TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 419.452 | Formula: C19H21N3O6S
H donors: 4 H acceptors: 6 LogP: 1.1 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: C[C@@H](C(=O)N[C@H](C(=O)O)Cc1ccccc1)NC(=O)c1ccc(cc1)S(=O)(=O)N
InChi: 1S/C19H21N3O6S/c1-12(21-18(24)14-7-9-15(10-8-14)29(20,27)28)17(23)22-16(19(25)26)11-13-5-3-2-4-6-13/h2-10,12,16H,11H2,1H3,(H,21,24)(H,22,23)(H,25,26)(H2,20,27,28)/t12-,16-/m0/s1
InChiKey: UDCDKGHUDICLCJ-LRDDRELGSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Bos taurus	Carbonic anhydrase IV	Starlite/ChEMBL	References
Homo sapiens	carbonic anhydrase I	Starlite/ChEMBL	References
Homo sapiens	carbonic anhydrase II	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma congolense	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Leishmania braziliensis	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Schistosoma japonicum	ko:K01672 carbonic anhydrase [EC4.2.1.1], putative	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	Get druggable targets OG5_127628	All targets in OG5_127628
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	Get druggable targets OG5_127628	All targets in OG5_127628
Leishmania infantum	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	Get druggable targets OG5_127628	All targets in OG5_127628
Brugia malayi	Putative carbonic anhydrase 5 precursor	Get druggable targets OG5_127628	All targets in OG5_127628
Loa Loa (eye worm)	carbonic anhydrase 3	Get druggable targets OG5_127628	All targets in OG5_127628
Leishmania donovani	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Echinococcus multilocularis	carbonic anhydrase II	Get druggable targets OG5_127628	All targets in OG5_127628
Leishmania major	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma brucei gambiense	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma brucei	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma congolense	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	Get druggable targets OG5_127628	All targets in OG5_127628
Leishmania mexicana	carbonic anhydrase-like protein	Get druggable targets OG5_127628	All targets in OG5_127628
Echinococcus granulosus	carbonic anhydrase II	Get druggable targets OG5_127628	All targets in OG5_127628
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	Get druggable targets OG5_127628	All targets in OG5_127628

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	carbonic anhydrase	Carbonic anhydrase IV	312 aa	304 aa	29.6 %
Schistosoma japonicum	ko:K01672 carbonic anhydrase [EC4.2.1.1], putative	Carbonic anhydrase IV	312 aa	253 aa	26.9 %
Brugia malayi	Carbonic anhydrase like protein 2 precursor	Carbonic anhydrase IV	312 aa	268 aa	24.6 %
Loa Loa (eye worm)	hypothetical protein	Carbonic anhydrase IV	312 aa	268 aa	25.4 %
Schistosoma japonicum	ko:K01672 carbonic anhydrase [EC4.2.1.1], putative	Carbonic anhydrase IV	312 aa	322 aa	28.3 %
Trypanosoma brucei	carbonic anhydrase-like protein	carbonic anhydrase I	261 aa	281 aa	25.3 %
Brugia malayi	Carbonic anhydrase like protein 2 precursor	carbonic anhydrase II	260 aa	259 aa	32.0 %
Leishmania infantum	carbonic anhydrase-like protein	Carbonic anhydrase IV	312 aa	277 aa	26.7 %
Schistosoma mansoni	carbonic anhydrase-related	Carbonic anhydrase IV	312 aa	265 aa	26.0 %
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	Carbonic anhydrase IV	312 aa	264 aa	25.4 %
Leishmania braziliensis	carbonic anhydrase-like protein	Carbonic anhydrase IV	312 aa	277 aa	25.6 %
Onchocerca volvulus		Carbonic anhydrase IV	312 aa	252 aa	23.4 %
Leishmania mexicana	carbonic anhydrase-like protein	Carbonic anhydrase IV	312 aa	287 aa	26.8 %
Schistosoma mansoni	carbonic anhydrase-related	Carbonic anhydrase IV	312 aa	264 aa	24.2 %
Echinococcus multilocularis	carbonic anhydrase	Carbonic anhydrase IV	312 aa	259 aa	30.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0187	0.1191	0.5624
Entamoeba histolytica	protein kinase, putative	0.0031	0.0103	0.2217
Trichomonas vaginalis	endoplasmin, putative	0.002	0.0028	0.0051
Mycobacterium tuberculosis	Probable hydrolase	0.0227	0.1469	0.1438
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0227	0.1469	0.1546
Loa Loa (eye worm)	beta-lactamase	0.0227	0.1469	0.7026
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0072	0.0386	0.119
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0036	0.0172
Schistosoma mansoni	ran	0.0021	0.0033	0.0035
Brugia malayi	hypothetical protein	0.0034	0.0122	0.0375
Loa Loa (eye worm)	hypothetical protein	0.0038	0.015	0.0717
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0072	0.0386	0.0406
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.0021	0.0022
Trypanosoma brucei	Heat shock protein 83, putative	0.0033	0.0119	0.0785
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0039	0.0157	0.0893
Brugia malayi	heat shock protein 90	0.0033	0.0119	0.0366
Mycobacterium tuberculosis	Conserved protein	0.0227	0.1469	0.1438
Trypanosoma cruzi	Aph-1 protein, putative	0.0096	0.0559	0.3789
Brugia malayi	protein-tyrosine kinase	0.0035	0.013	0.0401
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0035	0.0132	0.0727
Giardia lamblia	Grp94/Hsp90	0.0027	0.0071	0.0939
Trypanosoma brucei	Aph-1 protein, putative	0.0096	0.0559	0.3789
Echinococcus granulosus	geminin	0.1377	0.9497	1
Brugia malayi	Fibroblast growth factor family protein	0.0055	0.0266	0.0821
Entamoeba histolytica	calcium-transporting P-type ATPase, putative	0.0035	0.0132	0.2994
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0034	0.0122	0.0375
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0092	0.053	0.2534
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.007	0.0371	0.9429
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0039	0.0157	0.0752
Brugia malayi	intermediate filament protein	0.0028	0.0084	0.0258
Echinococcus granulosus	expressed protein	0.0377	0.2519	0.2652
Brugia malayi	RNA, U transporter 1	0.0082	0.0457	0.1407
Trypanosoma cruzi	heat shock protein 90, putative	0.0027	0.0071	0.0461
Trichomonas vaginalis	heat shock protein, putative	0.0027	0.0071	0.033
Echinococcus multilocularis	Na+:K+ ATPase alpha subunit	0.0079	0.0437	0.046
Trypanosoma cruzi	P-type H+-ATPase, putative	0.0022	0.0042	0.0264
Mycobacterium tuberculosis	Proteasome alpha subunit PrcA; assembles with beta subunit PrcB.	0.0842	0.5764	0.5749
Trypanosoma cruzi	hypothetical protein, conserved	0.0227	0.1469	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0227	0.1469	0.1546
Echinococcus granulosus	carbonic anhydrase	0.0101	0.0588	0.0619
Trypanosoma cruzi	Calcium ATPase SERCA-like	0.0035	0.0132	0.0876
Echinococcus multilocularis	nervana 2	0.0316	0.209	0.2201
Leishmania major	calcium-translocating P-type ATPase	0.0035	0.0132	0.0687
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0227	0.1469	0.2501
Toxoplasma gondii	hypothetical protein	0.0101	0.0588	0.3867
Echinococcus granulosus	calcium transporting atpase	0.0028	0.0083	0.0087
Plasmodium falciparum	amino acid transporter, putative	0.0032	0.0107	0.1405
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0038	0.015	0.0158
Echinococcus granulosus	microtubule associated protein 2	0.0704	0.4799	0.5053
Toxoplasma gondii	histone lysine-specific demethylase	0.0022	0.0036	0.0019
Leishmania major	P-type H -ATPase, putative	0.0022	0.0042	0.0063
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0038	0.015	0.0717
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0101	0.0588	0.1813
Schistosoma mansoni	endoplasmin	0.0033	0.0119	0.0125
Echinococcus multilocularis	lamin	0.0028	0.0084	0.0088
Mycobacterium tuberculosis	Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G)	0.0027	0.0071	0.0035
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0227	0.1469	0.1438
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0018	0.0011	0.0011
Schistosoma mansoni	heat shock protein	0.0033	0.0119	0.0125
Trichomonas vaginalis	heat shock protein, putative	0.0027	0.0071	0.033
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0038	0.015	0.0158
Echinococcus multilocularis	importin subunit beta 1	0.0029	0.0086	0.0091
Schistosoma mansoni	endoplasmin	0.0033	0.0119	0.0125
Leishmania major	P-type H -ATPase, putative	0.0022	0.0042	0.0063
Loa Loa (eye worm)	RGS-3 protein	0.0019	0.0021	0.0099
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0072	0.0386	0.0406
