0.0191	0.0465
Leishmania major	histone deacetylase, putative	0.0216	0.4114	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0038	0.0635	0.1544
Mycobacterium ulcerans	hypothetical protein	0.0038	0.0635	1
Schistosoma mansoni	histone deacetylase	0.0216	0.4114	0.4114
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0105	0.0105
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0008	0.0049	0.0119
Treponema pallidum	cyclic nucleotide binding protein	0.0005	0	0.5
Treponema pallidum	cyclic nucleotide binding protein	0.0005	0	0.5
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0008	0.0049	0.0049
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0105	0.0105
Trichomonas vaginalis	penicillin-binding protein, putative	0.0038	0.0635	0.1544
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0009	0.0023
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0006	0.0009	0.0009
Schistosoma mansoni	hypothetical protein	0.0006	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0095	0.1759	0.4276
Mycobacterium tuberculosis	Probable lipase LipE	0.0038	0.0635	0.1385
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0011	0.0117	0.0117
Loa Loa (eye worm)	hypothetical protein	0.001	0.0105	0.0256
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0008	0.0049	0.0049
Loa Loa (eye worm)	histone deacetylase	0.0075	0.1365	0.3318
Leishmania major	hypothetical protein, conserved	0.0016	0.0213	0.0519
Brugia malayi	Bromodomain containing protein	0.0078	0.1429	0.3474
Giardia lamblia	Cathepsin B precursor	0.0055	0.0967	0.235
Onchocerca volvulus	Histone deacetylase 10 homolog	0.0075	0.1365	0.7759

Activities

Activity type	Activity value	Assay description	Source	Reference
CC50 (functional)	= 9 uM	Cytotoxicity of the compound measured against human T-cells	ChEMBL.	11356112
IC50 (binding)	= 0.4 uM	In vitro inhibitory activity against the cytosolic portion of CD45 protein-tyrosine phosphatase using pNPP as the substrate	ChEMBL.	11356112
IC50 (binding)	= 0.4 uM	In vitro inhibitory activity against the cytosolic portion of CD45 protein-tyrosine phosphatase using pNPP as the substrate	ChEMBL.	11356112
IC50 (functional)	= 0.5 uM	In vitro inhibition of human T-cell proliferation	ChEMBL.	11356112
IC50 (binding)	= 4.4 uM	Inhibitory concentration against FAP-1 pNPP	ChEMBL.	11356112
IC50 (binding)	= 4.4 uM	Inhibitory concentration against FAP-1 pNPP	ChEMBL.	11356112
IC50 (binding)	= 4.7 uM	Inhibitory concentration against CD45 protein-tyrosine phosphatase using lck-10mer as substrate	ChEMBL.	11356112
IC50 (binding)	= 4.7 uM	Inhibitory concentration against CD45 protein-tyrosine phosphatase using lck-10mer as substrate	ChEMBL.	11356112
IC50 (binding)	> 10 uM	Inhibitory concentration against Cathepsin B	ChEMBL.	11356112
IC50 (binding)	> 10 uM	Inhibitory concentration against Cathepsin B	ChEMBL.	11356112
IC50 (binding)	> 30 uM	Inhibitory concentration against FAP-1 using lck-10 mer as substrate	ChEMBL.	11356112
IC50 (binding)	> 30 uM	Inhibitory concentration against FAP-1 using lck-10 mer as substrate	ChEMBL.	11356112

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL51579
PubChem: 10404797

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 74595