Echinococcus multilocularis	zinc finger protein	0.0021	0.0029	0.0031
Echinococcus granulosus	histone lysine methyltransferase setb	0.0048	0.0221	0.0232
Trypanosoma brucei	DNA polymerase kappa, putative	0.0027	0.0073	0.0473
Trypanosoma brucei	heat shock protein, putative	0.0033	0.0119	0.0785
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0214	0.1382	0.4259
Echinococcus granulosus	nervana 2	0.0194	0.1241	0.1306
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0037	0.0143	0.0763
Schistosoma mansoni	amine oxidase	0.0022	0.0036	0.0038
Trichomonas vaginalis	ap endonuclease, putative	0.0038	0.015	0.0848
Schistosoma mansoni	sodium/potassium-dependent atpase beta subunit	0.0316	0.209	0.2201
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.007	0.0371	0.2507
Trypanosoma brucei	heat shock protein, putative	0.0033	0.0119	0.0785
Schistosoma mansoni	sodium / potassium ATPase beta chain	0.0194	0.1241	0.1306
Echinococcus multilocularis	geminin	0.1377	0.9497	1
Brugia malayi	Ets-domain containing protein	0.0073	0.0396	0.1221
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0072	0.0386	0.1846
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0266	0.1275
Schistosoma mansoni	nuclear hormone receptor	0.0034	0.0122	0.0128
Schistosoma mansoni	DNA polymerase eta	0.0039	0.0157	0.0166
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0034	0.0122	0.0128
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0386	0.1846
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0308	0.0325
Echinococcus multilocularis	Ca2+ transporting ATPase plasma membrane	0.0028	0.0083	0.0087
Echinococcus multilocularis	plasma membrane calcium transporting ATPase	0.0028	0.0083	0.0087
Mycobacterium ulcerans	metal cation transporter p-type ATPase a	0.0086	0.0486	0.0786
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0063	0.0325	0.0342
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0086	0.0564
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.007	0.0371	0.2507
Echinococcus granulosus	lysosomal alpha glucosidase	0.0166	0.1045	0.1101
Loa Loa (eye worm)	steroid hormone receptor	0.0072	0.0386	0.1846
Toxoplasma gondii	HEAT repeat-containing protein	0.0029	0.0086	0.0369
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.007	0.0371	0.1775
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0209	0.1348	0.6447
Loa Loa (eye worm)	nuclear hormone receptor	0.0034	0.0122	0.0581
Toxoplasma gondii	hypothetical protein	0.0032	0.0107	0.0515
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0084	0.0258
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0092	0.053	0.1633
Trypanosoma brucei	glucosidase, putative	0.0037	0.0143	0.095
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0307	0.2029	0.9709
Brugia malayi	nuclear receptor NHR-88	0.0072	0.0386	0.119
Echinococcus multilocularis	regulator of G protein signaling	0.0019	0.0021	0.0022
Schistosoma mansoni	coup transcription factor	0.0072	0.0386	0.0406
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.053	0.0558
Loa Loa (eye worm)	hypothetical protein	0.0316	0.209	1
Brugia malayi	Steroid receptor seven-up type 2	0.0072	0.0386	0.119
Brugia malayi	ImpB/MucB/SamB family protein	0.0039	0.0157	0.0485
Toxoplasma gondii	P-type ATPase4, putative	0.0035	0.0132	0.0687
Trypanosoma cruzi	plasma membrane Ca2+ ATPase	0.0035	0.0132	0.0876
Treponema pallidum	sodium- and chloride- dependent transporter	0.0187	0.1191	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0513
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0039	0.0157	0.0166
Trypanosoma cruzi	hypothetical protein, conserved	0.0227	0.1469	1
Schistosoma mansoni	tyrosine kinase	0.0039	0.0157	0.0165
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0214	0.1382	0.1455
Leishmania major	heat shock protein 83-1	0.0033	0.0119	0.0595
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0038	0.015	0.0816
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0072	0.0386	0.1846
Brugia malayi	nuclear hormone receptor family member odr-7	0.0034	0.0122	0.0375
Echinococcus granulosus	nervana 2	0.0194	0.1241	0.1306
Brugia malayi	MH2 domain containing protein	0.0241	0.1567	0.483
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0048	0.0181
Brugia malayi	steroid hormone receptor	0.0072	0.0386	0.119
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0037	0.0143	0.0799
Entamoeba histolytica	hypothetical protein	0.0073	0.0392	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0221	0.1055
Onchocerca volvulus		0.0032	0.0107	0.0346
Onchocerca volvulus		0.0316	0.209	1
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0032	0.0107	0.0113
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0032	0.0107	0.033
Echinococcus multilocularis	regulator of G protein signaling 3	0.0019	0.0021	0.0022
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0022	0.0036	0.0221
Plasmodium falciparum	protoporphyrinogen oxidase	0.0022	0.0036	0.0135
Leishmania major	heat shock protein 83-1	0.0033	0.0119	0.0595
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0039	0.0157	0.0165
Echinococcus granulosus	GA binding protein alpha chain	0.0073	0.0396	0.0417
Brugia malayi	Na,K-ATPase alpha subunit	0.0086	0.0486	0.1499
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0122	0.0581
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0122	0.0581
Mycobacterium ulcerans	beta-lactamase	0.0227	0.1469	0.2501
Trypanosoma brucei	heat shock protein, putative	0.0033	0.0119	0.0785
Echinococcus granulosus	beta LACTamase domain containing family member	0.0227	0.1469	0.1546
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0033	0.0159
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0233	0.1113
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0019	0.0021	0.0022
Echinococcus multilocularis	carbonic anhydrase	0.0101	0.0588	0.0619
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0034	0.0123	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0513
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0073	0.0396	0.1896
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0588	0.2814
Onchocerca volvulus		0.0238	0.155	0.7369
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.007	0.0371	0.0391
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0101	0.0588	0.1813
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0072	0.0386	0.119
Trypanosoma brucei	heat shock protein 90, putative	0.0033	0.0119	0.0785
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0033	0.0119	0.2114
Echinococcus granulosus	fetal alzheimer antigen falz	0.0024	0.0051	0.0054
Mycobacterium ulcerans	proteasome PrcA	0.0842	0.5764	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.015	0.0717
Echinococcus multilocularis		0.0022	0.0036	0.0038
Entamoeba histolytica	hypothetical protein	0.0073	0.0392	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0072	0.0386	0.0406
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0038	0.015	0.0158
Mycobacterium tuberculosis	Probable lipase LipE	0.0227	0.1469	0.1438
Giardia lamblia	DINP protein human, muc B family	0.0039	0.0157	0.307
Leishmania major	vacuolar-type Ca2 -ATPase, putative	0.0035	0.0132	0.0687
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.0157	0.1049
Schistosoma mansoni	ets-related	0.0222	0.1436	0.1512
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0037	0.0143	0.0799
Echinococcus multilocularis	expressed protein	0.0377	0.2519	0.2652
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0187	0.1191	0.3672
Trypanosoma brucei	heat shock protein, putative	0.0033	0.0119	0.0785
Echinococcus granulosus	heat shock protein 90	0.0033	0.0119	0.0125
Onchocerca volvulus	Bile acid receptor homolog	0.0072	0.0386	0.1703
Mycobacterium leprae	conserved hypothetical protein	0.0227	0.1469	0.2501
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0061	0.0308	0.1917
Schistosoma mansoni	z-protein (S1r protein)	0.0019	0.0021	0.0022
Trypanosoma brucei	vacuolar-type Ca2+-ATPase 1	0.0035	0.0132	0.0876
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0032	0.0107	0.0113
Schistosoma mansoni	nuclear receptor	0.0034	0.0122	0.0128
Echinococcus multilocularis	dna polymerase kappa	0.0039	0.0157	0.0166
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0019	0.0021	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0227	0.1469	0.7026
Schistosoma mansoni	carbonic anhydrase-related	0.0101	0.0588	0.0619
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0227	0.1469	0.1438
Echinococcus multilocularis	GA binding protein alpha chain	0.0073	0.0396	0.0417
Toxoplasma gondii	heat shock protein HSP90	0.0033	0.0119	0.0595
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.0021	0.0022
Trichomonas vaginalis	D-aminoacylase, putative	0.0227	0.1469	0.9469
Echinococcus multilocularis	calcium transporting ATPase type 2C member	0.0035	0.0132	0.0139
Schistosoma mansoni	bromodomain containing protein	0.0067	0.0351	0.0369
Leishmania major	DNA polymerase eta, putative	0.0039	0.0157	0.0864
Schistosoma mansoni	RAR-like nuclear receptor	0.0072	0.0386	0.0406
Schistosoma mansoni	calcium-transporting atpase 2 (atpase 2)	0.0028	0.0083	0.0087
Trypanosoma brucei	vacuolar-type Ca2+-ATPase 2	0.0035	0.0132	0.0876
Brugia malayi	hypothetical protein	0.0038	0.015	0.0462
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0038	0.015	0.1001
Trypanosoma brucei	DNA polymerase kappa, putative	0.0027	0.0073	0.0473
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0072	0.0386	0.0406
Onchocerca volvulus		0.0227	0.1469	0.6973
Brugia malayi	RNA binding protein	0.0065	0.0336	0.1037
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0072	0.0386	0.1846
Leishmania major	heat shock protein 83-1	0.0033	0.0119	0.0595
Echinococcus granulosus	lamin dm0	0.0028	0.0084	0.0088
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0227	0.1469	0.1438
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0033	0.0035
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0072	0.0386	0.119
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0513
Brugia malayi	hypothetical protein	0.0019	0.0021	0.0064
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0072	0.0386	0.0406
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0019	0.0021	0.0022
Trichomonas vaginalis	penicillin-binding protein, putative	0.0227	0.1469	0.9469
Loa Loa (eye worm)	hypothetical protein	0.0227	0.1469	0.7026
Toxoplasma gondii	P-type ATPase PMA1	0.0022	0.0042	0.0063
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.0157	0.1049
Echinococcus multilocularis	gamma secretase subunit aph 1	0.0247	0.1613	0.1699
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0035	0.0132	0.0727
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0122	0.0581
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0072	0.0386	0.119
Trichomonas vaginalis	ap endonuclease, putative	0.0038	0.015	0.0848
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0022	0.0036	0.0135
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0039	0.0157	0.0165
Giardia lamblia	Hypothetical protein	0.0055	0.0266	0.5772
Schistosoma mansoni	sodium/potassium-dependent atpase beta subunit	0.0194	0.1241	0.1306
Trypanosoma cruzi	heat shock protein 85, putative	0.0033	0.0119	0.0785
Leishmania major	heat shock protein 83-1	0.0033	0.0119	0.0595
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0039	0.0157	0.0166
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0308	0.0475
Brugia malayi	Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type	0.0028	0.0083	0.0255
Schistosoma mansoni	ap endonuclease	0.0038	0.015	0.0158
Brugia malayi	Protein kinase domain containing protein	0.0116	0.0697	0.2148
Entamoeba histolytica	heat shock protein 90, putative	0.0033	0.0119	0.2638
Schistosoma mansoni	microtubule-associated protein tau	0.0704	0.4799	0.5053
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0122	0.0581
Echinococcus granulosus	nervana 2	0.0316	0.209	0.2201
Schistosoma mansoni	gabp alpha	0.0073	0.0396	0.0417
Loa Loa (eye worm)	hypothetical protein	0.004	0.0168	0.0802
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0038	0.015	0.2898
Trichomonas vaginalis	heat shock protein, putative	0.002	0.0028	0.0051
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0032	0.0107	0.0113
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0022	0.0036	0.0019
Plasmodium vivax	P-type ATPase4, putative	0.0035	0.0132	0.0687
Brugia malayi	Nuclear hormone receptor-like 1	0.0038	0.015	0.0462
Leishmania major	heat shock protein 83-1	0.0033	0.0119	0.0595
Echinococcus multilocularis	regulator of G protein signaling 7	0.0019	0.0021	0.0022
Echinococcus multilocularis	carbonic anhydrase II	0.0214	0.1382	0.1455
Plasmodium falciparum	heat shock protein 90	0.0033	0.0119	0.1611
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0072	0.0386	0.0406
Loa Loa (eye worm)	bromodomain containing protein	0.0019	0.0015	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0004	0.0017
Schistosoma mansoni	carbonic anhydrase	0.0101	0.0588	0.0619
Mycobacterium ulcerans	hypothetical protein	0.0227	0.1469	0.2501
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0039	0.0157	0.0165
Echinococcus granulosus	thyroid hormone receptor alpha	0.0034	0.0122	0.0128
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0019	0.0021	0.0022
Echinococcus granulosus	gamma secretase subunit aph 1	0.0247	0.1613	0.1699
Trypanosoma brucei	heat shock protein, putative	0.0033	0.0119	0.0785
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0084	0.0401
Echinococcus granulosus	carbonic anhydrase	0.0101	0.0588	0.0619
Loa Loa (eye worm)	hypothetical protein	0.0316	0.209	1
Schistosoma mansoni	lamin	0.0028	0.0084	0.0088
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0032	0.0107	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.0157	0.1049
Onchocerca volvulus		0.0028	0.0084	0.0232
Brugia malayi	TAR-binding protein	0.0065	0.0336	0.1037
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0033	0.0202
Schistosoma mansoni	heat shock protein	0.0033	0.0119	0.0125
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0039	0.0157	0.0864
Mycobacterium tuberculosis	Conserved protein	0.0227	0.1469	0.1438
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0072	0.0386	0.119
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0032	0.0107	0.0113
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0019	0.0021	0.0022
Brugia malayi	Fibroblast growth factor family protein	0.0055	0.0266	0.0821
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0386	0.1846
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0032	0.0107	0.0515
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0036	0.0172
Trypanosoma cruzi	DNA polymerase eta, putative	0.0039	0.0157	0.1049
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0034	0.0122	0.0128
Brugia malayi	Nuclear hormone receptor E75	0.0034	0.0122	0.0375
Echinococcus granulosus	FTZ F1 alpha	0.0072	0.0386	0.0406
Plasmodium vivax	SET domain protein, putative	0.003	0.0095	0.0431
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0034	0.0122	0.0128
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0072	0.0386	0.1703
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0018	0.0011	0.0011
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0024	0.0051	0.0054
Toxoplasma gondii	aldehyde dehydrogenase	0.0061	0.0308	0.1917
Trypanosoma brucei	DNA polymerase kappa, putative	0.0027	0.0073	0.0473
Schistosoma mansoni	ATPase	0.0035	0.0132	0.0139
Leishmania major	heat shock protein 83-1	0.0033	0.0119	0.0595
Trichomonas vaginalis	cation-transporting ATPase fungi, putative	0.0035	0.0132	0.0727
Echinococcus multilocularis	nuclear receptor nhr 48	0.0034	0.0122	0.0128
Echinococcus multilocularis	axis inhibition protein axin	0.0019	0.0021	0.0022
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0072	0.0386	0.0406
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0249	0.1623	0.7765
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0092	0.053	0.0558
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0019	0.0021	0.0099
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0336	0.0354
Trypanosoma cruzi	plasma membrane Ca2+ ATPase	0.0035	0.0132	0.0876
Mycobacterium ulcerans	DNA polymerase IV	0.0039	0.0157	0.0212
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.0157	0.1049
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0306	0.2024	0.3471
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0122	0.0581
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0086	0.0413
Brugia malayi	A-kinase anchor protein 10, precursor	0.0019	0.0021	0.0064
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0194	0.1241	0.1306
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0233	0.0717
Echinococcus multilocularis	heat shock protein 90	0.0027	0.0071	0.0075
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0039	0.0157	0.0165
Echinococcus granulosus	tar DNA binding protein	0.0065	0.0336	0.0354
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0037	0.0143	0.3288
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.0157	0.1049
Loa Loa (eye worm)	TK protein kinase	0.0031	0.0103	0.0493
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0048	0.0221	0.0232
Mycobacterium tuberculosis	Conserved protein	0.0227	0.1469	0.1438
Loa Loa (eye worm)	hypothetical protein	0.0227	0.1469	0.7026
Schistosoma mansoni	ATPase	0.0035	0.0132	0.0139
Echinococcus granulosus	plasma membrane calcium transporting ATPase 2	0.0035	0.0132	0.0139
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0039	0.0157	0.0165
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0072	0.0386	0.0406
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0037	0.0143	0.0799
Echinococcus multilocularis	endoplasmin	0.0027	0.0071	0.0075
Brugia malayi	SWIRM domain containing protein	0.0022	0.0036	0.0111
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0032	0.0107	0.033
Echinococcus multilocularis	axis inhibition protein axin	0.0019	0.0021	0.0022
Echinococcus granulosus	nuclear receptor nhr 48	0.0034	0.0122	0.0128
Brugia malayi	hypothetical protein	0.0073	0.0392	0.1209
Brugia malayi	beta-lactamase family protein	0.0227	0.1469	0.4526
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0122	0.0581
Echinococcus granulosus	calcium transporting ATPase type 2C member	0.0035	0.0132	0.0139
Brugia malayi	Sodium/potassium-transporting ATPase alpha chain, putative	0.0075	0.0407	0.1256
Leishmania major	calcium-transporting ATPase, putative	0.0028	0.0083	0.0344
Plasmodium falciparum	carbonic anhydrase	0.0101	0.0588	1
Brugia malayi	Pre-SET motif family protein	0.0209	0.1348	0.4154
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0022	0.0036	0.0038
Schistosoma mansoni	nuclear hormone receptor	0.0072	0.0386	0.0406
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0039	0.0157	0.1049
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0022	0.0036	0.0038
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.0157	0.1049
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0032	0.0107	0.0113
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0095	0.01
Brugia malayi	ecdysone receptor	0.0034	0.0122	0.0375
Plasmodium vivax	endoplasmin, putative	0.0033	0.0119	0.0595
Schistosoma mansoni	hypothetical protein	0.0022	0.0037	0.0039
Loa Loa (eye worm)	E1-E2 ATPase	0.0022	0.0042	0.0202
Loa Loa (eye worm)	TAR-binding protein	0.0065	0.0336	0.161
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0122	0.0581
Leishmania major	calcium motive p-type ATPase, putative	0.0028	0.0083	0.0344
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0033	0.0035
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.0157	0.1049
Toxoplasma gondii	plasma membrane-type Ca(2+)-ATPase A1 PMCAA1	0.0028	0.0083	0.0344
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0035	0.013	0.0137
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0039	0.0157	0.0165
Echinococcus granulosus	intermediate filament protein	0.0028	0.0084	0.0088
Echinococcus multilocularis	regulator of G protein signaling 3	0.0019	0.0021	0.0022
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0034	0.0122	0.0128
Loa Loa (eye worm)	hypothetical protein	0.0227	0.1469	0.7026
Brugia malayi	RNA recognition motif domain containing protein	0.0065	0.0336	0.1037
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0039	0.0157	0.0165
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0032	0.0107	0.0113
Echinococcus multilocularis	nervana 2	0.0194	0.1241	0.1306
Echinococcus multilocularis	sodium:potassium transporting ATPase subunit	0.0316	0.209	0.2201
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0513
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0034	0.0122	0.0375
Brugia malayi	hypothetical protein	0.0022	0.0036	0.0111
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0048	0.0305
Entamoeba histolytica	hypothetical protein	0.0073	0.0392	1
Schistosoma mansoni	hypothetical protein	0.1377	0.9497	1
Plasmodium falciparum	non-SERCA-type Ca2+ -transporting P-ATPase	0.0035	0.0132	0.1847
Echinococcus multilocularis	regulator of G protein signaling 7	0.0019	0.0021	0.0022
Mycobacterium tuberculosis	Probable lipase LipD	0.0227	0.1469	0.1438
Schistosoma mansoni	hypothetical protein	0.0073	0.0392	0.0413
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0034	0.0122	0.0581
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.0157	0.1049
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0143	0.0799
Trichomonas vaginalis	DNA polymerase eta, putative	0.0039	0.0157	0.0893
Leishmania major	heat shock protein 83-1	0.0033	0.0119	0.0595
Brugia malayi	conserved hypotetical protein	0.0034	0.0122	0.0375
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0038	0.015	0.0158
Echinococcus granulosus	plasma membrane calcium transporting ATPase	0.0028	0.0083	0.0087
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0038	0.015	0.1001
Trypanosoma cruzi	P-type H+-ATPase, putative	0.0022	0.0042	0.0264
Schistosoma mansoni	transmemberane protein	0.0316	0.209	0.2201
Trypanosoma brucei	DNA polymerase IV, putative	0.0039	0.0157	0.1049
Onchocerca volvulus		0.0227	0.1469	0.6973
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0039	0.0157	0.0166
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0032	0.0107	0.0113
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.0157	0.1049
Loa Loa (eye worm)	hypothetical protein	0.0227	0.1469	0.7026
Loa Loa (eye worm)	transcription factor SMAD2	0.0241	0.1567	0.7496
Loa Loa (eye worm)	PHD-finger family protein	0.0022	0.0037	0.0178
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.0022	0.0036	0.0019
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0032	0.0107	0.0113
Onchocerca volvulus		0.0034	0.0122	0.0416
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0019	0.0021	0.0022
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0031	0.0103	0.0108
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0214	0.1382	0.661
Brugia malayi	exodeoxyribonuclease III family protein	0.0038	0.015	0.0463
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0032	0.0107	0.033
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0386	0.1846
Onchocerca volvulus		0.0028	0.0084	0.0232
Leishmania major	hypothetical protein, conserved	0.0227	0.1469	1
Leishmania major	heat shock protein 83-1	0.0033	0.0119	0.0595
Echinococcus multilocularis	nervana 2	0.0194	0.1241	0.1306
Trypanosoma brucei	carbonic anhydrase-like protein	0.0214	0.1382	0.9407
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0034	0.0122	0.0128
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0073	0.0392	0.0413
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0034	0.0122	0.0128
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0021	0.0022
Echinococcus multilocularis	FTZ F1 alpha	0.0072	0.0386	0.0406
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0018	0.0011	0.0011
Trypanosoma brucei	hypothetical protein, conserved	0.0227	0.1469	1
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0032	0.0107	0.0515
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.053	0.0558
Loa Loa (eye worm)	hypothetical protein	0.0187	0.1191	0.57
Echinococcus granulosus	tyrosine protein kinase Blk	0.0035	0.013	0.0137
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0038	0.015	0.0816
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.007	0.0371	0.0391
Loa Loa (eye worm)	TK protein kinase	0.0035	0.013	0.0623
Trichomonas vaginalis	D-aminoacylase, putative	0.0227	0.1469	0.9469
Mycobacterium ulcerans	cation-transporter ATPase I CtpI	0.0024	0.0053	0.0029
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0039	0.0157	0.0165
Echinococcus granulosus	heat shock protein 90	0.0027	0.0071	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0123	0.0587
Echinococcus multilocularis	microtubule associated protein 2	0.0704	0.4799	0.5053
Schistosoma mansoni	amine oxidase	0.0022	0.0036	0.0038
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0034	0.0122	0.0416
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0039	0.0157	0.0165
Toxoplasma gondii	ABC1 family protein	0.0227	0.1469	1
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0048	0.0105
Echinococcus granulosus	dna polymerase eta	0.0039	0.0157	0.0166
Mycobacterium ulcerans	heat shock protein 90	0.0027	0.0071	0.0061
Echinococcus granulosus	regulator of G protein signaling 7	0.0019	0.0021	0.0022
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0038	0.015	0.0158
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0032	0.0107	0.0113
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.0087	0.0092
Echinococcus granulosus	Regulator of G protein signaling 20	0.0019	0.0021	0.0022
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.007	0.0371	0.1143
Schistosoma mansoni	zinc finger protein	0.0021	0.0029	0.0031
Schistosoma mansoni	na+/k+ atpase alpha subunit	0.0079	0.0437	0.046
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0072	0.0386	0.0406
Giardia lamblia	Plasma membrane calcium-transporting ATPase 2	0.0028	0.0083	0.1224
Plasmodium vivax	amine transporter, putative	0.0032	0.0107	0.0515
Entamoeba histolytica	hypothetical protein	0.0073	0.0392	1
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0038	0.015	0.0707
Brugia malayi	photoreceptor-specific nuclear receptor	0.0072	0.0386	0.119
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0336	0.0354
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0084	0.0401
Loa Loa (eye worm)	calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type	0.0017	0.0004	0.0017
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0316	0.209	0.2201
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0185	0.0885
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0194	0.1241	0.1306
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0032	0.0107	0.0515
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0034	0.0122	0.0416
Echinococcus multilocularis	serotonin transporter	0.0187	0.1191	0.1255
Echinococcus multilocularis	snurportin 1	0.0307	0.2029	0.2137
Echinococcus granulosus	serotonin transporter	0.0187	0.1191	0.1255
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0306	0.2024	0.3471
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0072	0.0386	0.0406
Loa Loa (eye worm)	carbonic anhydrase 3	0.0214	0.1382	0.661
Onchocerca volvulus		0.0227	0.1469	0.6973
Loa Loa (eye worm)	hypothetical protein	0.005	0.0233	0.1113
Echinococcus multilocularis	transcription factor Dp 1	0.004	0.0166	0.0175
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0072	0.0386	0.0406
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0032	0.0107	0.0113
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0143	0.0799
Schistosoma mansoni	ap endonuclease	0.0038	0.015	0.0158
Trypanosoma brucei	DNA polymerase IV, putative	0.0039	0.0157	0.1049
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0092	0.053	0.0558
Brugia malayi	beta-lactamase family protein	0.0227	0.1469	0.4526
Schistosoma mansoni	plasma membrane calcium-transporting atpase	0.0028	0.0083	0.0087
Schistosoma mansoni	sodium/chloride dependent transporter	0.0187	0.1191	0.1255
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0486	0.2327
Echinococcus granulosus	axis inhibition protein axin	0.0019	0.0021	0.0022
Echinococcus multilocularis	carbonic anhydrase	0.0101	0.0588	0.0619
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0092	0.053	0.0558
Leishmania major	heat shock protein 83-1	0.0033	0.0119	0.0595
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0061	0.0308	0.0325
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0019	0.0021	0.0022
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0063	0.0325	0.0342
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0039	0.0157	0.0165
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0166	0.1045	0.1101
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0072	0.0386	0.1846
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0036	0.0172
Schistosoma mansoni	transcription factor LCR-F1	0.0073	0.0392	0.0413
Brugia malayi	Membrane calcium atpase protein 3	0.0028	0.0083	0.0255
Echinococcus granulosus	endoplasmin	0.0027	0.0071	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0038	0.015	0.0717
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.0021	0.0022
Echinococcus granulosus	axis inhibition protein axin	0.0019	0.0021	0.0022
Schistosoma mansoni	thyroid hormone receptor	0.0072	0.0386	0.0406
Loa Loa (eye worm)	hypothetical protein	0.0028	0.008	0.0383
Trypanosoma brucei	unspecified product	0.0039	0.0157	0.1049
Mycobacterium leprae	PROBABLE CATION-TRANSPORTER ATPASE I CTPI	0.0075	0.0407	0.0648
Plasmodium vivax	heat shock protein 86, putative	0.0033	0.0119	0.0595
Toxoplasma gondii	heat shock protein 90, putative	0.0033	0.0119	0.0595
Echinococcus multilocularis	nervana 2	0.0316	0.209	0.2201
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0072	0.0386	0.1846
Schistosoma mansoni	hypothetical protein	0.0101	0.0588	0.0619
Leishmania major	P-type ATPase, putative	0.0028	0.0083	0.0344
Mycobacterium tuberculosis	Possible metal cation transporting P-type ATPase CtpH	0.0024	0.0053	0.0017
Brugia malayi	regulator of G-protein signaling rgs-7	0.0019	0.0021	0.0064
Loa Loa (eye worm)	PXA domain-containing protein	0.0019	0.0021	0.0099
Trichomonas vaginalis	penicillin-binding protein, putative	0.0227	0.1469	0.9469
Leishmania major	carbonic anhydrase-like protein	0.0214	0.1382	0.9395
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0061	0.0308	0.0273
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.0027	0.0071	0.0075
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0143	0.0799
Brugia malayi	Endoplasmin precursor	0.0033	0.0119	0.0366
Onchocerca volvulus		0.0072	0.0386	0.1703
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0038	0.015	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0021	0.0099
Trypanosoma cruzi	calcium motive p-type ATPase, putative	0.0028	0.0083	0.054
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0072	0.0386	0.1846
Entamoeba histolytica	hypothetical protein	0.0023	0.0048	0.0743
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0072	0.0386	0.119
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0095	0.01
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0035	0.0132	0.0727
Schistosoma mansoni	calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump)	0.0028	0.0083	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0122	0.0581
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0187	0.1191	0.1255
Brugia malayi	nuclear receptor NHR-88	0.0034	0.0122	0.0375
Trypanosoma brucei	DNA polymerase IV, putative	0.0039	0.0157	0.1049
Leishmania major	DNA polymerase kappa, putative	0.0039	0.0157	0.0864
Echinococcus granulosus	neutral alpha glucosidase AB	0.0037	0.0143	0.015
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0038	0.015	0.0719
Loa Loa (eye worm)	endoplasmin	0.0033	0.0119	0.0568
Brugia malayi	Bromodomain containing protein	0.0079	0.0437	0.1347
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0316	0.209	0.2201
Trypanosoma cruzi	heat shock protein 85, putative	0.0033	0.0119	0.0785
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0032	0.0107	0.0113
Schistosoma mansoni	zinc finger protein	0.0034	0.0122	0.0128
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0386	0.1846
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0027	0.0071	0.0939
Brugia malayi	PHD-finger family protein	0.0026	0.0069	0.0212
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0039	0.0157	0.0165
Onchocerca volvulus		0.0032	0.0107	0.0346
Schistosoma mansoni	sodium/potassium-dependent atpase beta subunit	0.0316	0.209	0.2201
Echinococcus granulosus	heat shock protein	0.0033	0.0119	0.0125
Echinococcus granulosus	carbonic anhydrase II	0.0214	0.1382	0.1455
Loa Loa (eye worm)	hypothetical protein	0.0187	0.1191	0.57
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0143	0.0799
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0035	0.013	0.0137
Trichomonas vaginalis	ran, putative	0.0021	0.0033	0.0082
Brugia malayi	E1-E2 ATPase family protein	0.0022	0.0042	0.013
Toxoplasma gondii	exonuclease III APE	0.0038	0.015	0.0816
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	0.0027	0.0071	0.0264
Loa Loa (eye worm)	hypothetical protein	0.0064	0.033	0.1577
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.0035	0.0132	0.2994
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0037	0.0143	0.0799
Onchocerca volvulus		0.0086	0.0486	0.2192
Echinococcus granulosus	tyrosine protein kinase HCK	0.0031	0.0103	0.0108
Schistosoma mansoni	nuclear receptor nhr-48	0.0034	0.0122	0.0128
Trypanosoma brucei	vacuolar-type Ca2+-ATPase, putative	0.0035	0.0132	0.0876
Entamoeba histolytica	plasma membrane calcium-transporting ATPase 1, putative	0.002	0.0024	0.0097
Mycobacterium leprae	Probable lipase LipE	0.0227	0.1469	0.2501
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.007	0.0371	0.2353
Toxoplasma gondii	hypothetical protein	0.0032	0.0107	0.0515
Echinococcus multilocularis	lamin dm0	0.0028	0.0084	0.0088
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0084	0.0401
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0072	0.0386	0.0406
Brugia malayi	hypothetical protein	0.0038	0.015	0.0462
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0022	0.0036	0.0038
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0048	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0038	0.015	0.0717
Loa Loa (eye worm)	RNA binding protein	0.0065	0.0336	0.161
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0132	0.0631
Onchocerca volvulus		0.0096	0.0556	0.2533
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0227	0.1469	0.7026
Plasmodium falciparum	calcium-transporting ATPase	0.0028	0.0083	0.0968
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0039	0.0157	0.0122
Leishmania major	heat shock protein 83-1	0.0033	0.0119	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0021	0.0099
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0019	0.0021	0.0064
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0123	0.0378
Echinococcus granulosus	transcription factor Dp 1	0.004	0.0166	0.0175
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.0095	0.0431
Schistosoma mansoni	carbonic anhydrase-related	0.0101	0.0588	0.0619
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0035	0.0132	0.0727
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0122	0.0581
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0039	0.0157	0.1049
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0386	0.1846
Echinococcus granulosus	sodium and chloride dependent glycine	0.0032	0.0107	0.0113
Plasmodium vivax	hypothetical protein, conserved	0.0227	0.1469	1
Brugia malayi	nuclear receptor RXR	0.0038	0.015	0.0462
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0019	0.0021	0.0099
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0032	0.0107	0.0113
Echinococcus multilocularis	conserved hypothetical protein	0.0712	0.4855	0.5112
Onchocerca volvulus		0.003	0.0095	0.0288
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0072	0.0386	0.0406
Echinococcus granulosus	Ca2 transporting ATPase plasma membrane	0.0028	0.0083	0.0087
Brugia malayi	ImpB/MucB/SamB family protein	0.0039	0.0157	0.0485
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.0035	0.0132	0.2994
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0233	0.0717
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0035	0.013	0.0137
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0143	0.095
Mycobacterium ulcerans	lipase LipD	0.0227	0.1469	0.2501
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0035	0.0132	0.0727
Brugia malayi	nuclear receptor NHR-67	0.0034	0.0122	0.0375
Schistosoma mansoni	axis inhibition protein axin	0.0019	0.0021	0.0022
Toxoplasma gondii	calcium-translocating P-type ATPase, PMCA-type protein	0.0035	0.0132	0.0687
Echinococcus granulosus	nervana 2	0.0316	0.209	0.2201
Brugia malayi	nuclear receptor RXR	0.0034	0.0122	0.0375
Schistosoma mansoni	tyrosine kinase	0.0039	0.0157	0.0165
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0034	0.0122	0.0128
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0101	0.0588	0.2814
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0039	0.0157	0.0165
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0019	0.0021	0.0022
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0035	0.0132	0.0727
Loa Loa (eye worm)	DR-78	0.0034	0.0122	0.0581
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0697	0.3334
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0021	0.0022
Brugia malayi	PXA domain containing protein	0.0019	0.0021	0.0064
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0039	0.0157	0.0165
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0072	0.0386	0.0406
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0022	0.0036	0.0135
Trypanosoma brucei	calcium-translocating P-type ATPase	0.0028	0.0083	0.054
Trypanosoma cruzi	heat shock protein 85, putative	0.0033	0.0119	0.0785
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0092	0.053	0.0558
Leishmania major	heat shock protein 83-1	0.0033	0.0119	0.0595
Schistosoma mansoni	sodium/chloride dependent transporter	0.0032	0.0107	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0513
Leishmania major	UDP-galactopyranose mutase	0.0022	0.0036	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0588	0.2814
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0032	0.0107	0.0113
Echinococcus granulosus	dna polymerase kappa	0.0039	0.0157	0.0166
Schistosoma mansoni	alpha glucosidase	0.0037	0.0143	0.015
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0032	0.0107	0.033
Plasmodium vivax	hypothetical protein, conserved	0.0022	0.0036	0.0019
Brugia malayi	nuclear hormone receptor	0.0072	0.0386	0.119
Trypanosoma cruzi	Aph-1 protein, putative	0.0096	0.0559	0.3789
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0028	0.0083	0.0406
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0143	0.095
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0037	0.0143	0.0683
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.053	0.0558
Schistosoma mansoni	alpha-glucosidase	0.0143	0.0884	0.0931
Echinococcus multilocularis	Tetracycline resistance leader peptide, TetL	0.0035	0.0132	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0513
Brugia malayi	regulator of G-protein signaling egl-10	0.0019	0.0021	0.0064
Echinococcus multilocularis	musashi	0.0028	0.0084	0.0088
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0038	0.015	0.02
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0018	0.0011	0.0011
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0214	0.1382	0.9407
Brugia malayi	hypothetical protein	0.0032	0.0107	0.033
Mycobacterium ulcerans	metal cation-transporting p-type ATPase F, CtpF	0.0035	0.0132	0.0167
Schistosoma mansoni	hypothetical protein	0.0052	0.025	0.0264
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0072	0.0386	0.119
Schistosoma mansoni	calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump)	0.0028	0.0083	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0038	0.015	0.0717
Schistosoma mansoni	ran	0.0021	0.0033	0.0035
Echinococcus multilocularis	sarco:endoplasmic reticulum calcium ATPase	0.0035	0.0132	0.0139
Schistosoma mansoni	retinoic acid receptor RXR	0.0072	0.0386	0.0406
Brugia malayi	follicle stimulating hormone receptor	0.0249	0.1623	0.5003
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0166	0.1045	0.5001
Trypanosoma brucei	DNA polymerase kappa, putative	0.0039	0.0157	0.1049
Schistosoma mansoni	hypothetical protein	0.0307	0.2029	0.2137
Echinococcus granulosus	importin subunit beta 1	0.0029	0.0086	0.0091
Leishmania major	heat shock protein 83-1	0.0033	0.0119	0.0595
Schistosoma mansoni	hypothetical protein	0.1377	0.9497	1
Trypanosoma brucei	DNA polymerase eta, putative	0.0039	0.0157	0.1049
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0122	0.0581
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0035	0.0132	0.0727
Leishmania major	heat shock protein 83-1	0.0033	0.0119	0.0595
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0032	0.0107	0.0113
Trichomonas vaginalis	heat shock protein, putative	0.0033	0.0119	0.0641
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0035	0.013	0.0137
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0021	0.0022
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0316	0.209	0.2201
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0039	0.0157	0.0165
Echinococcus granulosus	lamin	0.0028	0.0084	0.0088
Plasmodium vivax	importin-beta 2, putative	0.0029	0.0086	0.0369
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0072	0.0386	0.119
Trichomonas vaginalis	set domain proteins, putative	0.0238	0.155	1
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0032	0.0107	0.0113
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0143	0.0799
Echinococcus granulosus	ecdysone induced protein 78C	0.0072	0.0386	0.0406
Loa Loa (eye worm)	hypothetical protein	0.0227	0.1469	0.7026
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0021	0.0099
Brugia malayi	Importin beta-1 subunit	0.0029	0.0086	0.0266
Entamoeba histolytica	Plasma membrane calcium-transporting ATPase, putative	0.0035	0.0132	0.2994
Leishmania major	heat shock protein 83-1	0.0033	0.0119	0.0595
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0187	0.1191	0.57
Trichomonas vaginalis	cation-transporting ATPase, putative	0.0022	0.0042	0.0141
Schistosoma mansoni	axis inhibition protein axin	0.0019	0.0021	0.0022
Schistosoma mansoni	gamma-secretase subunit aph-1	0.0247	0.1613	0.1699
Loa Loa (eye worm)	sodium/potassium-transporting ATPase subunit alpha	0.0075	0.0407	0.1949
Leishmania major	heat shock protein 83-1	0.0033	0.0119	0.0595
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0101	0.0588	0.1813
Mycobacterium leprae	probable proteasome (alpha subunit) PrcA	0.0842	0.5764	1
Leishmania major	vacuolar-type Ca2 -ATPase, putative	0.0035	0.0132	0.0687
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0122	0.0581
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0065	0.0336	0.161
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0072	0.0386	0.0406
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0157	0.0752
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0021	0.0033	0.0085
Schistosoma mansoni	importin beta-1	0.0029	0.0086	0.0091
Brugia malayi	Pre-SET motif family protein	0.003	0.0095	0.0293
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0227	0.1469	0.4526
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0039	0.0157	0.0166
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0336	0.0354
Trypanosoma brucei	calcium motive p-type ATPase, putative	0.0028	0.0083	0.054
Trypanosoma brucei	heat shock protein, putative	0.0033	0.0119	0.0785
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0034	0.0122	0.0128
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0032	0.0107	0.0113
Onchocerca volvulus	Protein ultraspiracle homolog	0.0072	0.0386	0.1703
Brugia malayi	orphan nuclear receptor NR2E1	0.0034	0.0122	0.0375
Schistosoma mansoni	hypothetical protein	0.0034	0.0123	0.0129
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0072	0.0386	0.119
Echinococcus multilocularis	heat shock protein 90	0.0033	0.0119	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0122	0.0581
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0101	0.0588	0.1813
Plasmodium vivax	hypothetical protein, conserved	0.0032	0.0107	0.0515
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0039	0.0157	0.3677
Trichomonas vaginalis	esterase, putative	0.0227	0.1469	0.9469
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0032	0.0107	0.0113
Brugia malayi	tailless protein	0.0034	0.0122	0.0375
Schistosoma mansoni	nuclear receptor	0.0034	0.0122	0.0128
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0019	0.0021	0.0064
Schistosoma mansoni	thyroid hormone receptor	0.0072	0.0386	0.0406
Entamoeba histolytica	plasma membrane calcium ion-transporting ATPase, putative	0.002	0.0024	0.0097
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0038	0.015	0.349
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0406	0.194
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0316	0.209	0.2201
Trypanosoma cruzi	carbonic anhydrase-like protein, putative	0.0214	0.1382	0.9407
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0122	0.0581
Echinococcus multilocularis	dna polymerase eta	0.0039	0.0157	0.0166
Trypanosoma brucei	heat shock protein, putative	0.0033	0.0119	0.0785
Giardia lamblia	Potassium-transporting ATPase alpha chain 1	0.0079	0.0437	1
Echinococcus granulosus	Na:K ATPase alpha subunit	0.0079	0.0437	0.046
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0022	0.0036	0.0019
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0024	0.0051	0.0054
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0022	0.0036	0.0038
Trypanosoma cruzi	Heat shock protein 83, putative	0.0033	0.0119	0.0785
Echinococcus granulosus	snurportin 1	0.0307	0.2029	0.2137
Plasmodium vivax	hypothetical protein, conserved	0.0022	0.0036	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0199	0.0953
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0037	0.0143	0.3288
Echinococcus granulosus	carbonic anhydrase	0.0101	0.0588	0.0619
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0072	0.0386	0.119
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0072	0.0386	0.119
Brugia malayi	hypothetical protein	0.0034	0.0122	0.0375
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0022	0.0036	0.0221
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0061	0.0308	0.0325
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0086	0.0564
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.0095	0.01
Trypanosoma cruzi	heat shock protein 90, putative	0.0033	0.0119	0.0785
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0101	0.0588	0.1813
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0034	0.0122	0.0128
Schistosoma mansoni	lamin	0.0028	0.0084	0.0088
Onchocerca volvulus		0.0034	0.0122	0.0416
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0036	0.0172
Onchocerca volvulus		0.0194	0.1241	0.5864
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0022	0.0036	0.0038
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0072	0.0386	0.0406
Trypanosoma cruzi	heat shock protein 85, putative	0.0027	0.0071	0.0461
Trypanosoma brucei	unspecified product	0.0027	0.0073	0.0473
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0072	0.0386	0.0406
Loa Loa (eye worm)	MH2 domain-containing protein	0.0241	0.1567	0.7496
Leishmania major	heat shock protein 83-1	0.0033	0.0119	0.0595
Mycobacterium ulcerans	DNA polymerase IV	0.0039	0.0157	0.0212
Echinococcus granulosus	regulator of G protein signaling 3	0.0019	0.0021	0.0022
Schistosoma mansoni	carbonic anhydrase II (carbonate dehydratase II)	0.0214	0.1382	0.1455
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0048	0.0221	0.0232
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0021	0.0099
Trypanosoma cruzi	heat shock protein 90, putative	0.002	0.0023	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0322	0.1541
Loa Loa (eye worm)	calcium ATPase	0.002	0.0024	0.0116
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0072	0.0386	0.1846
Brugia malayi	Fli-1 protein	0.0222	0.1436	0.4427
Entamoeba histolytica	heat shock protein 90, putative	0.0033	0.0119	0.2638
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.007	0.0371	0.0391
Plasmodium falciparum	importin beta, putative	0.0029	0.0086	0.1032
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0038	0.015	0.0158
Loa Loa (eye worm)	serotonin transporter b	0.0187	0.1191	0.57
Loa Loa (eye worm)	norepinephrine transporter	0.0187	0.1191	0.57
Leishmania major	heat shock protein 83-1	0.0033	0.0119	0.0595
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0034	0.0122	0.0128
Trypanosoma brucei	unspecified product	0.0027	0.0073	0.0473
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0308	0.0325
Entamoeba histolytica	Ran family GTPase	0.0021	0.0033	0.0339
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0039	0.0157	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0386	0.1846
Brugia malayi	SRC-1	0.0039	0.0157	0.0483
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0021	0.0022
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0032	0.0107	0.0513
Loa Loa (eye worm)	hypothetical protein	0.0051	0.024	0.1148
Schistosoma mansoni	carbonic anhydrase-related	0.0101	0.0588	0.0619
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0072	0.0386	0.0406
Brugia malayi	ecdysteroid receptor	0.0072	0.0386	0.119
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0022	0.0036	0.0038
Brugia malayi	Ets-domain containing protein	0.0073	0.0396	0.1221
Echinococcus granulosus	zinc finger protein	0.0021	0.0029	0.0031
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0039	0.0157	0.0122
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0048	0.0221	0.0232
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0386	0.1846
Trichomonas vaginalis	plasma membrane calcium-transporting ATPase, putative	0.0035	0.0132	0.0727
Echinococcus granulosus	sodium:potassium transporting ATPase subunit	0.0316	0.209	0.2201
Echinococcus granulosus	sodium and chloride dependent glycine	0.0032	0.0107	0.0113
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.0285	0.1873	0.1844
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0037	0.0143	0.015
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0308	0.0475
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0032	0.0107	0.0113
Brugia malayi	hypothetical protein	0.0019	0.0021	0.0064
Echinococcus multilocularis	tar DNA binding protein	0.0065	0.0336	0.0354
Trypanosoma cruzi	calcium motive p-type ATPase, putative	0.0028	0.0083	0.054
Loa Loa (eye worm)	heat shock protein 90	0.0033	0.0119	0.0568
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0034	0.0123	0.0129
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.007	0.0371	0.2507
Echinococcus multilocularis	heat shock protein	0.0033	0.0119	0.0125
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0038	0.015	0.1001
Echinococcus granulosus	sarco:endoplasmic reticulum calcium ATPase	0.0035	0.0132	0.0139
Brugia malayi	Putative carbonic anhydrase 5 precursor	0.0214	0.1382	0.4259
Loa Loa (eye worm)	hypothetical protein	0.0187	0.1191	0.57
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0038	0.015	1
Brugia malayi	Serotonin receptor	0.0481	0.3245	1
Schistosoma mansoni	sodium/chloride dependent transporter	0.0032	0.0107	0.0113
Mycobacterium ulcerans	esterase/lipase LipP	0.0227	0.1469	0.2501
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0386	0.1846
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0033	0.0202
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0019	0.0021	0.0022
Brugia malayi	Nuclear hormone receptor E75	0.0034	0.0122	0.0375
Trypanosoma brucei	P-type H+-ATPase, putative	0.0022	0.0042	0.0264
Leishmania major	alpha glucosidase II subunit, putative	0.0037	0.0143	0.0763
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0039	0.0157	0.1049
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0072	0.0386	0.0406
Echinococcus multilocularis	calcium transporting atpase	0.0028	0.0083	0.0087
Schistosoma mansoni	intermediate filament proteins	0.0028	0.0084	0.0088
Brugia malayi	haloacid dehalogenase-like hydrolase family protein	0.002	0.0024	0.0075
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0336	0.0354
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0039	0.0157	0.1049
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0073	0.0392	0.0413
Giardia lamblia	Plasma membrane calcium-transporting ATPase 2	0.0035	0.0132	0.2442
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0166	0.1045	0.1101
Schistosoma mansoni	nuclear hormone receptor	0.0034	0.0122	0.0128
Loa Loa (eye worm)	Na,K-ATPase alpha subunit	0.0086	0.0486	0.2327
Onchocerca volvulus		0.0032	0.0107	0.0346
Echinococcus granulosus	regulator of G protein signaling 7	0.0019	0.0021	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0036	0.0172
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0038	0.015	0.0115
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0072	0.0386	0.119
Echinococcus granulosus	regulator of G protein signaling 3	0.0019	0.0021	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0021	0.0099
Loa Loa (eye worm)	SRC-1	0.0039	0.0157	0.0749
Trypanosoma brucei	heat shock protein 90, putative	0.0033	0.0119	0.0785
Trichomonas vaginalis	heat shock protein, putative	0.0027	0.0071	0.033
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0039	0.0157	0.0165
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0034	0.0122	0.0128
Brugia malayi	amine oxidase, flavin-containing family protein	0.0022	0.0036	0.0111
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0166	0.1045	0.3222
Trypanosoma brucei	heat shock protein, putative	0.0033	0.0119	0.0785
Loa Loa (eye worm)	fli-1 protein	0.0222	0.1436	0.6872
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0308	0.0475
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0034	0.0122	0.0581
Toxoplasma gondii	sarco/endoplasmic reticulum Ca2+-ATPase	0.0035	0.0132	0.0687
Plasmodium vivax	calcium-transporting ATPase, putative	0.0035	0.0132	0.0687
Trypanosoma brucei	P-type H+-ATPase, putative	0.0022	0.0042	0.0264
Brugia malayi	Nuclear hormone receptor-like 1	0.0038	0.015	0.0462
Brugia malayi	Probable calcium-transporting ATPase KIAA0703	0.0017	0.0004	0.0011
Trichomonas vaginalis	D-aminoacylase, putative	0.0227	0.1469	0.9469
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0038	0.015	0.2176
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0019	0.0021	0.0099
Plasmodium falciparum	transporter, putative	0.0032	0.0107	0.1405
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0021	0.0022
Brugia malayi	Nuclear hormone receptor-like 1	0.0072	0.0386	0.119
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0033	0.0102
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0072	0.0386	0.119
Loa Loa (eye worm)	gamma-secretase subunit aph-1	0.0247	0.1613	0.7719
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0032	0.0107	0.0513
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0021	0.0033	0.0202
Brugia malayi	beta-lactamase	0.0227	0.1469	0.4526
Mycobacterium tuberculosis	Probable esterase LipL	0.0227	0.1469	0.1438
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0039	0.0157	0.0165
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0072	0.0386	0.0406
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0036	0.0172
Brugia malayi	gamma-secretase subunit aph-1	0.0247	0.1613	0.4973
Echinococcus multilocularis	ecdysone induced protein 78C	0.0072	0.0386	0.0406
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0021	0.0099
Brugia malayi	PXA domain containing protein	0.0019	0.0021	0.0064
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0072	0.0386	0.0406
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0038	0.015	0.0158
Schistosoma mansoni	Na+/K+ transporting ATPase subunit alpha	0.0086	0.0486	0.0512
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0336	0.0354
Schistosoma mansoni	plasma membrane calcium-transporting atpase	0.0028	0.0083	0.0087
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0048	0.0181
Schistosoma mansoni	alpha-glucosidase	0.0143	0.0884	0.0931
Brugia malayi	Bromodomain containing protein	0.004	0.0167	0.0515
Brugia malayi	nuclear hormone receptor	0.0034	0.0122	0.0375
Echinococcus granulosus	hypothetical protein	0.0718	0.4901	0.5161
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0107	0.0513
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0227	0.1469	0.1546
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0266	0.1275
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0588	0.2814
Echinococcus multilocularis	carbonic anhydrase	0.0101	0.0588	0.0619
Echinococcus granulosus	tyrosine kinase	0.0035	0.013	0.0137
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0037	0.0143	0.044
Mycobacterium leprae	PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G)	0.0027	0.0071	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0318	0.152

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 12 nM	Binding affinity against human carbonic anhydrase II (hCA -II)	ChEMBL.	11425561
Ki (binding)	= 12 nM	Binding affinity against human carbonic anhydrase II (hCA -II)	ChEMBL.	11425561
Ki (binding)	= 24 nM	Compound was evaluated for binding affinity against bovine carbonic anhydrase IV (bCA IV)	ChEMBL.	11425561
Ki (binding)	= 24 nM	Compound was evaluated for binding affinity against bovine carbonic anhydrase IV (bCA IV)	ChEMBL.	11425561
Ki (binding)	= 320 nM	Binding affinity against human carbonic anhydrase I (hCA I)	ChEMBL.	11425561
Ki (binding)	= 320 nM	Binding affinity against human carbonic anhydrase I (hCA I)	ChEMBL.	11425561

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL296390

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 74630